diff --git a/ChangeLog.md b/ChangeLog.md
index 2da5b39dae..a2c0923957 100644
--- a/ChangeLog.md
+++ b/ChangeLog.md
@@ -34,6 +34,9 @@ Other enhancements:
   See [#3716](https://github.com/commercialhaskell/stack/issues/3716)
 * Improve the error message when an `extra-dep` from a path or git reference can't be found
   See [#3808](https://github.com/commercialhaskell/stack/pull/3808)
+* Nix integration is now disabled on windows even if explicitly enabled,
+  since it isn't supported. See
+  [#3600](https://github.com/commercialhaskell/stack/issues/3600)
 
 Bug fixes:
 * 1.6.1 introduced a change that made some precompiled cache files use
diff --git a/src/Stack/Config/Nix.hs b/src/Stack/Config/Nix.hs
index b747777df5..99ab32689f 100644
--- a/src/Stack/Config/Nix.hs
+++ b/src/Stack/Config/Nix.hs
@@ -11,18 +11,20 @@ module Stack.Config.Nix
 import Stack.Prelude
 import qualified Data.Text as T
 import Distribution.System (OS (..))
+import Stack.Constants
 import Stack.Types.Version
 import Stack.Types.Nix
 import Stack.Types.Compiler
+import Stack.Types.Runner
 
 -- | Interprets NixOptsMonoid options.
 nixOptsFromMonoid
-    :: MonadUnliftIO m
+    :: HasRunner env
     => NixOptsMonoid
     -> OS
-    -> m NixOpts
+    -> RIO env NixOpts
 nixOptsFromMonoid NixOptsMonoid{..} os = do
-    let nixEnable = fromFirst False nixMonoidEnable
+    let nixEnable0 = fromFirst False nixMonoidEnable
         defaultPure = case os of
           OSX -> False
           _ -> True
@@ -32,6 +34,12 @@ nixOptsFromMonoid NixOptsMonoid{..} os = do
         nixShellOptions = fromFirst [] nixMonoidShellOptions
                           ++ prefixAll (T.pack "-I") (fromFirst [] nixMonoidPath)
         nixAddGCRoots   = fromFirst False nixMonoidAddGCRoots
+    nixEnable <-
+      if nixEnable0 && osIsWindows
+        then do
+          logInfo "Note: Disabling nix integration, since this is being run in Windows"
+          return False
+        else return nixEnable0
     when (not (null nixPackages) && isJust nixInitFile) $
        throwIO NixCannotUseShellFileAndPackagesException
     return NixOpts{..}
diff --git a/src/test/Stack/NixSpec.hs b/src/test/Stack/NixSpec.hs
index 870ca9e3be..3864273c94 100644
--- a/src/test/Stack/NixSpec.hs
+++ b/src/test/Stack/NixSpec.hs
@@ -1,14 +1,17 @@
 {-# LANGUAGE NoImplicitPrelude #-}
 {-# LANGUAGE FlexibleContexts #-}
 {-# LANGUAGE RecordWildCards  #-}
-{-# LANGUAGE TemplateHaskell, OverloadedStrings #-}
+{-# LANGUAGE OverloadedStrings #-}
 module Stack.NixSpec where
 
+import Data.Maybe (fromJust)
 import Options.Applicative
 import Path
+import Prelude (writeFile)
 import Stack.Config
-import Stack.Options.NixParser
 import Stack.Config.Nix
+import Stack.Constants
+import Stack.Options.NixParser
 import Stack.Prelude
 import Stack.Types.Compiler
 import Stack.Types.Config
@@ -18,8 +21,6 @@ import Stack.Types.Version
 import System.Directory
 import System.Environment
 import Test.Hspec
-import Prelude (writeFile)
-import Data.Maybe (fromJust)
 
 sampleConfigNixEnabled :: String
 sampleConfigNixEnabled =
@@ -37,9 +38,6 @@ sampleConfigNixDisabled =
   "nix:\n" ++
   "   enable: False"
 
-stackDotYaml :: Path Rel File
-stackDotYaml = $(mkRelFile "stack.yaml")
-
 setup :: IO ()
 setup = unsetEnv "STACK_YAML"
 
@@ -62,6 +60,7 @@ spec = beforeAll setup $ do
         (info (nixOptsParser False) mempty)
         cmdLineOpts
       parseOpts cmdLineOpts = mempty { configMonoidNixOpts = parseNixOpts cmdLineOpts }
+  let trueOnNonWindows = not osIsWindows
   describe "nix disabled in config file" $
     around_ (withStackDotYaml sampleConfigNixDisabled) $ do
       it "sees that the nix shell is not enabled" $ do
@@ -70,11 +69,11 @@ spec = beforeAll setup $ do
       describe "--nix given on command line" $
         it "sees that the nix shell is enabled" $ do
           lc <- loadConfig' (parseOpts ["--nix"])
-          nixEnable (configNix $ lcConfig lc) `shouldBe` True
+          nixEnable (configNix $ lcConfig lc) `shouldBe` trueOnNonWindows
       describe "--nix-pure given on command line" $
         it "sees that the nix shell is enabled" $ do
           lc <- loadConfig' (parseOpts ["--nix-pure"])
-          nixEnable (configNix $ lcConfig lc) `shouldBe` True
+          nixEnable (configNix $ lcConfig lc) `shouldBe` trueOnNonWindows
       describe "--no-nix given on command line" $
         it "sees that the nix shell is not enabled" $ do
           lc <- loadConfig' (parseOpts ["--no-nix"])
@@ -87,7 +86,7 @@ spec = beforeAll setup $ do
     around_ (withStackDotYaml sampleConfigNixEnabled) $ do
       it "sees that the nix shell is enabled" $ do
         lc <- loadConfig' mempty
-        nixEnable (configNix $ lcConfig lc) `shouldBe` True
+        nixEnable (configNix $ lcConfig lc) `shouldBe` trueOnNonWindows
       describe "--no-nix given on command line" $
         it "sees that the nix shell is not enabled" $ do
           lc <- loadConfig' (parseOpts ["--no-nix"])
@@ -95,11 +94,11 @@ spec = beforeAll setup $ do
       describe "--nix-pure given on command line" $
         it "sees that the nix shell is enabled" $ do
           lc <- loadConfig' (parseOpts ["--nix-pure"])
-          nixEnable (configNix $ lcConfig lc) `shouldBe` True
+          nixEnable (configNix $ lcConfig lc) `shouldBe` trueOnNonWindows
       describe "--no-nix-pure given on command line" $
         it "sees that the nix shell is enabled" $ do
           lc <- loadConfig' (parseOpts ["--no-nix-pure"])
-          nixEnable (configNix $ lcConfig lc) `shouldBe` True
+          nixEnable (configNix $ lcConfig lc) `shouldBe` trueOnNonWindows
       it "sees that the only package asked for is glpk and asks for the correct GHC derivation" $ do
         lc <- loadConfig' mempty
         nixPackages (configNix $ lcConfig lc) `shouldBe` ["glpk"]