diff --git a/source/common/upstream/upstream_impl.cc b/source/common/upstream/upstream_impl.cc
index ae816c2db5f5..d796b41730e4 100644
--- a/source/common/upstream/upstream_impl.cc
+++ b/source/common/upstream/upstream_impl.cc
@@ -854,6 +854,13 @@ ClusterInfoImpl::ClusterInfoImpl(
               : absl::nullopt),
       factory_context_(
           std::make_unique<FactoryContextImpl>(*stats_scope_, runtime, factory_context)) {
+#ifdef WIN32
+  if (set_local_interface_name_on_upstream_connections_) {
+    throw EnvoyException("set_local_interface_name_on_upstream_connections_ cannot be set to true"
+                         "on Windows platforms");
+  }
+#endif
+
   if (config.has_max_requests_per_connection() &&
       http_protocol_options_->common_http_protocol_options_.has_max_requests_per_connection()) {
     throw EnvoyException("Only one of max_requests_per_connection from Cluster or "
diff --git a/test/integration/protocol_integration_test.cc b/test/integration/protocol_integration_test.cc
index c6ff749b4c86..fa8ed99539c1 100644
--- a/test/integration/protocol_integration_test.cc
+++ b/test/integration/protocol_integration_test.cc
@@ -3665,7 +3665,13 @@ TEST_P(ProtocolIntegrationTest, LocalInterfaceNameForUpstreamConnection) {
         ->mutable_upstream_connection_options()
         ->set_set_local_interface_name_on_upstream_connections(true);
   });
+#ifdef WIN32
+  EXPECT_THROW_WITH_MESSAGE(initialize(), Envoy::EnvoyException,
+                            "set_local_interface_name_on_upstream_connections_ cannot be set to "
+                            "true on Windows platforms");
+#else
   initialize();
+#endif
 
   codec_client_ = makeHttpConnection(lookupPort("http"));
 
@@ -3682,9 +3688,6 @@ TEST_P(ProtocolIntegrationTest, LocalInterfaceNameForUpstreamConnection) {
 
   // Make sure that the local interface name was populated due to runtime override.
   // TODO: h3 upstreams don't have local interface name
-#ifdef WIN32
-  EXPECT_TRUE(response->headers().get(Http::LowerCaseString("local_interface_name")).empty());
-#else
   if (GetParam().upstream_protocol == Http::CodecType::HTTP3) {
     EXPECT_TRUE(response->headers().get(Http::LowerCaseString("local_interface_name")).empty());
   } else {