From e3c53da55a6ca729c95a64ed5607d3c5cce3a012 Mon Sep 17 00:00:00 2001 From: Constantine Rafikov <2constantine@protonmail.com> Date: Fri, 8 Sep 2023 23:44:12 -0300 Subject: [PATCH] #158. Update studies on age-related changes in gene expression, methylation or protein activity --- .../08-09-2023-update-items-human-mrna.csv | 579 ++++++++++++++++++ .../expression_change_human_mrna/replace.py | 18 +- 2 files changed, 587 insertions(+), 10 deletions(-) create mode 100644 scripts/expression_change_human_mrna/08-09-2023-update-items-human-mrna.csv diff --git a/scripts/expression_change_human_mrna/08-09-2023-update-items-human-mrna.csv b/scripts/expression_change_human_mrna/08-09-2023-update-items-human-mrna.csv new file mode 100644 index 0000000..2e7389e --- /dev/null +++ b/scripts/expression_change_human_mrna/08-09-2023-update-items-human-mrna.csv @@ -0,0 +1,579 @@ +gene_symbol,doi,model_organism,organism_line_id,sex,change_value,p_value,sample,min_age_of_controls,min_age_of_experiment,mean_age_of_controls,mean_age_of_experiment,max_age_of_controls,max_age_of_experiment,age_units,change_type,n_of_controls,n_of_experiment,statistical_method,change_evaluation_by,measurement_method,comment,pmid +GDF11,10.1007/s10522-018-09789-9,fish Nothobranchius guentheri,n/a,all,55.0%,<0.001,serum,n/a,n/a,6,9,n/a,n/a,months,decreased gene expression,3,3,ANOVA,protein,ELISA,"It was found that GDF11 concentration in the sera of 9-month-old fish was considerably lower than that of 6-month-old fish (p<0.001). Similarly, GDF11 concentration in the different tissues including the intestine was significantly reduced in 9-month-old fish, compared with that of 6-month-old fish. For both 6- and 9-month-old fish, GDF11 level was highest in the brain. Broadly speaking, the change pattern of GDF11 levels was basically consistent with that of gdf11 mRNA levels. The only difference was that in the intestine, GDF11 content decreased with age but gdf11 mRNA did not.",n/a +ADIPOQ,10.1007/s10522-013-9428-5,human,n/a,all,48.1%,<0.001,plasma,18,69,23,74,30,81,years,increased gene expression,152,260,Mann-Whitney test,protein,ELISA,n/a,n/a +ADIPOQ,10.1007/s10522-013-9428-5,human,n/a,male,"52,60%",<0.001,plasma,18,69,23,74,30,81,years,increased gene expression,74,128,Mann-Whitney test,protein,ELISA,n/a,n/a +ADIPOQ,10.1007/s10522-013-9428-5,human,n/a,female,"64,40%",<0.001,plasma,18,69,23,74,30,81,years,increased gene expression,78,132,Mann-Whitney test,protein,ELISA,n/a,n/a +IGF1,10.1007/s10522-013-9428-5,human,n/a,male,"47,10%",<0.001,plasma,18,69,23,74,30,81,years,decreased gene expression,74,128,Mann-Whitney test,protein,ELISA,"In old subjects adiponectin, resistin and the resistin/IGF-1 ratio (but not IGF-1 alone) were associated with age-dependent loss of muscle strength.",n/a +IGF1,10.1007/s10522-013-9428-5,human,n/a,female,"47,70%",<0.001,plasma,18,69,23,74,30,81,years,decreased gene expression,78,132,Mann-Whitney test,protein,ELISA,"In old subjects adiponectin, resistin and the resistin/IGF-1 ratio (but not IGF-1 alone) were associated with age-dependent loss of muscle strength.",n/a +LEP,10.1007/s10522-013-9428-5,human,n/a,male,"82,60%",<0.001,plasma,18,69,23,74,30,81,years,increased gene expression,74,128,Mann-Whitney test,protein,ELISA,Age-related changes in plasma leptin level were significant only in men. But leptin level was significantly higher both in young and elderly women compared to men.,n/a +LEP,10.1007/s10522-013-9428-5,human,n/a,female,"9,10%",0.46,plasma,18,69,23,74,30,81,years,increased gene expression,78,132,Mann-Whitney test,protein,ELISA,Age-related changes in plasma leptin level were significant only in men. But leptin level was significantly higher both in young and elderly women compared to men.,n/a +RGN,10.1007/BF00925738,rat,Wistar,male,116.0%,,liver,n/a,n/a,1,3,n/a,n/a,weeks,increased gene expression,5,5,n/a,protein,ELISA,n/a,n/a +RGN,10.1007/BF00925738,rat,Wistar,male,244.0%,,liver,n/a,n/a,1,5,n/a,n/a,weeks,increased gene expression,5,5,n/a,protein,ELISA,n/a,n/a +RGN,10.1007/BF00925738,rat,Wistar,male,27.0%,,liver,n/a,n/a,5,10,n/a,n/a,weeks,decreased gene expression,5,5,n/a,protein,ELISA,n/a,n/a +RGN,10.1007/BF00925738,rat,Wistar,male,50.0%,,liver,n/a,n/a,5,30,n/a,n/a,weeks,decreased gene expression,5,5,n/a,protein,ELISA,n/a,n/a +RGN,10.1007/BF00925738,rat,Wistar,male,210.0%,,kidney,n/a,n/a,1,5,n/a,n/a,weeks,increased gene expression,5,5,n/a,protein,ELISA,n/a,n/a +SIRT6,10.1007/s10517-020-04986-4,human,n/a,all,83.0%,<0.01,saliva,n/a,n/a,63,82,n/a,n/a,years,decreased gene expression,58,64,n/a,protein,ELISA,n/a,n/a +HMGB2,10.1007/s11357-018-0015-1,human,n/a,all,209.0%,,plasma,20,70,20,70,24,84,years,increased gene expression,4,108,Pearson correlation,protein,ELISA,"The data for 20-24 vs. 70-80 years old. Circulating levels of HMGB2 in human plasma were investigated. Control - young donors 20-24 years old (n=4). The old donors were a cohort of 108 people aged 70 to 100 years (n=108). Protein concentrations were measured by the ELISA kit from Lifespan Biosciences (LS-F11643-1). HMGB2 levels increased with age (R2 value=0.0826, Pearson correlation=0.546). Absolute levels of HMGB2 ranged from 0.4 to 7.9 ng/ml.",n/a +HMGB2,10.1007/s11357-018-0015-1,human,n/a,all,292.0%,,plasma,20,90,20,90,24,100,years,increased gene expression,4,108,Pearson correlation,protein,ELISA,"The data for 20-24 vs. 90-100 years old. Circulating levels of HMGB2 in human plasma were investigated. Control - young donors 20-24 years old (n=4). The old donors were a cohort of 108 people aged 70 to 100 years (n=108). Protein concentrations were measured by the ELISA kit from Lifespan Biosciences (LS-F11643-1). HMGB2 levels increased with age (R2 value=0.0826, Pearson correlation=0.546). Absolute levels of HMGB2 ranged from 0.4 to 7.9 ng/ml.",n/a +FOXO1,10.1007/s10522-007-9114-6,rat,F344,male,66.0%,<0.001,kidney,n/a,n/a,6,24,n/a,n/a,months,reduced protein activity,3,3,"ANOVA, Fisher's test",protein,EMSA,The EMSA method was used to compare nuclear FOXO binding activities in kidney nuclear protein from rats. FOXO activity was decreased with age. The caloric restriction protects from age-related FOXO binding activity decreasing.,n/a +FOS,10.1002/jnr.10428,rat,F344,all,32.0%,<0.02,hippocampus,n/a,n/a,3,30,n/a,n/a,months,reduced protein activity,4,4,two-tailed t test,protein,EMSA,"Measurements of AP-1 binding activity by EMSA over time after hyperoxia also showed significant increases in AP-1 DNA binding activity after 24 hr of hyperoxia. When aged animals were also challenged with a hyperoxia insult, there were no significant increases in AP-1 binding activity",n/a +LAIR1,10.1002/eji.200636678,human,n/a,all,30.0%,<0.001,CD4+ T lymphocytes,"0,4",22,n/a,n/a,1,68,years,decreased gene expression,16,25,Mann-Whitney test,protein,flow cytometry,"110 healthy humans of varios age participated in the stuly. The Lair1 gene expression decreases in the CD4 T lymphocytes with age, significant diferences were found between the ages 0 and >20 years. At the same time, these differences were caused by the reduction of the naive T-cells and not by the change in the Lair1 expression in the any of the T-cell subpopulations. The Lair1 expression was consistently higher in the naive T-cells, than in the memory T-cells and do not shows any significant changes with time in the any T-cell subpopulation.",n/a +LAIR1,10.1002/eji.200636678,human,n/a,all,47.0%,0.002,CD8+ T lymphocytes,"0,4",22,n/a,n/a,1,68,years,decreased gene expression,16,25,Mann-Whitney test,protein,flow cytometry,"110 healthy humans of varios age participated in the stuly. The Lair1 gene expression decreases in the CD8 T lymphocytes with age, significant diferences were found between the ages 0 and >20 years. At the same time, these differences were caused by the reduction of the naive T-cells and not by the change in Lair1 expression in the any of the T-cell subpopulations. The Lair1 expression was consistently higher in the naive T-cells, than in the memory T-cells and do not shows any significant changes with time in the any T-cell subpopulation.",n/a +PDGFRA,10.1002/oby.21727,mouse,C57BL/6J,male,30.6%,<0.05,inguinal white adipose tissue,n/a,n/a,4,20,n/a,n/a,months,decreased gene expression,7,7,n/a,number of cells expressing the gene,flow cytometry,Flow cytometry.,n/a +IFNG,10.1006/clim.2000.4894,human,n/a,all,n/a,<0.01,T-cells,n/a,17,n/a,n/a,n/a,62,years,increased gene expression,n/a,50,Spearman coefficient,protein,flow cytometry,The production of IFN-γ in CD8+high T cells is directly correlated with age. 50 individuals were investigated.,n/a +NGB,10.1007/s10072-017-3168-2,mouse,B6CBAF1/J,male,50.0%,<0.05,striatum,n/a,n/a,7,13,n/a,n/a,months,decreased gene expression,4,4,"ANOVA, Tukey's test",protein,immunohistochemistry,n/a,n/a +NGB,10.1007/s10072-017-3168-2,mouse,B6CBAF1/J,female,27.0%,<0.05,striatum,n/a,n/a,7,13,n/a,n/a,months,decreased gene expression,4,4,"ANOVA, Tukey's test",protein,immunohistochemistry,n/a,n/a +NGF,10.1007/s11011-008-9084-7,mouse,ICR,male,166.0%,<0.05,hippocampal CA1 region,n/a,40,8,41,n/a,42,weeks,increased gene expression,5-7,5-7,Dunnett’s test,number of cells expressing the gene,immunohistochemistry,A significant increase in the NGF immunoreactivity was observed in glial cells of the hippocampal CA1 sector from 40-42 to 50-59 weeks of birth.,n/a +NGF,10.1007/s11011-008-9084-7,mouse,ICR,male,71.0%,<0.05,hippocampal CA1 region,n/a,n/a,2,8,n/a,n/a,weeks,increased gene expression,5-7,5-7,Dunnett’s test,number of cells expressing the gene,immunohistochemistry,n/a,n/a +EFEMP1,10.1002/art.39963,mouse,C57BL/6J,all,25.0%,,cartilage,n/a,n/a,4,6,n/a,n/a,months,decreased gene expression,10,10,n/a,number of cells expressing the gene,immunohistochemistry,n/a,n/a +EFEMP1,10.1002/art.39963,mouse,C57BL/6J,all,30.0%,,cartilage,n/a,n/a,4,9,n/a,n/a,months,decreased gene expression,10,10,n/a,number of cells expressing the gene,immunohistochemistry,n/a,n/a +EFEMP1,10.1002/art.39963,mouse,C57BL/6J,all,85.0%,,cartilage,n/a,n/a,4,12,n/a,n/a,months,decreased gene expression,10,7,n/a,number of cells expressing the gene,immunohistochemistry,n/a,n/a +SIRT6,10.1007/s10517-020-04986-4,human,n/a,all,60.6%,<0.01,hippocampus,n/a,n/a,67,81,n/a,n/a,years,decreased gene expression,48,56,n/a,number of cells expressing the gene,immunohistochemistry,n/a,n/a +PCNA,10.1007/s004410050793,rat,F344,male,97.0%,<0.05,liver,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,3,7,n/a,number of cells expressing the gene,immunohistochemistry,n/a,n/a +PCNA,10.1007/s004410050793,rat,F344,male,54.0%,<0.05,liver,n/a,n/a,3,6,n/a,n/a,months,decreased gene expression,3,3,n/a,number of cells expressing the gene,immunohistochemistry,n/a,n/a +NGF,10.1002/nau.21174,rat,Wistar,female,30.0%,ns,epithelial lining of the urethra,n/a,n/a,3,18,n/a,n/a,months,decreased gene expression,12,12,Spearman coefficient,protein,immunohistochemistry,n/a,n/a +NGF,10.1002/nau.21174,rat,Wistar,female,22.0%,ns,muscular lining of the urethra,n/a,n/a,3,18,n/a,n/a,months,decreased gene expression,12,12,Spearman coefficient,protein,immunohistochemistry,n/a,n/a +FLT1,10.1002/ar.a.10103,rat,Sprague Dawley,male,n/a,,brain vessels,n/a,n/a,1,90,n/a,n/a,days,decreased gene expression,n/a,n/a,Student t-test,number of cells expressing the gene,immunohistochemistry,"A time-course analysis showed that both Flt-1 and Flk-1 were highly expressed in the cerebral vessel of rats on 1, 7, and 14 days after birth, and then declined in adults, consistent with the development of angiogenesis in neonates.",n/a +FLT1,10.1002/ar.a.10103,rat,Sprague Dawley,male,87.0%,<0.05,cingulate cortex,n/a,n/a,1,30,n/a,n/a,days,decreased gene expression,n/a,n/a,Student t-test,number of cells expressing the gene,immunohistochemistry,"In the neurons, Flt-1 was highest in the cerebral cortex and hippocampus of rats on 1-14 days after birth (P1-P14), and then gradually decreased. The results of cell counting showed that the number of Flt-1-positive neurons persisted at the same level in the cingulate cortex from P1 (908 ± 320 cells/mm2) to P14 (639 ± 98 cells/mm2), decreased to 109 ± 96 cells/mm2 on P30 (P < 0.05 vs. P1 and P14, respectively), and further declined to a barely detectable level on P90.",n/a +FLT1,10.1002/ar.a.10103,rat,Sprague Dawley,male,67.0%,ns,hippocampus,n/a,n/a,7,90,n/a,n/a,days,decreased gene expression,n/a,n/a,Student t-test,number of cells expressing the gene,immunohistochemistry,"Flt-1- and Flk-1-positive cells in the hippocampus were counted, and the results showed that Flt-1-positive staining was highest on P7 (107 ± 16 cells/ mm2) and gradually decreased from 90 ± 6 cells/mm2 to 35 ± 0 cells/mm2 on P14–P90, respectively.",n/a +KDR,10.1002/ar.a.10103,rat,Sprague Dawley,male,n/a,,brain vessels,n/a,n/a,1,90,n/a,n/a,days,decreased gene expression,n/a,n/a,Student t-test,number of cells expressing the gene,immunohistochemistry,"A time-course analysis showed that both Flt-1 and Flk-1 were highly expressed in the cerebral vessel of rats on 1, 7, and 14 days after birth, and then declined in adults, consistent with the development of angiogenesis in neonates.",n/a +KDR,10.1002/ar.a.10103,rat,Sprague Dawley,male,123.0%,<0.05,cingulate cortex,n/a,n/a,1,30,n/a,n/a,days,increased gene expression,n/a,n/a,Student t-test,number of cells expressing the gene,immunohistochemistry,"In the neurons Flk-1 abruptly increased and reached its highest level in adults. For the Flk-1 receptor, the amount of positive cells did not significantly change in the cingulate cortex of rats from 1 (729 ± 492 cells/mm2) to 14 (625 ± 270 cells/mm2) days after birth. However, it significantly increased to 1,631 ± 480 per mm2 on day 30 (P < 0.05 vs. P1 and P14, respectively; Fig. 2), and further increased to 2,276 ± 210 cells/mm2 on day 90 (P < 0.05 vs. P30).",n/a +KDR,10.1002/ar.a.10103,rat,Sprague Dawley,male,40.0%,<0.05,cingulate cortex,n/a,n/a,30,90,n/a,n/a,days,increased gene expression,n/a,n/a,Student t-test,number of cells expressing the gene,immunohistochemistry,"In the neurons Flk-1 abruptly increased and reached its highest level in adults. For the Flk-1 receptor, the amount of positive cells did not significantly change in the cingulate cortex of rats from 1 (729 ± 492 cells/mm2) to 14 (625 ± 270 cells/mm2) days after birth. However, it significantly increased to 1,631 ± 480 per mm2 on day 30 (P < 0.05 vs. P1 and P14, respectively; Fig. 2), and further increased to 2,276 ± 210 cells/mm2 on day 90 (P < 0.05 vs. P30).",n/a +KDR,10.1002/ar.a.10103,rat,Sprague Dawley,male,813.0%,ns,hippocampus,n/a,n/a,1,30,n/a,n/a,days,increased gene expression,n/a,n/a,Student t-test,number of cells expressing the gene,immunohistochemistry,"Flk-1-positive cells in the hippocampus progressively increased from 1 (15 ± 5 cells/mm2) to 30 (137 ± 6 cells/mm2) days after birth, and abruptly increased to a very high level on day 90 (1,800 ± 30 cells/mm2).",n/a +KDR,10.1002/ar.a.10103,rat,Sprague Dawley,male,1213.0%,<0.05,hippocampus,n/a,n/a,30,90,n/a,n/a,days,increased gene expression,n/a,n/a,Student t-test,number of cells expressing the gene,immunohistochemistry,"Flk-1-positive cells in the hippocampus progressively increased from 1 (15 ± 5 cells/mm2) to 30 (137 ± 6 cells/mm2) days after birth, and abruptly increased to a very high level on day 90 (1,800 ± 30 cells/mm2).",n/a +HMGB2,10.1002/dvdy.24559,mouse,C57BL/6N,all,77.6%,<0.05,"brain, hippocampus dentate gyrus",n/a,n/a,2,4,n/a,n/a,months,decreased gene expression,4,4,Student t-test,number of cells expressing the gene,immunohistochemistry,"The brain (hippocampus dentate gyrus) was removed from WT mice aged 2 months (n=4) and 6 months (n=4). Immunohistochemistry, rabbit anti-HMGB2 (1:500; abcam, ab67282). Pvalue ＜ 0.05.",n/a +PTGS2,10.1007/s00210-007-0153-y,rat,Sprague Dawley,male,470.0%,<0.05,aorta,n/a,n/a,8,54,n/a,n/a,weeks,increased gene expression,3,3,Student t-test,number of cells expressing the gene,immunohistochemistry,Immunohistochemistry. P<0.05.,n/a +PTGS2,10.1007/s00210-007-0153-y,rat,Sprague Dawley,male,143.0%,<0.05,cremaster muscle arterioles,n/a,n/a,8,54,n/a,n/a,weeks,increased gene expression,3,3,Student t-test,number of cells expressing the gene,immunohistochemistry,Immunohistochemistry. P<0.05.,n/a +HOXB7,10.1002/stem.1897,mouse,FVB/N,all,53.0%,<0.05,bone epiphyseal part,n/a,n/a,11,90,n/a,n/a,days,decreased gene expression,3,3,two-tailed t-test,mRNA,immunohistochemistry,n/a,n/a +HOXB7,10.1002/stem.1897,mouse,FVB/N,all,65.5%,<0.05,bone epiphyseal part,n/a,n/a,11,180,n/a,n/a,days,decreased gene expression,3,3,two-tailed t-test,mRNA,immunohistochemistry,n/a,n/a +HOXB7,10.1002/stem.1897,mouse,FVB/N,all,86.0%,<0.05,bone metaphyseal part,n/a,n/a,11,90,n/a,n/a,days,decreased gene expression,3,3,two-tailed t-test,mRNA,immunohistochemistry,n/a,n/a +HOXB7,10.1002/stem.1897,mouse,FVB/N,all,93.0%,<0.05,bone metaphyseal part,n/a,n/a,11,180,n/a,n/a,days,decreased gene expression,3,3,two-tailed t-test,mRNA,immunohistochemistry,n/a,n/a +HOXB7,10.1002/stem.1897,mouse,FVB/N,all,87.0%,<0.05,bone diaphyseal part,n/a,n/a,11,90,n/a,n/a,days,decreased gene expression,3,3,two-tailed t-test,mRNA,immunohistochemistry,n/a,n/a +HOXB7,10.1002/stem.1897,mouse,FVB/N,all,95.0%,<0.05,bone diaphyseal part,n/a,n/a,11,180,n/a,n/a,days,decreased gene expression,3,3,two-tailed t-test,mRNA,immunohistochemistry,n/a,n/a +COL4A1,10.1016/S0378-5122(96)01066-3,human,n/a,female,35.0%,,skin,n/a,n/a,36.62,40.83,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A1,10.1016/S0378-5122(96)01066-3,human,n/a,female,57.0%,,skin,n/a,n/a,36.62,46.67,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A1,10.1016/S0378-5122(96)01066-3,human,n/a,female,71.0%,,skin,n/a,n/a,36.62,51.5,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A1,10.1016/S0378-5122(96)01066-3,human,n/a,female,81.0%,,skin,n/a,n/a,36.62,56.8,n/a,n/a,years,decreased gene expression,8,5,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A1,10.1016/S0378-5122(96)01066-3,human,n/a,female,87.0%,,skin,n/a,n/a,36.62,61.25,n/a,n/a,years,decreased gene expression,8,4,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A2,10.1016/S0378-5122(96)01066-3,human,n/a,female,35.0%,,skin,n/a,n/a,36.62,40.83,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A2,10.1016/S0378-5122(96)01066-3,human,n/a,female,57.0%,,skin,n/a,n/a,36.62,46.67,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A2,10.1016/S0378-5122(96)01066-3,human,n/a,female,71.0%,,skin,n/a,n/a,36.62,51.5,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A2,10.1016/S0378-5122(96)01066-3,human,n/a,female,81.0%,,skin,n/a,n/a,36.62,56.8,n/a,n/a,years,decreased gene expression,8,5,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A2,10.1016/S0378-5122(96)01066-3,human,n/a,female,87.0%,,skin,n/a,n/a,36.62,61.25,n/a,n/a,years,decreased gene expression,8,4,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A3,10.1016/S0378-5122(96)01066-3,human,n/a,female,35.0%,,skin,n/a,n/a,36.62,40.83,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A3,10.1016/S0378-5122(96)01066-3,human,n/a,female,57.0%,,skin,n/a,n/a,36.62,46.67,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A3,10.1016/S0378-5122(96)01066-3,human,n/a,female,71.0%,,skin,n/a,n/a,36.62,51.5,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A3,10.1016/S0378-5122(96)01066-3,human,n/a,female,81.0%,,skin,n/a,n/a,36.62,56.8,n/a,n/a,years,decreased gene expression,8,5,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A3,10.1016/S0378-5122(96)01066-3,human,n/a,female,87.0%,,skin,n/a,n/a,36.62,61.25,n/a,n/a,years,decreased gene expression,8,4,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A4,10.1016/S0378-5122(96)01066-3,human,n/a,female,35.0%,,skin,n/a,n/a,36.62,40.83,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A4,10.1016/S0378-5122(96)01066-3,human,n/a,female,57.0%,,skin,n/a,n/a,36.62,46.67,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A4,10.1016/S0378-5122(96)01066-3,human,n/a,female,71.0%,,skin,n/a,n/a,36.62,51.5,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A4,10.1016/S0378-5122(96)01066-3,human,n/a,female,81.0%,,skin,n/a,n/a,36.62,56.8,n/a,n/a,years,decreased gene expression,8,5,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A4,10.1016/S0378-5122(96)01066-3,human,n/a,female,87.0%,,skin,n/a,n/a,36.62,61.25,n/a,n/a,years,decreased gene expression,8,4,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A5,10.1016/S0378-5122(96)01066-3,human,n/a,female,35.0%,,skin,n/a,n/a,36.62,40.83,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A5,10.1016/S0378-5122(96)01066-3,human,n/a,female,57.0%,,skin,n/a,n/a,36.62,46.67,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A5,10.1016/S0378-5122(96)01066-3,human,n/a,female,71.0%,,skin,n/a,n/a,36.62,51.5,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A5,10.1016/S0378-5122(96)01066-3,human,n/a,female,81.0%,,skin,n/a,n/a,36.62,56.8,n/a,n/a,years,decreased gene expression,8,5,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A5,10.1016/S0378-5122(96)01066-3,human,n/a,female,87.0%,,skin,n/a,n/a,36.62,61.25,n/a,n/a,years,decreased gene expression,8,4,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A6,10.1016/S0378-5122(96)01066-3,human,n/a,female,35.0%,,skin,n/a,n/a,36.62,40.83,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A6,10.1016/S0378-5122(96)01066-3,human,n/a,female,57.0%,,skin,n/a,n/a,36.62,46.67,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A6,10.1016/S0378-5122(96)01066-3,human,n/a,female,71.0%,,skin,n/a,n/a,36.62,51.5,n/a,n/a,years,decreased gene expression,8,6,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A6,10.1016/S0378-5122(96)01066-3,human,n/a,female,81.0%,,skin,n/a,n/a,36.62,56.8,n/a,n/a,years,decreased gene expression,8,5,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +COL4A6,10.1016/S0378-5122(96)01066-3,human,n/a,female,87.0%,,skin,n/a,n/a,36.62,61.25,n/a,n/a,years,decreased gene expression,8,4,n/a,protein,immunostaining,The type IV Collagen level in the skin basal membrane was determined by immunostaining. Probably the antibody used was of the broad specificity and interacted with different Collagen IV subtypes.,n/a +LOX,10.1007/BF03323883,rat,Wistar,male,41.0%,,skin,n/a,n/a,1,18,n/a,n/a,days,increased protein activity,n/a,n/a,n/a,n/a,lysyl oxidase assay,"The PBS soluble lysyl oxidase, representing the amount of newly synthesized enzyme, showed uniformly low rates of activity at all ages examined. By contrast, the activity of the 8 M urea extracted lysyl oxidase, i.e. the substrate-bound enzyme, appeared to be differently modulated during the variousstages oflife: a progressive increase during the period of growth, reaching a maximum at 60 d, was followed by a lowersteady state in the adult and old animals.",n/a +LOX,10.1007/BF03323883,rat,Wistar,male,186.0%,,skin,n/a,n/a,1,60,n/a,n/a,days,increased protein activity,n/a,n/a,n/a,n/a,lysyl oxidase assay,"The PBS soluble lysyl oxidase, representing the amount of newly synthesized enzyme, showed uniformly low rates of activity at all ages examined. By contrast, the activity of the 8 M urea extracted lysyl oxidase, i.e. the substrate-bound enzyme, appeared to be differently modulated during the variousstages oflife: a progressive increase during the period of growth, reaching a maximum at 60 d, was followed by a lowersteady state in the adult and old animals.",n/a +LOX,10.1007/BF03323883,rat,Wistar,male,56.0%,,skin,n/a,n/a,60,240,n/a,n/a,days,reduced protein activity,n/a,n/a,n/a,n/a,lysyl oxidase assay,"The PBS soluble lysyl oxidase, representing the amount of newly synthesized enzyme, showed uniformly low rates of activity at all ages examined. By contrast, the activity of the 8 M urea extracted lysyl oxidase, i.e. the substrate-bound enzyme, appeared to be differently modulated during the variousstages oflife: a progressive increase during the period of growth, reaching a maximum at 60 d, was followed by a lowersteady state in the adult and old animals.",n/a +LOX,10.1007/BF03323883,rat,Wistar,male,54.0%,,skin,n/a,n/a,60,480,n/a,n/a,days,reduced protein activity,n/a,n/a,n/a,n/a,lysyl oxidase assay,"The PBS soluble lysyl oxidase, representing the amount of newly synthesized enzyme, showed uniformly low rates of activity at all ages examined. By contrast, the activity of the 8 M urea extracted lysyl oxidase, i.e. the substrate-bound enzyme, appeared to be differently modulated during the variousstages oflife: a progressive increase during the period of growth, reaching a maximum at 60 d, was followed by a lowersteady state in the adult and old animals.",n/a +LOX,10.1007/BF03323883,rat,Wistar,male,59.0%,,skin,n/a,n/a,60,720,n/a,n/a,days,reduced protein activity,n/a,n/a,n/a,n/a,lysyl oxidase assay,"The PBS soluble lysyl oxidase, representing the amount of newly synthesized enzyme, showed uniformly low rates of activity at all ages examined. By contrast, the activity of the 8 M urea extracted lysyl oxidase, i.e. the substrate-bound enzyme, appeared to be differently modulated during the variousstages oflife: a progressive increase during the period of growth, reaching a maximum at 60 d, was followed by a lowersteady state in the adult and old animals.",n/a +COL3A1,10.1007/s00125-015-3837-8,rat,Wistar,male,67.0%,<0.01,pancreas,n/a,n/a,3,15,n/a,n/a,months,decreased gene methylation,4-10,4-10,Mann-Whitney test,n/a,massArray,Authors found the age-associated decline by 67 percent in the COL3A1 gene promoter methylation in the pancreatic islet.,n/a +BCL6,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.009410906,skin,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,BCL6 is upregulated in aged human skin as revealed by microarray analysis and logistic regression model.,n/a +ERCC5,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.00035677,skin,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,Gene expression of ERCC5 increases with age in human skin.,n/a +FJX1,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.000617105,skin,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,Gene expression of FJX1 increases with age in the abdominal skin. 856 female twins in the age range of 39-85 years were investigated.,n/a +FOLR2,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.00028212,skin,n/a,39,n/a,n/a,n/a,85,years,decreased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,"Using a linear mixed model, differential expression with age was identified in FOLR2 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of female twins.",n/a +GPX4,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.000609809,skin,n/a,39,n/a,n/a,n/a,85,years,decreased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,Gene expression of GPX4 decreases with age.,n/a +MTR,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.000118645,skin,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,"Using a linear mixed model, differential expression with age was identified in MTR in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of female twins. The linear mixed model was used to examine gene expression variability by age.",n/a +NIPBL,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.001537566,skin,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,A linear mixed model was used to examine gene expression variability by age in samples from photoprotected infra-umbilical skin of female twins.,n/a +RET,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.004114123,fat,n/a,39,n/a,n/a,n/a,85,years,decreased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,"Using a linear mixed model, differential expression with age was identified in RET in the adipose tissue. Biopsies were taken from relatively photo-protected infra-umbilical skin of female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age.",n/a +SMOC1,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.002063429,fat,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,Biopsies were taken from relatively photo-protected infra-umbilical skin of female twins. Subcutaneous adipose tissue was dissected from the biopsy site. The linear mixed model was used to examine gene expression variability by age.,n/a +SMOC2,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.00305753,skin,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,Biopsies were taken from relatively photo-protected infra-umbilical skin of female twins. The linear mixed model was used to examine gene expression variability by age.,n/a +TRPV1,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.007947182,skin,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,Differential expression with age was identified in TRPV1 in skin. Biopsies were taken from relatively photo-protected infra-umbilical skin of female twins. The linear mixed model was used to examine gene expression variability by age.,n/a +UCP2,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.000403425,skin,n/a,39,n/a,n/a,n/a,85,years,decreased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,Gene expression of UCP2 decreases with age in а female skin.,n/a +AHSP,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,2.56e-05,skin,n/a,39,n/a,n/a,n/a,85,years,decreased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,Expression of the AHSP gene decreases with age in the skin of the abdomen. A total of 856 female twins at the age from 39 to 85 years old were investigated.,n/a +ELMO1,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.008517023,skin,n/a,39,n/a,n/a,n/a,85,years,decreased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,ELMO1 is downregulated in aged human skin as revealed by microarray analysis and logistic regression model.,n/a +DLK2,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,5.31e-08,skin,n/a,39,n/a,n/a,n/a,85,years,increased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,DLK2 is upregulated in aged human skin as revealed by microarray analysis and logistic regression model.,n/a +BCL6,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,9.15e-06,fat,n/a,39,n/a,n/a,n/a,85,years,decreased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,BCL6 is downregulated in aged human adipose tissue as revealed by microarray analysis and logistic regression model.,n/a +PPM1H,10.1186/gb-2013-14-7-r75,human,n/a,female,n/a,0.007007389,skin,n/a,39,n/a,n/a,n/a,85,years,decreased gene expression,n/a,856,"chi-square, Benjamini-Hochberg correction for multiple testing",mRNA,microarray,"Punch biopsies (8mm) were taken from photoprotected infra-umbilical skin of female twins. A linear mixed model was used to examine gene expression variability by age and confounding factors including as fixed effect batch and RNA concentration (only in skin samples), and as random effects family relationship and zygosity. Information about gene is in additional online files.",n/a +IKBKB,10.1007/s10495-013-0806-x,rhesus monkey,Macaca mulatta,all,125.0%,0.0034,oral mucosa,3,18,n/a,n/a,7,23,years,increased gene expression,5,5,linear regression,mRNA,"microarray, qPCR",n/a,n/a +IKBKB,10.1007/s10495-013-0806-x,rhesus monkey,Macaca mulatta,all,50.0%,0.0034,oral mucosa,3,12,n/a,n/a,7,16,years,increased gene expression,5,8,linear regression,mRNA,"microarray, qPCR",n/a,n/a +COL3A1,10.1007/s00125-015-3837-8,rat,Wistar,male,331.0%,<0.05,pancreas,n/a,n/a,3,15,n/a,n/a,months,increased gene expression,4-10,4-10,n/a,mRNA,"microarray, qPCR",The COL3A1 gene mRNA level in the pancreatic islet was estimated.,n/a +RB1,10.1002/reg2.25,axolotl,Ambystoma mexicanum,n/a,n/a,<0.05,iris,n/a,n/a,7,91,n/a,n/a,days,increased gene expression,n/a,n/a,Student t-test,mRNA,"microarray, qPCR",n/a,n/a +TYMS,10.1002/reg2.25,axolotl,Ambystoma mexicanum,n/a,n/a,<0.05,iris,n/a,n/a,7,90,n/a,n/a,days,decreased gene expression,n/a,n/a,Student t-test,mRNA,"microarray, qPCR",n/a,n/a +NIPSNAP1,10.1002/hipo.20703,mouse,C57BL/6,female,17.0%,<0.025,hippocampus,n/a,n/a,4,18,n/a,n/a,months,decreased gene expression,26,28,two-tailed t test,mRNA,"microarray, qPCR","In aged mice (18 months), NIPSNAP1 estradiol-induced expression was decreased compared to young (4 months) or middle-aged (12 months) mice.",n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,26.0%,<0.05,liver,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,45.0%,<0.05,kidney,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,27.0%,<0.05,lung,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,20.0%,<0.05,blood,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,20.0%,<0.05,liver,n/a,n/a,3,12,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,38.0%,<0.05,kidney,n/a,n/a,3,12,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,26.0%,<0.05,liver,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,45.0%,<0.05,kidney,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,27.0%,<0.05,lung,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,20.0%,<0.05,blood,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,20.0%,<0.05,liver,n/a,n/a,3,12,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,38.0%,<0.05,kidney,n/a,n/a,3,12,n/a,n/a,months,reduced protein activity,n/a,n/a,ANOVA,n/a,n/a,"GCL activity was significantly decreased with increased age in liver, kidney, lung, and red blood cells (RBC). Parallel with the decreased enzyme activity, the protein and mRNA contents of both GCL subunits also changed inversely with age in liver, kidney, and lung, implying a decreased GCL gene expression during aging.",n/a +IL6,10.1007/s11357-011-9244-2,human,n/a,female,67.5%,ns,serum,22,32,n/a,n/a,31,41,years,increased gene expression,30,48,"ANOVA, Bonferroni’s post hoc",protein,n/a,n/a,n/a +IL6,10.1007/s11357-011-9244-2,human,n/a,female,121.0%,<0.05,serum,22,52,n/a,n/a,31,63,years,increased gene expression,30,67,"ANOVA, Bonferroni’s post hoc",protein,n/a,n/a,n/a +MSRA,10.1007/s10522-008-9152-8,rat,Wistar,female,36.0%,0.021,tongue,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,12,10,"ANOVA, Scheffe post hoc test",protein,n/a,n/a,n/a +MSRA,10.1007/s10522-008-9152-8,rat,Wistar,female,23.0%,0.011,esophagus,n/a,n/a,3,24,n/a,n/a,months,reduced protein activity,10,9,"ANOVA, Scheffe post hoc test",protein,n/a,n/a,n/a +PON1,10.1007/s10238-008-0156-0,human,n/a,all,57.0%,<0.001,serum,22,66,n/a,n/a,45,89,years,reduced protein activity,29,32,Kruskal-Wallis test,n/a,n/a,"Serum PON1 activities of elderly subjects were significantly decreased compared with those of the young subjects (p < 0.001). Young group: n=29, 22-45 yrs Elderly group: n=32, 66-89 yrs Plasma PON1 activity was assayed using synthetic paraoxon (diethyl-p-nitrophenyl phosphate) as substrate. PON1 activity was determined by measuring the initial rate of substrate hydrolysis to p-nitrophenol, the absorbance of which was monitored at 412 nm.",n/a +TERT,10.1002/(SICI)1520-6408(1996)18:2<173::AID-DVG10>3.0.CO;2-3,human,n/a,all,100.0%,,skin,n/a,n/a,0,37,n/a,n/a,years,reduced protein activity,n/a,n/a,n/a,protein,n/a,"Telomerase activity was detected in fetal, newborn, and adult testes and ovaries, but not in mature spermatozoa or oocytes. Blastocysts expressed high levels of telomerase activity as did most human somatic tissues at 16-20 weeks of development with the exception of human brain tissue.",n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,18.6%,,hypothalamus,n/a,n/a,2,24,n/a,n/a,months,increased protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,21.2%,,cortex,n/a,n/a,2,24,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,38.1%,,hippocampus,n/a,n/a,2,24,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,26.2%,,liver,n/a,n/a,2,24,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,18.6%,,kidney,n/a,n/a,2,24,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,27.7%,,spleen,n/a,n/a,2,24,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,female,8.65%,,ovary,n/a,n/a,2,24,n/a,n/a,months,increased protein activity,4,4,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,male,27.9%,,testis,n/a,n/a,2,24,n/a,n/a,months,reduced protein activity,4,4,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,83.0%,,hypothalamus,n/a,n/a,2,12,n/a,n/a,months,increased protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,61.0%,,cerebellum,n/a,n/a,2,12,n/a,n/a,months,increased protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,54.0%,,cortex,n/a,n/a,2,12,n/a,n/a,months,increased protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,8.6%,,hippocampus,n/a,n/a,2,12,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,14.0%,,liver,n/a,n/a,2,12,n/a,n/a,months,increased protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,35.0%,,kidney,n/a,n/a,2,12,n/a,n/a,months,increased protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,20.0%,,spleen,n/a,n/a,2,12,n/a,n/a,months,increased protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,female,32.0%,,ovary,n/a,n/a,2,12,n/a,n/a,months,increased protein activity,4,4,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,male,62.0%,,testis,n/a,n/a,2,12,n/a,n/a,months,increased protein activity,4,4,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,12.0%,,hypothalamus,n/a,n/a,2,6,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,15.0%,,cerebellum,n/a,n/a,2,6,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,10.0%,,cortex,n/a,n/a,2,6,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,25.0%,,hippocampus,n/a,n/a,2,6,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,44.0%,,kidney,n/a,n/a,2,6,n/a,n/a,months,increased protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,all,33.0%,,spleen,n/a,n/a,2,6,n/a,n/a,months,reduced protein activity,8,8,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,female,35.0%,,ovary,n/a,n/a,2,6,n/a,n/a,months,reduced protein activity,4,4,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +POLB,10.1007/s11064-011-0694-9,rat,Wistar,male,16.0%,,testis,n/a,n/a,2,6,n/a,n/a,months,reduced protein activity,4,4,n/a,n/a,n/a,Polymerase assays were performed with activated DNA as template. The specific activity of pol b is expressed as nmol of radioactively labeled dCMP incorporated into acid insoluble fraction/mg protein/h multiplied by 4.,n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,195.8%,<0.05,kidney,n/a,n/a,1,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,5.8%,ns,tibia,n/a,n/a,1,6,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,32.7%,<0.05,tibia,n/a,n/a,1,18,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,"62,50%",ns,kidney,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,"121,90%",<0.05,kidney,n/a,n/a,1,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,"50,80%",<0.05,tibia,n/a,n/a,1,6,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,"47,60%",ns,tibia,n/a,n/a,1,18,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,83.0%,ns,quadriceps muscle,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,36.0%,<0.05,quadriceps muscle,n/a,n/a,6,18,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,44.0%,<0.05,thymus,n/a,n/a,1,6,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,100.0%,<0.05,thymus,n/a,n/a,6,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,44%,<0.05,thymus,n/a,n/a,1,6,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,"228,60%",<0.05,thymus,n/a,n/a,6,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,218.0%,<0.05,brain,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,86.0%,<0.05,brain,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,213.0%,<0.05,testis,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,43.0%,<0.05,quadriceps muscle,n/a,n/a,1,18,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,75.0%,<0.05,kidney,n/a,n/a,1,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,107.0%,<0.05,brain,n/a,n/a,1,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,30%,<0.05,quadriceps muscle,n/a,n/a,1,18,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,83%,<0.05,kidney,n/a,n/a,1,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,100%,<0.05,brain,n/a,n/a,1,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,173.0%,<0.05,testis,n/a,n/a,1,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,333.0%,<0.05,ovary,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,500.0%,<0.05,ovary,n/a,n/a,1,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,80.0%,<0.05,tibia,n/a,n/a,1,6,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,48.0%,<0.05,tibia,n/a,n/a,1,18,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,52.0%,<0.05,kidney,n/a,n/a,6,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,84%,<0.05,tibia,n/a,n/a,1,6,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,58%,<0.05,tibia,n/a,n/a,1,18,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +PAPPA,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,female,34%,<0.05,kidney,n/a,n/a,6,18,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,n/a,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +SIRT7,10.3389/fncel.2015.00167,rat,Wistar,female,91.0%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,protein,n/a,n/a,n/a +SIRT7,10.3389/fncel.2015.00167,rat,Wistar,female,145.0%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,protein,n/a,n/a,n/a +MSRA,10.1007/s11357-011-9268-7,rat,Wistar,female,38.0%,<0.05,spleen,n/a,n/a,2,24,n/a,n/a,months,reduced protein activity,15,17,Student t-test,protein,n/a,n/a,n/a +MSRA,10.1007/s11357-011-9268-7,rat,Wistar,female,52.0%,<0.05,liver,n/a,n/a,2,24,n/a,n/a,months,increased protein activity,15,17,Student t-test,protein,n/a,n/a,n/a +KL,10.1007/s11357-011-9315-4,rhesus monkey,Macaca mulatta,all,n/a,<0.05,white matter,"3,8",20,"7,68","24,35",15,"30,2",years,increased gene methylation,7,15,Student t-test,n/a,n/a,"Individual CpG motifs across the region of interest with increased methylation in old animals were identified. In vitro methyl modification of these individual cytosine residues confirmed that methylation of the promoter can decrease gene transcription. These results provide evidence that changes in KL gene expression with age may, at least in part, be the result of epigenetic changes to the 5′ regulatory region.",n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,47.0%,<0.05,whole organism,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,250.0%,<0.05,heart,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,120.0%,<0.05,heart,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,120.0%,<0.05,intestine,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,140.0%,<0.05,intestine,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,90.0%,<0.05,testis,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,210.0%,<0.001,testis,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,52.0%,<0.05,muscle,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT2,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,47.0%,<0.05,muscle,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,93.0%,,whole organism,n/a,n/a,0,5,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,86.0%,,whole organism,n/a,n/a,0,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,64.0%,,whole organism,n/a,n/a,0,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,58.3%,<0.01,brain,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,90.0%,<0.05,heart,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,230.0%,<0.001,heart,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,130.0%,<0.05,testis,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,160.0%,<0.01,testis,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT3,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,70.0%,<0.05,kidney,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,247.0%,,whole organism,n/a,n/a,0,5,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,133.0%,,whole organism,n/a,n/a,0,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,153.0%,,whole organism,n/a,n/a,0,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,220.0%,<0.01,liver,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,190.0%,<0.05,heart,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,83.3%,<0.05,heart,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,1440.0%,<0.05,intestine,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,1550.0%,<0.001,intestine,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,110.0%,<0.01,muscle,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT4,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,140.0%,<0.01,muscle,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,662.5%,,whole organism,n/a,n/a,0,5,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,"Levels of Sirt5a paralog were significantly increased, while levels of Sirt5b were unchanged.",n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,462.5%,,whole organism,n/a,n/a,0,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,"Levels of Sirt5a paralog were significantly increased, while levels of Sirt5b were unchanged.",n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,237.5%,,whole organism,n/a,n/a,0,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,"Levels of Sirt5a paralog were significantly increased, while levels of Sirt5b were unchanged.",n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,66.7%,<0.001,intestine,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5a paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,54.5%,<0.01,intestine,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5a paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,63.0%,<0.01,muscle,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5a paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,67.7%,<0.01,muscle,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5a paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,63.0%,<0.01,testis,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5a paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,44.4%,<0.001,testis,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5a paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,41.2%,<0.05,heart,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5b paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,90.0%,<0.001,muscle,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5b paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,60.0%,<0.05,kidney,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5b paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,54.4%,<0.05,testis,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5b paralog,n/a +SIRT5,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,44.4%,<0.001,testis,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,Sirt5b paralog,n/a +SIRT6,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,180.0%,<0.01,heart,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT6,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,200.0%,<0.01,heart,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT6,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,47.4%,<0.05,intestine,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT6,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,50.0%,<0.01,muscle,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT6,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,54.5%,<0.001,muscle,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,200.0%,,whole organism,n/a,n/a,0,5,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,83.0%,,whole organism,n/a,n/a,0,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,8.3%,,whole organism,n/a,n/a,0,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,100.0%,<0.05,brain,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,80.0%,<0.01,liver,n/a,n/a,5,11,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,100.0%,<0.05,liver,n/a,n/a,5,13,n/a,n/a,weeks,increased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,66.7%,<0.01,intestine,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,67.7%,<0.001,intestine,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,65.5%,<0.05,muscle,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,75.0%,<0.01,muscle,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,67.7%,<0.01,testis,n/a,n/a,5,11,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +SIRT7,10.1016/j.gep.2019.05.001,fish Nothobranchius furzeri,GRZ,male,56.5%,<0.01,testis,n/a,n/a,5,13,n/a,n/a,weeks,decreased gene expression,n/a,qPCR,Student t-test,mRNA,n/a,n/a,n/a +FOXO1,10.1002/jemt.10213,rat,F344/N,male,15.4%,ns,skeletal muscles,n/a,n/a,3,6,n/a,n/a,months,increased gene expression,5,5,ANOVA,mRNA,northern blot,The effect of age on the level of FOXO1 mRNA in the skeletal muscles of rats was investigated (n = 5 in each age group). The level of RNA expression was determined by Northern blot analysis.,n/a +FOXO1,10.1002/jemt.10213,rat,F344/N,male,6.15%,ns,skeletal muscles,n/a,n/a,3,12,n/a,n/a,months,increased gene expression,5,5,ANOVA,mRNA,northern blot,The effect of age on the level of FOXO1 mRNA in the skeletal muscles of rats was investigated (n = 5 in each age group). The level of RNA expression was determined by Northern blot analysis.,n/a +FOXO1,10.1002/jemt.10213,rat,F344/N,male,29.23%,ns,skeletal muscles,n/a,n/a,3,26,n/a,n/a,months,increased gene expression,5,5,ANOVA,mRNA,northern blot,The effect of age on the level of FOXO1 mRNA in the skeletal muscles of rats was investigated (n = 5 in each age group). The level of RNA expression was determined by Northern blot analysis.,n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,62.0%,<0.05,kidney,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,mRNA,northern blot,"The amounts of both GCS subunit mRNAs were significantly decreased with increased age in kidney (62% decrease in GCS-HS mRNA in 24 month old rats, compared with 3 month old rats).",n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,53.0%,<0.05,liver,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,mRNA,northern blot,"Decrease in GCS mRNA content with increased age was found in liver (53% decrease in GCS-HS in 24 month old rats, compared to 3 month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,20.0%,<0.05,kidney,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,mRNA,northern blot,"The amounts of both GCS subunit mRNAs were significantly decreased with increased age in kidney (20 and 60% decrease in GCS-LS mRNA in 12 and 24 month old rats, respectively, compared with 3 month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,60.0%,<0.05,kidney,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,mRNA,northern blot,"The amounts of both GCS subunit mRNAs were significantly decreased with increased age in kidney (20 and 60% decrease in GCS-LS mRNA in 12 and 24 month old rats, respectively, compared with 3 month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,30.0%,<0.05,liver,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,mRNA,northern blot,"Decrease in GCS mRNA content with increased age was found in liver (30 and 48% decrease in GCS-LS in 12 and 24 month old rats, respectively, compared to 3 month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,48.0%,<0.05,liver,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,mRNA,northern blot,"Decrease in GCS mRNA content with increased age was found in liver (30 and 48% decrease in GCS-LS in 12 and 24 month old rats, respectively, compared to 3 month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,33.0%,<0.05,lung,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,mRNA,northern blot,"In lung tissues however, only GCS-LS mRNA content was found to be significantly decreased (33%) in old rats compared to young and adult rats.",n/a +ERCC3,10.1096/fj.14.10.1325,human,n/a,all,64.0%,<0.002,skin fibroblasts,21,63,n/a,n/a,49,69,years,decreased gene expression,6,6,ANOVA with Fisher and Bonferroni/Dunn post hoc analysis,mRNA,northern blot,"The study took primary fibroblasts from human skin. There were three age groups, for the formation of each cells derived from 6 donors: 1 - newborns, 2 - young adults (21–34 years old) and 3 - old people (63–88 years old). In the old adult age group the ERCC3 gene mRNA level was reduced by 64% ± 11% (P",n/a +RET,10.1002/(SICI)1097-4547(19990715)57:2<153::AID-JNR1>3.0.CO;2-A,rat,Sprague Dawley,all,50.0%,<0.05,neurons,2,n/a,n/a,30,3,n/a,months,increased gene expression,9,9,ANOVA with Fisher’s LSD,mRNA,northern blot,c-ret mRNA is upregulated in both motoneurons and primary sensory neurons of aged rats.,n/a +UCP2,10.1006/bbrc.2000.3859,rat,F344/N,male,60.0%,<0.001,brain,n/a,n/a,6,26,n/a,n/a,months,increased gene expression,10,9,"ANOVA, Fisher's test",mRNA,northern blot,n/a,n/a +CDC42,10.1002/jor.20185,horse,wild type,all,7.0%,ns,cartilage,0,"7,5",3.75,11.25,"7,5",15,months,increased gene expression,8,6,"ANOVA, Tukey's test",mRNA,northern blot,"Age groups of horses: prepubescent (0-7,5 month, n=8); pubescent (7,5 to 15 months, n=6); postpubescent (15-24 months, n=6); fully mature (24 months, n=7). Mean age is not specified. The method is Northern blot. p=0.040.",n/a +CDC42,10.1002/jor.20185,horse,wild type,all,6.0%,ns,cartilage,"7,5",15,11.25,21.5,15,24,months,decreased gene expression,6,6,"ANOVA, Tukey's test",mRNA,northern blot,"Age groups of horses: prepubescent (0-7,5 month, n=8); pubescent (7,5 to 15 months, n=6); postpubescent (15-24 months, n=6); fully mature (24 months, n=7). Mean age is not specified. The method is Northern blot. p=0.040.",n/a +CDC42,10.1002/jor.20185,horse,wild type,all,50.0%,0.04,cartilage,"7,5",24,11.25,24,15,n/a,months,decreased gene expression,6,7,"ANOVA, Tukey's test",mRNA,northern blot,"Age groups of horses: prepubescent (0-7,5 month, n=8); pubescent (7,5 to 15 months, n=6); postpubescent (15-24 months, n=6); fully mature (24 months, n=7). Mean age is not specified. The method is Northern blot. p=0.040.",n/a +C1QB,10.1002/(SICI)1098-2396(19990315)31:4<278::AID-SYN5>3.0.CO;2-0,rat,F344,male,50.0%,<0.005,brain,5,24,n/a,n/a,12,30,months,increased gene expression,6,6,linear regression,mRNA,northern blot,"The striatum of male rats was examined for age-related changes in mRNA expressed in astrocytes and microglia in two rat genotypes, which differ by 35% in average and maximum lifespan: F344 and a hybrid with a longer-lived F1 (BN x F344). An increase in C1qb protein expression with age was found in F344 rats, but not in long-lived F1 hybrids (BN x F344). The study was carried out on 6 young and 6 old animals.",n/a +COL4A1,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,85.0%,,kidney,n/a,n/a,11,150,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A1,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,184.0%,,testis,n/a,n/a,60,90,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A1,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,70.0%,,testis,n/a,n/a,60,210,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A2,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,190.0%,,kidney,n/a,n/a,11,150,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A2,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,170.0%,,testis,n/a,n/a,60,90,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A2,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,73.0%,,testis,n/a,n/a,60,210,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A3,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,100.0%,,kidney,n/a,n/a,11,45,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A3,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,17.0%,,kidney,n/a,n/a,11,210,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A3,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,140.0%,,testis,n/a,n/a,60,90,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A3,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,37.0%,,testis,n/a,n/a,60,150,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A3,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,66.0%,,testis,n/a,n/a,60,210,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A4,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,12.0%,,kidney,n/a,n/a,11,60,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A4,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,66.0%,,kidney,n/a,n/a,11,210,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A4,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,179.0%,,testis,n/a,n/a,10,90,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A4,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,21.0%,,testis,n/a,n/a,60,120,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A4,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,12.0%,,testis,n/a,n/a,60,210,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A5,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,10.0%,,kidney,n/a,n/a,11,45,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A5,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,50.0%,,kidney,n/a,n/a,11,90,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A5,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,51.0%,,kidney,n/a,n/a,11,210,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A5,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,80.0%,,testis,n/a,n/a,60,90,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A5,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,58.0%,,testis,n/a,n/a,60,210,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A6,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,88.0%,,kidney,n/a,n/a,11,90,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A6,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,68.0%,,kidney,n/a,n/a,11,150,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A6,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,335.0%,,testis,n/a,n/a,60,90,n/a,n/a,days,increased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +COL4A6,10.1111/j.1523-1755.2005.00668.x,dog,n/a,male,10.0%,,testis,n/a,n/a,60,210,n/a,n/a,days,decreased gene expression,n/a,n/a,n/a,mRNA,northern blot,n/a,n/a +GCLC,10.1002/jcp.20496,rat,F344,male,30.0%,0.01,aorta,n/a,n/a,6,24,n/a,n/a,months,increased gene expression,4,4,Student t-test,mRNA,northern blot,"GCLC mRNA levels were higher in vascular smooth muscle cells from old rats compared to young, a pattern consistent with its protein levels.",n/a +TGM2,10.1007/s00726-016-2295-z,rat,F344,male,229.0%,0.004,heart,n/a,n/a,6,18,n/a,n/a,months,increased protein activity,6,6,"ANOVA, Tukey's test",n/a,protein acivity assay,The transamidation activity of TGM2 was assessed.,27438265 +CSF2,10.1007/s11033-012-2219-2,mouse,C57BL/6,male,1500.0%,<0.05,CD4+ T lymphocytes,n/a,n/a,2,16,n/a,n/a,weeks,increased gene expression,3,3,ANOVA,mRNA,qPCR,"CD4+ T cells were isolated from the spleens of C57BL/6 mice (weeks 2 and 16). Total RNA was obtained from unstimulated CD4+ T cells. In young mice (2 weeks old) a very low level of Csf2 mRNA expression was obtained, while in old mice, a significantly increased level of Csf2 expression was observed — approximately 15 times higher.",n/a +NFKB1,10.1007/s11033-012-2219-2,mouse,C57BL/6,male,446.0%,<0.05,CD4+ T lymphocytes,n/a,n/a,2,16,n/a,n/a,weeks,increased gene expression,3,3,ANOVA,mRNA,qPCR,"Populations of CD4+ T cells from the spleen were obtained. The method is real-time RT-PCR, the data are normalized to the UBC gene and presented as the average of three independent experiments. An extraordinary expression increase was shown - by 5.46 times.",n/a +NFKB2,10.1007/s11033-012-2219-2,mouse,C57BL/6,male,389.5%,<0.05,CD4+ T cells,n/a,n/a,2,16,n/a,n/a,weeks,increased gene expression,3,3,ANOVA,mRNA,qPCR,"Populations of CD4+ T cells from the spleen were obtained. The method is real-time RT-PCR, the data are normalized to the UBC gene and presented as the average of three independent experiments. An extraordinary expression increase was shown — by 4.89 times.",n/a +EGR1,10.1002/hipo.22583,rat,F344,male,55.0%,0.295,hippocampal dentate gyrus,9,24,n/a,n/a,12,32,months,decreased gene expression,3,3,"ANOVA, Bonferroni’s post hoc",mRNA,qPCR,"It was shown an age-related reduction in the transcription of Egr1 in the dentate gyrus following spatial behavior, whereas in the area CA1, Egr1 is reduced at rest, but its transcription can be effectively driven by spatial behavior to levels equivalent to those observed in adult animals. One mechanism possibly contributing to these aging-related changes is an age-associated, CpG site-specific change in methylation in DNA associated with the promoter region of the Egr1 gene. Complex transcriptional and epigenetic changes in the hippocampus significantly contribute to brain and cognitive aging. mRNA was measured by real time RT-PCR .",n/a +HTRA2,10.1007/s11357-012-9406-x,rat,Sprague Dawley,male,300.0%,<0.01,heart,6,20,7,22,8,24,months,increased gene expression,10,10,"ANOVA, Bonferroni’s post hoc",mRNA,qPCR,n/a,n/a +SIRT2,10.1007/s10522-013-9443-6,rat,Wistar,male,50.0%,<0.05,hippocampal dentate gyrus,n/a,n/a,2,22,n/a,n/a,months,decreased gene expression,7,8,"ANOVA, FIsher's test",mRNA,qPCR,n/a,n/a +NGF,10.1007/s11357-012-9495-6,rat,Wistar,all,30.0%,<0.05,cortex,n/a,n/a,6,24,n/a,n/a,months,decreased gene expression,5,5,"ANOVA, FIsher's test",mRNA,qPCR,"ProNGF (larger NGF precursor) was increased during aging in the rat cortex and hippocampus throughout the life span of the rat (6, 12, 18, and 24 months of age). Mature NGF gradually decreased in the cortex, and, in 24-month-old animals, it was 30% lower than that in adult 6-month-old rats. mRNA levels were assessed by RT-PCR and are expressed relative to the level of GAPDH mRNA ± SEM.",n/a +POLD1,10.1007/s11010-012-1432-6,human,n/a,all,12.3%,<0.05,lymphocytes,30,40,36,46,40,50,years,decreased gene expression,36,33,"ANOVA, post hoc test",mRNA,qPCR,RT-PCR.,n/a +POLD1,10.1007/s11010-012-1432-6,human,n/a,all,31.6%,<0.05,lymphocytes,30,50,36,55,40,60,years,decreased gene expression,36,40,"ANOVA, post hoc test",mRNA,qPCR,RT-PCR.,n/a +POLD1,10.1007/s11010-012-1432-6,human,n/a,all,49.0%,<0.001,lymphocytes,30,60,36,64,40,70,years,decreased gene expression,36,35,"ANOVA, post hoc test",mRNA,qPCR,RT-PCR.,n/a +POLD1,10.1007/s11010-012-1432-6,human,n/a,all,75.4%,<0.001,lymphocytes,30,70,36,79,40,n/a,years,decreased gene expression,36,29,"ANOVA, post hoc test",mRNA,qPCR,RT-PCR.,n/a +COL3A1,10.1007/s00223-014-9843-x,mouse,Agouti,female,93.0%,<0.01,bone,8,89,10.4,92.6,12,n/a,weeks,decreased gene expression,3,4,"ANOVA, Tukey's test",mRNA,qPCR,The COL3A1 mRNA level in the femora and tibiae was estimated.,n/a +GDF11,10.1007/s00395-016-0593-y,mouse,C57BL/6,male,40.0%,<0.01,heart,n/a,n/a,3,21,n/a,n/a,months,decreased gene expression,6,6,"ANOVA, Tukey's test",mRNA,qPCR,n/a,n/a +WNT2,10.1002/jcb.22010,human,n/a,all,50.0%,0.088,bone marrow,36,55,42,"69,3",50,85,years,decreased gene expression,9,10,Mann-Whitney test,mRNA,qPCR,n/a,n/a +WNT2B,10.1002/jcb.22010,human,n/a,all,20.0%,0.077,bone marrow,36,55,42,"69,3",50,85,years,decreased gene expression,9,10,Mann-Whitney test,mRNA,qPCR,n/a,n/a +WNT3,10.1002/jcb.22010,human,n/a,all,13.0%,ns,bone marrow,36,55,42,"69,3",50,85,years,decreased gene expression,9,10,Mann-Whitney test,mRNA,qPCR,n/a,n/a +WNT5A,10.1002/jcb.22010,human,n/a,female,15.0%,0.04,bone marrow,37,62,42,"70,4",46,85,years,decreased gene expression,5,7,Mann-Whitney test,mRNA,qPCR,n/a,n/a +WNT5B,10.1002/jcb.22010,human,n/a,all,18.0%,ns,bone marrow,36,55,42,"69,3",50,85,years,increased gene expression,9,10,Mann-Whitney test,mRNA,qPCR,n/a,n/a +WNT6,10.1002/jcb.22010,human,n/a,all,30.0%,ns,bone marrow,36,55,42,"69,3",50,85,years,decreased gene expression,9,10,Mann-Whitney test,mRNA,qPCR,n/a,n/a +WNT7B,10.1002/jcb.22010,human,n/a,all,22.0%,0.011,bone marrow,36,55,42,"69,3",50,85,years,decreased gene expression,9,10,Mann-Whitney test,mRNA,qPCR,n/a,n/a +Wnt9b,10.1002/jcb.22010,human,n/a,all,35.0%,0.02,bone marrow,36,55,42,"69,3",50,85,years,decreased gene expression,9,10,Mann-Whitney test,mRNA,qPCR,n/a,n/a +SIRT2,10.1007/s10522-014-9540-1,rat,Wistar,male,181.0%,0.006,colon,n/a,n/a,3,24,n/a,n/a,months,increased gene expression,6,6,Mann-Whitney test,mRNA,qPCR,n/a,n/a +EEF1A1,10.1007/s11033-015-3866-x,pig,Pietrain and Czech Large White breeds,all,71.0%,,muscle,n/a,n/a,0,n/a,n/a,n/a,days,decreased gene expression,3,3,n/a,mRNA,qPCR,"Expression of eEF1A1 in different tissues of pigs were compared (44-day-old fetuses, and one-, seven- and 14-day-old piglets). Piglets of all three ages had higher values in the muscle and heart tissues compared to adult pigs.In muscle tissue, the highest expression was in the 44-day-old fetuses, and then gradually decreased during postnatal first week. The age of adult pigs is unknown.",n/a +EEF1A1,10.1007/s11033-015-3866-x,pig,Czech Landrace,all,88.2%,,heart,n/a,n/a,1,n/a,n/a,n/a,days,decreased gene expression,3,3,n/a,mRNA,qPCR,"Expression of eEF1A1 in different tissues of pigs were compared (44-day-old fetuses, and one-, seven- and 14-day-old piglets). Piglets of all three ages had higher values in the muscle and heart tissues compared to adult pigs.In muscle tissue, the highest expression was in the 44-day-old fetuses, and then gradually decreased during postnatal first week. The age of adult pigs is unknown.",n/a +LRP2,10.1007/s11357-012-9410-1,rat,BN,male,n/a,<0.05,cortex,6,6,12,28,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,The LRP2 gene expression cannot be detected in 28 month males.,n/a +APC,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +APC,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,45.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +BTRC,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,20.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +BTRC,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +CCN4,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,58.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +CCN4,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +CCND1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,55.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +CCND1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,140.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +CCND2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,9.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +CCND2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,140.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +CCND2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +DIXDC1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +DIXDC1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,72.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +DIXDC1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,68.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +DVL2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,40.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +DVL2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,130.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FRZB,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,140.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FRZB,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,135.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FRZB,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,140.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FZD2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,30.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FZD2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,65.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FZD3,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,70.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FZD3,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,97.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FZD3,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,75.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FZD3,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,80.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FZD8,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,40.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +FZD8,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,64.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +LEF1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,560.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +LEF1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,340.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +LEF1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +LEF1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,95.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +LEF1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,90.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +LEF1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,65.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +MYC,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,108.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +MYC,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,37.0%,,muscle,n/a,n/a,24,36,n/a,n/a,months,reduced protein activity,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +PORCN,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +PORCN,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,60.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +SFRP1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,55.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SFRP1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,140.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SFRP2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,55.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SFRP2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,49.0%,,muscle,n/a,n/a,24,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +TCF3,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,70.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +TCF3,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,35.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +TCF3,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,60.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +TLE1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +WIF1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +WIF1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,60.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Gene expression was measured using the mouse Wnt signaling pathway RT2 Profiler PCR Array (SABiosciences/QIAGEN, PAMM-043E-4) using the manufacturer’s protocols. This array contains primers corresponding to 84 genes related to the Wnt pathway, five housekeeping genes for normalization, and positive and negative controls for the PCR reaction.",n/a +WNT1,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT10A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,60.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT10A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,24.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT10A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,80.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT10A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,1100.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT11,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,40.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain",n/a +WNT11,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,70.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain",n/a +WNT11,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,14.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT11,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,36.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT11,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT11,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,230.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT16,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,20.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,48.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain.",n/a +WNT2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,10.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain.",n/a +WNT2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,58.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,Wnt signaling appeared to decrease with age in the brain.,n/a +WNT2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,70.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle.,n/a +WNT2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,74.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle.,n/a +WNT2,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,12.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,Wnt signaling also decreased with age in the lung.,n/a +WNT2B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,15.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain",n/a +WNT2B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,40.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain",n/a +WNT2B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,15.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,Wnt signaling appeared to decrease with age in the brain,n/a +WNT2B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle,n/a +WNT2B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,35.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle,n/a +WNT2B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,20.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,Wnt signaling also decreased with age in the lung.,n/a +WNT3,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,11.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT3A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,34.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT3A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,35.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT4,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,This study is indicative of a general decrease in Wnt signaling with age in different tissues in mice.,n/a +WNT5A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,28.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain",n/a +WNT5A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,20.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT5A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,60.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle,n/a +WNT5A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,70.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle,n/a +WNT5A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,20.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle,n/a +WNT5B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,9.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain",n/a +WNT5B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,15.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,"Several genes related to Wnt signaling were differentially expressed with age in the liver, although the implications of these changes for Wnt pathway activity are somewhat contradictory and hence remain uncertain.",n/a +WNT5B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,11.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,Wnt signaling appeared to decrease with age in the brain.,n/a +WNT5B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle.,n/a +WNT5B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,30.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,All differentially expressed genes showed decreased expression in skeletal muscle.,n/a +WNT5B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,17.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,Wnt signaling also decreased with age in the lung.,n/a +WNT6,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,10.0%,,liver,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT6,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,1350.0%,,liver,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT6,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,100.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT7A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,5.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT7A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,99.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT7A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,17.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT7B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,34.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,Wnt signaling appeared to decrease with age in the brain,n/a +WNT7B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,90.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT7B,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,50.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT9A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,54.0%,,brain,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT9A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,70.0%,,muscle,n/a,n/a,5,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT9A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,20.0%,,muscle,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +WNT9A,10.1007/s11357-014-9618-3,mouse,C57BL/6J,male,20.0%,,lung,n/a,n/a,5,36,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT2,10.3389/fncel.2015.00167,rat,Wistar,female,715.0%,<0.01,occipital lobe,n/a,n/a,3,12,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT2,10.3389/fncel.2015.00167,rat,Wistar,female,1320.0%,<0.01,occipital lobe,n/a,n/a,3,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT3,10.3389/fncel.2015.00167,rat,Wistar,female,30.8%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT3,10.3389/fncel.2015.00167,rat,Wistar,female,81.0%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT3,10.3389/fncel.2015.00167,rat,Wistar,female,18.0%,<0.01,hippocampus,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT3,10.3389/fncel.2015.00167,rat,Wistar,female,44.0%,<0.01,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT4,10.3389/fncel.2015.00167,rat,Wistar,female,30.8%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT4,10.3389/fncel.2015.00167,rat,Wistar,female,81.2%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT4,10.3389/fncel.2015.00167,rat,Wistar,female,18.4%,<0.01,hippocampus,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT4,10.3389/fncel.2015.00167,rat,Wistar,female,43.9%,<0.01,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT5,10.3389/fncel.2015.00167,rat,Wistar,female,30.9%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT5,10.3389/fncel.2015.00167,rat,Wistar,female,81.0%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT5,10.3389/fncel.2015.00167,rat,Wistar,female,18.3%,<0.01,hippocampus,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT5,10.3389/fncel.2015.00167,rat,Wistar,female,43.8%,<0.01,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,43.4%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,50.7%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,43.4%,<0.01,temporal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,50.7%,<0.01,temporal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,43.3%,<0.01,occipital lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,50.7%,<0.01,occipital lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,43.4%,<0.01,hippocampus,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,50.7%,<0.01,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT7,10.3389/fncel.2015.00167,rat,Wistar,female,236.0%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +SIRT7,10.3389/fncel.2015.00167,rat,Wistar,female,993.0%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,mRNA,qPCR,n/a,n/a +IGFBP5,10.1016/j.exger.2014.04.011,mouse,C57BL/6 x 129,male,112.5%,<0.05,kidney,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,n/a,n/a,Pfaffl method,mRNA,qPCR,"qPCR. Relative quantification, fold change and statistical significance of gene expression were determined by the Pfaffl method using the relative expression software tool (REST) 2009 (QIAGEN Inc., Valencia, CA).",n/a +EFEMP1,10.1002/path.5203,mouse,C57BL/6J,male,250.0%,ns,intestine,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,5,5,Student t-test,mRNA,qPCR,n/a,n/a +EFEMP1,10.1002/path.5203,mouse,C57BL/6J,male,600.0%,<0.05,intestine,n/a,n/a,1,12,n/a,n/a,months,increased gene expression,5,5,Student t-test,mRNA,qPCR,n/a,n/a +EFEMP1,10.1002/path.5203,mouse,C57BL/6J,male,400.0%,<0.05,intestine,n/a,n/a,1,20,n/a,n/a,months,increased gene expression,5,5,Student t-test,mRNA,qPCR,n/a,n/a +WNT7B,10.1002/stem.3192,mouse,C57BL/6,all,96.0%,<0.001,bone,2,n/a,n/a,24,6,n/a,months,decreased gene expression,3,3,Student t-test,mRNA,qPCR,n/a,n/a +CYBB,10.1007/s00395-015-0506-5,mouse,C57BL/6,male,118.0%,<0.05,ventricles,2,24,3,25,4,26,months,increased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +HDAC1,10.1007/s00418-018-1687-4,fish Nothobranchius furzeri,MZM-04/10,male,40.0%,<0.001,brain,n/a,n/a,5,31,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,"Only 1st copy of Hdac1 was downregulated during aging, while expression levels of 2nd copy remained constant.",n/a +HDAC1,10.1007/s00418-018-1687-4,fish Nothobranchius furzeri,MZM-04/10,male,35.0%,<0.01,liver,n/a,n/a,5,31,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,"Only 1st copy of Hdac1 was downregulated during aging, while expression levels of 2nd copy remained constant.",n/a +HDAC1,10.1007/s00418-018-1687-4,fish Nothobranchius furzeri,MZM-04/10,male,41.0%,<0.05,muscle,n/a,n/a,5,31,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,"Only 1st copy of Hdac1 was downregulated during aging, while expression levels of 2nd copy remained constant.",n/a +HDAC3,10.1007/s00418-018-1687-4,fish Nothobranchius furzeri,MZM-04/10,male,43.0%,<0.001,liver,n/a,n/a,5,31,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,n/a,n/a +HDAC3,10.1007/s00418-018-1687-4,fish Nothobranchius furzeri,MZM-04/10,male,49.0%,<0.001,brain,n/a,n/a,5,31,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,n/a,n/a +HDAC3,10.1007/s00418-018-1687-4,fish Nothobranchius furzeri,MZM-04/10,male,42.0%,<0.05,muscle,n/a,n/a,5,31,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,n/a,n/a +HDAC2,10.1007/s00418-018-1687-4,mouse,C57BL/6J × 129/Sv,all,82.0%,<0.01,brain,n/a,n/a,0,8,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,n/a,n/a +HDAC2,10.1007/s00418-018-1687-4,mouse,C57BL/6J × 129/Sv,all,73.0%,<0.05,brain,n/a,n/a,8,104,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,n/a,n/a +HDAC3,10.1007/s00418-018-1687-4,mouse,C57BL/6J × 129/Sv,all,60.0%,<0.05,brain,n/a,n/a,0,8,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,n/a,n/a +HDAC3,10.1007/s00418-018-1687-4,mouse,C57BL/6J × 129/Sv,all,80.0%,<0.01,brain,n/a,n/a,8,104,n/a,n/a,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,n/a,n/a +ACOX1,10.1007/s10072-013-1509-3,rat,Sprague Dawley,male,25.0%,<0.01,liver,n/a,n/a,3,22,n/a,n/a,months,decreased gene expression,5,5,Student t-test,mRNA,qPCR,RT-PCR.,n/a +WNT1,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,50.0%,ns,bone,n/a,n/a,1.5,6,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT1,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,75.0%,<0.005,bone,n/a,n/a,1.5,18,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT10B,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,95.0%,<0.005,bone,n/a,n/a,1.5,6,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT10B,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,75.0%,<0.05,bone,n/a,n/a,1.5,18,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT3A,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,83.0%,<0.05,bone,n/a,n/a,1.5,6,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT3A,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,75.0%,ns,bone,n/a,n/a,1.5,18,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT5B,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,75.0%,<0.05,bone,n/a,n/a,1.5,6,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT5B,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,64.0%,<0.05,bone,n/a,n/a,1.5,18,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT7B,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,60.0%,ns,bone,n/a,n/a,1.5,6,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +WNT7B,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,80.0%,<0.05,bone,n/a,n/a,1.5,18,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +Wnt9b,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,50.0%,ns,bone,n/a,n/a,1.5,6,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +Wnt9b,10.1007/s11357-008-9069-9,mouse,C57BL/6J,male,63.0%,<0.01,bone,n/a,n/a,1.5,18,n/a,n/a,months,decreased gene expression,6,6,Student t-test,mRNA,qPCR,n/a,n/a +NGF,10.1007/s11357-011-9262-0,rat,Sprague Dawley,male,60.0%,ns,left ventricle,6,80,7,88,8,96,weeks,increased gene expression,3,3,Student t-test,mRNA,qPCR,"In both ventricles, a significant decrease in NGF expression from neonatal to young rats and a significant increase from young to old rats was observed.",n/a +NGF,10.1007/s11357-011-9262-0,rat,Sprague Dawley,male,52.0%,ns,left ventricle,"0,4",6,0.5,7,"0,6",8,weeks,decreased gene expression,3,3,Student t-test,mRNA,qPCR,"In both ventricles, a significant decrease in NGF expression from neonatal to young rats and a significant increase from young to old rats was observed.",n/a +MSRA,10.1007/s11357-011-9268-7,rat,Wistar,female,282.0%,<0.05,spleen,n/a,n/a,2,24,n/a,n/a,months,increased gene expression,15,17,Student t-test,mRNA,qPCR,n/a,n/a +MMP12,10.1002/phy2.90,rat,F344,male,490.0%,<0.05,kidney,n/a,n/a,4,24,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,The age-related enhancement of the MMP12 gene expression was absent in the calorie-restricted animals.,n/a +MMP14,10.1002/phy2.90,rat,F344,male,358.0%,<0.05,kidney,n/a,n/a,4,24,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,The age-related enhancement of the MMP14 gene expression was absent in the calorie-restricted animals.,n/a +MMP16,10.1002/phy2.90,rat,F344,male,767.0%,<0.05,kidney,n/a,n/a,4,24,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,The age-related enhancement of the MMP16 gene expression was absent in the calorie-restricted animals.,n/a +MMP17,10.1002/phy2.90,rat,F344,male,89.0%,<0.05,kidney,n/a,n/a,4,24,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,n/a,n/a +MMP20,10.1002/phy2.90,rat,F344,male,789.0%,<0.05,kidney,n/a,n/a,4,24,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,The age-related enhancement of the MMP20 gene expression was absent in the calorie-restricted animals.,n/a +MMP25,10.1002/phy2.90,rat,F344,male,740.0%,<0.05,kidney,n/a,n/a,4,24,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,The age-related enhancement of the MMP14 gene expression was partially prevented by calorie restriction.,n/a +MMP7,10.1002/phy2.90,rat,F344,male,1329.0%,<0.05,kidney,n/a,n/a,4,16,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,n/a,n/a +MMP7,10.1002/phy2.90,rat,F344,male,4471.0%,<0.05,kidney,n/a,n/a,4,18,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,n/a,n/a +MMP7,10.1002/phy2.90,rat,F344,male,11812.0%,<0.05,kidney,n/a,n/a,4,20,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,n/a,n/a +MMP7,10.1002/phy2.90,rat,F344,male,16223.0%,<0.05,kidney,n/a,n/a,4,22,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,n/a,n/a +MMP7,10.1002/phy2.90,rat,F344,male,56959.0%,<0.05,kidney,n/a,n/a,4,24,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,The age-related enhancement of the MMP7 gene expression was absent in the calorie-restricted animals.,n/a +MMP9,10.1002/phy2.90,rat,F344,male,233.0%,<0.05,kidney,n/a,n/a,4,24,n/a,n/a,months,increased gene expression,n/a,n/a,two-tailed t-test,mRNA,qPCR,The age-related enhancement of the MMP9 gene expression was absent in the calorie-restricted animals.,n/a +AKT1S1,10.1002/cbf.3539,mouse,C57BL/6,female,47.04%,<0.01,cortical femur,n/a,n/a,6,24,n/a,n/a,months,decreased gene expression,3,3,two-tailed independent-sample t test,mRNA,qPCR,RNA was isolated from the cortical part of the mouse femur. The number of animals in each group (6 months versus 24 months) is unclear. For gene AKT1S1 showed a decrease in expression in the older group.,n/a +SOD1,10.1002/jcp.1041650316,human,n/a,all,142.0%,0.024,skin fibroblasts,"0,25",17,0,25,"0,42",33,years,increased protein activity,8,10,ANOVA,protein,SOD activity,"SOD-1 activity was both observed to be significantly higher in cell lines derived from from postnatal skin (ages 17-94 years), than in lines established fetal skin . Human skin fibroblast cultures established from skin samples obtained from fetal (12-20 week gestational age), young (17-33 years), and old donors (78-94 years) were obtained from the National Institute on Aging cell .",n/a +SOD1,10.1002/jcp.1041650316,human,n/a,all,230.0%,0.0009,skin fibroblasts,"0,25",78,0,86,"0,42",94,years,increased protein activity,8,11,ANOVA,protein,SOD activity,"CuZn-SOD activity is decreased in centenarians, probably because of reduced demand for the enzyme at lower metabolic rate and oxygen consumption. 41 centenarians aged between 100 and 105 years and 52 community control subjects aged between 60 and 79 years were investigated.",n/a +TOP1,10.1002/cne.20793,mouse,CD-1,male,34.0%,,cerebellum,n/a,n/a,1,12,n/a,n/a,months,reduced protein activity,5,5,n/a,protein,TOPO I assay,The unwinding of supercoiled DNA was used as a measure of protein activity.,n/a +TOP1,10.1002/cne.20793,mouse,CD-1,male,80.0%,,cortex,n/a,n/a,1,12,n/a,n/a,months,reduced protein activity,5,5,n/a,protein,TOPO I assay,The unwinding of supercoiled DNA was used as a measure of protein activity.,n/a +TOP1,10.1002/cne.20793,mouse,CD-1,male,27.0%,,hippocampus,n/a,n/a,1,12,n/a,n/a,months,reduced protein activity,5,5,n/a,protein,TOPO I assay,The unwinding of supercoiled DNA was used as a measure of protein activity.,n/a +TOP1,10.1002/cne.20793,mouse,CD-1,male,474.0%,,hypothalamus,n/a,n/a,1,12,n/a,n/a,months,increased protein activity,5,5,n/a,protein,TOPO I assay,The unwinding of supercoiled DNA was used as a measure of protein activity.,n/a +TOP1,10.1002/cne.20793,mouse,CD-1,male,41.0%,,striatum,n/a,n/a,1,12,n/a,n/a,months,reduced protein activity,5,5,n/a,protein,TOPO I assay,The unwinding of supercoiled DNA was used as a measure of protein activity.,n/a +TOP1,10.1002/cne.20793,mouse,CD-1,female,96.0%,,hippocampus,n/a,n/a,1,12,n/a,n/a,months,reduced protein activity,5,5,n/a,protein,TOPO I assay,The unwinding of supercoiled DNA was used as a measure of protein activity.,n/a +TOP1,10.1002/cne.20793,mouse,CD-1,female,43.0%,,hypothalamus,n/a,n/a,1,12,n/a,n/a,months,increased protein activity,5,5,n/a,protein,TOPO I assay,The unwinding of supercoiled DNA was used as a measure of protein activity.,n/a +GCLM,10.1002/jnr.10217,rat,F344,male,55.0%,<0.05,cerebellum,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,5,5,ANOVA,protein,western blot,"The expression of the regulatory subunit of gamma-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in de novo GSH synthesis, decreases with age in cerebellum, cerebral cortex, and hippocampus of Fisher 344 rats. This was accompanied by a decline in GCS activity and GSH content. The results showed that there was no significant difference among the three age groups in the amount of GCS catalytic subunit in hippocampus, cerebral cortex, or cerebellum.",n/a +GCLM,10.1002/jnr.10217,rat,F344,male,63.0%,<0.05,cortex,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,5,5,ANOVA,protein,western blot,n/a,n/a +GCLM,10.1002/jnr.10217,rat,F344,male,25.0%,<0.05,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,5,5,ANOVA,protein,western blot,n/a,n/a +CYC1,10.1006/jmcc.2000.1273,rat,F344,all,50.0%,ns,heart,n/a,n/a,6,24,n/a,n/a,months,reduced protein activity,6,6,ANOVA,protein,western blot,"Complex III activity measured in interfibrillar population of cardiac mitochondria (IFM), from aging hearts was decreased by 49% compared to IFM from adults. The study was carried on 6 adults (6 months) and 6 old (24 months) animals.",n/a +BAD,10.1007/s11064-011-0558-3,rat,Sprague Dawley,male,89.0%,<0.05,substantia nigra,4,24,n/a,n/a,5,n/a,months,increased gene expression,8,6,ANOVA,protein,western blot,"Old rats were >=24 months, samples —substantia nigra compacta",n/a +KL,10.1007/s11357-010-9176-2,rat,F344,male,40.0%,<0.05,renal medulla,n/a,n/a,10,27,n/a,n/a,months,decreased gene expression,10,11,ANOVA,protein,western blot,Gene expression in young and old rats without cognitive impairment. Gene expression changes were more pronounced in aged rats with cognitive impairments.,n/a +KL,10.1007/s11357-010-9176-2,rat,F344,male,30.0%,<0.05,renal cortex,n/a,n/a,10,27,n/a,n/a,months,decreased gene expression,10,11,ANOVA,protein,western blot,Gene expression in young and old rats without cognitive impairment. Gene expression changes were more pronounced in aged rats with cognitive impairments.,n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,74.0%,<0.05,kidney,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,protein,western blot,"The amounts of both GCS subunit proteins were significantly decreased with increased age in kidney (66 and 74% decrease in GCS-HS in 12- and 24-month old rats respectively, compared to 3-month old rats),",n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,31.0%,<0.05,liver,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,protein,western blot,The amounts of both GCS subunit proteins were significantly decreased with increased age in liver (31% decrease in GCS-HS in 24-month old rats compared to 3-month old rats).,n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,31.0%,<0.05,lung,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,protein,western blot,The amounts of both GCS subunit proteins were significantly decreased with increased age in lung (31% decrease in GCS-HS in 24 month old rats compared with 3 month old rats).,n/a +GCLC,10.1016/s0891-5849(99)00269-5,rat,F344,all,66.0%,<0.05,kidney,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,protein,western blot,"The amounts of both GCS subunit proteins were significantly decreased with increased age in kidney (66 and 74% decrease in GCS-HS in 12- and 24-month old rats respectively, compared to 3-month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,72.0%,<0.05,kidney,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,protein,western blot,"The amounts of both GCS subunit proteins were significantly decreased with increased age in kidney (85 and 72% decrease in GCS-LS, in 12- and 24-month old rats, respectively, compared to 3-month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,69.0%,<0.05,liver,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,protein,western blot,The amounts of both GCS subunit proteins were significantly decreased with increased age in liver (69% decrease in GCS-LS in 24-month old rats compared to 3-month old rats).,n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,69.0%,<0.05,lung,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,protein,western blot,"The amounts of both GCS subunit proteins were significantly decreased with increased age in lung (27 and 69% decrease in GCS-LS in 12- and 24- month old rats, respectively, compared with 3 month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,85.0%,<0.05,kidney,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,ANOVA,protein,western blot,"The amounts of both GCS subunit proteins were significantly decreased with increased age in kidney (85 and 72% decrease in GCS-LS, in 12- and 24-month old rats, respectively, compared to 3-month old rats).",n/a +GCLM,10.1016/s0891-5849(99)00269-5,rat,F344,all,27.0%,<0.05,lung,n/a,n/a,3,12,n/a,n/a,months,increased gene expression,n/a,n/a,ANOVA,protein,western blot,"The amounts of both GCS subunit proteins were significantly decreased with increased age in lung (27 and 69% decrease in GCS-LS in 12- and 24- month old rats, respectively, compared with 3 month old rats).",n/a +HSPD1,10.1007/s10522-005-4906-z,rat,Sprague Dawley,male,35.0%,0.007,left ventricle,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,"ANOVA, Fisher's test",protein,western blot,Two different caloric restriction regimens counteract in part the decrease in the levels of Hsp expression in the aged heart tissue,n/a +HSPD1,10.1007/s10522-005-4906-z,rat,Sprague Dawley,male,69.5%,0.0001,right atrium,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,"ANOVA, Fisher's test",protein,western blot,Two different caloric restriction regimens counteract in part the decrease in the levels of Hsp expression in the aged heart tissue,n/a +FOXO1,10.1007/s10522-007-9114-6,rat,F344,male,n/a,<0.001,kidney,n/a,n/a,6,24,n/a,n/a,months,alteration of protein localization,3,3,"ANOVA, Fisher's test",protein,western blot,"In response to insulin or growth factors, for instance, FOXO proteins are phosphorylated by protein kinase B (PKB, also known as Akt), which results in the translocation of FOXO from the nucleus into the cytoplasm. Phosphorylation of FOXO1 was significantly increased in old rats. The FOXO1 level decreased in the nucleus by 80% and increased in the cytosol by 95% in old rats compared to young ones. The level of phosphorylated FOXO1 (Tre24) increased by 140%, the level of f-FOXO1 (Ser256) - by 120% in the cytosol in 24 months of rats. The level of f-FOXO1 (Tre24) increased by 106%, f-FOXO1 (Ser256) - by 244%.",n/a +RELA,10.1007/s11357-011-9207-7,rat,F344,male,25.0%,<0.01,kidney,n/a,n/a,6,24,n/a,n/a,months,increased level of activated protein,3,3,"ANOVA, FIsher's test",protein,western blot,Ser 536 phosphorylation levels of p65 were increased with aging.,n/a +POLD1,10.1007/s11010-012-1432-6,human,n/a,all,16.3%,<0.05,lymphocytes,30,40,36,46,40,50,years,decreased gene expression,36,33,"ANOVA, post hoc test",protein,western blot,Western blotting.,n/a +POLD1,10.1007/s11010-012-1432-6,human,n/a,all,30.0%,<0.05,lymphocytes,30,50,36,55,40,60,years,decreased gene expression,36,40,"ANOVA, post hoc test",protein,western blot,Western blotting.,n/a +POLD1,10.1007/s11010-012-1432-6,human,n/a,all,35.0%,<0.05,lymphocytes,30,60,36,64,40,70,years,decreased gene expression,36,35,"ANOVA, post hoc test",protein,western blot,Western blotting.,n/a +POLD1,10.1007/s11010-012-1432-6,human,n/a,all,81.4%,<0.001,lymphocytes,30,70,36,79,40,n/a,years,decreased gene expression,36,29,"ANOVA, post hoc test",protein,western blot,Western blotting.,n/a +SIRT7,10.1002/pmic.201400001,rat,wild type,all,43.0%,<0.01,liver,n/a,n/a,6,24,n/a,n/a,months,decreased gene expression,n/a,n/a,Fisher's exact test,protein,western blot,n/a,n/a +COL2A1,10.1007/s004410050857,pig,domestic pig,all,250.0%,,cartilage,n/a,n/a,1,3,n/a,n/a,years,increased gene expression,12,12,Kruskal-Wallis test,protein,western blot,The type II collagen level was estimated in the porcine mandibular condylar cartilage.,n/a +HTRA2,10.1007/s11357-012-9406-x,rat,Sprague Dawley,male,150.0%,<0.01,heart,6,20,7,22,8,24,months,increased gene expression,10,10,Kruskal-Wallis test,protein,western blot,n/a,n/a +KL,10.1002/glia.20593,mouse,B6D2F1,female,26.0%,ns,brain,n/a,n/a,12,18,n/a,n/a,months,decreased gene expression,3,3,linear regression,protein,western blot,130-kDa isoform.,n/a +KL,10.1002/glia.20593,mouse,B6D2F1,female,66.0%,<0.025,brain,n/a,n/a,12,24,n/a,n/a,months,decreased gene expression,3,3,linear regression,protein,western blot,130-kDa isoform.,n/a +KL,10.1002/glia.20593,mouse,B6D2F1,female,23.0%,ns,brain,n/a,n/a,12,18,n/a,n/a,months,decreased gene expression,3,3,linear regression,protein,western blot,65-kDa isoform.,n/a +KL,10.1002/glia.20593,mouse,B6D2F1,female,64.0%,<0.05,brain,n/a,n/a,12,24,n/a,n/a,months,decreased gene expression,3,3,linear regression,protein,western blot,65-kDa isoform.,n/a +KL,10.1002/glia.20593,mouse,B6D2F1,female,30.0%,ns,brain,n/a,n/a,4,12,n/a,n/a,months,increased gene expression,3,3,linear regression,protein,western blot,130-kDa isoform.,n/a +KL,10.1002/glia.20593,mouse,B6D2F1,female,44.0%,ns,brain,n/a,n/a,4,12,n/a,n/a,months,increased gene expression,3,3,linear regression,protein,western blot,65-kDa isoform.,n/a +KL,10.1002/glia.20593,rhesus monkey,Macaca mulatta,male,40.0%,0.007,white matter,4,20,5,25,7,n/a,years,decreased gene expression,4,4,linear regression,protein,western blot,Only a 130-kDa isoform was detected in monkey tissue.,n/a +SOD1,10.1002/jcp.1041650316,human,n/a,all,990.0%,0.0007,skin fibroblasts,"0,25",17,0,25,"0,42",33,years,increased gene expression,8,10,Mann-Whitney test,protein,western blot,n/a,n/a +SOD1,10.1002/jcp.1041650316,human,n/a,all,700.0%,0.0006,skin fibroblasts,"0,25",78,0,86,"0,42",94,years,increased gene expression,8,11,Mann-Whitney test,protein,western blot,"CuZn-SOD activity is decreased in centenarians, probably because of reduced demand for the enzyme at lower metabolic rate and oxygen consumption. 41 centenarians aged between 100 and 105 years and 52 community control subjects aged between 60 and 79 years were investigated.",n/a +BAD,10.1006/bbrc.1998.9577,rat,Wistar,male,100.0%,,brain,n/a,n/a,0,24,n/a,n/a,months,decreased gene expression,6,6,n/a,protein,western blot,"The protein level of Bad was highest at E19, decreasing gradually after birth until 2 weeks, and abruptly decreasing at 4 weeks. Sample = brain cortex",n/a +SIRT2,10.3389/fncel.2015.00167,rat,Wistar,female,87.5%,<0.01,occipital lobe,n/a,n/a,3,12,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT2,10.3389/fncel.2015.00167,rat,Wistar,female,124.0%,<0.01,occipital lobe,n/a,n/a,3,24,n/a,n/a,months,increased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT3,10.3389/fncel.2015.00167,rat,Wistar,female,2.0%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT3,10.3389/fncel.2015.00167,rat,Wistar,female,40.0%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT3,10.3389/fncel.2015.00167,rat,Wistar,female,15.0%,<0.01,hippocampus,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT3,10.3389/fncel.2015.00167,rat,Wistar,female,39.0%,<0.01,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT4,10.3389/fncel.2015.00167,rat,Wistar,female,22.0%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT4,10.3389/fncel.2015.00167,rat,Wistar,female,47.0%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT4,10.3389/fncel.2015.00167,rat,Wistar,female,2.0%,<0.01,hippocampus,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT4,10.3389/fncel.2015.00167,rat,Wistar,female,30.0%,<0.01,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT5,10.3389/fncel.2015.00167,rat,Wistar,female,22.0%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT5,10.3389/fncel.2015.00167,rat,Wistar,female,41.0%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT5,10.3389/fncel.2015.00167,rat,Wistar,female,30.9%,<0.01,hippocampus,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT5,10.3389/fncel.2015.00167,rat,Wistar,female,50.0%,<0.01,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,22.0%,<0.01,frontal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,38.0%,<0.01,frontal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,18.0%,<0.01,temporal lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,39.0%,<0.01,temporal lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,20.4%,<0.01,occipital lobe,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,37.8%,<0.01,occipital lobe,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,20.0%,<0.01,hippocampus,n/a,n/a,3,12,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT6,10.3389/fncel.2015.00167,rat,Wistar,female,40.0%,<0.01,hippocampus,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,n/a,n/a,n/a,protein,western blot,n/a,n/a +SIRT3,10.1002/art.39618,rat,F344xBN,male,77.0%,"0,006",cartilage,n/a,n/a,10,30,n/a,n/a,months,decreased gene expression,4,4,ANOVA,protein,western blot,n/a,n/a +EEF2,10.1002/jcb.25624,rat,Wistar,male,53.1%,<0.001,pineal gland,n/a,n/a,3,24,n/a,n/a,months,decreased gene expression,5,5,"ANOVA, Tukey's test",protein,western blot,Aging produced a significant decrease in total levels of eEF2,n/a +BAD,10.1002/cyto.a.20310,mouse,BALB/c,female,50.0%,<0.001,spleen,2,15,n/a,n/a,4,21,months,decreased level of inactivated protein,4,4,Student t-test,protein,western blot,"B-cells were isolated from spleen and studied. Expression of native BAD increased during aging (15% female), but phosphorylated BAD decreased (2 times). BAD, a proapoptotic member of Bcl-2 family was found inactivated by phosphorylation on serine residues in healthy cells. Phosphorylation (serine residues) of BAD protects cells from the deleterious effects of apoptotic stimuli and attenuates death pathway.",n/a +BAD,10.1002/cyto.a.20310,mouse,BALB/c,female,15.0%,<0.001,spleen,2,15,n/a,n/a,4,21,months,increased gene expression,4,4,Student t-test,protein,western blot,"B-cells were isolated from spleen and studied. Expression of native BAD increased during aging (15% female), but phosphorylated BAD decreased (2 times).",n/a +CREB1,10.1002/hipo.20099,rat,Wistar,male,n/a,<0.001,hippocampus,n/a,n/a,5,30,n/a,n/a,months,increased level of activated protein,4,4,Student t-test,protein,western blot,the ratio P-CREB/total-CREB was approximately doubled in the hippocampus of aged rats (increased for 90%),n/a +GCLC,10.1002/jcp.20496,rat,F344,male,38.0%,0.03,aorta,n/a,n/a,6,24,n/a,n/a,months,increased gene expression,4,4,Student t-test,protein,western blot,n/a,n/a +CYBB,10.1007/s00395-015-0506-5,mouse,C57BL/6,male,57.0%,<0.05,ventricles,2,24,3,25,4,26,months,increased gene expression,4-5,4-5,Student t-test,protein,western blot,n/a,n/a +UCP3,10.1007/s00424-003-1044-9,human,n/a,male,145.0%,0.09,muscle,22,61,25,75,31,86,years,increased gene expression,8,7,Student t-test,protein,western blot,In muscle biopsy samples of old male subjects [75 (range 61-86) years] UCP3 protein tended to be elevated (P=0.09) compared to group of eight young male subjects [25 (22-31) years].,n/a +TGM2,10.1007/s00726-016-2295-z,rat,F344,male,52.0%,0.02,heart,n/a,n/a,6,18,n/a,n/a,months,increased gene expression,8,8,Student t-test,protein,western blot,n/a,27438265 +ACOX1,10.1007/s10072-013-1509-3,rat,Sprague Dawley,male,32.0%,<0.05,liver,n/a,n/a,3,22,n/a,n/a,months,decreased gene expression,4,4,Student t-test,protein,western blot,Western blotting. P<0.05.,n/a +PPARA,10.1007/s11064-005-8341-y,rat,F344,female,48.0%,<0.05,spleen,n/a,n/a,3,18,n/a,n/a,months,decreased gene expression,4-6,4-6,Student t-test,protein,western blot,Method — Western Blot.,n/a +NRIP1,10.1007/s11357-008-9062-3,mouse,AKR,male,60.0%,<0.05,liver,20,60,25,65,30,70,weeks,decreased gene expression,n/a,n/a,Student t-test,protein,western blot,n/a,n/a +NRIP1,10.1007/s11357-008-9062-3,mouse,AKR,male,58.0%,<0.05,kidney,20,60,25,65,30,70,weeks,decreased gene expression,n/a,n/a,Student t-test,protein,western blot,n/a,n/a +NRIP1,10.1007/s11357-008-9062-3,mouse,AKR,male,325.0%,<0.05,fat,20,60,25,65,30,70,weeks,increased gene expression,n/a,n/a,Student t-test,protein,western blot,n/a,n/a +NGF,10.1007/s11357-011-9262-0,rat,Sprague Dawley,male,65.0%,<0.05,left ventricle,"0,4",6,0.5,7,"0,6",8,weeks,decreased gene expression,3,3,Student t-test,protein,western blot,n/a,n/a +NGF,10.1007/s11357-011-9262-0,rat,Sprague Dawley,male,150.0%,<0.05,left ventricle,6,80,7,88,8,96,weeks,increased gene expression,3,3,Student t-test,protein,western blot,n/a,n/a +NGF,10.1007/s11357-011-9262-0,rat,Sprague Dawley,male,50.0%,<0.05,left atrium,"0,4",6,0.5,7,"0,6",8,weeks,increased gene expression,3,3,Student t-test,protein,western blot,n/a,n/a +NGF,10.1007/s11357-011-9262-0,rat,Sprague Dawley,male,113.0%,<0.05,left atrium,6,80,7,88,8,96,weeks,increased gene expression,3,3,Student t-test,protein,western blot,n/a,n/a +MSRA,10.1007/s11357-011-9268-7,rat,Wistar,female,69.0%,<0.05,liver,n/a,n/a,2,24,n/a,n/a,months,decreased gene expression,15,17,Student t-test,protein,western blot,n/a,n/a +MSRA,10.1007/s11357-011-9268-7,rat,Wistar,female,55.0%,<0.05,spleen,n/a,n/a,2,24,n/a,n/a,months,decreased gene expression,15,17,Student t-test,protein,western blot,n/a,n/a +KL,10.1007/s11357-011-9315-4,rhesus monkey,Macaca mulatta,all,20.0%,<0.05,white matter,"3,8",20,"7,68","24,35",15,"30,2",years,decreased gene expression,5,8,Student t-test,protein,western blot,"Changes in KL gene expression with age may, at least in part, be the result of epigenetic changes to the 5′ regulatory region.",n/a +BIRC5,10.1007/s11357-011-9378-2,mouse,C57BL/6J,female,350.0%,,heart,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,3,3,Student t-test,protein,western blot,"The levels of survivin were higher in aged heart, liver, and lung mice tissues as compared to their levels in the same tissues extracted from young mice.",n/a +BIRC5,10.1007/s11357-011-9378-2,mouse,C57BL/6J,female,250.0%,,liver,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,3,3,Student t-test,protein,western blot,"The levels of survivin were higher in aged heart, liver, and lung mice tissues as compared to their levels in the same tissues extracted from young mice.",n/a +BIRC5,10.1007/s11357-011-9378-2,mouse,C57BL/6J,female,200.0%,,lung,n/a,n/a,1,6,n/a,n/a,months,increased gene expression,3,3,Student t-test,protein,western blot,"The levels of survivin were higher in aged heart, liver, and lung mice tissues as compared to their levels in the same tissues extracted from young mice.",n/a +MAPK14,10.1002/dmrr.932,rat,F344xBN,all,160.0%,<0.05,muscle soleus,n/a,n/a,6,33,n/a,n/a,months,increased protein activity,n/a,n/a,Tukey-Kramer,protein,western blot,The protein MAPK14 phosphorylation level was estimated.,n/a \ No newline at end of file diff --git a/scripts/expression_change_human_mrna/replace.py b/scripts/expression_change_human_mrna/replace.py index a838866..cafc6a9 100644 --- a/scripts/expression_change_human_mrna/replace.py +++ b/scripts/expression_change_human_mrna/replace.py @@ -1,13 +1,8 @@ -import json import logging import os import sys -import time from collections import namedtuple -from typing import List - import numpy as np -import pandas as pd from mysql.connector import MySQLConnection, cursor from pandas import DataFrame @@ -26,7 +21,6 @@ LOGGER.addHandler(HANDLER) LOGGER.addHandler(FILE_HANDLER) -REDUNDANT_DATASET_COLUMNS = ["gene_id", "q-value", "fc"] ORGANISM_SEX_NULL_VALUE = "not specified" PREFIX = "_name" DbTable = namedtuple( @@ -84,6 +78,7 @@ ), ) + def upload_data(cursor: cursor, df: DataFrame, table_name: str): try: df = df.replace({np.nan: None}) @@ -95,19 +90,21 @@ def upload_data(cursor: cursor, df: DataFrame, table_name: str): except Exception as e: LOGGER.error("Error while uploading data to %s: %s", table_name, str(e)) + def delete_existing_records(cursor: cursor, df: DataFrame, table_name: str): try: for index, row in df.iterrows(): doi = row["doi"] - gene_id = row["gene_id"] - cursor.execute(f"DELETE FROM {table_name} WHERE doi = %s AND gene_id = %s", (doi, gene_id)) + gene_symbol = row["gene_symbol"] + cursor.execute(f"DELETE FROM {table_name} WHERE doi = %s AND gene_symbol = %s" , (doi, gene_symbol)) except Exception as e: LOGGER.error("Error while deleting existing records from %s: %s", table_name, str(e)) + def main(): LOGGER.info("========== Upload script started ==========") - dataset_df = get_df_from_csv("scripts/expression_change_human_mrna/expression-change-human-mrna.csv") - + dataset_df = get_df_from_csv("scripts/expression_change_human_mrna/08-09-2023-update-items-human-mrna.csv") + for table in TABLES_TO_READ: id_values_df = get_df_from_db(cnx, table.name, table.columns) dataset_df = replace_id_values( @@ -135,5 +132,6 @@ def main(): cur.close() LOGGER.info("========== Upload script finished ==========\n") + if __name__ == "__main__": main()