diff --git a/Dockerfile b/Dockerfile
index a9e73699558b8..ebd802374ebda 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -26,7 +26,7 @@ RUN virtualization/Docker/setup_docker_prereqs
 # Install hass component dependencies
 COPY requirements_all.txt requirements_all.txt
 RUN pip3 install --no-cache-dir -r requirements_all.txt && \
-    pip3 install --no-cache-dir mysqlclient psycopg2 uvloop==0.12.2 cchardet cython tensorflow
+    pip3 install --no-cache-dir mysqlclient psycopg2 cchardet cython tensorflow
 
 # Copy source
 COPY . .
diff --git a/homeassistant/components/stream/__init__.py b/homeassistant/components/stream/__init__.py
index 4fd3e71a48b5f..50cc1d8169d6e 100644
--- a/homeassistant/components/stream/__init__.py
+++ b/homeassistant/components/stream/__init__.py
@@ -4,6 +4,11 @@
 
 import voluptuous as vol
 
+try:
+    import uvloop
+except ImportError:
+    uvloop = None
+
 from homeassistant.auth.util import generate_secret
 import homeassistant.helpers.config_validation as cv
 from homeassistant.const import EVENT_HOMEASSISTANT_STOP, CONF_FILENAME
@@ -38,7 +43,7 @@
         vol.Optional(CONF_LOOKBACK, default=0): int,
     }
 )
-
+DATA_UVLOOP_WARN = "stream_uvloop_warn"
 # Set log level to error for libav
 logging.getLogger("libav").setLevel(logging.ERROR)
 
@@ -49,6 +54,21 @@ def request_stream(hass, stream_source, *, fmt="hls", keepalive=False, options=N
     if DOMAIN not in hass.config.components:
         raise HomeAssistantError("Stream integration is not set up.")
 
+    if DATA_UVLOOP_WARN not in hass.data:
+        hass.data[DATA_UVLOOP_WARN] = True
+        # Warn about https://github.com/home-assistant/home-assistant/issues/22999
+        if (
+            uvloop is not None
+            and isinstance(hass.loop, uvloop.Loop)
+            and (
+                "shell_command" in hass.config.components
+                or "ffmpeg" in hass.config.components
+            )
+        ):
+            _LOGGER.warning(
+                "You are using UVLoop with stream and shell_command. This is known to cause issues. Please uninstall uvloop."
+            )
+
     if options is None:
         options = {}
 
diff --git a/virtualization/Docker/Dockerfile.dev b/virtualization/Docker/Dockerfile.dev
index 260a29cb3d09e..2e98c53cdf1b4 100644
--- a/virtualization/Docker/Dockerfile.dev
+++ b/virtualization/Docker/Dockerfile.dev
@@ -28,7 +28,7 @@ RUN virtualization/Docker/setup_docker_prereqs
 COPY requirements_all.txt requirements_all.txt
 
 RUN pip3 install --no-cache-dir -r requirements_all.txt && \
-    pip3 install --no-cache-dir mysqlclient psycopg2 uvloop==0.12.2 cchardet cython
+    pip3 install --no-cache-dir mysqlclient psycopg2 cchardet cython
 
 # BEGIN: Development additions