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MAR02381: 3-oxooleoyl-CoA + CoA --> acetyl-CoA + palmitoleoyl-CoA, GPR: (HADHB and ACAA2) or (ACAA1 and HADHB)
Expected behavior:
While HADHB, ACAA1, and ACAA2 can all catalyze 3-oxoacyl-CoA thiolysis reactions, ACAA1 is localized to peroxisomes, and MAR02381 is in the mitochondrial compartment. Also, HADHB and ACAA2 can catalyze this reaction independently of each other, so the GPR of MAR02381 should just be HADHB or ACAA2 (ENSG00000138029 or ENSG00000167315).
There are many other mitochondrial reactions associated with ACAA1, but they all have several other problems that I'm addressing in separate issues (so far, just #738 and #746, but there will be more)
Proposed changes:
Change the GPR of MAR02381 to ENSG00000138029 or ENSG00000167315
The text was updated successfully, but these errors were encountered:
Current behavior:
MAR02381
: 3-oxooleoyl-CoA + CoA --> acetyl-CoA + palmitoleoyl-CoA, GPR: (HADHB and ACAA2) or (ACAA1 and HADHB)Expected behavior:
While HADHB, ACAA1, and ACAA2 can all catalyze 3-oxoacyl-CoA thiolysis reactions, ACAA1 is localized to peroxisomes, and
MAR02381
is in the mitochondrial compartment. Also, HADHB and ACAA2 can catalyze this reaction independently of each other, so the GPR ofMAR02381
should just beHADHB or ACAA2
(ENSG00000138029 or ENSG00000167315
).There are many other mitochondrial reactions associated with ACAA1, but they all have several other problems that I'm addressing in separate issues (so far, just #738 and #746, but there will be more)
Proposed changes:
MAR02381
toENSG00000138029 or ENSG00000167315
The text was updated successfully, but these errors were encountered: