diff --git a/qa/L0_backend_python/argument_validation/models/argument_validation/1/model.py b/qa/L0_backend_python/argument_validation/models/argument_validation/1/model.py
new file mode 100644
index 0000000000..5af497aa0b
--- /dev/null
+++ b/qa/L0_backend_python/argument_validation/models/argument_validation/1/model.py
@@ -0,0 +1,176 @@
+# Copyright (c) 2022, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
+#
+# Redistribution and use in source and binary forms, with or without
+# modification, are permitted provided that the following conditions
+# are met:
+#  * Redistributions of source code must retain the above copyright
+#    notice, this list of conditions and the following disclaimer.
+#  * Redistributions in binary form must reproduce the above copyright
+#    notice, this list of conditions and the following disclaimer in the
+#    documentation and/or other materials provided with the distribution.
+#  * Neither the name of NVIDIA CORPORATION nor the names of its
+#    contributors may be used to endorse or promote products derived
+#    from this software without specific prior written permission.
+#
+# THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS ``AS IS'' AND ANY
+# EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
+# IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR
+# PURPOSE ARE DISCLAIMED.  IN NO EVENT SHALL THE COPYRIGHT OWNER OR
+# CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL,
+# EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO,
+# PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR
+# PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY
+# OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT
+# (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
+# OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
+
+import numpy as np
+import unittest
+import triton_python_backend_utils as pb_utils
+
+
+class ArgumentValidationTest(unittest.TestCase):
+
+    def test_infer_request_args(self):
+        # Dummy arguments used in the tests.
+        inputs = [pb_utils.Tensor('INPUT0', np.asarray([1, 2], dtype=np.int32))]
+        model_name = 'my_model'
+        requested_output_names = ['my_output']
+
+        #
+        # inputs field validation
+        #
+
+        # Test list of None as inputs
+        with self.assertRaises(pb_utils.TritonModelException) as e:
+            pb_utils.InferenceRequest(
+                inputs=[None],
+                model_name=model_name,
+                requested_output_names=requested_output_names)
+
+        # Test None object as list of inputs
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceRequest(
+                inputs=None,
+                model_name=model_name,
+                requested_output_names=requested_output_names)
+
+        # model_name validation
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceRequest(
+                model_name=None,
+                inputs=inputs,
+                requested_output_names=requested_output_names)
+
+        #
+        # Requested output name validations
+        #
+
+        # Test list of None objects as requested_output_names
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceRequest(requested_output_names=[None],
+                                      inputs=inputs,
+                                      model_name=model_name)
+
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceRequest(requested_output_names=None,
+                                      inputs=inputs,
+                                      model_name=model_name)
+
+        # Other arguments validation
+
+        # correlation_id set to None
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceRequest(
+                requested_output_names=requested_output_names,
+                inputs=inputs,
+                model_name=model_name,
+                correleation_id=None)
+
+        # request_id set to None
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceRequest(
+                requested_output_names=requested_output_names,
+                inputs=inputs,
+                model_name=model_name,
+                request_id=None)
+
+        # model_version set to None
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceRequest(
+                requested_output_names=requested_output_names,
+                inputs=inputs,
+                model_name=model_name,
+                model_version=None)
+
+        # flags set to None
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceRequest(
+                requested_output_names=requested_output_names,
+                inputs=inputs,
+                model_name=model_name,
+                flags=None)
+
+        # Empty lists should not raise an exception
+        pb_utils.InferenceRequest(requested_output_names=[],
+                                  inputs=[],
+                                  model_name=model_name)
+
+    def test_infer_response_args(self):
+        outputs = [
+            pb_utils.Tensor('OUTPUT0', np.asarray([1, 2], dtype=np.int32))
+        ]
+
+        # Test list of None object as output tensor
+        with self.assertRaises(pb_utils.TritonModelException) as e:
+            pb_utils.InferenceResponse(output_tensors=[None])
+
+        # Test None as output tensors
+        with self.assertRaises(TypeError) as e:
+            pb_utils.InferenceResponse(output_tensors=None)
+
+        # This should not raise an exception
+        pb_utils.InferenceResponse(output_tensors=[])
+        pb_utils.InferenceResponse(outputs)
+
+    def test_tensor_args(self):
+        np_array = np.asarray([1, 2], dtype=np.int32)
+
+        # Test None as tensor name
+        with self.assertRaises(TypeError) as e:
+            pb_utils.Tensor(None, np_array)
+
+        # Test None as Numpy array
+        with self.assertRaises(TypeError) as e:
+            pb_utils.Tensor("OUTPUT0", None)
+
+        # Test None as dlpack capsule
+        with self.assertRaises(TypeError) as e:
+            pb_utils.Tensor.from_dlpack("OUTPUT0", None)
+
+        # Test empty string as model name (from_dlpack)
+        with self.assertRaises(TypeError) as e:
+            pb_utils.Tensor.from_dlpack("", None)
+
+        # Test empty string as model name
+        with self.assertRaises(TypeError) as e:
+            pb_utils.Tensor("", None)
+
+
+class TritonPythonModel:
+    """This model tests the Python API arguments to make sure invalid args are
+    rejected."""
+
+    def execute(self, requests):
+        responses = []
+        for _ in requests:
+            # Run the unittest and store the results in InferenceResponse.
+            test = unittest.main('model', exit=False)
+            responses.append(
+                pb_utils.InferenceResponse([
+                    pb_utils.Tensor(
+                        'OUTPUT0',
+                        np.array([test.result.wasSuccessful()],
+                                 dtype=np.float16))
+                ]))
+        return responses
diff --git a/qa/L0_backend_python/argument_validation/models/argument_validation/config.pbtxt b/qa/L0_backend_python/argument_validation/models/argument_validation/config.pbtxt
new file mode 100644
index 0000000000..4c02983319
--- /dev/null
+++ b/qa/L0_backend_python/argument_validation/models/argument_validation/config.pbtxt
@@ -0,0 +1,39 @@
+# Copyright (c) 2022, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
+#
+# Redistribution and use in source and binary forms, with or without
+# modification, are permitted provided that the following conditions
+# are met:
+#  * Redistributions of source code must retain the above copyright
+#    notice, this list of conditions and the following disclaimer.
+#  * Redistributions in binary form must reproduce the above copyright
+#    notice, this list of conditions and the following disclaimer in the
+#    documentation and/or other materials provided with the distribution.
+#  * Neither the name of NVIDIA CORPORATION nor the names of its
+#    contributors may be used to endorse or promote products derived
+#    from this software without specific prior written permission.
+#
+# THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS ``AS IS'' AND ANY
+# EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
+# IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR
+# PURPOSE ARE DISCLAIMED.  IN NO EVENT SHALL THE COPYRIGHT OWNER OR
+# CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL,
+# EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO,
+# PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR
+# PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY
+# OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT
+# (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
+# OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
+
+name: "argument_validation"
+backend: "python"
+max_batch_size: 0
+
+output [
+  {
+    name: "OUTPUT0"
+    data_type: TYPE_FP32
+    dims: [ 1 ]
+  }
+]
+
+instance_group [{ kind: KIND_CPU }]
diff --git a/qa/L0_backend_python/argument_validation/test.sh b/qa/L0_backend_python/argument_validation/test.sh
new file mode 100644
index 0000000000..f80ce3e84b
--- /dev/null
+++ b/qa/L0_backend_python/argument_validation/test.sh
@@ -0,0 +1,77 @@
+# Copyright (c) 2022, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
+#
+# Redistribution and use in source and binary forms, with or without
+# modification, are permitted provided that the following conditions
+# are met:
+#  * Redistributions of source code must retain the above copyright
+#    notice, this list of conditions and the following disclaimer.
+#  * Redistributions in binary form must reproduce the above copyright
+#    notice, this list of conditions and the following disclaimer in the
+#    documentation and/or other materials provided with the distribution.
+#  * Neither the name of NVIDIA CORPORATION nor the names of its
+#    contributors may be used to endorse or promote products derived
+#    from this software without specific prior written permission.
+#
+# THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS ``AS IS'' AND ANY
+# EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
+# IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR
+# PURPOSE ARE DISCLAIMED.  IN NO EVENT SHALL THE COPYRIGHT OWNER OR
+# CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL,
+# EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO,
+# PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR
+# PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY
+# OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT
+# (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE
+# OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
+
+CLIENT_PY=../python_unittest.py
+CLIENT_LOG="./client.log"
+EXPECTED_NUM_TESTS="1"
+TEST_RESULT_FILE='test_results.txt'
+TRITON_DIR=${TRITON_DIR:="/opt/tritonserver"}
+SERVER=${TRITON_DIR}/bin/tritonserver
+BACKEND_DIR=${TRITON_DIR}/backends
+SERVER_ARGS="--model-repository=`pwd`/models --backend-directory=${BACKEND_DIR} --log-verbose=1"
+SERVER_LOG="./inference_server.log"
+
+RET=0
+source ../../common/util.sh
+
+rm -fr *.log
+
+run_server
+if [ "$SERVER_PID" == "0" ]; then
+    echo -e "\n***\n*** Failed to start $SERVER\n***"
+    cat $SERVER_LOG
+    RET=1
+fi
+
+set +e
+export MODEL_NAME="argument_validation"
+python3 $CLIENT_PY > $CLIENT_LOG 2>&1
+
+if [ $? -ne 0 ]; then
+    echo -e "\n***\n*** python_unittest.py FAILED. \n***"
+    RET=1
+else
+    check_test_results $TEST_RESULT_FILE $EXPECTED_NUM_TESTS
+    if [ $? -ne 0 ]; then
+        cat $CLIENT_LOG
+        echo -e "\n***\n*** Test Result Verification Failed\n***"
+        RET=1
+    fi
+fi
+set -e
+
+kill $SERVER_PID
+wait $SERVER_PID
+
+if [ $RET -eq 1 ]; then
+    cat $CLIENT_LOG
+    cat $SERVER_LOG
+    echo -e "\n***\n*** Argument validation test FAILED. \n***"
+else
+    echo -e "\n***\n*** Argument validation test PASSED. \n***"
+fi
+
+exit $RET
diff --git a/qa/L0_backend_python/test.sh b/qa/L0_backend_python/test.sh
index 664ae852a4..f5e9391bb1 100755
--- a/qa/L0_backend_python/test.sh
+++ b/qa/L0_backend_python/test.sh
@@ -391,6 +391,11 @@ if [ $? -ne 0 ]; then
   RET=1
 fi
 
+(cd argument_validation && bash -ex test.sh)
+if [ $? -ne 0 ]; then
+  RET=1
+fi
+
 if [ $RET -eq 0 ]; then
   echo -e "\n***\n*** Test Passed\n***"
 else