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ACAA1 should not be in the GPR of MAR02381 #759

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Devlin-Moyer opened this issue Dec 10, 2023 · 1 comment
Closed
1 task done

ACAA1 should not be in the GPR of MAR02381 #759

Devlin-Moyer opened this issue Dec 10, 2023 · 1 comment
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@Devlin-Moyer
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Devlin-Moyer commented Dec 10, 2023

Current behavior:

MAR02381: 3-oxooleoyl-CoA + CoA --> acetyl-CoA + palmitoleoyl-CoA, GPR: (HADHB and ACAA2) or (ACAA1 and HADHB)

Expected behavior:

While HADHB, ACAA1, and ACAA2 can all catalyze 3-oxoacyl-CoA thiolysis reactions, ACAA1 is localized to peroxisomes, and MAR02381 is in the mitochondrial compartment. Also, HADHB and ACAA2 can catalyze this reaction independently of each other, so the GPR of MAR02381 should just be HADHB or ACAA2 (ENSG00000138029 or ENSG00000167315).

There are many other mitochondrial reactions associated with ACAA1, but they all have several other problems that I'm addressing in separate issues (so far, just #738 and #746, but there will be more)

Proposed changes:

  • Change the GPR of MAR02381 to ENSG00000138029 or ENSG00000167315
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