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<HTML><body><h2>PSORT II Variables</h2>Last updated: January 12, 2005<p><table border align="left"><tr><th>Name<th>Description</tr><tr><td>psg<td>Score for the presence of signal peptides; the algorithm was basically developed by <a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?%0Auid=3000102&form=6&db=m&Dopt=r">McGeoch</a> and was expandes by <a href="http://psort.ims.u-tokyo.ac.jp/refs/GIW96.html">Nakai and Kanehisa</a> in 1992 </tr><tr><td>gvh<td>Original weight-matrix score of <a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3714490%0A&form=6&db=m&Dopt=r">von Heijne</a> for the recognition of cleavage sites of eukaryotic signal peptides subtracted by 7.5</tr><tr><td>alm<td>Discriminant score, calculated from the most hydrophobic 17 residue segment, given by the algorithm of <a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3838905%0A&form=6&db=m&Dopt=r">Klein, Kanehisa, DeLisi</a></tr><tr><td>top<td>Score for predicting the topology of membrane proteins, by <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&term=2762295%0A&doptcmdl=Citation%0A">Hartmann, Rapoport, Lodish's method</a>. It is essentially the net charge difference of 15 residues flanking the most N-terminal transmembrane segment on both sides</tr><tr><td>tms<td>Predicted number of transmembrane segments (except the cleavable signal peptide), given by <a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3838905%0A&form=6&db=m&Dopt=r">Klein, Kanehisa, DeLisi's algorithm</a></tr><tr><td>mit<td>Score for the presence of N-terminal mitochondrial targeting signal, which is calculated from the amino acid composition of the N-terminal 20 residues (developed by <a href="http://psort.ims.u-tokyo.ac.jp/refs/Nak92.html"> Nakai and Kanehisa</a>)</tr><tr><td>mip<td>Predicted position of the cleavage sites of mitochodrial targetign signals by <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=2290832&dopt=Citation%0A">Gavel and von Heijne's method</a></tr><tr><td>nuc<td>Discriminant score for being a nuclear protein, calculated from the presence of NLS motif, bipartite motif, and the amino acid composition, by <a href="http://psort.ims.u-tokyo.ac.jp/refs/Nak92.html">Nakai and Kanehisa</a>. NLSs are detected by the two rules: 4 residue pattern (called 'pat4') composed of 4 basic amino acids (K or R), or composed of three basic amino acids (K or R) and either H or P; the other (called 'pat7') is a pattern starting with P and followed within 3 residues by a basic segment containing 3 K/R residues out of 4. The bipartite pattern (called 'bipartite') is: 2 basic residues, 10 residue spacer, and another basic region consisting of at least 3 basic residues out of 5 residues.</tr><tr><td>erl<td>"1" if the "(K/H)DEL" motif exists on its C-terminus; "0" otherwise(for the prediction of ER luminal proteins)</tr><tr><td>erm<td>Score of being an ER membrane protein, calculated from the presence of the retention signals and the membrane topology (PSORT II original)</tr><tr><td>pax<td>Prediction of peroxisomal proteins from the presence of "SKL"-like motifs (PTS1) mainly on the C-terminus</tr><tr><td>px2<td>Prediction of peroxisomal proteins from the presence of the "(R/K)(L/I)xxxxx(H/Q)L" motif (see <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=8851661&dopt=Citation%0A">this review</a>)</tr><tr><td>vac<td>Presence of a possible/unreliable vacuolar targeting motif "(T/I/K)LP(L/K/I)" (<a href="http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8689553&form=6&%0Adb=m&Dopt=r">review</a>)</tr><tr><td>rnp<td>Presence of a motif of RNA-binding proteins "[RK]G[^EDRKHPCG][AGSCI][FY][LIVA].[FYM]" (taken from PROSITE)</tr><tr><td>act<td>Presence of 2 motifs for actinin-type actin-binding (taken from PROSITE) in the hope to detect some cytoskeletal proteins</tr><tr><td>caa<td>Presence of the CaaX motif ("C[^DENQ][LIVM].$") on the C-teminus for predicting isoprenylated proteins (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=8811180&dopt=Citation%0A">review</a>)</tr><tr><td>yqr<td>Presence of the "YQRL" motif in membrane proteins; this motif is used for the transport from the cell surface to Golgi</tr><tr><td>tyr<td>An arbitrary score calculated from the presence of the tyrosine-containing motif in the cytoplasmic tail of membrane proteins, which can be important for the selective inclusion in clathrin-coated vesicles (endocytosis) and lysosomal targeting</tr><tr><td>leu<td>An arbitrary score calculated from the presence of the dileucine motif "LL" in the cytoplasmic tail of membrane proteins, which can be important for the selective inclusion in clathrin-coated vesicles (endocytosis) and lysosomal targeting</tr><tr><td>gpi<td>Prediction of GPI-anchored proteins based on empirical knowledge that most of them are the type Ia membrane proteins with very short cytoplasmic tail (within 10 residues) (<a href="http://psort.ims.u-tokyo.ac.jp/refs/Nak92.html">Nakai and Kenehisa</a>)</tr><tr><td>myr<td>Presence of some features around the N-teminus for predicting N-myristoylated/palmitylated proteins (<a href="http://www.ncbi.nlm.nih.gov/%0Ahtbin-post/Entrez/query?uid=7979256&form=6&db=m&Dopt=r">review</a>)</tr><tr><td>dna<td>Presence of 63 PROSITE motifs related to DNA binding, which may be useful to distinguish nuclear proteins</tr><tr><td>rib<td>Presence of 71 motifs for ribosomal proteins obtained from PROSITE, which may be necessary for prediction because the sorting process of ribosomal proteins are quite complex</tr><tr><td>bac<td>Presence of 33 prokaryotic DNA binding motifs from PROSITE, which might be useful for the prediction of even eukaryotic nuclear proteins</tr><tr><td>m1a<td>"1" if it is predicted to be a membrane protein with the type 1a topology (having a cleavable signal sequence and one transmembrane segment); "0", otherwise; prediction is the combination of variaous methods (psg, gvh, alm, and top)</tr><tr><td>m1b<td>"1" if it is predicted to be a membrane protein with the type 1b topology; "0", otherwise; prediction is the combination of variaous methods (psg, gvh, alm, and top)</tr><tr><td>m2<td>"1" if it is predicted to be a membrane protein with the type 2 topology; "0", otherwise; prediction is the combination of variaous methods (psg, gvh, alm, and top)</tr><tr><td>mNt<td>"1" if it is predicted to be a membrane protein with the N-tail topology (having an uncleavable signal peptide and one transmembrane segment near its C-terminus); "0", otherwise; prediction is the combination of variaous methods (psg, gvh, alm, and top)</tr><tr><td>m3a<td>"1" if it is predicted to be a membrane protein with the type 3a topology (multiple transmembrane regions with its N-teminus facing the cytosolic? side); "0", otherwise; prediction is the combination of variaous methods (psg, gvh, alm, and top)</tr><tr><td>m3b<td>"1" if it is predicted to be a membrane protein with the type 3b topology (multiple transmembrane regions with its N-terminus facing the extra-cytosolic? side); "0", otherwise; prediction is the combination of variaous methods (psg, gvh, alm, and top)</tr><tr><td>m_<td>"1" if it is predicted to be a membrane protein with any exceptional topology; "0", otherwise; prediction is the combination of variaous methods (psg, gvh, alm, and top)</tr><tr><td>ncn<td>Score (called "NNCN") for discriminating the tendency to be at either the nucleus or the cytoplasm, calculated based on the amino acid composition with the neural network constructed by <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&term=%0A9547285&doptcmdl=Citation%0A">Reinhardt and Hubbard</a></tr><tr><td>lps<td>Predicted number of residues in the coiled-coil structure; prediction method is according to <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2031185&dopt=Abstract">Lupas et al.</a></tr><tr><td>len<td>Length of the input sequence</tr></table><P></body></HTML>