diff --git a/packages/google-cloud-bigquery-data-exchange/setup.py b/packages/google-cloud-bigquery-data-exchange/setup.py
index 500ae9dbbbc5..c138e0dac514 100644
--- a/packages/google-cloud-bigquery-data-exchange/setup.py
+++ b/packages/google-cloud-bigquery-data-exchange/setup.py
@@ -30,7 +30,8 @@
     # Until this issue is closed
     # https://github.com/googleapis/google-cloud-python/issues/10566
     "google-api-core[grpc] >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
-    "proto-plus >= 1.15.0",
+    "proto-plus >= 1.15.0, <2.0.0dev",
+    "protobuf >= 3.19.0, <4.0.0dev",
     "grpc-google-iam-v1 >= 0.12.4, <1.0.0dev",
 ]
 
diff --git a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.6.txt b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.6.txt
index 144ecb7b7b6b..11b63ba6d913 100644
--- a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.6.txt
+++ b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.6.txt
@@ -7,3 +7,4 @@
 google-api-core==1.31.5
 proto-plus==1.15.0
 grpc-google-iam-v1 >= 0.12.4
+protobuf==3.19.0
diff --git a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.7.txt b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.7.txt
index 144ecb7b7b6b..11b63ba6d913 100644
--- a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.7.txt
+++ b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.7.txt
@@ -7,3 +7,4 @@
 google-api-core==1.31.5
 proto-plus==1.15.0
 grpc-google-iam-v1 >= 0.12.4
+protobuf==3.19.0