It is simple program that creates blocks and blockchain with hashing each block. Appending transactions to the blockchain is possible by mining. It uses Flask for creating an API.
https://www.activestate.com/blog/how-to-build-a-blockchain-in-python/
https://medium.com/coinmonks/python-tutorial-build-a-blockchain-713c706f6531
https://hackernoon.com/learn-blockchains-by-building-one-117428612f46