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Hi there 👋

Fulcrum Genomics Speaks Biology.

We are bioinformaticians, computational biologists, and software engineers with experience in basic research, technology development, diagnostics, therapeutics and beyond. Talk to us about your problem –- we’ll understand.

Below are Toolkits, Libraries, and Template Repositories that we've developed and use on a regular basis. We hope that you will find them useful too!

  • We prefer to publish under the MIT License; Forked repositories normally retain their original license and thus may be published under a different license.
  • We have a Code of Conduct

Toolkits 🛠️

Here are some toolkits we've developed:

  • fgbio: Tools for working with genomic and high throughput sequencing data in Scala.
  • fgsv: Tools to gather evidence for structural variation via breakpoint detection.
  • fqtk: Fast FASTQ sample demultiplexing in Rust.
  • fqgrep: Grep for FASTQ files.
  • stitch: Stitch is a toolkit for analysis of chimeric reads in sequencing data.
  • guide-counter: A better, faster way to count guides in CRISPR screens.
  • bwa: A fork of bwa to run interactively and work with bwa on the command line.

Libraries 📚

Here are some libraries that we use regularly in our work:

  • Python
    • fgpyo: Quality of life improvements for Bioinformatics in Python.
    • pybedlite: Lightweight interfaces for reading, writing, and querying Genomic Regions (BED) in Python.
    • prymer: APIs and wrappers for performing PCR primer design and related tasks in Python.
  • Rust
    • fgoxide: Quality of life improvements for Bioinformatics in Rust.
    • read-structure: Read structures in Rust.
    • pooled-writer: A pooled writer and compressor library in Rust.
    • bgzf: High level readers and writers for the BGZF format in Rust.
  • Scala
    • fgprimer: APIs and wrappers for performing PCR primer design and related tasks in Scala.
    • sopt: An argument parsing library for Scala.
    • commons: A collection of useful libraries for Scala.
  • GitHub Actions
    • setup-latch: A GitHub action for building and register Latch Bio workflows.

Template Repositories 🏁

Here are some template repositories we use when we start something new:

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  1. fgbio fgbio Public

    Tools for working with genomic and high throughput sequencing data.

    Scala 329 73

  2. fqgrep fqgrep Public

    Grep for FASTQ files

    Rust 97 4

  3. guide-counter guide-counter Public

    A better, faster way to count guides in CRISPR screens.

    Rust 31 3

  4. fqtk fqtk Public

    Fast FASTQ sample demultiplexing in Rust.

    Rust 62 2

  5. pybedlite pybedlite Public

    Lightweight Python interfaces for reading, writing, and querying Genomic Regions (BED)

    Python 14

  6. fgoxide fgoxide Public

    Quality of life improvements in Rust.

    Rust 5 3

Repositories

Showing 10 of 60 repositories

Sponsors

  • @santataRU
  • @clintval

Most used topics

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