diff --git a/lib/Doctrine/DBAL/Driver/Mysqli/MysqliStatement.php b/lib/Doctrine/DBAL/Driver/Mysqli/MysqliStatement.php
index 8b4f9a58006..fe7d4c1297f 100644
--- a/lib/Doctrine/DBAL/Driver/Mysqli/MysqliStatement.php
+++ b/lib/Doctrine/DBAL/Driver/Mysqli/MysqliStatement.php
@@ -21,11 +21,16 @@
 
 use Doctrine\DBAL\Driver\Statement;
 use Doctrine\DBAL\Driver\StatementIterator;
+use Doctrine\DBAL\Exception\InvalidArgumentException;
 use Doctrine\DBAL\FetchMode;
 use Doctrine\DBAL\ParameterType;
 use function array_combine;
 use function array_fill;
 use function count;
+use function feof;
+use function fread;
+use function get_resource_type;
+use function is_resource;
 use function str_repeat;
 
 /**
@@ -42,7 +47,7 @@ class MysqliStatement implements \IteratorAggregate, Statement
         ParameterType::BOOLEAN      => 'i',
         ParameterType::NULL         => 's',
         ParameterType::INTEGER      => 'i',
-        ParameterType::LARGE_OBJECT => 's',
+        ParameterType::LARGE_OBJECT => 'b',
     ];
 
     /**
@@ -169,9 +174,11 @@ public function execute($params = null)
                     throw new MysqliException($this->_stmt->error, $this->_stmt->errno);
                 }
             } else {
-                if (! $this->_stmt->bind_param($this->types, ...$this->_bindedValues)) {
+                list($types, $values, $streams) = $this->separateBoundValues();
+                if (! $this->_stmt->bind_param($types, ...$values)) {
                     throw new MysqliException($this->_stmt->error, $this->_stmt->sqlstate, $this->_stmt->errno);
                 }
+                $this->sendLongData($streams);
             }
         }
 
@@ -228,6 +235,63 @@ public function execute($params = null)
         return true;
     }
 
+    /**
+     * Split $this->_bindedValues into those values that need to be sent using mysqli::send_long_data()
+     * and those that can be bound the usual way.
+     *
+     * @return array<int, array<int|string, mixed>|string>
+     */
+    private function separateBoundValues()
+    {
+        $streams = $values = [];
+        $types   = $this->types;
+
+        foreach ($this->_bindedValues as $parameter => $value) {
+            if (! isset($types[$parameter - 1])) {
+                $types[$parameter - 1] = static::$_paramTypeMap[ParameterType::STRING];
+            }
+
+            if ($types[$parameter - 1] === static::$_paramTypeMap[ParameterType::LARGE_OBJECT]) {
+                if (is_resource($value)) {
+                    if (get_resource_type($value) !== 'stream') {
+                        throw new InvalidArgumentException('Resources passed with the LARGE_OBJECT parameter type must be stream resources.');
+                    }
+                    $streams[$parameter] = $value;
+                    $values[$parameter]  = null;
+                    continue;
+                } else {
+                    $types[$parameter - 1] = static::$_paramTypeMap[ParameterType::STRING];
+                }
+            }
+
+            $values[$parameter] = $value;
+        }
+
+        return [$types, $values, $streams];
+    }
+
+    /**
+     * Handle $this->_longData after regular query parameters have been bound
+     *
+     * @throws MysqliException
+     */
+    private function sendLongData($streams)
+    {
+        foreach ($streams as $paramNr => $stream) {
+            while (! feof($stream)) {
+                $chunk = fread($stream, 8192);
+
+                if ($chunk === false) {
+                    throw new MysqliException("Failed reading the stream resource for parameter offset ${paramNr}.");
+                }
+
+                if (! $this->_stmt->send_long_data($paramNr - 1, $chunk)) {
+                    throw new MysqliException($this->_stmt->error, $this->_stmt->sqlstate, $this->_stmt->errno);
+                }
+            }
+        }
+    }
+
     /**
      * Binds a array of values to bound parameters.
      *
diff --git a/tests/Doctrine/Tests/DBAL/Functional/BlobTest.php b/tests/Doctrine/Tests/DBAL/Functional/BlobTest.php
index c8249d050ee..e409f5f5f5e 100644
--- a/tests/Doctrine/Tests/DBAL/Functional/BlobTest.php
+++ b/tests/Doctrine/Tests/DBAL/Functional/BlobTest.php
@@ -3,11 +3,13 @@
 namespace Doctrine\Tests\DBAL\Functional;
 
 use Doctrine\DBAL\Driver\PDOSqlsrv\Driver as PDOSQLSrvDriver;
+use Doctrine\DBAL\FetchMode;
 use Doctrine\DBAL\ParameterType;
 use Doctrine\DBAL\Schema\Table;
 use Doctrine\DBAL\Types\Type;
-use const CASE_LOWER;
-use function array_change_key_case;
+use function fopen;
+use function in_array;
+use function str_repeat;
 use function stream_get_contents;
 
 /**
@@ -49,6 +51,28 @@ public function testInsert()
         self::assertEquals(1, $ret);
     }
 
+    public function testInsertProcessesStream()
+    {
+        if (in_array($this->_conn->getDatabasePlatform()->getName(), ['oracle', 'db2'], true)) {
+            // https://github.com/doctrine/dbal/issues/3288 for DB2
+            // https://github.com/doctrine/dbal/issues/3290 for Oracle
+            $this->markTestIncomplete('Platform does not support stream resources as parameters');
+        }
+
+        $longBlob = str_repeat('x', 4 * 8192); // send 4 chunks
+        $this->_conn->insert('blob_table', [
+            'id'        => 1,
+            'clobfield' => 'ignored',
+            'blobfield' => fopen('data://text/plain,' . $longBlob, 'r'),
+        ], [
+            ParameterType::INTEGER,
+            ParameterType::STRING,
+            ParameterType::LARGE_OBJECT,
+        ]);
+
+        $this->assertBlobContains($longBlob);
+    }
+
     public function testSelect()
     {
         $this->_conn->insert('blob_table', [
@@ -86,14 +110,63 @@ public function testUpdate()
         $this->assertBlobContains('test2');
     }
 
+    public function testUpdateProcessesStream()
+    {
+        if (in_array($this->_conn->getDatabasePlatform()->getName(), ['oracle', 'db2'], true)) {
+            // https://github.com/doctrine/dbal/issues/3288 for DB2
+            // https://github.com/doctrine/dbal/issues/3290 for Oracle
+            $this->markTestIncomplete('Platform does not support stream resources as parameters');
+        }
+
+        $this->_conn->insert('blob_table', [
+            'id'          => 1,
+            'clobfield'   => 'ignored',
+            'blobfield'   => 'test',
+        ], [
+            ParameterType::INTEGER,
+            ParameterType::STRING,
+            ParameterType::LARGE_OBJECT,
+        ]);
+
+        $this->_conn->update('blob_table', [
+            'id'          => 1,
+            'blobfield'   => fopen('data://text/plain,test2', 'r'),
+        ], ['id' => 1], [
+            ParameterType::INTEGER,
+            ParameterType::LARGE_OBJECT,
+        ]);
+
+        $this->assertBlobContains('test2');
+    }
+
+    public function testBindParamProcessesStream()
+    {
+        if (in_array($this->_conn->getDatabasePlatform()->getName(), ['oracle', 'db2'], true)) {
+            // https://github.com/doctrine/dbal/issues/3288 for DB2
+            // https://github.com/doctrine/dbal/issues/3290 for Oracle
+            $this->markTestIncomplete('Platform does not support stream resources as parameters');
+        }
+
+        $stmt = $this->_conn->prepare("INSERT INTO blob_table(id, clobfield, blobfield) VALUES (1, 'ignored', ?)");
+
+        $stream = null;
+        $stmt->bindParam(1, $stream, ParameterType::LARGE_OBJECT);
+
+        // Bind param does late binding (bind by reference), so create the stream only now:
+        $stream = fopen('data://text/plain,test', 'r');
+
+        $stmt->execute();
+
+        $this->assertBlobContains('test');
+    }
+
     private function assertBlobContains($text)
     {
-        $rows = $this->_conn->fetchAll('SELECT * FROM blob_table');
+        $rows = $this->_conn->query('SELECT blobfield FROM blob_table')->fetchAll(FetchMode::COLUMN);
 
         self::assertCount(1, $rows);
-        $row = array_change_key_case($rows[0], CASE_LOWER);
 
-        $blobValue = Type::getType('blob')->convertToPHPValue($row['blobfield'], $this->_conn->getDatabasePlatform());
+        $blobValue = Type::getType('blob')->convertToPHPValue($rows[0], $this->_conn->getDatabasePlatform());
 
         self::assertInternalType('resource', $blobValue);
         self::assertEquals($text, stream_get_contents($blobValue));