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## Drug repurposing on COVID-19 proteins - Bonvin Lab, CSB group, UU
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- See : <a href="https://www.bonvinlab.org/covid/">https://www.bonvinlab.org/covid/</em>, https://www.bonvinlab.org/covid/</a>
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* See : <a href="https://www.bonvinlab.org/covid/">https://www.bonvinlab.org/covid/</em>, https://www.bonvinlab.org/covid/</a>
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## Importance of inactive data in models : application to virtual screening in human health and environnement - example of nuclear receptors - Cnam, GBCM
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Study of the evolution of the use of decoy compounds and true inactive data into model evaluation and construction for CADD
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- See : <a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01105">Réau <em>et al</em>, Front. Pharmacol. 2018</a>
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* See : <a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01105">Réau <em>et al</em>, Front. Pharmacol. 2018</a>
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Creation of the NR-DBIND (Nuclear Receptors DataBase Including Negative Data)
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- See : <a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01105">Réau <em>et al</em>, J. Med. Chem 2019</a>
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* See : <a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01105">Réau <em>et al</em>, J. Med. Chem 2019</a>
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Identification of computer-aided drug design (CADD) pipelines to identify modulators of different nuclear receptors
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- Docking approach
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- Pharmacophore modeling approach
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- See : <a href="https://www.mdpi.com/2073-4409/8/11/1431">Réau <em>et al</em>, Cells 2019</a>
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* Docking approach
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* Pharmacophore modeling approach
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* See : <a href="https://www.mdpi.com/2073-4409/8/11/1431">Réau <em>et al</em>, Cells 2019</a>
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Project coordinator : Marc Port, <a href="http://cmgpce.cnam.fr/cm-presentation-de-l-equipe-contacts-et-acces-703730.kjsp">Laboratoire de Chimie Moléculaire</a>, CNAM<br>
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The project is supported by an ANR grant: <a href="http://www.agence-nationale-recherche.fr/Project-ANR-17-CE18-0024">Read the full ANR project</a>
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#### Collaborators
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- Laboratoire CM (Chimie Moléculaire), CNAM, Paris
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- Laboratoire GBA (Génomique, Bioinformatique et Applications), CNAM, Paris
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- Laboratoire SATIE (Laboratoire des Systèmes et Applications des Technologies de l'Information et de l'Energie)
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- PEPTINOV SAS
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* Laboratoire CM (Chimie Moléculaire), CNAM, Paris
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* Laboratoire GBA (Génomique, Bioinformatique et Applications), CNAM, Paris
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* Laboratoire SATIE (Laboratoire des Systèmes et Applications des Technologies de l'Information et de l'Energie)
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* PEPTINOV SAS
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## CADD approaches to identify inhibitors of the NRP1/VEGF-A165 interaction - Cnam, GBCM
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#### Collaborators
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- Yves Lepelletier, Institut Imagine, Paris
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- Françoise Raynaud, APHP
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* Yves Lepelletier, Institut Imagine, Paris
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* Françoise Raynaud, APHP

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