diff --git a/cdc/sinkv2/eventsink/txn/mysql/mysql.go b/cdc/sinkv2/eventsink/txn/mysql/mysql.go
index 72f9f411c6d..098610e7b15 100644
--- a/cdc/sinkv2/eventsink/txn/mysql/mysql.go
+++ b/cdc/sinkv2/eventsink/txn/mysql/mysql.go
@@ -385,10 +385,23 @@ func (s *mysqlBackend) batchSingleTxnDmls(
 
 	// handle update
 	if len(updateRows) > 0 {
-		for _, rows := range updateRows {
-			s, v := s.genUpdateSQL(rows...)
-			sqls = append(sqls, s...)
-			values = append(values, v...)
+		if s.cfg.IsTiDB {
+			for _, rows := range updateRows {
+				s, v := s.genUpdateSQL(rows...)
+				sqls = append(sqls, s...)
+				values = append(values, v...)
+			}
+			// The behavior of update statement differs between TiDB and MySQL.
+			// So we don't use batch update statement when downstream is MySQL.
+			// Ref:https://docs.pingcap.com/tidb/stable/sql-statement-update#mysql-compatibility
+		} else {
+			for _, rows := range updateRows {
+				for _, row := range rows {
+					sql, value := row.GenSQL(sqlmodel.DMLUpdate)
+					sqls = append(sqls, sql)
+					values = append(values, value)
+				}
+			}
 		}
 	}
 
diff --git a/cdc/sinkv2/eventsink/txn/mysql/mysql_test.go b/cdc/sinkv2/eventsink/txn/mysql/mysql_test.go
index 259606e95a5..d57cf862d2b 100644
--- a/cdc/sinkv2/eventsink/txn/mysql/mysql_test.go
+++ b/cdc/sinkv2/eventsink/txn/mysql/mysql_test.go
@@ -1199,12 +1199,14 @@ func TestMysqlSinkSafeModeOff(t *testing.T) {
 func TestPrepareBatchDMLs(t *testing.T) {
 	t.Parallel()
 	testCases := []struct {
+		isTiDB   bool
 		input    []*model.RowChangedEvent
 		expected *preparedDMLs
 	}{
 		// empty event
 		{
-			input: []*model.RowChangedEvent{},
+			isTiDB: true,
+			input:  []*model.RowChangedEvent{},
 			expected: &preparedDMLs{
 				startTs: []model.Ts{},
 				sqls:    []string{},
@@ -1212,6 +1214,7 @@ func TestPrepareBatchDMLs(t *testing.T) {
 			},
 		},
 		{ // delete event
+			isTiDB: true,
 			input: []*model.RowChangedEvent{
 				{
 					StartTs:  418658114257813514,
@@ -1260,6 +1263,7 @@ func TestPrepareBatchDMLs(t *testing.T) {
 			},
 		},
 		{ // insert event
+			isTiDB: true,
 			input: []*model.RowChangedEvent{
 				{
 					StartTs:  418658114257813516,
@@ -1308,6 +1312,7 @@ func TestPrepareBatchDMLs(t *testing.T) {
 		},
 		// update event
 		{
+			isTiDB: true,
 			input: []*model.RowChangedEvent{
 				{
 					StartTs:  418658114257813516,
@@ -1390,6 +1395,7 @@ func TestPrepareBatchDMLs(t *testing.T) {
 		},
 		// mixed event
 		{
+			isTiDB: true,
 			input: []*model.RowChangedEvent{
 				{
 					StartTs:  418658114257813514,
@@ -1460,6 +1466,98 @@ func TestPrepareBatchDMLs(t *testing.T) {
 				rowCount: 3,
 			},
 		},
+		// update event and downstream is mysql and without pk
+		{
+			isTiDB: false,
+			input: []*model.RowChangedEvent{
+				{
+					StartTs:  418658114257813516,
+					CommitTs: 418658114257813517,
+					Table:    &model.TableName{Schema: "common_1", Table: "uk_without_pk"},
+					PreColumns: []*model.Column{nil, {
+						Name: "a1",
+						Type: mysql.TypeLong,
+						Flag: model.BinaryFlag |
+							model.MultipleKeyFlag |
+							model.HandleKeyFlag |
+							model.UniqueKeyFlag,
+						Value: 1,
+					}, {
+						Name:    "a3",
+						Type:    mysql.TypeVarchar,
+						Charset: charset.CharsetGBK,
+						Flag: model.BinaryFlag | model.MultipleKeyFlag |
+							model.HandleKeyFlag | model.UniqueKeyFlag,
+						Value: []byte("开发"),
+					}},
+					Columns: []*model.Column{nil, {
+						Name: "a1",
+						Type: mysql.TypeLong,
+						Flag: model.BinaryFlag |
+							model.MultipleKeyFlag |
+							model.HandleKeyFlag |
+							model.UniqueKeyFlag,
+						Value: 2,
+					}, {
+						Name:    "a3",
+						Type:    mysql.TypeVarchar,
+						Charset: charset.CharsetGBK,
+						Flag: model.BinaryFlag | model.MultipleKeyFlag |
+							model.HandleKeyFlag | model.UniqueKeyFlag,
+						Value: []byte("测试"),
+					}},
+					IndexColumns: [][]int{{1, 2}},
+				},
+				{
+					StartTs:  418658114257813516,
+					CommitTs: 418658114257813517,
+					Table:    &model.TableName{Schema: "common_1", Table: "uk_without_pk"},
+					PreColumns: []*model.Column{nil, {
+						Name: "a1",
+						Type: mysql.TypeLong,
+						Flag: model.BinaryFlag |
+							model.MultipleKeyFlag |
+							model.HandleKeyFlag |
+							model.UniqueKeyFlag,
+						Value: 3,
+					}, {
+						Name:    "a3",
+						Type:    mysql.TypeVarchar,
+						Charset: charset.CharsetGBK,
+						Flag: model.BinaryFlag | model.MultipleKeyFlag |
+							model.HandleKeyFlag | model.UniqueKeyFlag,
+						Value: []byte("纽约"),
+					}},
+					Columns: []*model.Column{nil, {
+						Name: "a1",
+						Type: mysql.TypeLong,
+						Flag: model.BinaryFlag |
+							model.MultipleKeyFlag |
+							model.HandleKeyFlag | model.UniqueKeyFlag,
+						Value: 4,
+					}, {
+						Name:    "a3",
+						Type:    mysql.TypeVarchar,
+						Charset: charset.CharsetGBK,
+						Flag: model.BinaryFlag | model.MultipleKeyFlag |
+							model.HandleKeyFlag | model.UniqueKeyFlag,
+						Value: []byte("北京"),
+					}},
+					IndexColumns: [][]int{{1, 2}},
+				},
+			},
+			expected: &preparedDMLs{
+				startTs: []model.Ts{418658114257813516},
+				sqls: []string{
+					"UPDATE `common_1`.`uk_without_pk` SET `a1` = ?, " +
+						"`a3` = ? WHERE `a1` = ? AND `a3` = ? LIMIT 1",
+					"UPDATE `common_1`.`uk_without_pk` SET `a1` = ?, " +
+						"`a3` = ? WHERE `a1` = ? AND `a3` = ? LIMIT 1",
+				},
+				values:   [][]interface{}{{2, "测试", 1, "开发"}, {4, "北京", 3, "纽约"}},
+				rowCount: 2,
+			},
+		},
 	}
 
 	ctx, cancel := context.WithCancel(context.Background())
@@ -1469,6 +1567,7 @@ func TestPrepareBatchDMLs(t *testing.T) {
 	ms.cfg.SafeMode = false
 	ms.cfg.EnableOldValue = true
 	for _, tc := range testCases {
+		ms.cfg.IsTiDB = tc.isTiDB
 		ms.events = make([]*eventsink.TxnCallbackableEvent, 1)
 		ms.events[0] = &eventsink.TxnCallbackableEvent{
 			Event: &model.SingleTableTxn{Rows: tc.input},
diff --git a/tests/integration_tests/charset_gbk/data/test.sql b/tests/integration_tests/charset_gbk/data/test.sql
index 68f7d9d8ed5..dc10d09644a 100644
--- a/tests/integration_tests/charset_gbk/data/test.sql
+++ b/tests/integration_tests/charset_gbk/data/test.sql
@@ -107,6 +107,8 @@ INSERT INTO t0
 VALUES (2, '部署', "美国", "纽约", "世界,你好"
 	, 0xCAC0BDE7C4E3BAC3);
 
+SELECT sleep(5);
+
 UPDATE t0
 SET name = '开发'
 WHERE name = '测试'