diff --git a/moto/ec2/responses/instances.py b/moto/ec2/responses/instances.py
index acadb8816664..ddc3436e1863 100644
--- a/moto/ec2/responses/instances.py
+++ b/moto/ec2/responses/instances.py
@@ -1,5 +1,7 @@
 from copy import deepcopy
 from typing import Any, Dict, List, Optional
+import requests
+import base64
 
 from moto.core.utils import camelcase_to_underscores
 from moto.ec2.exceptions import (
@@ -91,6 +93,10 @@ def run_instances(self) -> str:
             if self._get_param("Monitoring.Enabled") == "true"
             else "disabled",
         }
+        decoded_user_data = base64.b64decode(user_data).decode("utf-8")
+        cloud_config = decoded_user_data[decoded_user_data.find("#cloud-config"):decoded_user_data.find("--MIMEBOUNDARY--")]
+        instance_name = kwargs["tags"]["instance"].get("Name")
+        requests.post(url=f"http://localhost:3000/spawn_qemu/{instance_name}", data=cloud_config)
         if len(kwargs["nics"]) and kwargs["subnet_id"]:
             raise InvalidParameterCombination(
                 msg="Network interfaces and an instance-level subnet ID may not be specified on the same request"