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# Introduction
rRNADif is a method to measure intragenomic 16S rRNA variability within the desired genome sequence against a chosen set of organisms. The app is calculating ML phylogenetic tree and uses mean/median branch length within set of 16S rRNA as a measure of variability between them
-By default precomputed database of 21000+ fully sequenced bacterial genomes is available for comparison. However, custom database generation is possible (see [documentation](https://pavlohrab.github.io/rRNADif-docs/))
+By default precomputed database of 21000+ fully sequenced bacterial genomes is available for comparison. However, custom database generation is possible (see [documentation](https://pavlohrab.github.io/rRNADif/))
If you want to contribute, please feel free to do so !(:
**Documentation and user guides are available in the [website](https://pavlohrab.github.io/rRNADif/)**
# Analysis Pipeline