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From https://pandas.pydata.org/speed/pandas/#stat_ops.FrameOps.time_op?Cython=0.29.21&Cython=0.29.16&p-op='sum'&p-dtype='int'&p-axis=0&commits=3a043f2d-4c03d07b&x-axis-scale=date
Reproducer:
values = np.random.randn(100000, 4) df = pd.DataFrame(values).astype("int") %timeit df.sum()
increased with a factor 2 to 3 x somewhere the last days.