diff --git a/tox.ini b/tox.ini
index dfacdf3617..5a83c54d8b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -81,7 +81,7 @@ envlist =
 
     ; opentelemetry-instrumentation-flask
     py3{7,8,9,10,11}-test-instrumentation-flask{213,220}
-    pypy3-test-instrumentation-flask
+    pypy3-test-instrumentation-flask{213,220}
 
     ; opentelemetry-instrumentation-urllib
     py3{7,8,9,10,11}-test-instrumentation-urllib
@@ -254,8 +254,8 @@ deps =
   falcon1: falcon ==1.4.1
   falcon2: falcon >=2.0.0,<3.0.0
   falcon3: falcon >=3.0.0,<4.0.0
-  flask213: Flask<=2.1.3
-  flask220: Flask>=2.2.0
+  flask213: Flask ==2.1.3
+  flask220: Flask >=2.2.0
   grpc: pytest-asyncio
   sqlalchemy11: sqlalchemy>=1.1,<1.2
   sqlalchemy14: aiosqlite