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calculation of tau* from LDSC output #270

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cmlakhan opened this issue Feb 4, 2021 · 1 comment
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calculation of tau* from LDSC output #270

cmlakhan opened this issue Feb 4, 2021 · 1 comment

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@cmlakhan
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cmlakhan commented Feb 4, 2021

Just for clarification if you use partitioned LD score regression with the flag --print-coefficients then the coefficients are the unnormalized coefficients $/tau$, correct? If you want the normalized $/tau^*$ then we need to apply the formula below using the Coefficient and Coefficient_std_error columns in the .results file?

Screen Shot 2021-02-04 at 5 35 50 PM

@cmlakhan cmlakhan closed this as completed Jul 9, 2021
@dqq0404
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dqq0404 commented Jun 25, 2024

Hi,
Did you calculate the Tau_star? I do not understand what the meaning of alphabet in this formula.
Which of the following parameters can represent them respectively?
Prop._SNPs Prop._h2 Prop._h2_std_error Enrichment Enrichment_std_error Enrichment_p Coefficient Coefficient_std_error Coefficient_z-score

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