You can deploy an Akka gRPC application just like you would any other JVM-based project. For some general pointers on this topic, see the deployment section of the Akka documentation.
Remember that the unencrypted HTTP2 'h2c with preexisting knowledge' protocol is not compatible with HTTP/1.1, so if your infrastructure uses any proxies they must either understand this protocol or support generic TCP connections.
As an example, here is a complete project consisting of 2 applications (a gRPC service and an HTTP service that consumes the gRPC service) that can be deployed together in Kubernetes.