diff --git a/src-docs/src/views/call_out/info.js b/src-docs/src/views/call_out/info.js
index 27feb2d164..2afe71e4df 100644
--- a/src-docs/src/views/call_out/info.js
+++ b/src-docs/src/views/call_out/info.js
@@ -9,42 +9,65 @@
  * GitHub history for details.
  */
 
-import React from 'react';
+import React, { useState } from 'react';
 
 import { OuiCallOut, OuiLink, OuiSpacer } from '../../../../src/components';
 
-export default () => (
-  <div>
-    <OuiCallOut
-      title="Check it out, here's a really long title that will wrap within a narrower browser"
-      iconType="search">
-      <p>
-        Here&rsquo;s some stuff that you need to know. We can make this text
-        really long so that, when viewed within a browser that&rsquo;s fairly
-        narrow, it will wrap, too.
-      </p>
-      <p>
-        When possible, its recommended to include links to product{' '}
-        <OuiLink href="https://opensearch.org/docs/latest/">
-          documentation
-        </OuiLink>
-        .
-      </p>
-    </OuiCallOut>
-
-    <OuiSpacer size="m" />
-
-    <OuiCallOut
-      title="Callouts can exist as just a title. Simply omit the child content."
-      iconType="visVisualBuilder"
-    />
-
-    <OuiSpacer size="m" />
-
-    <OuiCallOut
-      size="s"
-      title="This is a small callout for more unintrusive but constant messages."
-      iconType="pin"
-    />
-  </div>
-);
+export default () => {
+  const [isCallOutVisible, setIsCallOutVisible] = useState(true);
+
+  const closeCallOut = () => setIsCallOutVisible(false);
+
+  let callOut;
+
+  if (isCallOutVisible) {
+    callOut = (
+      <OuiCallOut
+        title="Callouts can be dismissed when dismissible is set to true unless the color is danger or warning. "
+        iconType="wrench"
+        dismissible
+        onDismissible={closeCallOut}
+      />
+    );
+  }
+
+  return (
+    <div>
+      <OuiCallOut
+        title="Check it out, here's a really long title that will wrap within a narrower browser"
+        iconType="search">
+        <p>
+          Here&rsquo;s some stuff that you need to know. We can make this text
+          really long so that, when viewed within a browser that&rsquo;s fairly
+          narrow, it will wrap, too.
+        </p>
+        <p>
+          When possible, its recommended to include links to product{' '}
+          <OuiLink href="https://opensearch.org/docs/latest/">
+            documentation
+          </OuiLink>
+          .
+        </p>
+      </OuiCallOut>
+
+      <OuiSpacer size="m" />
+
+      <OuiCallOut
+        title="Callouts can exist as just a title. Simply omit the child content."
+        iconType="visVisualBuilder"
+      />
+
+      <OuiSpacer size="m" />
+
+      {callOut}
+
+      <OuiSpacer size="m" />
+
+      <OuiCallOut
+        size="s"
+        title="This is a small callout for more unintrusive but constant messages."
+        iconType="pin"
+      />
+    </div>
+  );
+};
diff --git a/src/components/call_out/__snapshots__/call_out.test.tsx.snap b/src/components/call_out/__snapshots__/call_out.test.tsx.snap
index 6860aa91bb..89a412f4ca 100644
--- a/src/components/call_out/__snapshots__/call_out.test.tsx.snap
+++ b/src/components/call_out/__snapshots__/call_out.test.tsx.snap
@@ -42,6 +42,92 @@ exports[`OuiCallOut props color warning is rendered 1`] = `
 />
 `;
 
+exports[`OuiCallOut props dismissible close callout after click 1`] = `
+<OuiCallOut
+  dismissible={true}
+  onDismissible={[MockFunction]}
+  title="This is a callout"
+>
+  <div
+    className="ouiCallOut ouiCallOut--primary"
+  >
+    <div
+      className="ouiCallOutHeader"
+    >
+      <span
+        className="ouiCallOutHeader__title"
+      >
+        This is a callout
+      </span>
+    </div>
+    <OuiButtonIcon
+      aria-label="dismissible_icon"
+      className="ouiCallOut__closeIcon"
+      data-test-subj="closeCallOutButton"
+      iconType="cross"
+      onClick={[MockFunction]}
+    >
+      <button
+        aria-label="dismissible_icon"
+        className="ouiButtonIcon ouiButtonIcon--primary ouiButtonIcon--empty ouiButtonIcon--xSmall ouiCallOut__closeIcon"
+        data-test-subj="closeCallOutButton"
+        disabled={false}
+        onClick={[MockFunction]}
+        type="button"
+      >
+        <OuiIcon
+          aria-hidden="true"
+          className="ouiButtonIcon__icon"
+          color="inherit"
+          size="m"
+          type="cross"
+        >
+          <span
+            aria-hidden="true"
+            className="ouiButtonIcon__icon"
+            color="inherit"
+            data-ouiicon-type="cross"
+            size="m"
+          />
+        </OuiIcon>
+      </button>
+    </OuiButtonIcon>
+  </div>
+</OuiCallOut>
+`;
+
+exports[`OuiCallOut props dismissible is not rendered when in danger color 1`] = `
+<div
+  class="ouiCallOut ouiCallOut--danger"
+/>
+`;
+
+exports[`OuiCallOut props dismissible is not rendered when in warning color 1`] = `
+<div
+  class="ouiCallOut ouiCallOut--warning"
+/>
+`;
+
+exports[`OuiCallOut props dismissible is rendered when set to true 1`] = `
+<div
+  class="ouiCallOut ouiCallOut--primary"
+>
+  <button
+    aria-label="dismissible_icon"
+    class="ouiButtonIcon ouiButtonIcon--primary ouiButtonIcon--empty ouiButtonIcon--xSmall ouiCallOut__closeIcon"
+    data-test-subj="closeCallOutButton"
+    type="button"
+  >
+    <span
+      aria-hidden="true"
+      class="ouiButtonIcon__icon"
+      color="inherit"
+      data-ouiicon-type="cross"
+    />
+  </button>
+</div>
+`;
+
 exports[`OuiCallOut props heading h1 is rendered 1`] = `
 <div
   class="ouiCallOut ouiCallOut--primary"
diff --git a/src/components/call_out/_call_out.scss b/src/components/call_out/_call_out.scss
index 626bc27967..117ecaab51 100644
--- a/src/components/call_out/_call_out.scss
+++ b/src/components/call_out/_call_out.scss
@@ -12,6 +12,7 @@
 .ouiCallOut {
   padding: $ouiSize;
   border-left: $ouiSizeXS / 2 solid transparent;
+  position: relative;
 
   &.ouiCallOut--small {
     padding: $ouiSizeS;
@@ -27,6 +28,12 @@
     @include ouiCallOutTitle;
     margin-bottom: 0; // In case it's nested inside OuiText
   }
+
+  .ouiCallOut__closeIcon {
+    position: absolute;
+    right: $ouiSizeS / 2;
+    top: 0;
+  }
 }
 
 // smaller font size for headers in small callout
@@ -47,6 +54,10 @@
     .ouiCallOutHeader__title {
       color: ouiCallOutColor($name, 'foreground');
     }
+
+    .ouiCallOut__closeIcon {
+      fill: ouiCallOutColor($name, 'foreground');
+    }
   }
 }
 
diff --git a/src/components/call_out/call_out.test.tsx b/src/components/call_out/call_out.test.tsx
index 187aab47fd..6f4d9aad9a 100644
--- a/src/components/call_out/call_out.test.tsx
+++ b/src/components/call_out/call_out.test.tsx
@@ -29,10 +29,11 @@
  */
 
 import React from 'react';
-import { render } from 'enzyme';
+import { mount, render } from 'enzyme';
 import { requiredProps } from '../../test/required_props';
 
 import { OuiCallOut, COLORS, HEADINGS } from './call_out';
+import { findTestSubject } from '../../test';
 
 describe('OuiCallOut', () => {
   test('is rendered', () => {
@@ -81,5 +82,43 @@ describe('OuiCallOut', () => {
         });
       });
     });
+
+    describe('dismissible', () => {
+      it('is rendered when set to true', () => {
+        const component = render(<OuiCallOut dismissible={true} />);
+
+        expect(component).toMatchSnapshot();
+      });
+
+      it('is not rendered when in warning color', () => {
+        const component = render(
+          <OuiCallOut dismissible={true} color={'warning'} />
+        );
+
+        expect(component).toMatchSnapshot();
+      });
+
+      it('is not rendered when in danger color', () => {
+        const component = render(
+          <OuiCallOut dismissible={true} color={'danger'} />
+        );
+
+        expect(component).toMatchSnapshot();
+      });
+
+      it('close callout after click', () => {
+        const onDismissible = jest.fn();
+        const component = mount(
+          <OuiCallOut
+            dismissible={true}
+            onDismissible={onDismissible}
+            title="This is a callout"
+          />
+        );
+        expect(component).toMatchSnapshot();
+        findTestSubject(component, 'closeCallOutButton').simulate('click');
+        expect(onDismissible).toBeCalled();
+      });
+    });
   });
 });
diff --git a/src/components/call_out/call_out.tsx b/src/components/call_out/call_out.tsx
index 1c6b57c0ef..24b796e89d 100644
--- a/src/components/call_out/call_out.tsx
+++ b/src/components/call_out/call_out.tsx
@@ -36,6 +36,7 @@ import { CommonProps, keysOf } from '../common';
 import { IconType, OuiIcon } from '../icon';
 
 import { OuiText } from '../text';
+import { OuiButtonIcon } from '../button';
 
 type Color = 'primary' | 'success' | 'warning' | 'danger';
 type Size = 's' | 'm';
@@ -48,6 +49,12 @@ export type OuiCallOutProps = CommonProps &
     color?: Color;
     size?: Size;
     heading?: Heading;
+    dismissible?: boolean;
+    onDismissible?: (
+      event?:
+        | React.KeyboardEvent<HTMLDivElement>
+        | React.MouseEvent<HTMLButtonElement>
+    ) => void;
   };
 
 const colorToClassNameMap: { [color in Color]: string } = {
@@ -75,6 +82,8 @@ export const OuiCallOut = forwardRef<HTMLDivElement, OuiCallOutProps>(
       children,
       className,
       heading,
+      dismissible = false,
+      onDismissible = () => {},
       ...rest
     },
     ref: Ref<HTMLDivElement>
@@ -100,6 +109,19 @@ export const OuiCallOut = forwardRef<HTMLDivElement, OuiCallOutProps>(
       );
     }
 
+    let dismissibleIcon;
+    if (dismissible && color !== 'warning' && color !== 'danger') {
+      dismissibleIcon = (
+        <OuiButtonIcon
+          iconType="cross"
+          onClick={onDismissible}
+          className="ouiCallOut__closeIcon"
+          aria-label="dismissible_icon"
+          data-test-subj="closeCallOutButton"
+        />
+      );
+    }
+
     let optionalChildren;
     if (children && size === 's') {
       optionalChildren = (
@@ -126,10 +148,13 @@ export const OuiCallOut = forwardRef<HTMLDivElement, OuiCallOutProps>(
         </div>
       );
     }
+
     return (
       <div className={classes} ref={ref} {...rest}>
         {header}
 
+        {dismissibleIcon}
+
         {optionalChildren}
       </div>
     );