diff --git a/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/runtime/hermes/HermesInstance.kt b/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/runtime/hermes/HermesInstance.kt
index 2f7697b249405b..41f3b4b83854c0 100644
--- a/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/runtime/hermes/HermesInstance.kt
+++ b/packages/react-native/ReactAndroid/src/main/java/com/facebook/react/runtime/hermes/HermesInstance.kt
@@ -9,13 +9,17 @@ package com.facebook.react.runtime.hermes
 
 import com.facebook.jni.HybridData
 import com.facebook.jni.annotations.DoNotStrip
+import com.facebook.react.fabric.ReactNativeConfig
 import com.facebook.react.runtime.JSEngineInstance
 import com.facebook.soloader.SoLoader
 
-class HermesInstance : JSEngineInstance(initHybrid()!!) {
+class HermesInstance constructor(reactNativeConfig: ReactNativeConfig?) :
+    JSEngineInstance(initHybrid(reactNativeConfig as Object?)) {
+
+  constructor() : this(null)
 
   companion object {
-    @JvmStatic @DoNotStrip protected external fun initHybrid(): HybridData?
+    @JvmStatic @DoNotStrip protected external fun initHybrid(reactNativeConfig: Object?): HybridData
 
     init {
       SoLoader.loadLibrary("hermesinstancejni")
diff --git a/packages/react-native/ReactAndroid/src/main/jni/react/runtime/hermes/jni/JHermesInstance.cpp b/packages/react-native/ReactAndroid/src/main/jni/react/runtime/hermes/jni/JHermesInstance.cpp
index 1de9439dc87024..3d8a9f74652443 100644
--- a/packages/react-native/ReactAndroid/src/main/jni/react/runtime/hermes/jni/JHermesInstance.cpp
+++ b/packages/react-native/ReactAndroid/src/main/jni/react/runtime/hermes/jni/JHermesInstance.cpp
@@ -8,12 +8,18 @@
 #include "JHermesInstance.h"
 
 #include <fbjni/fbjni.h>
+#include <react/fabric/ReactNativeConfigHolder.h>
 
 namespace facebook::react {
 
 jni::local_ref<JHermesInstance::jhybriddata> JHermesInstance::initHybrid(
-    jni::alias_ref<jhybridobject>) {
-  return makeCxxInstance();
+    jni::alias_ref<jclass> /* unused */,
+    jni::alias_ref<jobject> reactNativeConfig) {
+  std::shared_ptr<const ReactNativeConfig> config = reactNativeConfig != nullptr
+      ? std::make_shared<const ReactNativeConfigHolder>(reactNativeConfig)
+      : nullptr;
+
+  return makeCxxInstance(config);
 }
 
 void JHermesInstance::registerNatives() {
@@ -24,8 +30,8 @@ void JHermesInstance::registerNatives() {
 
 std::unique_ptr<jsi::Runtime> JHermesInstance::createJSRuntime(
     std::shared_ptr<MessageQueueThread> msgQueueThread) noexcept {
-  // TODO T105438175 Pass ReactNativeConfig to init Hermes with MobileConfig
-  return HermesInstance::createJSRuntime(nullptr, nullptr, msgQueueThread);
+  return HermesInstance::createJSRuntime(
+      reactNativeConfig_, nullptr, msgQueueThread);
 }
 
 } // namespace facebook::react
diff --git a/packages/react-native/ReactAndroid/src/main/jni/react/runtime/hermes/jni/JHermesInstance.h b/packages/react-native/ReactAndroid/src/main/jni/react/runtime/hermes/jni/JHermesInstance.h
index db12cfc4d5fcb8..9d500aaa3c3c30 100644
--- a/packages/react-native/ReactAndroid/src/main/jni/react/runtime/hermes/jni/JHermesInstance.h
+++ b/packages/react-native/ReactAndroid/src/main/jni/react/runtime/hermes/jni/JHermesInstance.h
@@ -8,12 +8,12 @@
 #pragma once
 
 #include <memory>
-#include <string>
 
 #include <cxxreact/MessageQueueThread.h>
 #include <fbjni/fbjni.h>
 #include <jni.h>
 #include <jsi/jsi.h>
+#include <react/config/ReactNativeConfig.h>
 #include <react/runtime/JSEngineInstance.h>
 #include <react/runtime/hermes/HermesInstance.h>
 #include "../../jni/JJSEngineInstance.h"
@@ -26,10 +26,15 @@ class JHermesInstance
   static constexpr auto kJavaDescriptor =
       "Lcom/facebook/react/runtime/hermes/HermesInstance;";
 
-  static jni::local_ref<jhybriddata> initHybrid(jni::alias_ref<jhybridobject>);
+  static jni::local_ref<jhybriddata> initHybrid(
+      jni::alias_ref<jclass> /* unused */,
+      jni::alias_ref<jobject> reactNativeConfig);
 
   static void registerNatives();
 
+  JHermesInstance(std::shared_ptr<const ReactNativeConfig> reactNativeConfig)
+      : reactNativeConfig_(reactNativeConfig){};
+
   std::unique_ptr<jsi::Runtime> createJSRuntime(
       std::shared_ptr<MessageQueueThread> msgQueueThread) noexcept;
 
@@ -37,6 +42,8 @@ class JHermesInstance
 
  private:
   friend HybridBase;
+
+  std::shared_ptr<const ReactNativeConfig> reactNativeConfig_;
 };
 
 } // namespace facebook::react