diff --git a/base/android/linker/modern_linker_jni.cc b/base/android/linker/modern_linker_jni.cc
index 1ed6a3fd7f9315..5bd7ee6ca6d199 100644
--- a/base/android/linker/modern_linker_jni.cc
+++ b/base/android/linker/modern_linker_jni.cc
@@ -312,7 +312,8 @@ bool CopyAndRemapRelocations(const LoadedLibraryMetadata& metadata, int* fd) {
   }
 
   memcpy(relro_copy_addr, relro_addr, metadata.relro_size);
-  int retval = mprotect(relro_copy_addr, metadata.relro_size, PROT_READ);
+  int retval =
+      HANDLE_EINTR(mprotect(relro_copy_addr, metadata.relro_size, PROT_READ));
   if (retval) {
     LOG_ERROR("Cannot call mprotect()");
     close(shared_mem_fd);
diff --git a/base/files/file_util_posix.cc b/base/files/file_util_posix.cc
index d74cf2bc510ca9..709b38fb62449c 100644
--- a/base/files/file_util_posix.cc
+++ b/base/files/file_util_posix.cc
@@ -1257,7 +1257,7 @@ BASE_EXPORT bool IsPathExecutable(const FilePath& path) {
     CHECK_GE(sizeof(pagesize), sizeof(sysconf_result));
     void* mapping = mmap(nullptr, pagesize, PROT_READ, MAP_SHARED, fd.get(), 0);
     if (mapping != MAP_FAILED) {
-      if (mprotect(mapping, pagesize, PROT_READ | PROT_EXEC) == 0)
+      if (HANDLE_EINTR(mprotect(mapping, pagesize, PROT_READ | PROT_EXEC)) == 0)
         result = true;
       munmap(mapping, pagesize);
     }
diff --git a/base/process/launch_posix.cc b/base/process/launch_posix.cc
index a8b1f0bdf95b0b..fea91101dd0a5f 100644
--- a/base/process/launch_posix.cc
+++ b/base/process/launch_posix.cc
@@ -413,7 +413,7 @@ Process LaunchProcess(const std::vector<std::string>& argv,
     // any hidden calls to malloc.
     void *malloc_thunk =
         reinterpret_cast<void*>(reinterpret_cast<intptr_t>(malloc) & ~4095);
-    mprotect(malloc_thunk, 4096, PROT_READ | PROT_WRITE | PROT_EXEC);
+    HANDLE_EINTR(mprotect(malloc_thunk, 4096, PROT_READ | PROT_WRITE | PROT_EXEC));
     memset(reinterpret_cast<void*>(malloc), 0xff, 8);
 #endif  // 0
 
diff --git a/chromeos/hugepage_text/hugepage_text.cc b/chromeos/hugepage_text/hugepage_text.cc
index 0effaca10a5fb0..10b99aed48892a 100644
--- a/chromeos/hugepage_text/hugepage_text.cc
+++ b/chromeos/hugepage_text/hugepage_text.cc
@@ -14,6 +14,7 @@
 
 #include "base/bit_cast.h"
 #include "base/logging.h"
+#include "base/posix/eintr_wrapper.h"
 
 // CHROMEOS_ORDERFILE_USE is a flag intended to use orderfile
 // to link Chrome. Only when orderfile is used, we will use hugepages.
@@ -134,7 +135,7 @@ static void MremapHugetlbText(void* vaddr, const size_t hsize) {
   NoAsanAlignedMemcpy(haddr, vaddr, hsize);
 
   // change mapping protection to read only now that it has done the copy
-  if (mprotect(haddr, hsize, PROT_READ | PROT_EXEC)) {
+  if (HANDLE_EINTR(mprotect(haddr, hsize, PROT_READ | PROT_EXEC))) {
     PLOG(INFO) << "can not change protection to r-x, fall back to small page";
     munmap(haddr, hsize);
     return;
diff --git a/components/gwp_asan/client/guarded_page_allocator_posix.cc b/components/gwp_asan/client/guarded_page_allocator_posix.cc
index 60aa7c75c822e2..868617af679d24 100644
--- a/components/gwp_asan/client/guarded_page_allocator_posix.cc
+++ b/components/gwp_asan/client/guarded_page_allocator_posix.cc
@@ -7,6 +7,7 @@
 #include <sys/mman.h>
 
 #include "base/check.h"
+#include "base/posix/eintr_wrapper.h"
 
 namespace gwp_asan {
 namespace internal {
@@ -25,7 +26,8 @@ void GuardedPageAllocator::UnmapRegion() {
 }
 
 void GuardedPageAllocator::MarkPageReadWrite(void* ptr) {
-  int err = mprotect(ptr, state_.page_size, PROT_READ | PROT_WRITE);
+  int err =
+      HANDLE_EINTR(mprotect(ptr, state_.page_size, PROT_READ | PROT_WRITE));
   PCHECK(err == 0) << "mprotect";
 }