diff --git a/CHANGELOG.md b/CHANGELOG.md
index a9dc18876..a11809b02 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -12,6 +12,7 @@
 - Fix Vernier profiler not stopping when already stopped [#2429](https://github.com/getsentry/sentry-ruby/pull/2429)
 - Fix `send_default_pii` handling in rails controller spans [#2443](https://github.com/getsentry/sentry-ruby/pull/2443)
   - Fixes [#2438](https://github.com/getsentry/sentry-ruby/issues/2438)
+- Fix `RescuedExceptionInterceptor` to handle an empty configuration [#2428](https://github.com/getsentry/sentry-ruby/pull/2428)
 
 ## 5.21.0
 
diff --git a/sentry-rails/lib/sentry/rails/rescued_exception_interceptor.rb b/sentry-rails/lib/sentry/rails/rescued_exception_interceptor.rb
index 43cb69db1..757377298 100644
--- a/sentry-rails/lib/sentry/rails/rescued_exception_interceptor.rb
+++ b/sentry-rails/lib/sentry/rails/rescued_exception_interceptor.rb
@@ -19,7 +19,16 @@ def call(env)
       end
 
       def report_rescued_exceptions?
-        Sentry.configuration.rails.report_rescued_exceptions
+        # In rare edge cases, `Sentry.configuration` might be `nil` here.
+        # Hence, we use a safe navigation and fallback to a reasonable default
+        # of `true` in case the configuration couldn't be loaded.
+        # See https://github.com/getsentry/sentry-ruby/issues/2386
+        report_rescued_exceptions = Sentry.configuration&.rails&.report_rescued_exceptions
+        return report_rescued_exceptions unless report_rescued_exceptions.nil?
+
+        # `true` is the default for `report_rescued_exceptions`, as specified in
+        # `sentry-rails/lib/sentry/rails/configuration.rb`.
+        true
       end
     end
   end