From a7c30cca3a5366c3dfc429fa7ba217d1b0b3215c Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 18:26:04 -0800 Subject: [PATCH 01/28] Add individual match and homoz files, with setters and getters --- Individual.cpp | 26 ++++++++++++++++++++++++++ Individual.h | 7 +++++++ 2 files changed, 33 insertions(+) diff --git a/Individual.cpp b/Individual.cpp index 8f5b73b..7ac5a58 100644 --- a/Individual.cpp +++ b/Individual.cpp @@ -216,5 +216,31 @@ ostream& operator<<(ostream &fout, Individual& ind) return fout; } +void Individual::setIndividualMatchFile() +{ + string ext = ".tsv"; + string dir = "individual_match_files/"; + string fileHandleName = dir + getID() + ext; + individualMatchFile = new ofstream(fileHandleName, ofstream::app); +} + +void Individual::setIndividualHomozFile() +{ + string ext = ".tsv"; + string dir = "individual_homoz_files/"; + string fileHandleName = dir + getID() + ext; + individualHomozFile = new ofstream(fileHandleName, ofstream::app); +} + +ofstream* Individual::getIndividualMatchFile() +{ + return individualMatchFile; +} + +ofstream* Individual::getIndividualHomozFile() +{ + return individualHomozFile; +} + // end Individual.cpp diff --git a/Individual.h b/Individual.h index 8d3a27b..ff22bd4 100644 --- a/Individual.h +++ b/Individual.h @@ -96,6 +96,11 @@ class Individual // clearMarkers(): clears all MarkerSets from this individual void clearMarkers(); + void setIndividualMatchFile(); + void setIndividualHomozFile(); + ofstream* getIndividualMatchFile(); + ofstream* getIndividualHomozFile(); + private: // ID of the individual @@ -108,6 +113,8 @@ class Individual streamoff offset; Match ** all_matches; + ofstream* individualMatchFile; + ofstream* individualHomozFile; }; From 836f07578691bc6bdee1bd6e5c5d5f1c5d83ee69 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 18:26:37 -0800 Subject: [PATCH 02/28] fix matches builder header guard --- MatchesBuilder.h | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/MatchesBuilder.h b/MatchesBuilder.h index 25aa127..b2b3e96 100644 --- a/MatchesBuilder.h +++ b/MatchesBuilder.h @@ -1,7 +1,7 @@ // MatchesBuilder.h: builds matches from individuals #ifndef MATCHESBUILDER_H -#define MATCHESBUILDERs_H +#define MATCHESBUILDER_H #include "BasicDefinitions.h" #include "Individuals.h" From 2b951d8a57b82a6b129cd6589e45a656b446ced8 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 18:33:15 -0800 Subject: [PATCH 03/28] Add single_id, haplotype, and is_new flag to Individual.h as public members, update the Sample loader to populate --- Individual.h | 4 ++++ PEDIndividualsExtractor.cpp | 4 ++++ 2 files changed, 8 insertions(+) diff --git a/Individual.h b/Individual.h index ff22bd4..44f8a12 100644 --- a/Individual.h +++ b/Individual.h @@ -101,6 +101,10 @@ class Individual ofstream* getIndividualMatchFile(); ofstream* getIndividualHomozFile(); + bool is_new; + string single_id; + string haplotype; + private: // ID of the individual diff --git a/PEDIndividualsExtractor.cpp b/PEDIndividualsExtractor.cpp index 12ba36b..41e791e 100644 --- a/PEDIndividualsExtractor.cpp +++ b/PEDIndividualsExtractor.cpp @@ -85,6 +85,10 @@ void PEDIndividualsExtractor::getIndividuals() new_ind[1]->setID( famID + " " + ID + ".1" ); new_ind[0]->setBaseID( baseID ); new_ind[1]->setBaseID( baseID ); + new_ind[0]->haplotype = "0"; + new_ind[1]->haplotype = "1"; + new_ind[0]->single_id = ID; + new_ind[1]->single_id = ID; individualsP->addIndividual( new_ind[0] ); individualsP->addIndividual( new_ind[1] ); From 08fb9ef4829cc8a0d3dbea3576ff51f41ac1e957 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 18:36:47 -0800 Subject: [PATCH 04/28] Have Sample loader set is_new --- PEDIndividualsExtractor.cpp | 9 +++++++++ 1 file changed, 9 insertions(+) diff --git a/PEDIndividualsExtractor.cpp b/PEDIndividualsExtractor.cpp index 41e791e..d2de231 100644 --- a/PEDIndividualsExtractor.cpp +++ b/PEDIndividualsExtractor.cpp @@ -89,6 +89,15 @@ void PEDIndividualsExtractor::getIndividuals() new_ind[1]->haplotype = "1"; new_ind[0]->single_id = ID; new_ind[1]->single_id = ID; + + if ( individualsP->isNew(new_ind[0]->getBaseID()) ) { + new_ind[0]->is_new = true; + new_ind[1]->is_new = true; + } + else { + new_ind[0]->is_new = false; + new_ind[1]->is_new = false; + } individualsP->addIndividual( new_ind[0] ); individualsP->addIndividual( new_ind[1] ); From 4bc5267dc121eb75ab4f62bfe8c25212b5193d3d Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 18:39:11 -0800 Subject: [PATCH 05/28] Add prints for old vs new sample loading, testing --- PEDIndividualsExtractor.cpp | 2 ++ 1 file changed, 2 insertions(+) diff --git a/PEDIndividualsExtractor.cpp b/PEDIndividualsExtractor.cpp index d2de231..270b1bd 100644 --- a/PEDIndividualsExtractor.cpp +++ b/PEDIndividualsExtractor.cpp @@ -93,10 +93,12 @@ void PEDIndividualsExtractor::getIndividuals() if ( individualsP->isNew(new_ind[0]->getBaseID()) ) { new_ind[0]->is_new = true; new_ind[1]->is_new = true; + cout << "Loaded new sample: " << new_ind[0]->single_id << endl; } else { new_ind[0]->is_new = false; new_ind[1]->is_new = false; + cout << "Loaded old sample: " << new_ind[0]->single_id << endl; } individualsP->addIndividual( new_ind[0] ); From 680060d3aa4f89149ba52e0bbeaa60013d303d21 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 18:41:38 -0800 Subject: [PATCH 06/28] Ok, so ALL_SAMPLES is used as a ref and individualsP is the working object --- PEDIndividualsExtractor.cpp | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/PEDIndividualsExtractor.cpp b/PEDIndividualsExtractor.cpp index 270b1bd..847f861 100644 --- a/PEDIndividualsExtractor.cpp +++ b/PEDIndividualsExtractor.cpp @@ -90,7 +90,7 @@ void PEDIndividualsExtractor::getIndividuals() new_ind[0]->single_id = ID; new_ind[1]->single_id = ID; - if ( individualsP->isNew(new_ind[0]->getBaseID()) ) { + if ( ALL_SAMPLES.isNew(new_ind[0]->getBaseID()) ) { new_ind[0]->is_new = true; new_ind[1]->is_new = true; cout << "Loaded new sample: " << new_ind[0]->single_id << endl; @@ -98,7 +98,7 @@ void PEDIndividualsExtractor::getIndividuals() else { new_ind[0]->is_new = false; new_ind[1]->is_new = false; - cout << "Loaded old sample: " << new_ind[0]->single_id << endl; + cout << "Loaded new sample: " << new_ind[0]->single_id << endl; } individualsP->addIndividual( new_ind[0] ); From 47dbf7e4ed94134419fa5375d24bec6529dd2861 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 19:06:44 -0800 Subject: [PATCH 07/28] Add file handle initialization during sample load --- Individuals.cpp | 10 ++++++++++ Individuals.h | 1 + PEDIndividualsExtractor.cpp | 3 ++- 3 files changed, 13 insertions(+), 1 deletion(-) diff --git a/Individuals.cpp b/Individuals.cpp index 36b9424..e9ca178 100644 --- a/Individuals.cpp +++ b/Individuals.cpp @@ -20,6 +20,16 @@ void Individuals::initialize() for ( iter = 0 ; iter < pedigree.size() ; iter++ ) pedigree[ iter ]->reserveMemory(); } +void Individuals::initializeOutputFileHandles() +{ + for ( iter = 0 ; iter < pedigree.size() ; iter++ ) { + if ( pedigree[ iter ]->is_new ) { + pedigree[ iter ]->setIndividualMatchFile(); + pedigree[ iter ]->setIndividualHomozFile(); + } + } +} + void Individuals::freeMatches() { for(begin();more();next()) pedigree[ iter ]->freeMatches(); diff --git a/Individuals.h b/Individuals.h index e5c1a55..ccfa87d 100644 --- a/Individuals.h +++ b/Individuals.h @@ -32,6 +32,7 @@ class Individuals void begin(); size_t size() { return pedigree.size(); } void initialize(); + void initializeOutputFileHandles(); void print( ostream& ); void freeMatches(); diff --git a/PEDIndividualsExtractor.cpp b/PEDIndividualsExtractor.cpp index 847f861..e271fe3 100644 --- a/PEDIndividualsExtractor.cpp +++ b/PEDIndividualsExtractor.cpp @@ -38,6 +38,7 @@ void PEDIndividualsExtractor::loadInput() } individualsP->initialize(); + individualsP->initializeOutputFileHandles(); stream.clear(); } @@ -98,7 +99,7 @@ void PEDIndividualsExtractor::getIndividuals() else { new_ind[0]->is_new = false; new_ind[1]->is_new = false; - cout << "Loaded new sample: " << new_ind[0]->single_id << endl; + cout << "Loaded old sample: " << new_ind[0]->single_id << endl; } individualsP->addIndividual( new_ind[0] ); From 6db6010daa082e4ee80d8c7e0116852188f313bb Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 20:10:12 -0800 Subject: [PATCH 08/28] Write out records for new keys only, print for homoz and new-new comparisons for the time being --- Individual.cpp | 1 + Match.cpp | 60 ++++++++++++++++++++++++++++++++++++++++++++++++++ Match.h | 3 +++ 3 files changed, 64 insertions(+) diff --git a/Individual.cpp b/Individual.cpp index 7ac5a58..d317f88 100644 --- a/Individual.cpp +++ b/Individual.cpp @@ -78,6 +78,7 @@ void Individual::clearMatch( size_t id ) void Individual::deleteMatch( size_t id ) { // try to print it + cout << "Writing results for: " << single_id << endl; all_matches[ id ]->print( MATCH_FILE ); delete all_matches[ id ]; diff --git a/Match.cpp b/Match.cpp index 3514ec1..c4fcbcd 100644 --- a/Match.cpp +++ b/Match.cpp @@ -331,6 +331,54 @@ void Match::print( ostream& fout ) fout.write( (char*) &hom[1] , sizeof( bool ) ); } else { + int key1 = stoi(node[0]->single_id); + int key2 = stoi(node[1]->single_id); + vector oline; + string joined_oline; + ofstream* ofs; + string chromosome = ALL_SNPS.getSNP(snp_start).getChr(); + string start_pos = to_string(ALL_SNPS.getSNP(snp_start).getPhysPos()); + string end_pos = to_string(ALL_SNPS.getSNP(snp_end).getPhysPos()); + + // homoz + if ( key1 == key2 && node[0]->is_new ) { + cout << "Writing out homoz" << endl; + } + // key1 is new, key2 is old + else if ( key1 > key2 && node[0]->is_new ) { + cout << "Writing match tracts for new key1 " << key1 << endl; + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[0]->getIndividualMatchFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; + } + // key2 is new, key1 is old + else if ( key2 > key1 && node[1]->is_new ) { + cout << "Writing match tracts for new key2 " << key2 << endl; + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[1]->getIndividualMatchFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; + } + // newdog : newdog comparison, write out same record twice + else if ( node[0]->is_new && node[1]->is_new && key1 != key2 ) { + cout << "Writing records for both keys"; + } + + /* + cout << stoi(node[1]->single_id) << endl; fout << node[0]->getID() << '\t'; fout << node[1]->getID() << '\t'; fout << ALL_SNPS.getSNP(snp_start).getChr() << '\t'; @@ -345,7 +393,19 @@ void Match::print( ostream& fout ) for ( int n = 0 ; n < 2 ; n++ ) if ( hom[n] ) fout << '\t' << 1; else fout << '\t' << 0; fout << endl; + */ } num_matches++; } +void join(const vector& v, char c, string& s) { + + s.clear(); + + for (vector::const_iterator p = v.begin(); + p != v.end(); ++p) { + s += *p; + if (p != v.end() - 1) + s += c; + } +} diff --git a/Match.h b/Match.h index 90b0534..05c049f 100644 --- a/Match.h +++ b/Match.h @@ -45,5 +45,8 @@ class Match bool isHom( int n , unsigned int ms ); }; + +void join(const vector& v, char c, string& s); + #endif From 4d6dea03c6c39b192e69f20eef0e75d025b2ac62 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 20:12:30 -0800 Subject: [PATCH 09/28] fix file handle output name --- Individual.cpp | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/Individual.cpp b/Individual.cpp index d317f88..72e0629 100644 --- a/Individual.cpp +++ b/Individual.cpp @@ -221,7 +221,7 @@ void Individual::setIndividualMatchFile() { string ext = ".tsv"; string dir = "individual_match_files/"; - string fileHandleName = dir + getID() + ext; + string fileHandleName = dir + single_id + ext; individualMatchFile = new ofstream(fileHandleName, ofstream::app); } @@ -229,7 +229,7 @@ void Individual::setIndividualHomozFile() { string ext = ".tsv"; string dir = "individual_homoz_files/"; - string fileHandleName = dir + getID() + ext; + string fileHandleName = dir + single_id + ext; individualHomozFile = new ofstream(fileHandleName, ofstream::app); } From 377af4551b476c6748003f7857a2da393c1ec4d1 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 21:14:29 -0800 Subject: [PATCH 10/28] completed implementation for new-new and homoz files --- Individual.cpp | 2 +- Match.cpp | 39 +++++++++++++++++++++++++++++++++++---- 2 files changed, 36 insertions(+), 5 deletions(-) diff --git a/Individual.cpp b/Individual.cpp index 72e0629..d6f48b2 100644 --- a/Individual.cpp +++ b/Individual.cpp @@ -78,7 +78,7 @@ void Individual::clearMatch( size_t id ) void Individual::deleteMatch( size_t id ) { // try to print it - cout << "Writing results for: " << single_id << endl; + // cout << "Writing results for: " << single_id << endl; all_matches[ id ]->print( MATCH_FILE ); delete all_matches[ id ]; diff --git a/Match.cpp b/Match.cpp index c4fcbcd..a58ec52 100644 --- a/Match.cpp +++ b/Match.cpp @@ -342,11 +342,21 @@ void Match::print( ostream& fout ) // homoz if ( key1 == key2 && node[0]->is_new ) { - cout << "Writing out homoz" << endl; + //cout << "Writing out homoz" << endl; + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[0]->getIndividualHomozFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; } // key1 is new, key2 is old else if ( key1 > key2 && node[0]->is_new ) { - cout << "Writing match tracts for new key1 " << key1 << endl; + //cout << "Writing match tracts for new key1 " << key1 << endl; oline.push_back(node[0]->single_id); oline.push_back(node[0]->haplotype); oline.push_back(node[1]->single_id); @@ -360,7 +370,7 @@ void Match::print( ostream& fout ) } // key2 is new, key1 is old else if ( key2 > key1 && node[1]->is_new ) { - cout << "Writing match tracts for new key2 " << key2 << endl; + //cout << "Writing match tracts for new key2 " << key2 << endl; oline.push_back(node[1]->single_id); oline.push_back(node[1]->haplotype); oline.push_back(node[0]->single_id); @@ -374,7 +384,28 @@ void Match::print( ostream& fout ) } // newdog : newdog comparison, write out same record twice else if ( node[0]->is_new && node[1]->is_new && key1 != key2 ) { - cout << "Writing records for both keys"; + //cout << "Writing records for both keys"; + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[0]->getIndividualMatchFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; + + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[1]->getIndividualMatchFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; } /* From 537032f779f127dd8ed250eb86def398ec50f415 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 21:27:36 -0800 Subject: [PATCH 11/28] Added minimal test set, will add instructions later --- .gitignore | 3 +- ..._new_dog_proxy_keys_germline_output.plinky | 5 + ..._old_dog_proxy_keys_germline_output.plinky | 5 + minimal_test/all_dogs.plinky | 10 + minimal_test/germline_params_new_new | 4 + minimal_test/germline_params_old_new | 4 + .../individual_homoz_files/1027227.tsv | 5 + .../individual_homoz_files/1027228.tsv | 0 .../individual_homoz_files/1027229.tsv | 0 .../individual_homoz_files/1027230.tsv | 0 .../individual_homoz_files/1027231.tsv | 0 .../individual_match_files/1027227.tsv | 0 .../individual_match_files/1027228.tsv | 1 + .../individual_match_files/1027229.tsv | 0 .../individual_match_files/1027230.tsv | 0 .../individual_match_files/1027231.tsv | 1 + minimal_test/minimal_comparison_set.map | 8500 +++++++++++++++++ minimal_test/minimal_comparison_set.ped | 10 + minimal_test/new_outs/test_out_new_new.match | 7 + minimal_test/new_outs/test_out_old_new.match | 8 + minimal_test/og_germline | Bin 0 -> 192964 bytes minimal_test/og_outs/test_out_new_new.match | 7 + minimal_test/og_outs/test_out_old_new.match | 8 + minimal_test/run.sh | 9 + minimal_test/run_new.sh | 17 + minimal_test/test_out_new_new.log | 19 + minimal_test/test_out_new_new.match | 0 minimal_test/test_out_old_new.log | 19 + minimal_test/test_out_old_new.match | 0 29 files changed, 8641 insertions(+), 1 deletion(-) create mode 100644 minimal_test/0000_new_dog_proxy_keys_germline_output.plinky create mode 100644 minimal_test/0000_old_dog_proxy_keys_germline_output.plinky create mode 100644 minimal_test/all_dogs.plinky create mode 100644 minimal_test/germline_params_new_new create mode 100644 minimal_test/germline_params_old_new create mode 100644 minimal_test/individual_homoz_files/1027227.tsv create mode 100644 minimal_test/individual_homoz_files/1027228.tsv create mode 100644 minimal_test/individual_homoz_files/1027229.tsv create mode 100644 minimal_test/individual_homoz_files/1027230.tsv create mode 100644 minimal_test/individual_homoz_files/1027231.tsv create mode 100644 minimal_test/individual_match_files/1027227.tsv create mode 100644 minimal_test/individual_match_files/1027228.tsv create mode 100644 minimal_test/individual_match_files/1027229.tsv create mode 100644 minimal_test/individual_match_files/1027230.tsv create mode 100644 minimal_test/individual_match_files/1027231.tsv create mode 100644 minimal_test/minimal_comparison_set.map create mode 100644 minimal_test/minimal_comparison_set.ped create mode 100644 minimal_test/new_outs/test_out_new_new.match create mode 100644 minimal_test/new_outs/test_out_old_new.match create mode 100755 minimal_test/og_germline create mode 100644 minimal_test/og_outs/test_out_new_new.match create mode 100644 minimal_test/og_outs/test_out_old_new.match create mode 100644 minimal_test/run.sh create mode 100644 minimal_test/run_new.sh create mode 100644 minimal_test/test_out_new_new.log create mode 100644 minimal_test/test_out_new_new.match create mode 100644 minimal_test/test_out_old_new.log create mode 100644 minimal_test/test_out_old_new.match diff --git a/.gitignore b/.gitignore index eb2e70e..8662ba9 100644 --- a/.gitignore +++ b/.gitignore @@ -1,4 +1,5 @@ +.vscode test/output *.o parse_bmatch -germline \ No newline at end of file +germline diff --git a/minimal_test/0000_new_dog_proxy_keys_germline_output.plinky b/minimal_test/0000_new_dog_proxy_keys_germline_output.plinky new file mode 100644 index 0000000..bd9e0dd --- /dev/null +++ b/minimal_test/0000_new_dog_proxy_keys_germline_output.plinky @@ -0,0 +1,5 @@ +1027227 1027227 +1027228 1027228 +1027229 1027229 +1027230 1027230 +1027231 1027231 diff --git a/minimal_test/0000_old_dog_proxy_keys_germline_output.plinky b/minimal_test/0000_old_dog_proxy_keys_germline_output.plinky new file mode 100644 index 0000000..516bd58 --- /dev/null +++ b/minimal_test/0000_old_dog_proxy_keys_germline_output.plinky @@ -0,0 +1,5 @@ +967975 967975 +967976 967976 +967977 967977 +967978 967978 +967979 967979 diff --git a/minimal_test/all_dogs.plinky b/minimal_test/all_dogs.plinky new file mode 100644 index 0000000..0941d40 --- /dev/null +++ b/minimal_test/all_dogs.plinky @@ -0,0 +1,10 @@ +1027227 1027227 +1027228 1027228 +1027229 1027229 +1027230 1027230 +1027231 1027231 +967975 967975 +967976 967976 +967977 967977 +967978 967978 +967979 967979 diff --git a/minimal_test/germline_params_new_new b/minimal_test/germline_params_new_new new file mode 100644 index 0000000..1e4aa9f --- /dev/null +++ b/minimal_test/germline_params_new_new @@ -0,0 +1,4 @@ +1 +minimal_comparison_set.map +minimal_comparison_set.ped +test_out_new_new diff --git a/minimal_test/germline_params_old_new b/minimal_test/germline_params_old_new new file mode 100644 index 0000000..1d0d4e9 --- /dev/null +++ b/minimal_test/germline_params_old_new @@ -0,0 +1,4 @@ +1 +minimal_comparison_set.map +minimal_comparison_set.ped +test_out_old_new diff --git a/minimal_test/individual_homoz_files/1027227.tsv b/minimal_test/individual_homoz_files/1027227.tsv new file mode 100644 index 0000000..a14011a --- /dev/null +++ b/minimal_test/individual_homoz_files/1027227.tsv @@ -0,0 +1,5 @@ +1027227 0 1027227 1 1 5409586 14391559 +1027227 0 1027227 1 1 32903322 35221407 +1027227 0 1027227 1 1 40647049 54430787 +1027227 0 1027227 1 1 91385138 97942807 +1027227 0 1027227 1 1 102119723 118876992 diff --git a/minimal_test/individual_homoz_files/1027228.tsv b/minimal_test/individual_homoz_files/1027228.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/individual_homoz_files/1027229.tsv b/minimal_test/individual_homoz_files/1027229.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/individual_homoz_files/1027230.tsv b/minimal_test/individual_homoz_files/1027230.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/individual_homoz_files/1027231.tsv b/minimal_test/individual_homoz_files/1027231.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/individual_match_files/1027227.tsv b/minimal_test/individual_match_files/1027227.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/individual_match_files/1027228.tsv b/minimal_test/individual_match_files/1027228.tsv new file mode 100644 index 0000000..cb1655d --- /dev/null +++ b/minimal_test/individual_match_files/1027228.tsv @@ -0,0 +1 @@ +1027228 1 1027227 1 1 79129921 81565205 diff --git a/minimal_test/individual_match_files/1027229.tsv b/minimal_test/individual_match_files/1027229.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/individual_match_files/1027230.tsv b/minimal_test/individual_match_files/1027230.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/individual_match_files/1027231.tsv b/minimal_test/individual_match_files/1027231.tsv new file mode 100644 index 0000000..a2111a2 --- /dev/null +++ b/minimal_test/individual_match_files/1027231.tsv @@ -0,0 +1 @@ +1027231 1 1027230 1 1 4272138 6198709 diff --git a/minimal_test/minimal_comparison_set.map b/minimal_test/minimal_comparison_set.map new file mode 100644 index 0000000..33a198e --- /dev/null +++ b/minimal_test/minimal_comparison_set.map @@ -0,0 +1,8500 @@ +1 BICF2P1383091 0.0580478 212740 +1 BICF2G630707905 0.0588854 251205 +1 chr1_266523 0.0592272 266523 +1 BICF2G630707908 0.0593824 273487 +1 BICF2G630707918 0.0623086 348210 +1 chr1_363618 0.0623897 363618 +1 chr1_363892 0.0623912 363892 +1 BICF2G630707932 0.0661014 420036 +1 BICF2P98519 0.076005 486173 +1 BICF2P1377001 0.0762848 497316 +1 BICF2G630707957 0.0786614 511277 +1 BICF2P1282632 0.0891723 573533 +1 TIGRP2P340_rs9005494 0.0923895 614572 +1 BICF2G630707991 0.0941044 650365 +1 BICF2G630708023 0.0957194 700273 +1 BICF2G630708028 0.0981756 717913 +1 BICF2G630708035 0.132905 765445 +1 EMB_chr1_784022 0.13379 784022 +1 BICF2G630708039 0.136489 860805 +1 BICF2P1357045 0.136497 867177 +1 BICF2P646761 0.137327 889117 +1 BICF2G630708043 0.138818 895636 +1 BICF2P303607 0.145253 968152 +1 BICF2P987431 0.146757 1012024 +1 BICF2P606693 0.147458 1027604 +1 BICF2P1277518 0.149199 1048637 +1 BICF2G630708061 0.149925 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BICF2P1339554 2.23697 7865281 +1 BICF2G630709805 2.26259 7890465 +1 BICF2G630709810 2.27554 7898583 +1 BICF2G630709825 2.2796 7909532 +1 BICF2G630709833 2.28263 7915508 +1 BICF2G630709842 2.28545 7925031 +1 chr1_7926268 2.286 7926268 +1 BICF2G630709860 2.28987 7935005 +1 BICF2P555245 2.31707 7960539 +1 BICF2G630709868 2.32739 7969723 +1 TIGRP2P7756_rs9025801 2.33884 7979763 +1 BICF2P533944 2.33909 7979804 +1 BICF2G630709873 2.38385 8001795 +1 BICF2P18236 2.39029 8007051 +1 BICF2G630709904 2.39997 8022725 +1 BICF2G630709926 2.40426 8032855 +1 BICF2G630709937 2.41263 8044418 +1 TIGRP2P7766_rs9177075 2.41548 8048010 +1 BICF2S23444329 2.42008 8054483 +1 TIGRP2P7768_rs9243118 2.42443 8060534 +1 BICF2S2337757 2.42672 8073090 +1 BICF2S23742583 2.42871 8084756 +1 BICF2G630709989 2.43096 8095387 +1 BICF2G630710011 2.43355 8111989 +1 BICF2P1068759 2.5282 8143422 +1 BICF2P617581 2.53638 8161870 +1 BICF2G630710036 2.53793 8165086 +1 BICF2G630710043 2.61058 8206602 +1 TIGRP2P7812_rs9060535 2.61207 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BICF2G630710286 2.7133 8573470 +1 BICF2G630710327 2.71731 8595207 +1 BICF2P230315 2.72024 8604276 +1 BICF2G630710345 2.72908 8613543 +1 BICF2G630710368 2.74573 8630247 +1 BICF2G630710409 2.76163 8647033 +1 BICF2G630710410 2.76239 8647955 +1 BICF2P801590 2.84952 8679834 +1 BICF2P1476 2.85682 8697663 +1 BICF2G630710467 2.87747 8711821 +1 BICF2G630710480 2.87889 8717703 +1 BICF2G630710495 2.88365 8728624 +1 BICF2S23321456 2.88921 8746315 +1 BICF2G630710527 2.89452 8751574 +1 BICF2G630710545 2.8993 8762788 +1 BICF2G630710563 2.90164 8775014 +1 BICF2G630710611 2.98542 8833676 +1 BICF2G630710632 3.0134 8847422 +1 BICF2G630710651 3.0171 8863032 +1 BICF2G630710660 3.02095 8870689 +1 BICF2S22945143 3.02574 8888552 +1 BICF2G630710699 3.02926 8899796 +1 BICF2G630710701 3.03022 8903354 +1 BICF2G630710724 3.04826 8926447 +1 BICF2G630710733 3.05546 8934509 +1 BICF2G630710760 3.06547 8955374 +1 BICF2G630710766 3.06674 8958598 +1 BICF2G630710800 3.07773 8975122 +1 BICF2G630710810 3.0959 8980525 +1 BICF2G630710819 3.10392 8993571 +1 BICF2G630710832 3.11956 9010909 +1 BICF2G630710837 3.12374 9017633 +1 BICF2P1120946 3.13346 9033858 +1 BICF2G630710853 3.13907 9041117 +1 BICF2G630710867 3.14667 9055097 +1 BICF2P463407 3.15249 9065606 +1 BICF2G630710914 3.17529 9094017 +1 BICF2S22931976 3.18019 9109243 +1 BICF2G630710959 3.18258 9120663 +1 BICF2P100940 3.1886 9134130 +1 BICF2G630711019 3.20315 9159357 +1 BICF2G630711036 3.20656 9166089 +1 BICF2G630711047 3.21742 9187067 +1 BICF2G630711049 3.21772 9190035 +1 BICF2G630711060 3.23873 9201414 +1 chr1_9202940 3.23916 9202940 +1 chr1_9203169 3.23923 9203169 +1 chr1_9204247 3.23953 9204247 +1 BICF2G630711067 3.24185 9212509 +1 BICF2G630711068 3.24238 9214283 +1 BICF2G630711082 3.24532 9224106 +1 BICF2G630711088 3.24796 9240098 +1 BICF2P158777 3.25202 9257013 +1 BICF2G630711094 3.26194 9273551 +1 BICF2S23513417 3.26947 9288943 +1 BICF2G630711105 3.27389 9296248 +1 TIGRP2P7951_rs9003035 3.29106 9309123 +1 TIGRP2P7957_rs9013755 3.30844 9325658 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BICF2G630711562 3.94692 10255636 +1 BICF2G630711594 4.00329 10309970 +1 BICF2G630711607 4.04484 10341135 +1 BICF2S23656672 4.08521 10357617 +1 BICF2P883221 4.12731 10403384 +1 BICF2P878157 4.18575 10508512 +1 TIGRP2P8190_rs9076964 4.19938 10549938 +1 chr1_10672540 4.29026 10672540 +1 chr1_10672746 4.29048 10672746 +1 BICF2P956517 4.32539 10699423 +1 BICF2P1008542 4.37354 10756573 +1 BICF2P1014047 4.38399 10780593 +1 BICF2P59100 4.3894 10792454 +1 BICF2P316588 4.43692 10847607 +1 BICF2P814850 4.44535 10878370 +1 BICF2S23155214 4.45398 10898701 +1 BICF2P407470 4.50245 10934077 +1 BICF2S22926875 4.52249 10976955 +1 BICF2S23731517 4.53127 11014965 +1 BICF2S2309684 4.5402 11052005 +1 BICF2P387634 4.56547 11091891 +1 TIGRP2P8291_rs8903611 4.57201 11111953 +1 BICF2P629544 4.57564 11119991 +1 chr1_11167678 4.6137 11167678 +1 BICF2P1082366 4.61385 11167979 +1 chr1_11168555 4.61413 11168555 +1 BICF2P258539 4.71268 11368842 +1 TIGRP2P8373_rs8521226 4.73017 11418720 +1 BICF2P380596 4.86361 11438606 +1 BICF2S23910124 4.88878 11465332 +1 TIGRP2P8419_rs8959368 4.91421 11497808 +1 BICF2S23412474 4.93356 11523463 +1 BICF2P1108272 4.94159 11539753 +1 BICF2P631496 4.94708 11564083 +1 BICF2S2369046 4.97696 11629081 +1 BICF2S23534100 4.99958 11653215 +1 BICF2P1277523 5.04697 11708684 +1 BICF2P779428 5.05362 11730119 +1 BICF2S23114218 5.06829 11774784 +1 BICF2P340398 5.06962 11779243 +1 BICF2P654352 5.16361 11834885 +1 TIGRP2P8517_rs8894908 5.17864 11844563 +1 TIGRP2P8538_rs8853941 5.19367 11884008 +1 TIGRP2P8553_rs8392830 5.23607 11946797 +1 TIGRP2P8555_rs8792137 5.24743 11951448 +1 BICF2S23214790 5.26229 12007076 +1 BICF2P1401451 5.27545 12024782 +1 TIGRP2P8605_rs8516721 5.2918 12055950 +1 TIGRP2P15313_rs9161584 5.32153 12124292 +1 BICF2P1162632 5.33705 12144103 +1 BICF2P301927 5.35258 12156624 +1 chr1_12239369 5.41228 12239369 +1 BICF2P630488 5.4405 12267375 +1 BICF2P630489 5.44182 12268168 +1 BICF2P1045220 5.45274 12292936 +1 TIGRP2P15426_rs8702677 5.45762 12305086 +1 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BICF2P1372927 6.77214 13369932 +1 BICF2S23354689 6.79389 13375903 +1 BICF2P897678 6.81917 13385246 +1 BICF2P1346707 6.85608 13412399 +1 BICF2P1409469 6.85723 13428072 +1 BICF2S23661189 6.85887 13431034 +1 BICF2P342283 6.86398 13446742 +1 chr1_13466714 6.86694 13466714 +1 BICF2P561513 6.86763 13471855 +1 BICF2P1240331 6.86851 13478424 +1 chr1_13481722 6.8771 13481722 +1 BICF2P1038853 6.90758 13493435 +1 BICF2P1038854 6.90769 13493609 +1 chr1_13495946 6.90919 13495946 +1 chr1_13505603 6.9154 13505603 +1 BICF2S23513984 6.91569 13506057 +1 chr1_13518860 6.92842 13518860 +1 chr1_13518974 6.92854 13518974 +1 chr1_13519154 6.92872 13519154 +1 chr1_13525098 6.93478 13525098 +1 chr1_13526109 6.93592 13526109 +1 BICF2P915283 6.95175 13540188 +1 BICF2P1035482 6.98762 13554172 +1 BICF2P263531 7.02741 13560487 +1 TIGRP2P15804_rs9196392 7.0436 13567459 +1 BICF2S23454139 7.04386 13568168 +1 BICF2P352064 7.05032 13585953 +1 BICF2P404481 7.05207 13590516 +1 TIGRP2P15814_rs9074722 7.05321 13601070 +1 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BICF2P964152 29.6912 36225211 +1 BICF2G630720576 29.7038 36239728 +1 BICF2P752126 29.7193 36259655 +1 BICF2G630720587 29.7215 36264476 +1 BICF2G630720595 29.7327 36280826 +1 BICF2S23279 29.7358 36288835 +1 BICF2G630720636 29.748 36313177 +1 BICF2G630720663 29.7704 36329546 +1 BICF2G630720671 29.7797 36339975 +1 BICF2G630720686 29.784 36349594 +1 BICF2G630720705 29.7861 36356989 +1 BICF2P1285557 29.7916 36382088 +1 BICF2G630720734 29.7963 36396681 +1 BICF2G630720740 29.7973 36402559 +1 BICF2G630720749 29.8075 36422541 +1 BICF2G630720764 29.8148 36429047 +1 BICF2G630720803 29.8329 36454652 +1 BICF2G630720825 29.8379 36463819 +1 BICF2G630720826 29.838 36464061 +1 BICF2S2364852 29.8417 36475826 +1 BICF2G630720860 29.8518 36495146 +1 BICF2G630720888 29.8574 36512245 +1 BICF2G630720901 29.8619 36519495 +1 BICF2G630720931 29.8786 36538454 +1 BICF2P382853 29.8835 36552056 +1 BICF2G630720986 29.8978 36571665 +1 BICF2G630720990 29.9012 36577840 +1 BICF2G630721003 29.9354 36601007 +1 BICF2G630721007 29.9446 36604059 +1 BICF2G630721015 29.9514 36610807 +1 BICF2G630721036 29.956 36622135 +1 BICF2S2374060 29.9722 36644251 +1 BICF2P1367862 29.9812 36657753 +1 BICF2G630721062 29.9937 36673705 +1 BICF2G630721071 29.9985 36686369 +1 BICF2G630721074 30.0012 36692974 +1 BICF2G630721083 30.0036 36704379 +1 BICF2G630721085 30.0064 36714267 +1 BICF2G630721102 30.0098 36729928 +1 BICF2S23611165 30.0146 36745888 +1 BICF2G630721126 30.016 36748302 +1 BICF2G630721153 30.018 36760706 +1 BICF2G630721176 30.0204 36772682 +1 BICF2G630721211 30.0237 36787409 +1 BICF2G630721242 30.0273 36804338 +1 BICF2G630721275 30.0302 36817117 +1 BICF2G630721283 30.0392 36850780 +1 BICF2G630721285 30.0393 36852831 +1 BICF2G630721318 30.0455 36870091 +1 BICF2G630721326 30.0462 36872593 +1 BICF2P115550 30.0504 36878165 +1 BICF2G630721344 30.0558 36895640 +1 BICF2S23035765 30.0593 36917636 +1 BICF2G630721366 30.1005 36987391 +1 BICF2P1285497 30.1022 37016160 +1 BICF2G630721382 30.1399 37026442 +1 BICF2S23312152 30.1679 37037066 +1 BICF2P1085387 30.188 37060353 +1 chr1_37074514 30.2053 37074514 +1 chr1_37074524 30.2053 37074524 +1 BICF2P1116763 30.2071 37077583 +1 BICF2G630721437 30.2123 37111000 +1 TIGRP2P1828_rs8575956 30.2126 37115768 +1 TIGRP2P1833_rs9165233 30.2145 37143848 +1 BICF2S23353207 30.2154 37157890 +1 BICF2P77050 30.2456 37171191 +1 TIGRP2P1835_rs9207819 30.2688 37173573 +1 BICF2G630721454 30.2714 37186063 +1 BICF2G630721469 30.2732 37196331 +1 chr1_37208218 30.3138 37208218 +1 BICF2G630721487 30.3176 37209352 +1 BICF2G630721511 30.3302 37224099 +1 BICF2G630721518 30.3475 37257893 +1 BICF2P1378636 30.3512 37268118 +1 BICF2G630721531 30.3583 37284904 +1 BICF2G630721540 30.3603 37290802 +1 BICF2S23310200 30.3632 37302061 +1 BICF2S23542212 30.3858 37349722 +1 BICF2S23222673 30.3873 37357318 +1 chr1_37384850 30.4009 37384850 +1 chr1_37395206 30.4082 37395206 +1 chr1_37401584 30.4101 37401584 +1 BICF2G630721557 30.4164 37426515 +1 BICF2G630721564 30.4227 37439030 +1 BICF2P759837 30.4282 37454560 +1 BICF2G630721572 30.4316 37462908 +1 BICF2G630721591 30.4425 37474433 +1 BICF2G630721594 30.4677 37515789 +1 BICF2G630721599 30.4765 37525538 +1 BICF2G630721613 30.4782 37531775 +1 BICF2G630721654 30.4881 37550366 +1 TIGRP2P1869_rs9052224 30.489 37555761 +1 EMB_chr1_37564500 30.4908 37564500 +1 chr1_37564831 30.4909 37564831 +1 BICF2G630721688 30.491 37565339 +1 BICF2S2305057 30.4954 37585204 +1 BICF2G630721725 30.496 37587673 +1 chr1_37598539 30.5379 37598539 +1 chr1_37598686 30.5385 37598686 +1 BICF2G630721758 30.5405 37599223 +1 chr1_37599941 30.5429 37599941 +1 chr1_37600445 30.5446 37600445 +1 chr1_37600859 30.5459 37600859 +1 BICF2P697483 30.5944 37615639 +1 BICF2P933515 30.6061 37632961 +1 BICF2G630721786 30.6099 37637717 +1 BICF2G630721795 30.6131 37644771 +1 BICF2P41911 30.62 37656324 +1 BICF2G630721816 30.6292 37670200 +1 BICF2P198688 30.6319 37679664 +1 BICF2G630721833 30.6482 37695038 +1 BICF2G630721837 30.7069 37706400 +1 chr1_37706508 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chr1_57676828 46.5221 57676828 +1 BICF2S22932542 46.5222 57677535 +1 BICF2S23136251 46.5232 57681729 +1 BICF2S23645370 46.5233 57683433 +1 BICF2S23141406 46.5323 57714989 +1 BICF2P1345427 46.5376 57738613 +1 BICF2S23157765 46.5388 57740064 +1 BICF2P230349 46.5501 57771837 +1 chr1_57787758 46.652 57787758 +1 BICF2P345595 46.6627 57790010 +1 BICF2P509251 46.6978 57832492 +1 BICF2S23727674 46.7026 57845037 +1 BICF2S2313185 46.7056 57857027 +1 chr1_57892864 46.7152 57892864 +1 chr1_57895988 46.7168 57895988 +1 chr1_57896118 46.7169 57896118 +1 chr1_57907132 46.7216 57907132 +1 chr1_57932254 46.7295 57932254 +1 chr1_57947420 46.7338 57947420 +1 G33f55S254 46.7357 57953943 +1 BICF2P103641 46.7413 57983341 +1 BICF2P1371035 46.7441 57998366 +1 BICF2S2379314 46.7724 58008401 +1 BICF2P1444407 46.8364 58015608 +1 BICF2P158753 46.8546 58045353 +1 BICF2P475643 46.8546 58051793 +1 BICF2P565781 46.8546 58059041 +1 BICF2P842454 46.857 58072362 +1 BICF2S22951721 46.8595 58095443 +1 BICF2P791027 46.8603 58105106 +1 chr1_58108556 46.861 58108556 +1 chr1_58163301 46.8726 58163301 +1 chr1_58181758 46.8765 58181758 +1 G36f46S215 46.8849 58234057 +1 BICF2S2448702 46.8893 58264903 +1 BICF2P945147 46.9096 58311953 +1 BICF2S22918213 46.9214 58338091 +1 BICF2S23229031 46.9255 58349909 +1 BICF2P543586 46.9285 58359279 +1 BICF2P1463420 46.9301 58370461 +1 BICF2P205507 46.9377 58395694 +1 chr1_58398913 46.9385 58398913 +1 chr1_58400463 46.9389 58400463 +1 BICF2S22944455 46.9439 58418690 +1 BICF2P418546 46.9507 58430491 +1 BICF2S2303565 46.9594 58446495 +1 TIGRP2P5010_rs8795703 46.9654 58454768 +1 TIGRP2P5014_rs8988688 46.9664 58462804 +1 BICF2P1308012 46.9703 58501178 +1 BICF2P158818 46.9711 58523439 +1 BICF2P1194006 46.9721 58561006 +1 TIGRP2P5040_rs8753353 46.9762 58610276 +1 chr1_58637322 46.9941 58637322 +1 BICF2P913417 46.9975 58642418 +1 BICF2P894088 47.0106 58646627 +1 BICF2S23545144 47.02 58660082 +1 BICF2P164271 47.0234 58669830 +1 BICF2P1323271 47.0295 58685574 +1 BICF2S23333537 47.0338 58696186 +1 BICF2P967716 47.0363 58704433 +1 BICF2P640496 47.0875 58716603 +1 BICF2S22961369 47.0968 58734734 +1 BICF2S23511091 47.0991 58742417 +1 BICF2S23214535 47.1014 58748545 +1 chr1_58765865 47.1053 58765865 +1 BICF2S23159102 47.1057 58772897 +1 BICF2P752644 47.1083 58820361 +1 BICF2S23725185 47.1098 58828661 +1 TIGRP2P5113_rs8978027 47.1232 58880057 +1 BICF2P297226 47.124 58903371 +1 BICF2P367464 47.1257 58923384 +1 BICF2S23249335 47.1257 58946192 +1 chr1_58968503 47.1259 58968503 +1 TIGRP2P5126_rs9181117 47.1728 59013778 +1 BICF2P1138416 47.177 59025089 +1 TIGRP2P5152_rs8705679 47.1868 59051479 +1 BICF2P1285126 47.1898 59059107 +1 BICF2P562745 47.1995 59072032 +1 TIGRP2P5158_rs9245849 47.2126 59084968 +1 BICF2P460602 47.2137 59093016 +1 chr1_59106827 47.2163 59106827 +1 chr1_59107134 47.2163 59107134 +1 chr1_59108395 47.2166 59108395 +1 BICF2P631882 47.2183 59117982 +1 BICF2P1406498 47.2212 59134758 +1 BICF2S23417524 47.2278 59160460 +1 BICF2P1080370 47.2291 59177329 +1 TIGRP2P5194_rs9126340 47.2315 59188765 +1 BICF2P452292 47.2321 59196310 +1 TIGRP2P5213_rs9039903 47.2355 59236354 +1 BICF2S23454979 47.2392 59260751 +1 BICF2P201475 47.2465 59270226 +1 BICF2P1289728 47.3254 59312399 +1 TIGRP2P5241_rs9015974 47.3354 59324087 +1 BICF2P384567 47.3419 59334411 +1 TIGRP2P5257_rs8614896 47.3487 59349371 +1 BICF2S23440160 47.3595 59357892 +1 BICF2P793318 47.397 59391326 +1 BICF2P652224 47.402 59406426 +1 TIGRP2P5288_rs9246693 47.4066 59429543 +1 BICF2P867890 47.416 59438856 +1 BICF2P519429 47.4237 59457650 +1 TIGRP2P5299_rs8955469 47.4285 59463119 +1 BICF2P1065229 47.4363 59489614 +1 BICF2P672624 47.4517 59509394 +1 BICF2P722934 47.4581 59518929 +1 BICF2S23337304 47.482 59548384 +1 TIGRP2P5303_rs9240371 47.4938 59563436 +1 BICF2S23526909 47.5118 59606787 +1 BICF2S23326712 47.514 59616730 +1 TIGRP2P5330_rs8798123 47.5187 59642323 +1 BICF2P470443 47.5447 59702763 +1 BICF2P1006126 47.5603 59747079 +1 BICF2S2368602 47.5609 59749641 +1 TIGRP2P5384_rs8845507 47.563 59761730 +1 TIGRP2P5386_rs8632534 47.5738 59788153 +1 TIGRP2P5388_rs8618283 47.5752 59794452 +1 TIGRP2P5402_rs8858204 47.5891 59836461 +1 BICF2P742868 47.5911 59841648 +1 TIGRP2P5414_rs9146508 47.5961 59858599 +1 BICF2S23353787 47.5986 59867731 +1 TIGRP2P5430_rs8672240 47.6005 59875245 +1 BICF2P460568 47.6199 59889940 +1 BICF2P1093806 47.6269 59901913 +1 BICF2P1199977 47.6332 59932162 +1 BICF2P1163055 47.6356 59937752 +1 BICF2S23433159 47.6426 59960193 +1 TIGRP2P5469_rs8876430 47.6517 59978699 +1 BICF2P1152287 47.6578 59998963 +1 BICF2P57965 47.6609 60006609 +1 BICF2S23714689 47.6643 60014196 +1 BICF2P1021866 47.6681 60029300 +1 BICF2P587925 47.6735 60054845 +1 BICF2P310789 47.6764 60082153 +1 BICF2P1415158 47.6808 60116175 +1 BICF2P107089 47.6833 60151731 +1 BICF2P247065 47.685 60196871 +1 TIGRP2P5571_rs8586432 47.6861 60211815 +1 chr1_60262327 47.6923 60262327 +1 BICF2S23731944 47.6935 60269071 +1 BICF2P1092054 47.6962 60284046 +1 TIGRP2P5600_rs9204440 47.6979 60301460 +1 BICF2P1414947 47.7044 60352504 +1 BICF2P1445371 47.7072 60400681 +1 BICF2P1408108 47.7085 60419833 +1 BICF2S23633613 47.7089 60428587 +1 TIGRP2P5689_rs8857820 47.7096 60439477 +1 BICF2P438368 47.7119 60478574 +1 BICF2P226709 47.7142 60514471 +1 BICF2S2349632 47.7166 60567517 +1 chr1_60588425 47.7183 60588425 +1 BICF2S2326068 47.7183 60593569 +1 chr1_60614427 47.72 60614427 +1 chr1_60628331 47.7217 60628331 +1 BICF2S24416631 47.7233 60642261 +1 chr1_60651983 47.7261 60651983 +1 chr1_60661002 47.7286 60661002 +1 chr1_60682766 47.7339 60682766 +1 BICF2S23734939 47.742 60722335 +1 BICF2S23544215 47.7435 60743827 +1 BICF2P281805 47.7454 60769256 +1 BICF2P885063 47.7455 60776534 +1 BICF2P1383877 47.7475 60829226 +1 chr1_60873526 47.7506 60873526 +1 chr1_60878110 47.7511 60878110 +1 chr1_60882852 47.7517 60882852 +1 chr1_60906636 47.7544 60906636 +1 chr1_60921104 47.7552 60921104 +1 BICF2P644785 47.7685 60937420 +1 TIGRP2P5736_rs9132587 47.7721 60949292 +1 BICF2P703726 47.7831 60987853 +1 TIGRP2P5749_rs9019306 47.7845 60997705 +1 chr1_61000384 47.7851 61000384 +1 BICF2P1145727 47.7913 61019607 +1 BICF2S22926681 47.7946 61028343 +1 BICF2P578625 47.8036 61057534 +1 BICF2P291169 47.8038 61059187 +1 BICF2P793939 47.8129 61076374 +1 BICF2P485288 47.8165 61090950 +1 BICF2P485292 47.8168 61093370 +1 BICF2P717050 47.819 61114340 +1 BICF2P731476 47.8274 61126382 +1 TIGRP2P5763_rs9066343 47.837 61145611 +1 BICF2P188917 47.842 61160748 +1 BICF2P1241098 47.8509 61200610 +1 BICF2P328416 47.8547 61209677 +1 BICF2S23053659 47.8584 61223135 +1 BICF2P1166414 47.8614 61233718 +1 BICF2S23653905 47.8642 61243054 +1 chr1_61280771 47.8754 61280771 +1 BICF2P734114 47.8907 61321213 +1 BICF2P1119423 47.8919 61323467 +1 BICF2S2356588 47.8956 61342758 +1 BICF2P284754 47.8972 61349142 +1 BICF2P1325123 47.9011 61384838 +1 TIGRP2P5874_rs9040524 47.9111 61448122 +1 BICF2P395802 47.9121 61452236 +1 BICF2S23122651 47.9167 61470773 +1 BICF2P32260 47.9179 61475612 +1 TIGRP2P5904_rs8785730 47.9186 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TIGRP2P6414_rs8812774 49.2222 63906480 +1 BICF2P608807 49.2253 63915085 +1 BICF2P663603 49.2276 63923520 +1 BICF2S23226845 49.2298 63931917 +1 BICF2P340605 49.2349 63950105 +1 BICF2P197298 49.2393 63955666 +1 BICF2P1222457 49.2519 63967994 +1 TIGRP2P6430_rs8868087 49.2586 63987879 +1 BICF2P423317 49.2627 63997725 +1 TIGRP2P6445_rs8998807 49.2644 64003690 +1 BICF2P1263104 49.2684 64023389 +1 BICF2P361555 49.2806 64036641 +1 BICF2P1016961 49.2833 64047589 +1 TIGRP2P6469_rs9167228 49.285 64057055 +1 BICF2P398401 49.2887 64068553 +1 BICF2P322545 49.2934 64091045 +1 BICF2P1045596 49.2939 64093482 +1 BICF2P1042439 49.3019 64113898 +1 BICF2P769514 49.3281 64128725 +1 BICF2P517038 49.3386 64148602 +1 BICF2P310911 49.3678 64157359 +1 BICF2S23127842 49.3758 64168721 +1 BICF2S23127179 49.3815 64173043 +1 BICF2P351231 49.3902 64183829 +1 BICF2S23742910 49.4211 64195773 +1 BICF2S22950496 49.4588 64214953 +1 chr1_64217277 49.46 64217277 +1 BICF2S22947976 49.4675 64235297 +1 BICF2S23748263 49.471 64242647 +1 BICF2S23236759 49.5033 64293254 +1 BICF2S2328357 49.5183 64347874 +1 BICF2S23323423 49.5362 64376128 +1 BICF2S23223261 49.5531 64420106 +1 BICF2S23520191 49.5565 64430704 +1 BICF2S24112496 49.5852 64483913 +1 TIGRP2P6497_rs8705613 49.598 64502133 +1 G39f63S25 49.6126 64535082 +1 BICF2S23055094 49.6242 64561281 +1 G40f43S131 49.632 64591512 +1 BICF2S23146106 49.6491 64638097 +1 BICF2S23211873 49.6585 64655903 +1 BICF2S23124877 49.6774 64733783 +1 BICF2P222818 49.6843 64759945 +1 BICF2S23218693 49.687 64772470 +1 chr1_64815317 49.7034 64815317 +1 G41f47S182 49.7046 64820609 +1 BICF2P79007 49.915 64912244 +1 BICF2P1013065 49.9176 64927348 +1 BICF2P418390 49.9331 64935479 +1 BICF2P718286 49.9347 64943457 +1 BICF2P1159669 49.9403 64961794 +1 BICF2P109075 49.9464 64980051 +1 BICF2P1178391 49.957 65007124 +1 chr1_65015171 49.9624 65015171 +1 chr1_65028854 49.9761 65028854 +1 chr1_65035498 49.9839 65035498 +1 chr1_65041660 49.9912 65041660 +1 chr1_65064440 50 65064440 +1 BICF2S23212854 50.0008 65069671 +1 BICF2S23334208 50.0024 65080474 +1 BICF2S23224862 50.0075 65126359 +1 BICF2P513082 50.0081 65129676 +1 chr1_65178744 50.0218 65178744 +1 BICF2P47248 50.0296 65198985 +1 BICF2P448058 50.0304 65212166 +1 BICF2S23030888 50.0323 65278718 +1 BICF2P501513 50.0336 65293673 +1 BICF2P1224350 50.036 65319664 +1 BICF2P1421713 50.0383 65345162 +1 BICF2P131738 50.0398 65361637 +1 BICF2P75459 50.0417 65395968 +1 BICF2P1389527 50.0428 65431404 +1 BICF2P142922 50.0554 65471433 +1 BICF2P29816 50.0636 65502863 +1 BICF2S23046966 50.0705 65534578 +1 BICF2P807659 50.0728 65544408 +1 BICF2P1350924 50.0748 65554952 +1 BICF2P208850 50.0752 65559204 +1 BICF2P1308570 50.0758 65562449 +1 BICF2P522315 50.0804 65580232 +1 BICF2P266914 50.0842 65607494 +1 BICF2P1393316 50.0862 65617855 +1 BICF2P758929 50.088 65624578 +1 BICF2P657105 50.0901 65634800 +1 BICF2P539084 50.0929 65652725 +1 BICF2P785373 50.0953 65658636 +1 BICF2P1020233 50.1009 65678966 +1 BICF2P1020236 50.1012 65679580 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TIGRP2P6610_rs9008904 50.3442 66166327 +1 TIGRP2P6615_rs8975906 50.35 66174724 +1 BICF2P345133 50.3523 66185882 +1 BICF2P385635 50.3575 66198282 +1 BICF2P1032579 50.3826 66233169 +1 BICF2P1369483 50.3872 66247958 +1 TIGRP2P6651_rs9050247 50.3888 66261433 +1 chr1_66270636 50.3913 66270636 +1 TIGRP2P6657_rs8744401 50.3914 66271045 +1 chr1_66274490 50.3925 66274490 +1 BICF2P555517 50.3943 66279834 +1 BICF2S23532243 50.3979 66295232 +1 TIGRP2P6672_rs8848190 50.4034 66314036 +1 BICF2P1169631 50.4065 66323382 +1 BICF2S23032952 50.4102 66337807 +1 TIGRP2P6688_rs8978040 50.4135 66348437 +1 TIGRP2P6699_rs8897894 50.4154 66358395 +1 chr1_66363221 50.4176 66363221 +1 chr1_66364036 50.418 66364036 +1 BICF2S23033104 50.4237 66376836 +1 BICF2P1297790 50.4332 66387318 +1 BICF2S23741424 50.4348 66399264 +1 BICF2P324841 50.4357 66406974 +1 BICF2P36560 50.4423 66433882 +1 BICF2P1355649 50.4451 66449289 +1 BICF2S24321665 50.4521 66480941 +1 BICF2P777545 50.4531 66493267 +1 BICF2P1254208 50.4559 66502400 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66824296 +1 BICF2P1441808 50.578 66833054 +1 BICF2P835323 50.5783 66842521 +1 TIGRP2P6847_rs8809290 50.581 66862339 +1 BICF2P582519 50.5845 66866914 +1 TIGRP2P6849_rs9159202 50.5885 66885633 +1 EMB_chr1_66934265 50.6022 66934265 +1 BICF2P508358 50.6035 66940821 +1 BICF2S22916508 50.6062 66946428 +1 BICF2S23221303 50.6148 66974398 +1 BICF2P689797 50.6172 66982510 +1 BICF2S2318918 50.6283 67031933 +1 BICF2S23232957 50.631 67044646 +1 BICF2S23645876 50.634 67050209 +1 BICF2S23553487 50.6392 67064634 +1 BICF2S23140555 50.6403 67073662 +1 TIGRP2P6868_rs8680339 50.6521 67093243 +1 BICF2P457877 50.6625 67109219 +1 BICF2S2442183 50.6655 67117924 +1 chr1_67120284 50.6666 67120284 +1 chr1_67129854 50.671 67129854 +1 chr1_67138366 50.6748 67138366 +1 chr1_67151935 50.6799 67151935 +1 chr1_67177813 50.6862 67177813 +1 chr1_67188594 50.6888 67188594 +1 BICF2S2411310 50.6898 67192704 +1 BICF2S24117969 50.7028 67232261 +1 BICF2P858100 50.724 67269061 +1 BICF2P509823 50.7242 67280803 +1 BICF2P839236 50.7266 67297309 +1 BICF2S23426202 50.7291 67314425 +1 G42f39S101 50.7319 67338729 +1 G42f44S100 50.7338 67350616 +1 BICF2S23715288 50.7391 67376280 +1 BICF2P444685 50.7441 67429883 +1 BICF2P614145 50.7464 67456316 +1 BICF2P1468022 50.7501 67481189 +1 BICF2S2312247 50.751 67486314 +1 BICF2S23423809 50.7519 67500249 +1 chr1_67514401 50.7687 67514401 +1 TIGRP2P6907_rs8887669 50.7757 67528812 +1 BICF2P685593 50.7774 67539306 +1 BICF2P872777 50.7792 67551246 +1 TIGRP2P6918_rs9173563 50.7799 67554955 +1 BICF2P565098 50.7833 67573199 +1 BICF2P1452152 50.7849 67585231 +1 TIGRP2P6930_rs9067891 50.7892 67605969 +1 BICF2P1247762 50.7937 67621428 +1 BICF2S2302754 50.7953 67624401 +1 TIGRP2P6947_rs8564115 50.8052 67641729 +1 BICF2P1370920 50.8108 67680635 +1 BICF2P611468 50.8136 67689922 +1 BICF2P598149 50.8197 67706395 +1 BICF2P652111 50.8264 67718504 +1 BICF2P814549 50.8338 67728530 +1 TIGRP2P6983_rs9001172 50.8395 67743210 +1 BICF2P784586 50.8415 67752099 +1 BICF2S23444493 50.8433 67763276 +1 BICF2S23014431 50.8469 67782131 +1 BICF2S23716729 50.8471 67785249 +1 TIGRP2P7004_rs9031950 50.8557 67826031 +1 BICF2S23531720 50.8577 67836364 +1 BICF2P1506487 50.8615 67843651 +1 BICF2P170297 50.8627 67860272 +1 chr1_67897107 50.8793 67897107 +1 BICF2P343250 50.886 67922585 +1 TIGRP2P7015_rs8580463 50.8868 67928321 +1 chr1_67932820 50.8875 67932820 +1 BICF2P1077022 50.889 67943666 +1 TIGRP2P7021_rs9247707 50.8926 67952227 +1 chr1_67972954 50.8935 67972954 +1 TIGRP2P7032_rs8889167 50.8938 67974555 +1 TIGRP2P7058_rs8820934 50.8975 68001568 +1 BICF2S23131558 50.8993 68024707 +1 BICF2P802523 50.9015 68048836 +1 BICF2S23542873 50.9017 68063413 +1 BICF2P1047996 50.9266 68074486 +1 chr1_68095734 50.9296 68095734 +1 BICF2P956398 50.9297 68097192 +1 chr1_68097855 50.9298 68097855 +1 chr1_68100132 50.9302 68100132 +1 BICF2P750804 50.9347 68122489 +1 BICF2P1434427 50.9376 68131920 +1 BICF2P954802 50.9467 68152162 +1 BICF2S23746661 50.9524 68170645 +1 TIGRP2P7123_rs9165143 50.9543 68178311 +1 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BICF2P1213149 51.2341 68626561 +1 BICF2S2304872 51.251 68652597 +1 BICF2S2309194 51.2545 68658546 +1 chr1_68680373 51.2592 68680373 +1 BICF2P1442349 51.2613 68684984 +1 chr1_68692019 51.2628 68692019 +1 BICF2P713250 51.263 68693227 +1 chr1_68694937 51.2636 68694937 +1 BICF2P763096 51.2683 68710518 +1 BICF2P292572 51.2698 68714786 +1 BICF2P285656 51.3047 68728867 +1 BICF2P798620 51.3126 68744462 +1 BICF2P388805 51.3142 68749575 +1 BICF2P492033 51.3234 68766653 +1 BICF2P492035 51.3236 68767088 +1 BICF2S23348124 51.3256 68773343 +1 BICF2S23434269 51.3456 68787601 +1 BICF2P718950 51.3504 68800172 +1 BICF2P313555 51.3596 68810631 +1 BICF2P288706 51.3679 68831463 +1 BICF2S23256835 51.3844 68848054 +1 chr1_68848198 51.3845 68848198 +1 chr1_68848260 51.3846 68848260 +1 BICF2S23256799 51.3877 68851389 +1 BICF2P1364371 51.3897 68858524 +1 BICF2P1300049 51.4004 68868261 +1 BICF2P615548 51.4146 68887751 +1 BICF2P1239790 51.4203 68915318 +1 BICF2P1414891 51.4237 68933926 +1 BICF2S23135033 51.4825 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51.6545 69601041 +1 chr1_69631561 51.6647 69631561 +1 chr1_69637368 51.6667 69637368 +1 BICF2P770749 51.6745 69660500 +1 BICF2P368697 51.6753 69663040 +1 chr1_69670542 51.6824 69670542 +1 BICF2P1359193 51.6849 69673213 +1 chr1_69687628 51.6868 69687628 +1 chr1_69687683 51.6868 69687683 +1 chr1_69687846 51.6869 69687846 +1 BICF2P425836 51.6874 69691600 +1 BICF2P202778 51.6874 69694170 +1 BICF2S23053811 51.6908 69719395 +1 chr1_69729466 51.6933 69729466 +1 chr1_69730963 51.6937 69730963 +1 chr1_69731830 51.6939 69731830 +1 chr1_69732259 51.694 69732259 +1 BICF2S23415963 51.6954 69737931 +1 BICF2S2377557 51.7003 69758964 +1 BICF2P777131 51.7045 69810626 +1 BICF2P200767 51.7053 69815282 +1 BICF2S23415113 51.7105 69844056 +1 BICF2P368904 51.7131 69867895 +1 BICF2P967674 51.7151 69880964 +1 BICF2S2354053 51.7165 69902367 +1 BICF2P963798 51.7233 69924783 +1 BICF2P1001119 51.724 69928630 +1 BICF2P799195 51.7811 69938971 +1 BICF2S23517715 51.7914 69977248 +1 BICF2P536727 51.7933 69991759 +1 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BICF2S23912241 52.5054 70985616 +1 BICF2P430038 52.5113 71012223 +1 BICF2P775731 52.5161 71024695 +1 BICF2P1422040 52.5386 71049023 +1 BICF2P605233 52.5516 71052965 +1 BICF2S23638824 52.5578 71066958 +1 BICF2S2345926 52.5687 71092750 +1 BICF2S23533472 52.5765 71127228 +1 BICF2P736173 52.578 71135050 +1 BICF2P1179193 52.5786 71140451 +1 BICF2P827987 52.5813 71146198 +1 BICF2S23260488 52.5894 71162763 +1 BICF2S23317177 52.594 71177950 +1 BICF2P252290 52.6013 71189046 +1 BICF2P937210 52.6899 71244607 +1 chr1_71266460 52.7316 71266460 +1 chr1_71280216 52.7327 71280216 +1 chr1_71296709 52.7382 71296709 +1 chr1_71303925 52.741 71303925 +1 TIGRP2P7450_rs8935704 52.7422 71306958 +1 BICF2P1357738 52.746 71317488 +1 BICF2P126411 52.7535 71326240 +1 chr1_71341352 52.7659 71341352 +1 chr1_71367700 52.8217 71367700 +1 BICF2P742089 52.8718 71391400 +1 BICF2P530800 52.8727 71409271 +1 BICF2P1046893 52.8733 71420622 +1 TIGRP2P7469_rs9121932 52.8753 71464953 +1 BICF2P78417 52.8764 71479907 +1 TIGRP2P7472_rs9113111 52.8769 71487661 +1 BICF2P1185323 52.8776 71499156 +1 chr1_71623423 52.886 71623423 +1 BICF2P766669 52.8936 71668711 +1 chr1_71672296 52.9089 71672296 +1 TIGRP2P7496_rs8921592 52.9441 71680527 +1 TIGRP2P7500_rs8543686 52.9446 71685118 +1 TIGRP2P7513_rs9061016 52.9459 71698376 +1 BICF2P846764 52.9537 71717095 +1 BICF2P1434242 52.9563 71738643 +1 BICF2P1197500 52.9573 71746434 +1 TIGRP2P7522_rs8845605 52.9589 71751238 +1 chr1_71761323 52.9599 71761323 +1 BICF2P681442 52.9643 71771762 +1 BICF2P222629 52.9708 71793487 +1 BICF2P230878 52.972 71811304 +1 BICF2P266502 52.9721 71812460 +1 BICF2P879347 52.9748 71827992 +1 BICF2P175933 52.9768 71863172 +1 TIGRP2P7534_rs8706493 52.9769 71867853 +1 TIGRP2P7536_rs8936102 52.9779 71918438 +1 BICF2P232991 52.978 71923930 +1 BICF2S23125194 52.9785 71945625 +1 TIGRP2P7539_rs9074096 52.9793 71955957 +1 BICF2P343404 52.9801 71999670 +1 BICF2P1433860 53.0011 72031054 +1 BICF2P1078270 53.0036 72044598 +1 BICF2P252630 53.0057 72051829 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53.6958 72922859 +1 TIGRP2P8862_rs8944869 53.7727 72932160 +1 BICF2S23114592 53.8251 72978533 +1 BICF2P1154083 53.8318 72988135 +1 TIGRP2P8874_rs9079828 53.8458 72999457 +1 BICF2P465737 53.87 73024441 +1 BICF2S23543026 53.872 73029141 +1 BICF2P153289 53.8748 73037797 +1 BICF2P623335 53.8832 73041552 +1 TIGRP2P8892_rs8951310 53.8995 73059006 +1 BICF2P605378 53.9008 73065681 +1 BICF2P1164480 53.9051 73078225 +1 BICF2P1406542 53.9348 73096935 +1 BICF2P378826 53.9389 73110029 +1 BICF2S23136204 53.9401 73115499 +1 BICF2P410259 53.9426 73120007 +1 BICF2S23647312 53.9506 73139075 +1 BICF2S23027737 53.9523 73144655 +1 BICF2S23315198 53.9539 73158947 +1 BICF2P1262536 53.9575 73166684 +1 BICF2P1185329 53.9608 73181907 +1 BICF2P714726 53.9621 73190420 +1 TIGRP2P8947_rs8960593 54.0445 73230509 +1 BICF2P32533 54.0583 73243681 +1 BICF2P1386832 54.0606 73247640 +1 BICF2P731208 54.0857 73256342 +1 TIGRP2P8954_rs8684015 54.0889 73259192 +1 BICF2S23759708 54.1037 73273290 +1 BICF2S23759709 54.1037 73273307 +1 BICF2S2332432 54.1171 73285468 +1 TIGRP2P8965_rs8668022 54.1606 73296025 +1 BICF2S23056086 54.266 73330045 +1 BICF2P365254 54.2747 73347881 +1 TIGRP2P9011_rs8689802 54.2781 73359920 +1 BICF2P1172028 54.2789 73361770 +1 TIGRP2P9029_rs8940201 54.2919 73379361 +1 BICF2P375414 54.2955 73395133 +1 chr1_73402343 54.3768 73402343 +1 TIGRP2P9038_rs8982284 54.3769 73402354 +1 BICF2P1257787 54.3785 73416338 +1 chr1_73429220 54.3785 73429220 +1 TIGRP2P9047_rs9000173 54.3785 73447835 +1 chr1_73465122 54.3816 73465122 +1 chr1_73465979 54.3824 73465979 +1 BICF2P319445 54.3842 73467882 +1 BICF2P821713 54.4672 73480956 +1 G48f25S318 54.4712 73501913 +1 chr1_73526433 54.4732 73526433 +1 BICF2S23355424 54.4745 73541591 +1 BICF2P516972 54.4781 73547121 +1 BICF2P363909 54.4845 73560565 +1 BICF2P545686 54.4867 73572662 +1 BICF2P535994 54.4993 73584397 +1 BICF2P949343 54.5033 73592288 +1 BICF2S2416345 54.5356 73631884 +1 BICF2S2313738 54.5378 73644902 +1 chr1_73645744 54.5379 73645744 +1 BICF2S22957404 54.5387 73669109 +1 BICF2S23544825 54.5387 73687660 +1 G49f29S258 54.5405 73725138 +1 BICF2S22937083 54.5479 73761312 +1 BICF2P176445 54.5537 73765292 +1 BICF2P1326293 54.5617 73813188 +1 BICF2P165026 54.5789 73852045 +1 BICF2P1256316 54.6452 73890728 +1 BICF2P1438570 54.6452 73907299 +1 BICF2P491996 54.646 73916791 +1 TIGRP2P9083_rs9072631 54.648 73938978 +1 BICF2P1259066 54.6533 73986134 +1 chr1_74029893 54.6567 74029893 +1 BICF2P814822 54.6567 74030835 +1 TIGRP2P9108_rs8791832 54.6623 74033326 +1 BICF2P850049 54.74 74107747 +1 BICF2S23144357 54.7402 74110269 +1 BICF2P1248726 54.7435 74149655 +1 BICF2P815276 54.7435 74171949 +1 BICF2P821978 54.7453 74185106 +1 BICF2S2304032 54.7497 74220037 +1 TIGRP2P9146_rs9198263 54.7508 74226537 +1 TIGRP2P9150_rs8699011 54.7531 74236134 +1 BICF2P485298 54.7634 74264556 +1 BICF2P1188523 54.7662 74270346 +1 BICF2P439963 54.7723 74283721 +1 BICF2P76815 54.7894 74298728 +1 BICF2P391462 54.8016 74305005 +1 BICF2P1183670 54.8423 74321808 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55.243 74733287 +1 BICF2P475947 55.2747 74760175 +1 TIGRP2P9311_rs9067523 55.3443 74787500 +1 BICF2P439457 55.3458 74791902 +1 TIGRP2P9315_rs9020387 55.3485 74801159 +1 BICF2P235355 55.3549 74822842 +1 BICF2P257936 55.36 74844451 +1 BICF2P431761 55.3665 74858007 +1 BICF2P1456733 55.3671 74863351 +1 BICF2P1039511 55.3766 74876621 +1 BICF2P210193 55.3792 74883806 +1 BICF2P592791 55.3867 74900519 +1 BICF2P1016225 55.3882 74907963 +1 BICF2P942892 55.3909 74919097 +1 BICF2P1072508 55.3979 74937356 +1 BICF2P910501 55.4072 74965868 +1 BICF2P1091098 55.4275 74992943 +1 BICF2P833884 55.4365 75010004 +1 BICF2S2346982 55.4479 75030999 +1 chr1_75067152 55.4584 75067152 +1 chr1_75075548 55.4605 75075548 +1 chr1_75089383 55.4641 75089383 +1 BICF2P1418468 55.4943 75159741 +1 BICF2S23424894 55.5045 75206105 +1 BICF2P859642 55.5067 75221153 +1 BICF2S23313904 55.5112 75230621 +1 BICF2S22916498 55.5162 75239254 +1 BICF2P212206 55.5171 75252359 +1 chr1_75302096 55.5329 75302096 +1 BICF2P17166 55.5349 75308519 +1 BICF2P368418 55.5413 75319272 +1 TIGRP2P9579_rs9019944 55.5451 75341296 +1 BICF2P657867 55.5575 75394102 +1 BICF2P387863 55.5644 75455904 +1 TIGRP2P9599_rs8932442 55.571 75482536 +1 BICF2P1198542 55.6258 75500960 +1 chr1_75502097 55.626 75502097 +1 chr1_75511759 55.628 75511759 +1 chr1_75512143 55.6281 75512143 +1 BICF2P887377 55.6286 75514589 +1 chr1_75537834 55.6719 75537834 +1 chr1_75572183 55.712 75572183 +1 BICF2P735591 55.7269 75591441 +1 chr1_75636853 55.7325 75636853 +1 BICF2P607285 55.7331 75645002 +1 chr1_75662455 55.7897 75662455 +1 BICF2P671112 55.7904 75662674 +1 BICF2P823167 55.8094 75711718 +1 chr1_75732877 55.8334 75732877 +1 BICF2S2366796 55.8752 75769888 +1 BICF2S2327467 55.8761 75815663 +1 chr1_75820502 55.8791 75820502 +1 chr1_75821201 55.8796 75821201 +1 BICF2S23614171 55.8799 75821646 +1 chr1_75822011 55.8801 75822011 +1 BICF2S23149368 55.8912 75837245 +1 BICF2S237680 55.9137 75856453 +1 BICF2S23251255 55.9234 75865335 +1 BICF2P314384 55.9737 75894587 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61.1448 82563392 +1 BICF2G630791838 61.1676 82584276 +1 BICF2P552968 61.1825 82602914 +1 BICF2P610306 61.2089 82640620 +1 BICF2G630791807 61.215 82647331 +1 BICF2P765555 61.2154 82647962 +1 BICF2G630791788 61.2286 82661900 +1 BICF2G630791786 61.2295 82665633 +1 BICF2G630791785 61.2553 82693440 +1 BICF2P1122804 61.277 82721640 +1 TIGRP2P10924_rs8922846 61.2791 82724746 +1 TIGRP2P10928_rs9020766 61.2831 82742016 +1 BICF2P1073485 61.2896 82747050 +1 BICF2G630791777 61.3343 82784180 +1 BICF2G630791774 61.3371 82791360 +1 BICF2G630791761 61.3445 82803921 +1 BICF2G630791746 61.3521 82813911 +1 BICF2P659633 61.4017 82855074 +1 BICF2G630791722 61.4095 82864847 +1 BICF2P651480 61.415 82872743 +1 BICF2G630791694 61.4173 82884626 +1 BICF2G630791690 61.4225 82894574 +1 BICF2G630791671 61.4373 82910526 +1 BICF2P519832 61.4448 82918039 +1 TIGRP2P10953_rs8817124 61.5038 82962835 +1 BICF2P403014 61.5065 82963870 +1 BICF2G630791643 61.5312 82978819 +1 BICF2G630791626 61.5371 82987094 +1 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BICF2G630790944 63.1438 84073934 +1 BICF2P1234455 63.1513 84102597 +1 BICF2P458062 63.1524 84114304 +1 TIGRP2P11188_rs8626585 63.1575 84129397 +1 BICF2P133463 63.1617 84137615 +1 BICF2P536449 63.1666 84151091 +1 BICF2P1454594 63.1728 84168109 +1 BICF2P328111 63.1762 84177262 +1 BICF2P1136701 63.1822 84190014 +1 BICF2S23252755 63.1859 84198661 +1 BICF2S22942888 63.1896 84206081 +1 BICF2S23528454 63.1942 84224945 +1 BICF2P1291301 63.1956 84228909 +1 chr1_84241180 63.2 84241180 +1 chr1_84258039 63.2064 84258039 +1 TIGRP2P11214_rs8805033 63.3378 84281686 +1 BICF2P539236 63.3993 84289122 +1 chr1_84299438 63.4508 84299438 +1 chr1_84322486 63.566 84322486 +1 BICF2P873926 63.6065 84333049 +1 BICF2P988261 63.6148 84358746 +1 BICF2P351299 63.6223 84373771 +1 BICF2P161501 63.6299 84390848 +1 TIGRP2P11229_rs8933778 63.6537 84423496 +1 BICF2S23241294 63.6617 84453553 +1 BICF2P591798 63.6693 84471462 +1 BICF2P770158 63.6814 84507690 +1 BICF2P653927 63.6827 84516632 +1 BICF2S23523128 63.6848 84531656 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84940206 +1 BICF2S2351377 63.9883 84955260 +1 BICF2S22910363 63.9926 84991606 +1 BICF2S23657915 64.0412 85027342 +1 BICF2S23720924 64.0463 85043205 +1 chr1_85046335 64.0475 85046335 +1 BICF2S2394142 64.0489 85049805 +1 BICF2P276137 64.0779 85088172 +1 BICF2S23314699 64.0847 85093300 +1 BICF2S23117931 64.0998 85107955 +1 BICF2P1176002 64.1166 85124120 +1 BICF2P822437 64.129 85142223 +1 BICF2P1043996 64.1324 85154867 +1 BICF2P35475 64.1392 85163681 +1 BICF2P1307534 64.1464 85186983 +1 BICF2P547127 64.1549 85201084 +1 TIGRP2P11380_rs8881496 64.1631 85211486 +1 BICF2P251061 64.1737 85225896 +1 TIGRP2P11391_rs8905601 64.1793 85234934 +1 TIGRP2P11399_rs9102682 64.1889 85249480 +1 BICF2P1034239 64.1974 85253799 +1 TIGRP2P11408_rs8990946 64.2056 85264710 +1 TIGRP2P11409_rs8890090 64.2252 85279851 +1 BICF2P293188 64.2326 85289685 +1 BICF2P1368509 64.2495 85300143 +1 BICF2P738681 64.2597 85314595 +1 BICF2P1068599 64.2639 85325798 +1 TIGRP2P11437_rs9143733 64.2727 85341818 +1 BICF2P629327 64.2757 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BICF2S23613241 65.8582 86865286 +1 TIGRP2P11950_rs8949870 65.8751 86881825 +1 BICF2P817615 65.8803 86895543 +1 BICF2P1343455 65.8977 86915211 +1 BICF2S22940418 65.9042 86920556 +1 BICF2S23329956 65.9553 86939071 +1 TIGRP2P11972_rs8852013 66.0201 86961588 +1 BICF2S23147224 66.0379 86968930 +1 BICF2S24414901 66.0615 86978467 +1 BICF2P19328 66.0974 86995784 +1 TIGRP2P11983_rs8960170 66.1101 87001810 +1 BICF2P1115497 66.203 87022155 +1 TIGRP2P11997_rs8991078 66.24 87036523 +1 BICF2P444688 66.2882 87049062 +1 BICF2P792413 66.3121 87058626 +1 TIGRP2P12008_rs8742332 66.3339 87072473 +1 TIGRP2P12012_rs9069720 66.3674 87090381 +1 TIGRP2P12014_rs8907409 66.391 87100625 +1 TIGRP2P12017_rs8614797 66.5226 87119369 +1 BICF2P1183772 66.5871 87133089 +1 BICF2P797493 66.5929 87143521 +1 BICF2S23911533 66.6034 87162170 +1 BICF2P1206124 66.6196 87178114 +1 BICF2P397480 66.6272 87201517 +1 BICF2S23531522 66.6289 87219934 +1 BICF2S23029627 66.6298 87237138 +1 BICF2P831959 66.6333 87279884 +1 BICF2P1231220 66.6579 87288554 +1 chr1_87303914 66.6629 87303914 +1 BICF2P584872 66.6653 87311513 +1 BICF2S23428507 66.6667 87321580 +1 TIGRP2P12109_rs8498218 66.6781 87339720 +1 TIGRP2P12113_rs9009286 66.7011 87357735 +1 BICF2P932063 66.7205 87374235 +1 BICF2S23537561 66.7431 87392895 +1 BICF2S23660342 66.8045 87446951 +1 TIGRP2P12132_rs8733793 66.8523 87460673 +1 BICF2P569224 66.8808 87473014 +1 BICF2P1390826 66.9282 87496095 +1 BICF2P1364159 66.9399 87515156 +1 BICF2P1035315 66.947 87523061 +1 BICF2S22958404 66.9661 87560374 +1 BICF2P1097020 66.9726 87613765 +1 TIGRP2P12162_rs8858676 66.9769 87660038 +1 BICF2S23913195 66.9814 87700886 +1 BICF2P1370058 66.9814 87710109 +1 BICF2S22922641 66.9832 87727109 +1 BICF2P489556 66.9848 87740738 +1 BICF2P1129598 66.9848 87749401 +1 chr1_87750774 66.9849 87750774 +1 chr1_87750923 66.9849 87750923 +1 BICF2P390643 66.9857 87759924 +1 BICF2P1070367 67.0112 87799429 +1 BICF2P293725 67.0149 87807348 +1 BICF2S2334022 67.017 87819391 +1 BICF2S233487 67.0236 87844437 +1 BICF2P1325899 67.0243 87852748 +1 BICF2P739399 67.0384 87869981 +1 BICF2P542383 67.044 87881264 +1 BICF2P299311 67.0527 87889913 +1 BICF2P1269559 67.0649 87906264 +1 BICF2P708865 67.0696 87914263 +1 BICF2P939465 67.1103 87924666 +1 BICF2S23144101 67.1187 87933709 +1 TIGRP2P12238_rs9110020 67.1348 87945490 +1 chr1_87952291 67.1428 87952291 +1 BICF2P1162793 67.1547 87962476 +1 TIGRP2P12243_rs8598182 67.1612 87967826 +1 TIGRP2P12245_rs8674891 67.1744 87969932 +1 chr1_87980483 67.2408 87980483 +1 TIGRP2P12265_rs8739853 67.2844 87987409 +1 TIGRP2P12273_rs8958768 67.3225 87991197 +1 BICF2S237392 67.3447 88003835 +1 chr1_88004773 67.3464 88004773 +1 BICF2S2321651 67.3481 88005743 +1 chr1_88010473 67.3489 88010473 +1 BICF2P619577 67.3496 88014231 +1 chr1_88018144 67.3509 88018144 +1 BICF2P145966 67.3535 88026530 +1 BICF2P622460 67.3737 88055772 +1 BICF2P1374048 67.3887 88068919 +1 BICF2P16768 67.403 88078348 +1 TIGRP2P12316_rs8782863 67.4051 88086745 +1 BICF2S23016165 67.4124 88117620 +1 chr1_88126257 67.4575 88126257 +1 BICF2P1447878 67.4804 88131782 +1 BICF2P995064 67.482 88141496 +1 TIGRP2P12350_rs8592398 67.4958 88158788 +1 TIGRP2P12353_rs8884857 67.5019 88164715 +1 BICF2P797847 67.5084 88177062 +1 BICF2P1418363 67.5236 88190203 +1 BICF2P1359707 67.532 88195684 +1 BICF2S2441123 67.5486 88199691 +1 chr1_88213728 67.5752 88213728 +1 chr1_88213785 67.5753 88213785 +1 chr1_88213842 67.5754 88213842 +1 chr1_88213930 67.5756 88213930 +1 BICF2P648315 67.5949 88224120 +1 chr1_88230562 67.606 88230562 +1 BICF2P468053 67.6282 88244106 +1 BICF2S23510612 67.6996 88261527 +1 BICF2S23059367 67.7086 88270209 +1 chr1_88286534 67.7395 88286534 +1 chr1_88287930 67.7421 88287930 +1 TIGRP2P12370_rs9133849 67.7463 88290162 +1 BICF2P388388 67.7557 88300880 +1 chr1_88311654 67.7637 88311654 +1 BICF2S2333854 67.7674 88316574 +1 BICF2S2379353 67.7846 88332286 +1 TIGRP2P12382_rs8840648 67.7896 88337654 +1 chr1_88359725 67.7942 88359725 +1 BICF2P617358 67.7946 88361867 +1 TIGRP2P12399_rs9168356 67.801 88373607 +1 BICF2P704682 67.8154 88388679 +1 BICF2P1218530 67.8281 88398146 +1 BICF2P59989 67.8337 88404523 +1 BICF2P60202 67.8394 88420801 +1 TIGRP2P12425_rs8727571 67.8425 88428152 +1 BICF2S22929886 67.8511 88443527 +1 BICF2P310864 67.8592 88453487 +1 BICF2S23323431 67.8694 88466382 +1 BICF2P1382482 67.8825 88479318 +1 BICF2P693221 67.8871 88493146 +1 TIGRP2P12470_rs8552194 67.8881 88498728 +1 BICF2P1380009 67.8917 88511666 +1 TIGRP2P12484_rs8580225 67.8944 88520600 +1 BICF2P993606 67.8987 88536447 +1 BICF2P827716 67.9029 88544959 +1 BICF2P1193019 67.9114 88557725 +1 BICF2S22945104 67.9181 88573573 +1 TIGRP2P12493_rs8794151 67.9192 88577871 +1 BICF2P1080780 67.9461 88591681 +1 BICF2P778997 67.9525 88610004 +1 TIGRP2P12501_rs8906750 67.9529 88611225 +1 BICF2S23331004 67.9651 88628125 +1 BICF2S23310572 67.9661 88628567 +1 BICF2S23319111 67.9732 88644668 +1 BICF2S23515737 68.0512 88671391 +1 BICF2S23152588 68.0712 88702455 +1 BICF2S23426717 68.0757 88706825 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68.5919 89201892 +1 BICF2P903204 68.6285 89230432 +1 BICF2P1305167 68.6342 89246426 +1 TIGRP2P12635_rs8631386 68.6405 89251453 +1 BICF2P616203 68.6455 89257825 +1 BICF2P528911 68.6594 89271008 +1 BICF2P700476 68.6768 89283883 +1 BICF2P226377 68.7038 89299599 +1 chr1_89303450 68.7078 89303450 +1 BICF2P262933 68.7136 89308901 +1 TIGRP2P12661_rs9242229 68.7248 89323556 +1 TIGRP2P12662_rs9242228 68.7254 89324285 +1 TIGRP2P12666_rs8912433 68.7401 89348993 +1 BICF2P386024 68.7495 89359346 +1 BICF2P879703 68.7519 89363561 +1 BICF2P388481 68.7584 89370058 +1 BICF2S23337909 68.7898 89380758 +1 BICF2S23333989 68.7915 89384182 +1 BICF2P567279 68.802 89390864 +1 TIGRP2P12687_rs9059141 68.8212 89405885 +1 BICF2S23128693 68.8643 89422459 +1 BICF2P629010 68.8794 89435717 +1 BICF2S23153091 68.8881 89443029 +1 BICF2P1250699 68.9073 89451125 +1 BICF2P957693 68.9319 89465941 +1 BICF2S23534449 68.9454 89478126 +1 TIGRP2P12727_rs9029693 68.9578 89493418 +1 BICF2P320625 68.9612 89502699 +1 BICF2P320623 68.9616 89503094 +1 BICF2S23321736 69.0143 89536487 +1 BICF2P169797 69.0385 89549084 +1 BICF2S2355546 69.0635 89559109 +1 BICF2P1023013 69.098 89571648 +1 BICF2P239880 69.1114 89580792 +1 chr1_89589161 69.1398 89589161 +1 chr1_89589221 69.14 89589221 +1 BICF2P523560 69.154 89593357 +1 chr1_89606643 69.222 89606643 +1 BICF2S23649844 69.2253 89607274 +1 BICF2S23443181 69.2468 89613134 +1 BICF2P780209 69.2687 89630497 +1 TIGRP2P12766_rs8624937 69.2827 89636417 +1 BICF2P349561 69.2948 89643917 +1 BICF2S23162050 69.3121 89649827 +1 BICF2P926294 69.3222 89655664 +1 BICF2P971082 69.3264 89658715 +1 BICF2P360757 69.4215 89698126 +1 BICF2S23356235 69.4245 89699575 +1 BICF2P138781 69.4334 89703806 +1 TIGRP2P12805_rs8769304 69.4997 89735660 +1 BICF2P1241788 69.5142 89743275 +1 BICF2P46068 69.5196 89752268 +1 BICF2P230438 69.6423 89765615 +1 BICF2P9727 69.6632 89782753 +1 BICF2S23434603 69.675 89785001 +1 chr1_89790365 69.706 89790365 +1 chr1_89790517 69.7069 89790517 +1 BICF2P650872 69.7407 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BICF2P489495 70.6013 90628441 +1 BICF2S23759481 70.612 90638289 +1 BICF2P1380310 70.6239 90656276 +1 BICF2P588381 70.6276 90659305 +1 BICF2P1030355 70.7403 90687835 +1 BICF2P558580 70.7561 90694216 +1 BICF2P156557 70.7842 90707649 +1 BICF2S22927524 70.8508 90720865 +1 BICF2S23660350 70.8672 90727743 +1 BICF2S24412827 70.9215 90748177 +1 BICF2P29953 70.9338 90757800 +1 BICF2P29966 70.9364 90759756 +1 BICF2P153251 70.948 90768050 +1 BICF2P1105636 70.9854 90789385 +1 BICF2P1209010 71.0193 90795837 +1 TIGRP2P13155_rs9036832 71.0608 90804223 +1 BICF2S2335685 71.0639 90808431 +1 BICF2P224250 71.0643 90809296 +1 BICF2S23231732 71.0915 90835513 +1 BICF2P1102357 71.1049 90851958 +1 BICF2P825861 71.1316 90860923 +1 BICF2P1419206 71.1332 90868918 +1 BICF2P888709 71.1396 90898271 +1 BICF2S23123706 71.1434 90904551 +1 BICF2P387293 71.1466 90918175 +1 TIGRP2P13214_rs8824112 71.1586 90928884 +1 BICF2P1322137 71.1739 90942122 +1 TIGRP2P13221_rs9135575 71.1799 90946596 +1 BICF2S23440043 71.181 90947977 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71.6114 91271271 +1 BICF2G630790917 71.6281 91301287 +1 BICF2P96206 71.6424 91322267 +1 BICF2S23636945 71.657 91335228 +1 chr1_91338233 71.6936 91338233 +1 BICF2S2293259 71.7278 91341034 +1 BICF2P334685 71.7308 91350352 +1 BICF2S23434466 71.7338 91359719 +1 BICF2S2394909 71.7452 91385138 +1 chr1_91391618 71.7461 91391618 +1 BICF2S2448229 71.7693 91411795 +1 BICF2P53834 71.7704 91421530 +1 BICF2P914459 71.7713 91434164 +1 BICF2S23730814 71.8361 91445563 +1 BICF2P1021017 71.896 91462863 +1 BICF2G630790911 71.8964 91463706 +1 BICF2G630790899 71.8996 91470832 +1 BICF2G630790883 71.9055 91481101 +1 BICF2P1294473 71.9124 91484001 +1 BICF2S2416029 71.9279 91490415 +1 BICF2S23661354 71.9804 91523631 +1 BICF2G630790875 71.9981 91534901 +1 BICF2S2301009 72.0104 91551210 +1 BICF2G630790862 72.0183 91570568 +1 chr1_91586621 72.0229 91586621 +1 BICF2G630790827 72.0262 91595636 +1 BICF2G630790819 72.0357 91632976 +1 BICF2P1047457 72.0446 91657069 +1 BICF2P319037 72.0467 91663802 +1 BICF2P392435 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chr1_115090336 87.0096 115090336 +1 BICF2P794097 87.0126 115128336 +1 BICF2P543122 87.0126 115142144 +1 BICF2P1167507 87.0143 115162623 +1 BICF2P1088021 87.0194 115185474 +1 BICF2P72912 87.0195 115197761 +1 BICF2P42933 87.0209 115206927 +1 BICF2P281632 87.0242 115237740 +1 BICF2P1380911 87.026 115250872 +1 BICF2P506122 87.0271 115259198 +1 BICF2P429500 87.0352 115273139 +1 chr1_115296299 87.0536 115296299 +1 chr1_115302091 87.055 115302091 +1 chr1_115304947 87.0557 115304947 +1 chr1_115305406 87.0558 115305406 +1 chr1_115312424 87.0575 115312424 +1 chr1_115323619 87.0596 115323619 +1 BICF2S23627313 87.0633 115400782 +1 BICF2P48998 87.0652 115424062 +1 BICF2S23540830 87.069 115457264 +1 chr1_115472025 87.0732 115472025 +1 chr1_115473279 87.0735 115473279 +1 chr1_115513981 87.0803 115513981 +1 chr1_115548388 87.0804 115548388 +1 BICF2S23433000 87.0868 115582685 +1 chr1_115589094 87.0871 115589094 +1 chr1_115590728 87.0872 115590728 +1 BICF2S2339225 87.0876 115599956 +1 chr1_115601608 87.088 115601608 +1 BICF2P706537 87.0951 115639025 +1 chr1_115657055 87.0967 115657055 +1 BICF2P484240 87.0967 115659985 +1 BICF2S23016817 87.0973 115687183 +1 BICF2P730038 87.0983 115691075 +1 BICF2P1048090 87.1148 115702102 +1 BICF2P1048091 87.115 115702509 +1 chr1_115720655 87.1205 115720655 +1 BICF2P1114453 87.1235 115751383 +1 BICF2P868280 87.124 115754273 +1 chr1_115762466 87.1256 115762466 +1 chr1_115784646 87.1298 115784646 +1 chr1_115786684 87.1302 115786684 +1 chr1_115788482 87.1305 115788482 +1 chr1_115804659 87.1355 115804659 +1 chr1_115829990 87.1571 115829990 +1 chr1_115837992 87.1639 115837992 +1 BICF2P24152 87.1668 115841345 +1 chr1_115853739 87.1684 115853739 +1 BICF2S23025549 87.1685 115854614 +1 chr1_115870956 87.1709 115870956 +1 chr1_115872701 87.1712 115872701 +1 chr1_115905463 87.1756 115905463 +1 chr1_115917279 87.1763 115917279 +1 G104f38S164 87.1809 115974463 +1 chr1_115994179 87.1863 115994179 +1 chr1_115996135 87.1868 115996135 +1 chr1_115997062 87.187 115997062 +1 G105f22S238 87.1942 116023740 +1 chr1_116049985 87.1966 116049985 +1 BICF2S23144692 87.2097 116087102 +1 BICF2S23531031 87.2098 116089672 +1 chr1_116090320 87.2098 116090320 +1 BICF2S23142887 87.2098 116090515 +1 BICF2S2294178 87.2106 116111354 +1 chr1_116185241 87.2284 116185241 +1 chr1_116186909 87.2287 116186909 +1 chr1_116188034 87.2288 116188034 +1 chr1_116188781 87.2289 116188781 +1 chr1_116189616 87.229 116189616 +1 BICF2S23330892 87.2292 116191218 +1 BICF2S23429870 87.2321 116226799 +1 chr1_116252675 87.2374 116252675 +1 chr1_116276518 87.2765 116276518 +1 chr1_116303049 87.2984 116303049 +1 BICF2S23540163 87.2987 116303382 +1 chr1_116304827 87.299 116304827 +1 chr1_116337606 87.3062 116337606 +1 chr1_116355496 87.3101 116355496 +1 BICF2S23237407 87.3105 116357251 +1 chr1_116386676 87.3119 116386676 +1 chr1_116407091 87.3136 116407091 +1 chr1_116427188 87.3153 116427188 +1 BICF2S22936290 87.3199 116473324 +1 BICF2P466866 87.3271 116521091 +1 chr1_116547788 87.3328 116547788 +1 BICF2S23637562 87.3328 116547876 +1 chr1_116549998 87.3393 116549998 +1 BICF2S23534796 87.3813 116563752 +1 chr1_116576219 87.386 116576219 +1 chr1_116589401 87.3904 116589401 +1 chr1_116589514 87.3904 116589514 +1 chr1_116596422 87.3909 116596422 +1 BICF2S23060654 87.3922 116617099 +1 BICF2S23454311 87.3922 116626054 +1 BICF2S23244630 87.4132 116663470 +1 BICF2S23619450 87.4155 116674568 +1 chr1_116678423 87.4163 116678423 +1 BICF2P1003271 87.4489 116702674 +1 chr1_116710699 87.455 116710699 +1 BICF2P149859 87.4591 116716022 +1 chr1_116716148 87.4594 116716148 +1 BICF2S2336087 87.5084 116741161 +1 BICF2P547258 87.5384 116764052 +1 chr1_116774011 87.5744 116774011 +1 chr1_116774492 87.5761 116774492 +1 chr1_116784973 87.6139 116784973 +1 EMB_chr1_116785027a_dup 87.6141 116785027 +1 chr1_116788874 87.628 116788874 +1 BICF2P294320 87.6342 116790584 +1 BICF2P1032874 87.6452 116799809 +1 BICF2P729716 87.6552 116808540 +1 BICF2S23226736 87.6747 116826651 +1 BICF2S23246972 87.6782 116831647 +1 chr1_116836457 87.6822 116836457 +1 chr1_116851620 87.7286 116851620 +1 BICF2P512946 87.732 116852360 +1 chr1_116853249 87.736 116853249 +1 BICF2P876990 87.76 116858534 +1 BICF2P497753 87.7845 116868565 +1 chr1_116875954 87.7919 116875954 +1 BICF2P951575 87.7935 116877583 +1 chr1_116893594 87.8976 116893594 +1 chr1_116897996 87.8978 116897996 +1 BICF2P98559 87.8979 116898174 +1 BICF2P880389 87.9466 116915476 +1 BICF2P454992 87.9837 116931543 +1 chr1_116938436 87.9925 116938436 +1 chr1_116938502 87.9926 116938502 +1 chr1_116939362 87.994 116939362 +1 chr1_116940712 87.9962 116940712 +1 chr1_116940843 87.9964 116940843 +1 BICF2P1057238 88.0041 116945742 +1 BICF2S23148126 88.0134 116963202 +1 BICF2S23226755 88.0162 116970053 +1 chr1_116995111 88.0764 116995111 +1 BICF2P392127 88.0869 117028481 +1 BICF2P1453001 88.0895 117052328 +1 chr1_117054844 88.0904 117054844 +1 chr1_117055098 88.0905 117055098 +1 chr1_117082600 88.101 117082600 +1 BICF2P958673 88.1011 117082847 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117310723 +1 BICF2S23425358 88.3362 117320160 +1 chr1_117320259 88.3369 117320259 +1 chr1_117320280 88.3371 117320280 +1 chr1_117362363 88.4471 117362363 +1 chr1_117362465 88.4473 117362465 +1 chr1_117367087 88.4523 117367087 +1 BICF2S2331742 88.4599 117375527 +1 BICF2P160939 88.4639 117382779 +1 BICF2P1268728 88.4774 117408453 +1 BICF2P212310 88.4812 117411254 +1 BICF2S22943440 88.4913 117418568 +1 chr1_117419893 88.495 117419893 +1 chr1_117439238 88.5485 117439238 +1 chr1_117452637 88.5837 117452637 +1 chr1_117453132 88.5847 117453132 +1 chr1_117453447 88.5854 117453447 +1 chr1_117453740 88.586 117453740 +1 BICF2S2444924 88.6007 117460731 +1 BICF2S2344037 88.6045 117462550 +1 BICF2P6706 88.6283 117480794 +1 BICF2P872880 88.6346 117485293 +1 chr1_117503813 88.6693 117503813 +1 BICF2P158508 88.6703 117504340 +1 BICF2S2353974 88.6748 117506724 +1 BICF2S23022981 88.6812 117509709 +1 BICF2S2357734 88.6833 117510670 +1 chr1_117511455 88.6851 117511455 +1 chr1_117515144 88.6934 117515144 +1 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117887567 +1 BICF2P275233 89.2893 117910809 +1 BICF2S23729822 89.3499 117917907 +1 BICF2P388245 89.3521 117924008 +1 BICF2S23228778 89.3718 117936408 +1 BICF2S2341721 89.4354 117952001 +1 chr1_117966626 89.4532 117966626 +1 G108f48S228 89.4665 117977612 +1 BICF2P852373 89.4682 118024299 +1 BICF2S2319910 89.5678 118046988 +1 BICF2P272266 89.5704 118060464 +1 BICF2P1117362 89.5704 118062602 +1 BICF2S231174 89.5704 118074005 +1 BICF2S23052560 89.5717 118115697 +1 BICF2S2348891 89.5843 118121221 +1 BICF2P763794 89.5993 118133446 +1 BICF2P115405 89.6257 118141922 +1 BICF2P246885 89.6383 118155970 +1 BICF2P154161 89.6541 118167444 +1 BICF2S23238613 89.7051 118194236 +1 BICF2P918020 89.7145 118229781 +1 BICF2S23236221 89.7324 118252125 +1 BICF2P1405234 89.7558 118275961 +1 BICF2P743916 89.7619 118285584 +1 BICF2S23160492 89.7682 118298166 +1 BICF2P818195 89.7729 118308623 +1 BICF2P215028 89.7774 118320216 +1 BICF2P953353 89.7811 118321543 +1 BICF2P919320 89.7832 118326745 +1 BICF2P22651 89.7842 118328591 +1 BICF2P1326382 89.7994 118341039 +1 BICF2S23111848 89.8116 118356236 +1 BICF2P79380 89.8196 118366911 +1 BICF2P79401 89.8241 118371712 +1 BICF2P226508 89.8957 118400796 +1 BICF2P1316208 89.902 118410649 +1 chr1_118422537 89.928 118422537 +1 BICF2S23161083 90.0185 118433395 +1 BICF2P1246179 90.0232 118434639 +1 BICF2P1077685 90.0901 118452371 +1 chr1_118458601 90.1161 118458601 +1 BICF2P1214272 90.128 118461448 +1 BICF2P1166246 90.1338 118463922 +1 BICF2P1226056 90.1451 118472397 +1 BICF2S22940628 90.1683 118484553 +1 BICF2S23127630 90.1921 118494061 +1 BICF2S22935904 90.221 118505652 +1 chr1_118523918 90.2535 118523918 +1 chr1_118524011 90.2538 118524011 +1 chr1_118524182 90.2545 118524182 +1 BICF2P963462 90.2659 118527129 +1 BICF2P818561 90.3417 118550244 +1 BICF2P1060799 90.3734 118567328 +1 BICF2P508443 90.3877 118574606 +1 BICF2P1344789 90.4929 118593862 +1 BICF2P1317706 90.5587 118615341 +1 BICF2P1389043 90.5636 118626442 +1 BICF2P866721 90.6139 118638344 +1 BICF2P345667 90.6511 118652492 +1 BICF2P157670 90.6668 118657648 +1 BICF2P636988 90.7417 118672952 +1 BICF2S22952046 90.7457 118673776 +1 BICF2S22956241 90.7691 118682641 +1 BICF2S234633 90.8554 118720877 +1 BICF2P1033868 90.8652 118726698 +1 BICF2S23240365 90.9337 118735252 +1 BICF2P889331 90.9992 118752544 +1 BICF2S23351800 91.0612 118774197 +1 BICF2P344986 91.0663 118775960 +1 BICF2P296640 91.1118 118786160 +1 BICF2P106695 91.1786 118802322 +1 BICF2P695227 91.2011 118808504 +1 BICF2P1393253 91.2222 118820170 +1 BICF2P526598 91.229 118827142 +1 BICF2S23716322 91.3222 118851986 +1 BICF2P417839 91.363 118864482 +1 BICF2S23156285 91.408 118876992 +1 BICF2P1390400 91.5104 118897206 +1 BICF2P1226084 91.5905 118913020 +1 BICF2P405934 91.5961 118917792 +1 BICF2P566711 91.6011 118918741 +1 chr1_118929651 91.6722 118929651 +1 BICF2P974934 91.6989 118933737 +1 BICF2S23536328 91.7769 118949304 +1 BICF2S23354729 91.7879 118954721 +1 chr1_118962475 91.831 118962475 +1 BICF2P240143 91.8813 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G C C G G G G G G C C G G A A G G A A A C A A A A C C A A G G C C G G G A G A C C G A G A G A G A G A G A G G G A G G G A A G G G G G G A A G G A G G G A A A A A G A G G G G A G G G A G G G A G G A G A A A A C A G C G A A G G G A A G A G G A G G A G G A G A A A G A G A G A A G T T G A A G G G G G A G A T A A A C A G C A G A A G A G G G A G G A G A G A G G A C G A A A T T A A G G A A G G A G G G G G G G C C A A G G G G A A G G C C A A G G A A G C G G G G A G A A G G A A G G G G G G A A A A G G G G A A G G C C G G G G G G A A A A A G G G A G G G A G A A G G G G C C G G C C T T C C C C G G G G G G A A A A G G T T G G G G A A A G C C G A G A G A A A A A C G A G G G A G G G A A G G A A G G G G A A A A G G T T A A A A G G C C G G T T A A A A T T A A A A G G G G A A G G G G C C A A A A C C G G G G A A G G A A A A C C G G A A A G G G G G C C A G G G G G G G C A G A A A C C G A A A G G G G A A A A G A A G A G A A G A G G G G G A G G G A C A A A G G C C A A G G C C A A A G G G C C A A G G G A T A G G G G G G A A G G G G A A A A G G G G A A G G A A A A G G C C A A G G G A A A A A A A A A A A G C A C A A A A A A A A A G A G A G A A G G G A G G G G A G G A A A A A C C A A A A A A G G C C A A G G G G G G G G A A G A G C A G A G A A G A A A G G A G G G A A G A G A A G G G A A C A A A A G A G A G A A G G A G A A G G G A G A G A C A A G A G A G C A A A C C A G G A A G C C G G G G G A C C G A C A A C G G C C C C A A A C G C C A A A A G C A G A A A A A A A A A G G G G G G A A A A G G A A G G A A G G A A A A G G C C A A G G G G A A A A A A T T G G G G A A A A A A A A G G G G C C A A A G G G G G A A A G G G A A I I A G G G G G G A G G G G G G A A A G G G A A A G A G G G A A G G A G C C C C A G G A G G G G A C G G G A G G A G A A C G A A C A A A G G A G G G C C G G G G G G A A G G G G G G G G G G A A A A G A C C A A G G G G A A C A A G A G A A G G G G G G T A G G A A A G G A C C A A A G G A C A A G G G A A A A A C A A A A A A G G A G C C G G A G G A C C A T A G G G A A G G A G G G A A G A G A T T G A G A A C A G G G G A A G G A G G G A G G C C A A C G G G G G A A A G C C A C G A A G A T T T C C A A A A A A A A G G G G A A C C G A A G A A A A G G G G G G A A G G T T G A G A A C C A G G G A G A G A A C A A A A C C A A A A G G A A A G A A G G A A G G G G A G A A G G A A A A G G A A G G A A A A A A G G G G G G G G G G A A A A A G A G G G G A G G A C G A A A T T G A G G G G A A A A A A G G G G A A C C G G G G G G T T G G G G A A A A G G A A T T G G G G G G G G A G G A A A C C G G A A G G G G G A G A A A G G A A A A G G C C A A G G G A A A A A C C A A A A G G G G G G D D A A G G G A C C G A A A G G G G A G G A A G A G G A G G G A A C C C A G A A C C A G A A A A A A G G G G A A A G A G A A G G A A G G A A A G A G A C A C G A G G G G A A G A A C A G A A A G A C G A A C A A G G G A G G A A G A G G D I A A G G I I I I A G G G G G G A A G A G A A G G T T G G G G G A A G G G G A A G A G A G G A A A G A A A A A A A C C A G A A A A G G A G G G G A A G A G A A A A A G A A A A G A A A G G A A A A A G G A A G G G G G A A A A T T A C G G A G A A G G A A G A G G A A A A A C A A G G A A A A C A A A A G A G A A A A G G G A A G C C A G G G G G T T A A G G A G G A A G G A A A G G G A G A G G G G G G G G A A A G A A G G A A A A G G A A G G G G C C G G C C G A G A A G A A A G A G A G G A G G A G G A A C G G G G G G C A G G G G A A A A A A G G G A A A G A G A G G A A A A A A A A C C G A A G C G A G T A A A A A G G T T G G A A G G C C T T G G A A A A C C C C A A A A A A G G G A A C A G A G G C A C A G G A A G A C G A A A A G G G C C G G G G G G G G A G A A A A G G C C A A G G G G G A G G A A G G A A C G G G A A C A A G G G T A A G G A A G A G A A G G G G A G C C G G A G G A A A G A A G A G G A A C A C A C A A G G G G A A A C G G A G G G G G C C G G A A A A G G G G A A A A G G A A A G G G C C G G C C G A T T C C A G A G G G A A A A A A A A G G A A G G G G C C G G C C A A G G G G A A A G A G G A G A A G A C A A A G G G C C G G C C A G G G A G G G A A A G A G T A C G G G G A A A A G A G A G G A A A G A A C G G A A G G G G A A A A A A A G G A C C G G G G G A G G A A A C G A G A A G G A G A A C A A A G A A A A A A G G A C A G A G G A C A A A G G A G G G A A G G A G C A A A A G A G C A C C G G C C A G G G G G G A A G A G G G A G A A G G G G G G G G C C A G D D G A G G G A A G A A A A G G C C A A G G G G A C G A C C T A G G A A A A G A A A G G G A C C G G C C A C C A G A G G G G G G A G G G A G A A A G A G G G G A C C G A G G G G G G G G A C G G G G A A A A C C A A A A G A A A G G A A A A T T G A G G G G G G G A C C A A A A G G A A C A A G G G G A A G A G A A G G A A G G A G G A G G A G G G C C G G A A A A G G A C G G G A G G A A G G C C A A C C A A A G C A T T C C G G A A G A G G A A C C A A A G G G G G G G G G A A G G A A G A G G G G G G G G A A A A G G A G A G A G A A G G G G A G G G A A G A C A A A G G A A T T G A A C G A G G G A G A A A G G G G A A G G G G A A G G A A A A G G A A G A G A G G G G C A G G A G A G A C G C G A G G C C A A A A G G G G G G G A G 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G A A A A C A A A A G G G A T G A A C A A G G A A A A A A G G G G G G A A A G A G A G G A A A G G G A G G G G A A G G A A G G G G G G C C C C A A G G C C A A A A G G G G G G A A A A G G A A G G G G C C G G C C G G A A A A G G G G A A A A A A A A C C G G A G G A A G A A G G C C A A G A A C A A G A A C A A G G G G G G A A G G A A A A A A A A G G G G A A A A A G G G A A G G G G A A A A A A G G G G A A A A G G G G A A G G A A G G A A G G G G G G G A A G G G G A A C G G G A A A T T T T G A A A G G T A C C A G G G A A A A A A A A G G A G A G A G G G G G A A C C A G G G A A A G G A A A G C A A A G A A A A A A A G A C G G A A G C A G G A G G G G G G A A G G A G G G G A A A G A A A A A G G A A C C C C A A C C G G G G A A T T G G G G A A G G A A G G A A A A G G A A A C G G G G A A G G A G G A C C A G A G A A G A A C G A G G A A G G C C G G A A A A G G G G T T G G G A G G A A G G G G C C A A A A A C C C G A A G G G G G C C G A A C C A A A G G G G G C A G G G A A G G A A G G G G G G A A G G A A G 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BICF2G630709098 106 0.82 cM 0 1 1 +1027227 1027227.0 1027227 1027227.1 1 5409586 14391559 BICF2P1437031 BICF2P510074 522 6.53 cM 0 1 1 +1027227 1027227.0 1027227 1027227.1 1 32903322 35221407 BICF2G630718404 BICF2G630720080 190 1.85 cM 0 1 1 +1027227 1027227.0 1027227 1027227.1 1 40647049 54430787 BICF2S23518030 BICF2P879340 965 10.09 cM 0 1 1 +1027228 1027228.1 1027227 1027227.1 1 79129921 81565205 BICF2G630793295 BICF2P609178 132 1.82 cM 0 1 1 +1027227 1027227.0 1027227 1027227.1 1 91385138 97942807 BICF2S2394909 chr1_97942807 461 5.06 cM 0 1 1 +1027227 1027227.0 1027227 1027227.1 1 102119723 118876992 BICF2P113349 BICF2S23156285 1340 14.00 cM 0 1 1 diff --git a/minimal_test/og_outs/test_out_old_new.match b/minimal_test/og_outs/test_out_old_new.match new file mode 100644 index 0000000..981cd9c --- /dev/null +++ b/minimal_test/og_outs/test_out_old_new.match @@ -0,0 +1,8 @@ +967977 967977.1 1027230 1027230.1 1 4272138 6271129 BICF2G630708412 BICF2G630709168 111 0.84 cM 0 1 1 +967977 967977.1 1027231 1027231.1 1 4134195 6198709 TIGRP2P2774_rs8786396 BICF2G630709098 117 0.86 cM 0 1 1 +967979 967979.1 1027229 1027229.1 1 33043620 34553147 BICF2S23124643 BICF2G630719567 125 1.10 cM 0 1 1 +967978 967978.1 1027231 1027231.1 1 34470566 35816804 BICF2P731875 TIGRP2P1607_rs8963881 97 1.56 cM 0 1 1 +967976 967976.1 1027230 1027230.1 1 56402518 57503655 chr1_56402518 BICF2P496109 124 0.81 cM 0 1 1 +967978 967978.1 1027230 1027230.1 1 56418435 57503655 BICF2P340125 BICF2P496109 115 0.79 cM 0 1 1 +967977 967977.1 1027227 1027227.0 1 112649941 113661798 chr1_112649941 BICF2P126755 105 0.72 cM 0 1 1 +967977 967977.1 1027227 1027227.1 1 112649941 113661798 chr1_112649941 BICF2P126755 105 0.72 cM 0 1 1 diff --git a/minimal_test/run.sh b/minimal_test/run.sh new file mode 100644 index 0000000..36d9047 --- /dev/null +++ b/minimal_test/run.sh @@ -0,0 +1,9 @@ +./og_germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ + -samples_to_compare_to 0000_old_dog_proxy_keys_germline_output.plinky \ + -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ + < germline_params_old_new + +./og_germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ + -samples_to_compare_to 0000_new_dog_proxy_keys_germline_output.plinky \ + -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ + < germline_params_new_new diff --git a/minimal_test/run_new.sh b/minimal_test/run_new.sh new file mode 100644 index 0000000..a6f60bf --- /dev/null +++ b/minimal_test/run_new.sh @@ -0,0 +1,17 @@ +#!/bin/bash + +set -e + +if [ "$1" == "old-new" ]; then + /Users/mikezhong/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ + -samples_to_compare_to 0000_old_dog_proxy_keys_germline_output.plinky \ + -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ + < germline_params_old_new +fi + +if [ "$1" == "new-new" ]; then + /Users/mikezhong/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ + -samples_to_compare_to 0000_new_dog_proxy_keys_germline_output.plinky \ + -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ + < germline_params_new_new +fi diff --git a/minimal_test/test_out_new_new.log b/minimal_test/test_out_new_new.log new file mode 100644 index 0000000..9ed0580 --- /dev/null +++ b/minimal_test/test_out_new_new.log @@ -0,0 +1,19 @@ +---------------------------------------------------------------- + Welcome to GERMLINE, a tool for detecting long segments shared + by descent between pairs of individuals in near-linear time. + + For more details, please see the paper [ PMID: 18971310 ] + or the web-site [ http://www.cs.columbia.edu/~gusev/germline/ ] + + GERMLINE was coded by Alexander Gusev and collaborators in + Itsik Pe'er's Computational Biology Lab at Columbia University + Run 'germline -version' to view version number. +---------------------------------------------------------------- +/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples +---------------------------------------------------------------- +Minimum match length: 0.5 cM +Allowed mismatching bits: 0 0 +Word size: 90 +Target region: all +Total IBD segments: 7 +Total runtime (sec): 0 diff --git a/minimal_test/test_out_new_new.match b/minimal_test/test_out_new_new.match new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/test_out_old_new.log b/minimal_test/test_out_old_new.log new file mode 100644 index 0000000..cf83825 --- /dev/null +++ b/minimal_test/test_out_old_new.log @@ -0,0 +1,19 @@ +---------------------------------------------------------------- + Welcome to GERMLINE, a tool for detecting long segments shared + by descent between pairs of individuals in near-linear time. + + For more details, please see the paper [ PMID: 18971310 ] + or the web-site [ http://www.cs.columbia.edu/~gusev/germline/ ] + + GERMLINE was coded by Alexander Gusev and collaborators in + Itsik Pe'er's Computational Biology Lab at Columbia University + Run 'germline -version' to view version number. +---------------------------------------------------------------- +/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples +---------------------------------------------------------------- +Minimum match length: 0.5 cM +Allowed mismatching bits: 0 0 +Word size: 90 +Target region: all +Total IBD segments: 8 +Total runtime (sec): 0 diff --git a/minimal_test/test_out_old_new.match b/minimal_test/test_out_old_new.match new file mode 100644 index 0000000..e69de29 From b899ea81425f9f2a42db4b7c713b14de15d015fc Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Thu, 16 Dec 2021 21:45:04 -0800 Subject: [PATCH 12/28] properly parameterized the useEmbarkRFGermlineOutput boolean flag to optionally generate this output. If not using --new-samples or --samples-to-compare-to, the germline code will generate the usual single .match file --- GERMLINE_0001.cpp | 3 + Individuals.h | 2 + Match.cpp | 189 +++++++++++++++++++++++----------------------- 3 files changed, 101 insertions(+), 93 deletions(-) diff --git a/GERMLINE_0001.cpp b/GERMLINE_0001.cpp index 3425cc9..c29b26f 100644 --- a/GERMLINE_0001.cpp +++ b/GERMLINE_0001.cpp @@ -27,6 +27,7 @@ int main(int argc, char* argv[]) rs_range[0] = ""; rs_range[1] = ""; string params = argv[0]; + ALL_SAMPLES.useEmbarkRFGermlineOutput = false; bool bad_param = false; for(int i=1; isingle_id); - int key2 = stoi(node[1]->single_id); - vector oline; - string joined_oline; - ofstream* ofs; - string chromosome = ALL_SNPS.getSNP(snp_start).getChr(); - string start_pos = to_string(ALL_SNPS.getSNP(snp_start).getPhysPos()); - string end_pos = to_string(ALL_SNPS.getSNP(snp_end).getPhysPos()); - - // homoz - if ( key1 == key2 && node[0]->is_new ) { - //cout << "Writing out homoz" << endl; - oline.push_back(node[0]->single_id); - oline.push_back(node[0]->haplotype); - oline.push_back(node[1]->single_id); - oline.push_back(node[1]->haplotype); - oline.push_back(chromosome); - oline.push_back(start_pos); - oline.push_back(end_pos); - ofs = node[0]->getIndividualHomozFile(); - join(oline, '\t', joined_oline); - *ofs << joined_oline << endl; - } - // key1 is new, key2 is old - else if ( key1 > key2 && node[0]->is_new ) { - //cout << "Writing match tracts for new key1 " << key1 << endl; - oline.push_back(node[0]->single_id); - oline.push_back(node[0]->haplotype); - oline.push_back(node[1]->single_id); - oline.push_back(node[1]->haplotype); - oline.push_back(chromosome); - oline.push_back(start_pos); - oline.push_back(end_pos); - ofs = node[0]->getIndividualMatchFile(); - join(oline, '\t', joined_oline); - *ofs << joined_oline << endl; - } - // key2 is new, key1 is old - else if ( key2 > key1 && node[1]->is_new ) { - //cout << "Writing match tracts for new key2 " << key2 << endl; - oline.push_back(node[1]->single_id); - oline.push_back(node[1]->haplotype); - oline.push_back(node[0]->single_id); - oline.push_back(node[0]->haplotype); - oline.push_back(chromosome); - oline.push_back(start_pos); - oline.push_back(end_pos); - ofs = node[1]->getIndividualMatchFile(); - join(oline, '\t', joined_oline); - *ofs << joined_oline << endl; - } - // newdog : newdog comparison, write out same record twice - else if ( node[0]->is_new && node[1]->is_new && key1 != key2 ) { - //cout << "Writing records for both keys"; - oline.push_back(node[0]->single_id); - oline.push_back(node[0]->haplotype); - oline.push_back(node[1]->single_id); - oline.push_back(node[1]->haplotype); - oline.push_back(chromosome); - oline.push_back(start_pos); - oline.push_back(end_pos); - ofs = node[0]->getIndividualMatchFile(); - join(oline, '\t', joined_oline); - *ofs << joined_oline << endl; - - oline.push_back(node[1]->single_id); - oline.push_back(node[1]->haplotype); - oline.push_back(node[0]->single_id); - oline.push_back(node[0]->haplotype); - oline.push_back(chromosome); - oline.push_back(start_pos); - oline.push_back(end_pos); - ofs = node[1]->getIndividualMatchFile(); - join(oline, '\t', joined_oline); - *ofs << joined_oline << endl; + if ( ALL_SAMPLES.useEmbarkRFGermlineOutput ) { + int key1 = stoi(node[0]->single_id); + int key2 = stoi(node[1]->single_id); + vector oline; + string joined_oline; + ofstream* ofs; + string chromosome = ALL_SNPS.getSNP(snp_start).getChr(); + string start_pos = to_string(ALL_SNPS.getSNP(snp_start).getPhysPos()); + string end_pos = to_string(ALL_SNPS.getSNP(snp_end).getPhysPos()); + + // homoz + if ( key1 == key2 && node[0]->is_new ) { + //cout << "Writing out homoz" << endl; + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[0]->getIndividualHomozFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; + } + // key1 is new, key2 is old + else if ( key1 > key2 && node[0]->is_new ) { + //cout << "Writing match tracts for new key1 " << key1 << endl; + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[0]->getIndividualMatchFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; + } + // key2 is new, key1 is old + else if ( key2 > key1 && node[1]->is_new ) { + //cout << "Writing match tracts for new key2 " << key2 << endl; + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[1]->getIndividualMatchFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; + } + // newdog : newdog comparison, write out same record twice + else if ( node[0]->is_new && node[1]->is_new && key1 != key2 ) { + //cout << "Writing records for both keys"; + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[0]->getIndividualMatchFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; + + oline.push_back(node[1]->single_id); + oline.push_back(node[1]->haplotype); + oline.push_back(node[0]->single_id); + oline.push_back(node[0]->haplotype); + oline.push_back(chromosome); + oline.push_back(start_pos); + oline.push_back(end_pos); + ofs = node[1]->getIndividualMatchFile(); + join(oline, '\t', joined_oline); + *ofs << joined_oline << endl; + } + } + // Generate regular germline outputs for matches against ref panel or other use cases + else { + + cout << stoi(node[1]->single_id) << endl; + fout << node[0]->getID() << '\t'; + fout << node[1]->getID() << '\t'; + fout << ALL_SNPS.getSNP(snp_start).getChr() << '\t'; + fout << ALL_SNPS.getSNP(snp_start).getPhysPos() << ' '; + fout << ALL_SNPS.getSNP(snp_end).getPhysPos() << '\t'; + fout << ALL_SNPS.getSNP(snp_start).getSNPID() << ' '; + fout << ALL_SNPS.getSNP(snp_end).getSNPID() << '\t'; + fout << ( snp_end - snp_start + 1) << '\t'; + fout << setiosflags(ios::fixed) << setprecision(2) << distance << '\t'; + if ( genetic ) fout << "cM" << '\t'; else fout << "MB" << '\t'; + fout << dif; + for ( int n = 0 ; n < 2 ; n++ ) + if ( hom[n] ) fout << '\t' << 1; else fout << '\t' << 0; + fout << endl; } - - /* - cout << stoi(node[1]->single_id) << endl; - fout << node[0]->getID() << '\t'; - fout << node[1]->getID() << '\t'; - fout << ALL_SNPS.getSNP(snp_start).getChr() << '\t'; - fout << ALL_SNPS.getSNP(snp_start).getPhysPos() << ' '; - fout << ALL_SNPS.getSNP(snp_end).getPhysPos() << '\t'; - fout << ALL_SNPS.getSNP(snp_start).getSNPID() << ' '; - fout << ALL_SNPS.getSNP(snp_end).getSNPID() << '\t'; - fout << ( snp_end - snp_start + 1) << '\t'; - fout << setiosflags(ios::fixed) << setprecision(2) << distance << '\t'; - if ( genetic ) fout << "cM" << '\t'; else fout << "MB" << '\t'; - fout << dif; - for ( int n = 0 ; n < 2 ; n++ ) - if ( hom[n] ) fout << '\t' << 1; else fout << '\t' << 0; - fout << endl; - */ } num_matches++; } From c23c2d09336307485843005883e61925dc1f5a7c Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 10:12:41 -0800 Subject: [PATCH 13/28] Add flag for individual output, also add flag for chromosome, conditionally create the individual file handles --- GERMLINE_0001.cpp | 11 ++++++++--- Individual.cpp | 8 ++++---- Individual.h | 4 ++-- Individuals.cpp | 6 +++--- Individuals.h | 3 ++- PEDIndividualsExtractor.cpp | 4 +++- 6 files changed, 22 insertions(+), 14 deletions(-) diff --git a/GERMLINE_0001.cpp b/GERMLINE_0001.cpp index c29b26f..5033617 100644 --- a/GERMLINE_0001.cpp +++ b/GERMLINE_0001.cpp @@ -20,7 +20,7 @@ int MAX_ERR_HET = 1; int main(int argc, char* argv[]) { // parse arguments - string rs_range[2], map, samples_to_compare_to, new_samples; + string rs_range[2], map, samples_to_compare_to, new_samples, chromosome; samples_to_compare_to = ""; new_samples = ""; map = ""; @@ -28,6 +28,7 @@ int main(int argc, char* argv[]) rs_range[1] = ""; string params = argv[0]; ALL_SAMPLES.useEmbarkRFGermlineOutput = false; + ALL_SAMPLES.chromosome = "1"; bool bad_param = false; for(int i=1; ireserveMemory(); } -void Individuals::initializeOutputFileHandles() +void Individuals::initializeOutputFileHandles(string chromosome) { for ( iter = 0 ; iter < pedigree.size() ; iter++ ) { if ( pedigree[ iter ]->is_new ) { - pedigree[ iter ]->setIndividualMatchFile(); - pedigree[ iter ]->setIndividualHomozFile(); + pedigree[ iter ]->setIndividualMatchFile(chromosome); + pedigree[ iter ]->setIndividualHomozFile(chromosome); } } } diff --git a/Individuals.h b/Individuals.h index afe01a4..770d771 100644 --- a/Individuals.h +++ b/Individuals.h @@ -32,7 +32,7 @@ class Individuals void begin(); size_t size() { return pedigree.size(); } void initialize(); - void initializeOutputFileHandles(); + void initializeOutputFileHandles(string chromosome); void print( ostream& ); void freeMatches(); @@ -44,6 +44,7 @@ class Individuals bool hasRestrictions(); bool useEmbarkRFGermlineOutput; + string chromosome; // used for individual file handle outputs private: diff --git a/PEDIndividualsExtractor.cpp b/PEDIndividualsExtractor.cpp index e271fe3..0b6d702 100644 --- a/PEDIndividualsExtractor.cpp +++ b/PEDIndividualsExtractor.cpp @@ -38,7 +38,9 @@ void PEDIndividualsExtractor::loadInput() } individualsP->initialize(); - individualsP->initializeOutputFileHandles(); + if ( ALL_SAMPLES.useEmbarkRFGermlineOutput ) { + individualsP->initializeOutputFileHandles(ALL_SAMPLES.chromosome); + } stream.clear(); } From c8c29cf285b6a457cbb5dc00615316018cfce71e Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 11:16:54 -0800 Subject: [PATCH 14/28] set up chromosome with padding --- GERMLINE_0001.cpp | 12 ++++++++---- PEDIndividualsExtractor.cpp | 4 ++-- minimal_test/individual_homoz_files/1027227.tsv | 5 ----- minimal_test/individual_homoz_files/1027228.tsv | 0 minimal_test/individual_homoz_files/1027229.tsv | 0 minimal_test/individual_homoz_files/1027230.tsv | 0 minimal_test/individual_homoz_files/1027231.tsv | 0 minimal_test/individual_match_files/1027227.tsv | 0 minimal_test/individual_match_files/1027228.tsv | 1 - minimal_test/individual_match_files/1027229.tsv | 0 minimal_test/individual_match_files/1027230.tsv | 0 minimal_test/individual_match_files/1027231.tsv | 1 - minimal_test/run_new.sh | 8 ++++++-- 13 files changed, 16 insertions(+), 15 deletions(-) delete mode 100644 minimal_test/individual_homoz_files/1027227.tsv delete mode 100644 minimal_test/individual_homoz_files/1027228.tsv delete mode 100644 minimal_test/individual_homoz_files/1027229.tsv delete mode 100644 minimal_test/individual_homoz_files/1027230.tsv delete mode 100644 minimal_test/individual_homoz_files/1027231.tsv delete mode 100644 minimal_test/individual_match_files/1027227.tsv delete mode 100644 minimal_test/individual_match_files/1027228.tsv delete mode 100644 minimal_test/individual_match_files/1027229.tsv delete mode 100644 minimal_test/individual_match_files/1027230.tsv delete mode 100644 minimal_test/individual_match_files/1027231.tsv diff --git a/GERMLINE_0001.cpp b/GERMLINE_0001.cpp index 5033617..b5d6f5e 100644 --- a/GERMLINE_0001.cpp +++ b/GERMLINE_0001.cpp @@ -28,7 +28,7 @@ int main(int argc, char* argv[]) rs_range[1] = ""; string params = argv[0]; ALL_SAMPLES.useEmbarkRFGermlineOutput = false; - ALL_SAMPLES.chromosome = "1"; + ALL_SAMPLES.chromosome = ""; bool bad_param = false; for(int i=1; igetBaseID()) ) { new_ind[0]->is_new = true; new_ind[1]->is_new = true; - cout << "Loaded new sample: " << new_ind[0]->single_id << endl; + // cout << "Loaded new sample: " << new_ind[0]->single_id << endl; } else { new_ind[0]->is_new = false; new_ind[1]->is_new = false; - cout << "Loaded old sample: " << new_ind[0]->single_id << endl; + // cout << "Loaded old sample: " << new_ind[0]->single_id << endl; } individualsP->addIndividual( new_ind[0] ); diff --git a/minimal_test/individual_homoz_files/1027227.tsv b/minimal_test/individual_homoz_files/1027227.tsv deleted file mode 100644 index a14011a..0000000 --- a/minimal_test/individual_homoz_files/1027227.tsv +++ /dev/null @@ -1,5 +0,0 @@ -1027227 0 1027227 1 1 5409586 14391559 -1027227 0 1027227 1 1 32903322 35221407 -1027227 0 1027227 1 1 40647049 54430787 -1027227 0 1027227 1 1 91385138 97942807 -1027227 0 1027227 1 1 102119723 118876992 diff --git a/minimal_test/individual_homoz_files/1027228.tsv b/minimal_test/individual_homoz_files/1027228.tsv deleted file mode 100644 index e69de29..0000000 diff --git a/minimal_test/individual_homoz_files/1027229.tsv b/minimal_test/individual_homoz_files/1027229.tsv deleted file mode 100644 index e69de29..0000000 diff --git a/minimal_test/individual_homoz_files/1027230.tsv b/minimal_test/individual_homoz_files/1027230.tsv deleted file mode 100644 index e69de29..0000000 diff --git a/minimal_test/individual_homoz_files/1027231.tsv b/minimal_test/individual_homoz_files/1027231.tsv deleted file mode 100644 index e69de29..0000000 diff --git a/minimal_test/individual_match_files/1027227.tsv b/minimal_test/individual_match_files/1027227.tsv deleted file mode 100644 index e69de29..0000000 diff --git a/minimal_test/individual_match_files/1027228.tsv b/minimal_test/individual_match_files/1027228.tsv deleted file mode 100644 index cb1655d..0000000 --- a/minimal_test/individual_match_files/1027228.tsv +++ /dev/null @@ -1 +0,0 @@ -1027228 1 1027227 1 1 79129921 81565205 diff --git a/minimal_test/individual_match_files/1027229.tsv b/minimal_test/individual_match_files/1027229.tsv deleted file mode 100644 index e69de29..0000000 diff --git a/minimal_test/individual_match_files/1027230.tsv b/minimal_test/individual_match_files/1027230.tsv deleted file mode 100644 index e69de29..0000000 diff --git a/minimal_test/individual_match_files/1027231.tsv b/minimal_test/individual_match_files/1027231.tsv deleted file mode 100644 index a2111a2..0000000 --- a/minimal_test/individual_match_files/1027231.tsv +++ /dev/null @@ -1 +0,0 @@ -1027231 1 1027230 1 1 4272138 6198709 diff --git a/minimal_test/run_new.sh b/minimal_test/run_new.sh index a6f60bf..a0ee1b4 100644 --- a/minimal_test/run_new.sh +++ b/minimal_test/run_new.sh @@ -3,15 +3,19 @@ set -e if [ "$1" == "old-new" ]; then - /Users/mikezhong/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ + ~/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ -samples_to_compare_to 0000_old_dog_proxy_keys_germline_output.plinky \ -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ + -chromosome 1 \ + -individual_outputs \ < germline_params_old_new fi if [ "$1" == "new-new" ]; then - /Users/mikezhong/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ + ~/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ -samples_to_compare_to 0000_new_dog_proxy_keys_germline_output.plinky \ -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ + -chromosome 1 \ + -individual_outputs \ < germline_params_new_new fi From 57d656021d925e393052ea504fe37793d08ff632 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 11:18:27 -0800 Subject: [PATCH 15/28] set up proper output directory + file names --- Individual.cpp | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/Individual.cpp b/Individual.cpp index aa52e5e..745a89c 100644 --- a/Individual.cpp +++ b/Individual.cpp @@ -221,7 +221,7 @@ void Individual::setIndividualMatchFile(string chromosome) { string ext = ".tsv"; string dir = "dog_level_match_files/"; - string fileHandleName = dir + single_id + ext; + string fileHandleName = dir + single_id + "/" + "chr" + chromosome + ext; individualMatchFile = new ofstream(fileHandleName, ofstream::app); } @@ -229,7 +229,7 @@ void Individual::setIndividualHomozFile(string chromosome) { string ext = ".tsv"; string dir = "dog_level_homoz_files/"; - string fileHandleName = dir + single_id + ext; + string fileHandleName = dir + single_id + "/" + "chr" + chromosome + ext; individualHomozFile = new ofstream(fileHandleName, ofstream::app); } From 98ff261e3c5d3225360b364bd510f0570e6ce236 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 13:17:14 -0800 Subject: [PATCH 16/28] Use filesystem to check if necessary paths exist and make them if not --- GERMLINE_0001.cpp | 7 +++++-- Individual.cpp | 18 ++++++++++++++---- Individual.h | 1 + Makefile | 2 +- Match.cpp | 8 ++++---- minimal_test/test_out_new_new.log | 2 +- minimal_test/test_out_old_new.log | 2 +- 7 files changed, 27 insertions(+), 13 deletions(-) diff --git a/GERMLINE_0001.cpp b/GERMLINE_0001.cpp index b5d6f5e..371c7c8 100644 --- a/GERMLINE_0001.cpp +++ b/GERMLINE_0001.cpp @@ -95,13 +95,16 @@ int main(int argc, char* argv[]) } else if (strncmp(argv[i], "-chromosome", strlen("-chromosome")) == 0 && i < argc-1) { chromosome = argv[++i]; - chromosome.insert(chromosome.begin(), 20 - chromosome.length(), '0'); + chromosome.insert(chromosome.begin(), 2 - chromosome.length(), '0'); ALL_SAMPLES.chromosome = chromosome; + cout << "Generating outputs for chromosome: " << chromosome << endl; } - else if (strncmp(argv[i], "-individual_outputs", strlen("-individual_outputs")) == 0 && i < argc-1) { + else if (strncmp(argv[i], "-individual_outputs", strlen("-individual_outputs")) == 0) { ALL_SAMPLES.useEmbarkRFGermlineOutput = true; + cout << "Generating individual outputs" << endl; } else { + cout << argv[i] << endl; bad_param = true; } } diff --git a/Individual.cpp b/Individual.cpp index 745a89c..f1efc3a 100644 --- a/Individual.cpp +++ b/Individual.cpp @@ -220,16 +220,26 @@ ostream& operator<<(ostream &fout, Individual& ind) void Individual::setIndividualMatchFile(string chromosome) { string ext = ".tsv"; - string dir = "dog_level_match_files/"; - string fileHandleName = dir + single_id + "/" + "chr" + chromosome + ext; + string dir = "dog_level_match_files/" + single_id; + filesystem::path _dir(dir); + if ( !filesystem::exists(_dir) ) { + filesystem::create_directories(_dir); + } + string fileHandleName = dir + "/chr" + chromosome + ext; + // cout << fileHandleName << endl; individualMatchFile = new ofstream(fileHandleName, ofstream::app); } void Individual::setIndividualHomozFile(string chromosome) { string ext = ".tsv"; - string dir = "dog_level_homoz_files/"; - string fileHandleName = dir + single_id + "/" + "chr" + chromosome + ext; + string dir = "dog_level_homoz_files/" + single_id; + filesystem::path _dir(dir); + if ( !filesystem::exists(_dir) ) { + filesystem::create_directories(_dir); + } + string fileHandleName = dir + "/chr" + chromosome + ext; + // cout << fileHandleName << endl; individualHomozFile = new ofstream(fileHandleName, ofstream::app); } diff --git a/Individual.h b/Individual.h index 6ab89bb..8a71434 100644 --- a/Individual.h +++ b/Individual.h @@ -12,6 +12,7 @@ #include #include #include +#include using namespace std; diff --git a/Makefile b/Makefile index 3e1eb86..c2563b9 100644 --- a/Makefile +++ b/Makefile @@ -1,5 +1,5 @@ CC= g++ -OPT= -O3 -I include +OPT= -std=c++17 -O3 -I include SRCS= GERMLINE_0001.cpp GERMLINE.cpp Share.cpp Chromosome.cpp ChromosomePair.cpp HMIndividualsExtractor.cpp MarkerSet.cpp Individual.cpp Individuals.cpp InputManager.cpp MatchFactory.cpp MatchesBuilder.cpp NucleotideMap.cpp PEDIndividualsExtractor.cpp Match.cpp PolymorphicIndividualsExtractor.cpp SNP.cpp SNPPositionMap.cpp SNPs.cpp OBJS= GERMLINE_0001.o GERMLINE.o Chromosome.o Share.o ChromosomePair.o HMIndividualsExtractor.o MarkerSet.o Individual.o Individuals.o InputManager.o MatchFactory.o MatchesBuilder.o NucleotideMap.o PEDIndividualsExtractor.o Match.o PolymorphicIndividualsExtractor.o SNP.o SNPPositionMap.o SNPs.o MAIN= germline diff --git a/Match.cpp b/Match.cpp index 878f994..4d9c3be 100644 --- a/Match.cpp +++ b/Match.cpp @@ -343,7 +343,7 @@ void Match::print( ostream& fout ) // homoz if ( key1 == key2 && node[0]->is_new ) { - //cout << "Writing out homoz" << endl; + cout << "Writing out homoz" << endl; oline.push_back(node[0]->single_id); oline.push_back(node[0]->haplotype); oline.push_back(node[1]->single_id); @@ -357,7 +357,7 @@ void Match::print( ostream& fout ) } // key1 is new, key2 is old else if ( key1 > key2 && node[0]->is_new ) { - //cout << "Writing match tracts for new key1 " << key1 << endl; + cout << "Writing match tracts for new key1 " << key1 << endl; oline.push_back(node[0]->single_id); oline.push_back(node[0]->haplotype); oline.push_back(node[1]->single_id); @@ -371,7 +371,7 @@ void Match::print( ostream& fout ) } // key2 is new, key1 is old else if ( key2 > key1 && node[1]->is_new ) { - //cout << "Writing match tracts for new key2 " << key2 << endl; + cout << "Writing match tracts for new key2 " << key2 << endl; oline.push_back(node[1]->single_id); oline.push_back(node[1]->haplotype); oline.push_back(node[0]->single_id); @@ -385,7 +385,7 @@ void Match::print( ostream& fout ) } // newdog : newdog comparison, write out same record twice else if ( node[0]->is_new && node[1]->is_new && key1 != key2 ) { - //cout << "Writing records for both keys"; + cout << "Writing records for both keys"; oline.push_back(node[0]->single_id); oline.push_back(node[0]->haplotype); oline.push_back(node[1]->single_id); diff --git a/minimal_test/test_out_new_new.log b/minimal_test/test_out_new_new.log index 9ed0580..d0e5220 100644 --- a/minimal_test/test_out_new_new.log +++ b/minimal_test/test_out_new_new.log @@ -9,7 +9,7 @@ Itsik Pe'er's Computational Biology Lab at Columbia University Run 'germline -version' to view version number. ---------------------------------------------------------------- -/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples +/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples -chromosome -individual_outputs ---------------------------------------------------------------- Minimum match length: 0.5 cM Allowed mismatching bits: 0 0 diff --git a/minimal_test/test_out_old_new.log b/minimal_test/test_out_old_new.log index cf83825..5450d91 100644 --- a/minimal_test/test_out_old_new.log +++ b/minimal_test/test_out_old_new.log @@ -9,7 +9,7 @@ Itsik Pe'er's Computational Biology Lab at Columbia University Run 'germline -version' to view version number. ---------------------------------------------------------------- -/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples +/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples -chromosome -individual_outputs ---------------------------------------------------------------- Minimum match length: 0.5 cM Allowed mismatching bits: 0 0 From f35dab7ef36557a60d3fd51d65d4a973d6812ab1 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 13:19:52 -0800 Subject: [PATCH 17/28] Comment back out the print blocks --- Match.cpp | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/Match.cpp b/Match.cpp index 4d9c3be..f0ee8f3 100644 --- a/Match.cpp +++ b/Match.cpp @@ -343,7 +343,7 @@ void Match::print( ostream& fout ) // homoz if ( key1 == key2 && node[0]->is_new ) { - cout << "Writing out homoz" << endl; + // cout << "Writing out homoz" << endl; oline.push_back(node[0]->single_id); oline.push_back(node[0]->haplotype); oline.push_back(node[1]->single_id); @@ -357,7 +357,7 @@ void Match::print( ostream& fout ) } // key1 is new, key2 is old else if ( key1 > key2 && node[0]->is_new ) { - cout << "Writing match tracts for new key1 " << key1 << endl; + // cout << "Writing match tracts for new key1 " << key1 << endl; oline.push_back(node[0]->single_id); oline.push_back(node[0]->haplotype); oline.push_back(node[1]->single_id); @@ -371,7 +371,7 @@ void Match::print( ostream& fout ) } // key2 is new, key1 is old else if ( key2 > key1 && node[1]->is_new ) { - cout << "Writing match tracts for new key2 " << key2 << endl; + // cout << "Writing match tracts for new key2 " << key2 << endl; oline.push_back(node[1]->single_id); oline.push_back(node[1]->haplotype); oline.push_back(node[0]->single_id); @@ -385,7 +385,7 @@ void Match::print( ostream& fout ) } // newdog : newdog comparison, write out same record twice else if ( node[0]->is_new && node[1]->is_new && key1 != key2 ) { - cout << "Writing records for both keys"; + // cout << "Writing records for both keys"; oline.push_back(node[0]->single_id); oline.push_back(node[0]->haplotype); oline.push_back(node[1]->single_id); From 9095bc2352aafe6722c88f7b6b059dba814c4573 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 13:25:09 -0800 Subject: [PATCH 18/28] Throw exception when unable to process a match --- Match.cpp | 3 +++ Match.h | 1 + 2 files changed, 4 insertions(+) diff --git a/Match.cpp b/Match.cpp index f0ee8f3..a13c317 100644 --- a/Match.cpp +++ b/Match.cpp @@ -408,6 +408,9 @@ void Match::print( ostream& fout ) join(oline, '\t', joined_oline); *ofs << joined_oline << endl; } + else { + throw runtime_error("Unable to process match"); + } } // Generate regular germline outputs for matches against ref panel or other use cases else { diff --git a/Match.h b/Match.h index 05c049f..e580149 100644 --- a/Match.h +++ b/Match.h @@ -7,6 +7,7 @@ #include "Individual.h" #include "math.h" #include +#include class Individual; From 76deaf35fe347d6734de50c5c5bb4de121a3b2ae Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 13:26:17 -0800 Subject: [PATCH 19/28] Add test files --- minimal_test/README.md | 0 minimal_test/dog_level_homoz_files/1027227/chr01.tsv | 0 minimal_test/dog_level_homoz_files/1027228/chr01.tsv | 0 minimal_test/dog_level_homoz_files/1027229/chr01.tsv | 0 minimal_test/dog_level_homoz_files/1027230/chr01.tsv | 0 minimal_test/dog_level_homoz_files/1027231/chr01.tsv | 0 minimal_test/dog_level_match_files/1027227/chr01.tsv | 2 ++ minimal_test/dog_level_match_files/1027228/chr01.tsv | 0 minimal_test/dog_level_match_files/1027229/chr01.tsv | 1 + minimal_test/dog_level_match_files/1027230/chr01.tsv | 3 +++ minimal_test/dog_level_match_files/1027231/chr01.tsv | 2 ++ 11 files changed, 8 insertions(+) create mode 100644 minimal_test/README.md create mode 100644 minimal_test/dog_level_homoz_files/1027227/chr01.tsv create mode 100644 minimal_test/dog_level_homoz_files/1027228/chr01.tsv create mode 100644 minimal_test/dog_level_homoz_files/1027229/chr01.tsv create mode 100644 minimal_test/dog_level_homoz_files/1027230/chr01.tsv create mode 100644 minimal_test/dog_level_homoz_files/1027231/chr01.tsv create mode 100644 minimal_test/dog_level_match_files/1027227/chr01.tsv create mode 100644 minimal_test/dog_level_match_files/1027228/chr01.tsv create mode 100644 minimal_test/dog_level_match_files/1027229/chr01.tsv create mode 100644 minimal_test/dog_level_match_files/1027230/chr01.tsv create mode 100644 minimal_test/dog_level_match_files/1027231/chr01.tsv diff --git a/minimal_test/README.md b/minimal_test/README.md new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_homoz_files/1027227/chr01.tsv b/minimal_test/dog_level_homoz_files/1027227/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_homoz_files/1027228/chr01.tsv b/minimal_test/dog_level_homoz_files/1027228/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_homoz_files/1027229/chr01.tsv b/minimal_test/dog_level_homoz_files/1027229/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_homoz_files/1027230/chr01.tsv b/minimal_test/dog_level_homoz_files/1027230/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_homoz_files/1027231/chr01.tsv b/minimal_test/dog_level_homoz_files/1027231/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_match_files/1027227/chr01.tsv b/minimal_test/dog_level_match_files/1027227/chr01.tsv new file mode 100644 index 0000000..fc8ab73 --- /dev/null +++ b/minimal_test/dog_level_match_files/1027227/chr01.tsv @@ -0,0 +1,2 @@ +1027227 0 967977 1 1 112649941 113661798 +1027227 1 967977 1 1 112649941 113661798 diff --git a/minimal_test/dog_level_match_files/1027228/chr01.tsv b/minimal_test/dog_level_match_files/1027228/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_match_files/1027229/chr01.tsv b/minimal_test/dog_level_match_files/1027229/chr01.tsv new file mode 100644 index 0000000..4b6e5a6 --- /dev/null +++ b/minimal_test/dog_level_match_files/1027229/chr01.tsv @@ -0,0 +1 @@ +1027229 1 967979 1 1 33043620 34553147 diff --git a/minimal_test/dog_level_match_files/1027230/chr01.tsv b/minimal_test/dog_level_match_files/1027230/chr01.tsv new file mode 100644 index 0000000..877962c --- /dev/null +++ b/minimal_test/dog_level_match_files/1027230/chr01.tsv @@ -0,0 +1,3 @@ +1027230 1 967977 1 1 4272138 6271129 +1027230 1 967976 1 1 56402518 57503655 +1027230 1 967978 1 1 56418435 57503655 diff --git a/minimal_test/dog_level_match_files/1027231/chr01.tsv b/minimal_test/dog_level_match_files/1027231/chr01.tsv new file mode 100644 index 0000000..5af97a0 --- /dev/null +++ b/minimal_test/dog_level_match_files/1027231/chr01.tsv @@ -0,0 +1,2 @@ +1027231 1 967977 1 1 4134195 6198709 +1027231 1 967978 1 1 34470566 35816804 From 0492bf0448057eb2fa4f55837744e64ba047c0c3 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 14:06:13 -0800 Subject: [PATCH 20/28] Update test runners. Update the homoz tracts to exclude first 4 columns per existing spec --- Match.cpp | 4 --- minimal_test/README.md | 12 +++++++++ .../dog_level_homoz_files/1027227/chr01.tsv | 5 ++++ .../dog_level_match_files/1027228/chr01.tsv | 1 + .../dog_level_match_files/1027231/chr01.tsv | 1 + minimal_test/run.sh | 27 +++++++++++++++++++ minimal_test/test_out_old_new.log | 2 +- minimal_test/test_out_old_new.match | 8 ++++++ 8 files changed, 55 insertions(+), 5 deletions(-) diff --git a/Match.cpp b/Match.cpp index a13c317..db94e3f 100644 --- a/Match.cpp +++ b/Match.cpp @@ -344,10 +344,6 @@ void Match::print( ostream& fout ) // homoz if ( key1 == key2 && node[0]->is_new ) { // cout << "Writing out homoz" << endl; - oline.push_back(node[0]->single_id); - oline.push_back(node[0]->haplotype); - oline.push_back(node[1]->single_id); - oline.push_back(node[1]->haplotype); oline.push_back(chromosome); oline.push_back(start_pos); oline.push_back(end_pos); diff --git a/minimal_test/README.md b/minimal_test/README.md index e69de29..4f3a0aa 100644 --- a/minimal_test/README.md +++ b/minimal_test/README.md @@ -0,0 +1,12 @@ +# Minimal Test + +This directory contains a minimal test data set and runners. The purpose of these tests is to show parity against the `germline` code from `a1bdd07d84dd5ac69725c7566cab6ebb42c8e443`. + +## Resoources + +* list of old dog keys (plink and txt format) +* list of new dog keys (plink and txt format) +* compiled germline binary from `a1bdd07d84dd5ac69725c7566cab6ebb42c8e443` +* compiled rust code for Mac (local testing) +* Runner script to run the old germline binary with old-new compset, and new-new compsets and the follow-up rust code +* Runner script to run the new germline binary with old-new compset, and new-new compsets \ No newline at end of file diff --git a/minimal_test/dog_level_homoz_files/1027227/chr01.tsv b/minimal_test/dog_level_homoz_files/1027227/chr01.tsv index e69de29..a14011a 100644 --- a/minimal_test/dog_level_homoz_files/1027227/chr01.tsv +++ b/minimal_test/dog_level_homoz_files/1027227/chr01.tsv @@ -0,0 +1,5 @@ +1027227 0 1027227 1 1 5409586 14391559 +1027227 0 1027227 1 1 32903322 35221407 +1027227 0 1027227 1 1 40647049 54430787 +1027227 0 1027227 1 1 91385138 97942807 +1027227 0 1027227 1 1 102119723 118876992 diff --git a/minimal_test/dog_level_match_files/1027228/chr01.tsv b/minimal_test/dog_level_match_files/1027228/chr01.tsv index e69de29..cb1655d 100644 --- a/minimal_test/dog_level_match_files/1027228/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027228/chr01.tsv @@ -0,0 +1 @@ +1027228 1 1027227 1 1 79129921 81565205 diff --git a/minimal_test/dog_level_match_files/1027231/chr01.tsv b/minimal_test/dog_level_match_files/1027231/chr01.tsv index 5af97a0..ce458c9 100644 --- a/minimal_test/dog_level_match_files/1027231/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027231/chr01.tsv @@ -1,2 +1,3 @@ 1027231 1 967977 1 1 4134195 6198709 1027231 1 967978 1 1 34470566 35816804 +1027231 1 1027230 1 1 4272138 6198709 diff --git a/minimal_test/run.sh b/minimal_test/run.sh index 36d9047..02d1b01 100644 --- a/minimal_test/run.sh +++ b/minimal_test/run.sh @@ -1,9 +1,36 @@ +#!/bin/bash + +set -e + +for f in `cat new_dogs.txt`; +do + mkdir -p test_rust_out_old_new/$f + mkdir -p test_rust_homoz_old_new/$f + mkdir -p test_rust_out_new_new/$f + mkdir -p test_rust_homoz_new_new/$f +done + ./og_germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ -samples_to_compare_to 0000_old_dog_proxy_keys_germline_output.plinky \ -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ < germline_params_old_new +./split_germline_output_for_new_dog.bin \ + --chromosome 1 \ + --new-dog-list new_dogs.txt \ + --pair-output-directory test_rust_out_old_new \ + --homoz-output-directory test_rust_homoz_old_new \ + < test_out_old_new.match + ./og_germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ -samples_to_compare_to 0000_new_dog_proxy_keys_germline_output.plinky \ -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ < germline_params_new_new + +./split_germline_output_for_new_dog.bin \ + --chromosome 1 \ + --new-dog-list new_dogs.txt \ + --include-new-new-dog-pairs --include-new-dog-homoz \ + --pair-output-directory test_rust_out_new_new \ + --homoz-output-directory test_rust_homoz_new_new \ + < test_out_new_new.match diff --git a/minimal_test/test_out_old_new.log b/minimal_test/test_out_old_new.log index 5450d91..48589b2 100644 --- a/minimal_test/test_out_old_new.log +++ b/minimal_test/test_out_old_new.log @@ -9,7 +9,7 @@ Itsik Pe'er's Computational Biology Lab at Columbia University Run 'germline -version' to view version number. ---------------------------------------------------------------- -/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples -chromosome -individual_outputs +./og_germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples ---------------------------------------------------------------- Minimum match length: 0.5 cM Allowed mismatching bits: 0 0 diff --git a/minimal_test/test_out_old_new.match b/minimal_test/test_out_old_new.match index e69de29..981cd9c 100644 --- a/minimal_test/test_out_old_new.match +++ b/minimal_test/test_out_old_new.match @@ -0,0 +1,8 @@ +967977 967977.1 1027230 1027230.1 1 4272138 6271129 BICF2G630708412 BICF2G630709168 111 0.84 cM 0 1 1 +967977 967977.1 1027231 1027231.1 1 4134195 6198709 TIGRP2P2774_rs8786396 BICF2G630709098 117 0.86 cM 0 1 1 +967979 967979.1 1027229 1027229.1 1 33043620 34553147 BICF2S23124643 BICF2G630719567 125 1.10 cM 0 1 1 +967978 967978.1 1027231 1027231.1 1 34470566 35816804 BICF2P731875 TIGRP2P1607_rs8963881 97 1.56 cM 0 1 1 +967976 967976.1 1027230 1027230.1 1 56402518 57503655 chr1_56402518 BICF2P496109 124 0.81 cM 0 1 1 +967978 967978.1 1027230 1027230.1 1 56418435 57503655 BICF2P340125 BICF2P496109 115 0.79 cM 0 1 1 +967977 967977.1 1027227 1027227.0 1 112649941 113661798 chr1_112649941 BICF2P126755 105 0.72 cM 0 1 1 +967977 967977.1 1027227 1027227.1 1 112649941 113661798 chr1_112649941 BICF2P126755 105 0.72 cM 0 1 1 From 810a4090bff2d5664740e1da7097bdea372745bc Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Mon, 20 Dec 2021 14:13:50 -0800 Subject: [PATCH 21/28] update readme and include all test files --- minimal_test/README.md | 8 ++++++-- .../dog_level_homoz_files/1027227/chr01.tsv | 10 +++++----- .../dog_level_match_files/1027227/chr01.tsv | 2 -- .../dog_level_match_files/1027229/chr01.tsv | 1 - .../dog_level_match_files/1027230/chr01.tsv | 3 --- .../dog_level_match_files/1027231/chr01.tsv | 2 -- minimal_test/new_dogs.txt | 5 +++++ minimal_test/old_dogs.txt | 5 +++++ minimal_test/run_new.sh | 3 +++ .../split_germline_output_for_new_dog.bin | Bin 0 -> 1223608 bytes minimal_test/test_out_old_new.log | 2 +- minimal_test/test_out_old_new.match | 8 -------- .../1027227/chr01_chr_start_end.tsv | 5 +++++ .../test_rust_out_new_new/1027228/chr01.tsv | 1 + .../test_rust_out_new_new/1027231/chr01.tsv | 1 + .../test_rust_out_old_new/1027227/chr01.tsv | 2 ++ .../test_rust_out_old_new/1027229/chr01.tsv | 1 + .../test_rust_out_old_new/1027230/chr01.tsv | 3 +++ .../test_rust_out_old_new/1027231/chr01.tsv | 2 ++ 19 files changed, 40 insertions(+), 24 deletions(-) create mode 100644 minimal_test/new_dogs.txt create mode 100644 minimal_test/old_dogs.txt create mode 100755 minimal_test/split_germline_output_for_new_dog.bin create mode 100644 minimal_test/test_rust_homoz_new_new/1027227/chr01_chr_start_end.tsv create mode 100644 minimal_test/test_rust_out_new_new/1027228/chr01.tsv create mode 100644 minimal_test/test_rust_out_new_new/1027231/chr01.tsv create mode 100644 minimal_test/test_rust_out_old_new/1027227/chr01.tsv create mode 100644 minimal_test/test_rust_out_old_new/1027229/chr01.tsv create mode 100644 minimal_test/test_rust_out_old_new/1027230/chr01.tsv create mode 100644 minimal_test/test_rust_out_old_new/1027231/chr01.tsv diff --git a/minimal_test/README.md b/minimal_test/README.md index 4f3a0aa..07f2a33 100644 --- a/minimal_test/README.md +++ b/minimal_test/README.md @@ -2,11 +2,15 @@ This directory contains a minimal test data set and runners. The purpose of these tests is to show parity against the `germline` code from `a1bdd07d84dd5ac69725c7566cab6ebb42c8e443`. -## Resoources +## Resources * list of old dog keys (plink and txt format) * list of new dog keys (plink and txt format) * compiled germline binary from `a1bdd07d84dd5ac69725c7566cab6ebb42c8e443` * compiled rust code for Mac (local testing) * Runner script to run the old germline binary with old-new compset, and new-new compsets and the follow-up rust code -* Runner script to run the new germline binary with old-new compset, and new-new compsets \ No newline at end of file +* Runner script to run the new germline binary with old-new compset, and new-new compsets + +## Usage + +Simply run the shell scripts included, they are not guaranteed to work as they were not tested beyond my (MZ) system and setup. \ No newline at end of file diff --git a/minimal_test/dog_level_homoz_files/1027227/chr01.tsv b/minimal_test/dog_level_homoz_files/1027227/chr01.tsv index a14011a..16f5704 100644 --- a/minimal_test/dog_level_homoz_files/1027227/chr01.tsv +++ b/minimal_test/dog_level_homoz_files/1027227/chr01.tsv @@ -1,5 +1,5 @@ -1027227 0 1027227 1 1 5409586 14391559 -1027227 0 1027227 1 1 32903322 35221407 -1027227 0 1027227 1 1 40647049 54430787 -1027227 0 1027227 1 1 91385138 97942807 -1027227 0 1027227 1 1 102119723 118876992 +1 5409586 14391559 +1 32903322 35221407 +1 40647049 54430787 +1 91385138 97942807 +1 102119723 118876992 diff --git a/minimal_test/dog_level_match_files/1027227/chr01.tsv b/minimal_test/dog_level_match_files/1027227/chr01.tsv index fc8ab73..e69de29 100644 --- a/minimal_test/dog_level_match_files/1027227/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027227/chr01.tsv @@ -1,2 +0,0 @@ -1027227 0 967977 1 1 112649941 113661798 -1027227 1 967977 1 1 112649941 113661798 diff --git a/minimal_test/dog_level_match_files/1027229/chr01.tsv b/minimal_test/dog_level_match_files/1027229/chr01.tsv index 4b6e5a6..e69de29 100644 --- a/minimal_test/dog_level_match_files/1027229/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027229/chr01.tsv @@ -1 +0,0 @@ -1027229 1 967979 1 1 33043620 34553147 diff --git a/minimal_test/dog_level_match_files/1027230/chr01.tsv b/minimal_test/dog_level_match_files/1027230/chr01.tsv index 877962c..e69de29 100644 --- a/minimal_test/dog_level_match_files/1027230/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027230/chr01.tsv @@ -1,3 +0,0 @@ -1027230 1 967977 1 1 4272138 6271129 -1027230 1 967976 1 1 56402518 57503655 -1027230 1 967978 1 1 56418435 57503655 diff --git a/minimal_test/dog_level_match_files/1027231/chr01.tsv b/minimal_test/dog_level_match_files/1027231/chr01.tsv index ce458c9..a2111a2 100644 --- a/minimal_test/dog_level_match_files/1027231/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027231/chr01.tsv @@ -1,3 +1 @@ -1027231 1 967977 1 1 4134195 6198709 -1027231 1 967978 1 1 34470566 35816804 1027231 1 1027230 1 1 4272138 6198709 diff --git a/minimal_test/new_dogs.txt b/minimal_test/new_dogs.txt new file mode 100644 index 0000000..494f286 --- /dev/null +++ b/minimal_test/new_dogs.txt @@ -0,0 +1,5 @@ +1027227 +1027228 +1027229 +1027230 +1027231 diff --git a/minimal_test/old_dogs.txt b/minimal_test/old_dogs.txt new file mode 100644 index 0000000..ae00643 --- /dev/null +++ b/minimal_test/old_dogs.txt @@ -0,0 +1,5 @@ +967975 +967976 +967977 +967978 +967979 diff --git a/minimal_test/run_new.sh b/minimal_test/run_new.sh index a0ee1b4..4ded99d 100644 --- a/minimal_test/run_new.sh +++ b/minimal_test/run_new.sh @@ -2,6 +2,9 @@ set -e +rm -rf dog_level_match_files/* +rm -rf dog_level_homoz_files/* + if [ "$1" == "old-new" ]; then ~/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ -samples_to_compare_to 0000_old_dog_proxy_keys_germline_output.plinky \ diff --git a/minimal_test/split_germline_output_for_new_dog.bin b/minimal_test/split_germline_output_for_new_dog.bin new file mode 100755 index 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-min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples +/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples -chromosome -individual_outputs ---------------------------------------------------------------- Minimum match length: 0.5 cM Allowed mismatching bits: 0 0 diff --git a/minimal_test/test_out_old_new.match b/minimal_test/test_out_old_new.match index 981cd9c..e69de29 100644 --- a/minimal_test/test_out_old_new.match +++ b/minimal_test/test_out_old_new.match @@ -1,8 +0,0 @@ -967977 967977.1 1027230 1027230.1 1 4272138 6271129 BICF2G630708412 BICF2G630709168 111 0.84 cM 0 1 1 -967977 967977.1 1027231 1027231.1 1 4134195 6198709 TIGRP2P2774_rs8786396 BICF2G630709098 117 0.86 cM 0 1 1 -967979 967979.1 1027229 1027229.1 1 33043620 34553147 BICF2S23124643 BICF2G630719567 125 1.10 cM 0 1 1 -967978 967978.1 1027231 1027231.1 1 34470566 35816804 BICF2P731875 TIGRP2P1607_rs8963881 97 1.56 cM 0 1 1 -967976 967976.1 1027230 1027230.1 1 56402518 57503655 chr1_56402518 BICF2P496109 124 0.81 cM 0 1 1 -967978 967978.1 1027230 1027230.1 1 56418435 57503655 BICF2P340125 BICF2P496109 115 0.79 cM 0 1 1 -967977 967977.1 1027227 1027227.0 1 112649941 113661798 chr1_112649941 BICF2P126755 105 0.72 cM 0 1 1 -967977 967977.1 1027227 1027227.1 1 112649941 113661798 chr1_112649941 BICF2P126755 105 0.72 cM 0 1 1 diff --git a/minimal_test/test_rust_homoz_new_new/1027227/chr01_chr_start_end.tsv b/minimal_test/test_rust_homoz_new_new/1027227/chr01_chr_start_end.tsv new file mode 100644 index 0000000..16f5704 --- /dev/null +++ b/minimal_test/test_rust_homoz_new_new/1027227/chr01_chr_start_end.tsv @@ -0,0 +1,5 @@ +1 5409586 14391559 +1 32903322 35221407 +1 40647049 54430787 +1 91385138 97942807 +1 102119723 118876992 diff --git a/minimal_test/test_rust_out_new_new/1027228/chr01.tsv b/minimal_test/test_rust_out_new_new/1027228/chr01.tsv new file mode 100644 index 0000000..cb1655d --- /dev/null +++ b/minimal_test/test_rust_out_new_new/1027228/chr01.tsv @@ -0,0 +1 @@ +1027228 1 1027227 1 1 79129921 81565205 diff --git a/minimal_test/test_rust_out_new_new/1027231/chr01.tsv b/minimal_test/test_rust_out_new_new/1027231/chr01.tsv new file mode 100644 index 0000000..a2111a2 --- /dev/null +++ b/minimal_test/test_rust_out_new_new/1027231/chr01.tsv @@ -0,0 +1 @@ +1027231 1 1027230 1 1 4272138 6198709 diff --git a/minimal_test/test_rust_out_old_new/1027227/chr01.tsv b/minimal_test/test_rust_out_old_new/1027227/chr01.tsv new file mode 100644 index 0000000..fc8ab73 --- /dev/null +++ b/minimal_test/test_rust_out_old_new/1027227/chr01.tsv @@ -0,0 +1,2 @@ +1027227 0 967977 1 1 112649941 113661798 +1027227 1 967977 1 1 112649941 113661798 diff --git a/minimal_test/test_rust_out_old_new/1027229/chr01.tsv b/minimal_test/test_rust_out_old_new/1027229/chr01.tsv new file mode 100644 index 0000000..4b6e5a6 --- /dev/null +++ b/minimal_test/test_rust_out_old_new/1027229/chr01.tsv @@ -0,0 +1 @@ +1027229 1 967979 1 1 33043620 34553147 diff --git a/minimal_test/test_rust_out_old_new/1027230/chr01.tsv b/minimal_test/test_rust_out_old_new/1027230/chr01.tsv new file mode 100644 index 0000000..877962c --- /dev/null +++ b/minimal_test/test_rust_out_old_new/1027230/chr01.tsv @@ -0,0 +1,3 @@ +1027230 1 967977 1 1 4272138 6271129 +1027230 1 967976 1 1 56402518 57503655 +1027230 1 967978 1 1 56418435 57503655 diff --git a/minimal_test/test_rust_out_old_new/1027231/chr01.tsv b/minimal_test/test_rust_out_old_new/1027231/chr01.tsv new file mode 100644 index 0000000..5af97a0 --- /dev/null +++ b/minimal_test/test_rust_out_old_new/1027231/chr01.tsv @@ -0,0 +1,2 @@ +1027231 1 967977 1 1 4134195 6198709 +1027231 1 967978 1 1 34470566 35816804 From 2e9eaa01115b8a7fc2f18919dfe348326ced0bf4 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Tue, 21 Dec 2021 09:52:29 -0800 Subject: [PATCH 22/28] Clean up run_new.sh to not blow away results, show parity with proper append mode --- minimal_test/dog_level_match_files/1027227/chr01.tsv | 2 ++ minimal_test/dog_level_match_files/1027229/chr01.tsv | 1 + minimal_test/dog_level_match_files/1027230/chr01.tsv | 3 +++ minimal_test/dog_level_match_files/1027231/chr01.tsv | 2 ++ minimal_test/run_new.sh | 2 -- 5 files changed, 8 insertions(+), 2 deletions(-) diff --git a/minimal_test/dog_level_match_files/1027227/chr01.tsv b/minimal_test/dog_level_match_files/1027227/chr01.tsv index e69de29..fc8ab73 100644 --- a/minimal_test/dog_level_match_files/1027227/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027227/chr01.tsv @@ -0,0 +1,2 @@ +1027227 0 967977 1 1 112649941 113661798 +1027227 1 967977 1 1 112649941 113661798 diff --git a/minimal_test/dog_level_match_files/1027229/chr01.tsv b/minimal_test/dog_level_match_files/1027229/chr01.tsv index e69de29..4b6e5a6 100644 --- a/minimal_test/dog_level_match_files/1027229/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027229/chr01.tsv @@ -0,0 +1 @@ +1027229 1 967979 1 1 33043620 34553147 diff --git a/minimal_test/dog_level_match_files/1027230/chr01.tsv b/minimal_test/dog_level_match_files/1027230/chr01.tsv index e69de29..877962c 100644 --- a/minimal_test/dog_level_match_files/1027230/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027230/chr01.tsv @@ -0,0 +1,3 @@ +1027230 1 967977 1 1 4272138 6271129 +1027230 1 967976 1 1 56402518 57503655 +1027230 1 967978 1 1 56418435 57503655 diff --git a/minimal_test/dog_level_match_files/1027231/chr01.tsv b/minimal_test/dog_level_match_files/1027231/chr01.tsv index a2111a2..ce458c9 100644 --- a/minimal_test/dog_level_match_files/1027231/chr01.tsv +++ b/minimal_test/dog_level_match_files/1027231/chr01.tsv @@ -1 +1,3 @@ +1027231 1 967977 1 1 4134195 6198709 +1027231 1 967978 1 1 34470566 35816804 1027231 1 1027230 1 1 4272138 6198709 diff --git a/minimal_test/run_new.sh b/minimal_test/run_new.sh index 4ded99d..0ae9304 100644 --- a/minimal_test/run_new.sh +++ b/minimal_test/run_new.sh @@ -2,8 +2,6 @@ set -e -rm -rf dog_level_match_files/* -rm -rf dog_level_homoz_files/* if [ "$1" == "old-new" ]; then ~/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ From e1534ddc08bef0263ab121cf4e08e63ef76e18a8 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Tue, 21 Dec 2021 12:03:36 -0800 Subject: [PATCH 23/28] Deleted log files, updated runner, test results are from binary built on ubuntu 20.04 --- .gitignore | 1 + minimal_test/run_new.sh | 4 ++-- minimal_test/test_out_new_new.log | 19 ------------------- minimal_test/test_out_old_new.log | 19 ------------------- 4 files changed, 3 insertions(+), 40 deletions(-) delete mode 100644 minimal_test/test_out_new_new.log delete mode 100644 minimal_test/test_out_old_new.log diff --git a/.gitignore b/.gitignore index 8662ba9..f74fd4a 100644 --- a/.gitignore +++ b/.gitignore @@ -1,3 +1,4 @@ +minimal_test/*.log .vscode test/output *.o diff --git a/minimal_test/run_new.sh b/minimal_test/run_new.sh index 0ae9304..1b07aee 100644 --- a/minimal_test/run_new.sh +++ b/minimal_test/run_new.sh @@ -4,7 +4,7 @@ set -e if [ "$1" == "old-new" ]; then - ~/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ + ../germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ -samples_to_compare_to 0000_old_dog_proxy_keys_germline_output.plinky \ -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ -chromosome 1 \ @@ -13,7 +13,7 @@ if [ "$1" == "old-new" ]; then fi if [ "$1" == "new-new" ]; then - ~/dev/GERMLINE/germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ + ../germline -haploid -min_m 0.5 -err_hom 0 -err_het 0 -bits 90 -w_extend \ -samples_to_compare_to 0000_new_dog_proxy_keys_germline_output.plinky \ -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ -chromosome 1 \ diff --git a/minimal_test/test_out_new_new.log b/minimal_test/test_out_new_new.log deleted file mode 100644 index d0e5220..0000000 --- a/minimal_test/test_out_new_new.log +++ /dev/null @@ -1,19 +0,0 @@ ----------------------------------------------------------------- - Welcome to GERMLINE, a tool for detecting long segments shared - by descent between pairs of individuals in near-linear time. - - For more details, please see the paper [ PMID: 18971310 ] - or the web-site [ http://www.cs.columbia.edu/~gusev/germline/ ] - - GERMLINE was coded by Alexander Gusev and collaborators in - Itsik Pe'er's Computational Biology Lab at Columbia University - Run 'germline -version' to view version number. ----------------------------------------------------------------- -/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples -chromosome -individual_outputs ----------------------------------------------------------------- -Minimum match length: 0.5 cM -Allowed mismatching bits: 0 0 -Word size: 90 -Target region: all -Total IBD segments: 7 -Total runtime (sec): 0 diff --git a/minimal_test/test_out_old_new.log b/minimal_test/test_out_old_new.log deleted file mode 100644 index 5450d91..0000000 --- a/minimal_test/test_out_old_new.log +++ /dev/null @@ -1,19 +0,0 @@ ----------------------------------------------------------------- - Welcome to GERMLINE, a tool for detecting long segments shared - by descent between pairs of individuals in near-linear time. - - For more details, please see the paper [ PMID: 18971310 ] - or the web-site [ http://www.cs.columbia.edu/~gusev/germline/ ] - - GERMLINE was coded by Alexander Gusev and collaborators in - Itsik Pe'er's Computational Biology Lab at Columbia University - Run 'germline -version' to view version number. ----------------------------------------------------------------- -/Users/mikezhong/dev/GERMLINE/germline -haploid -min_m -err_hom -err_het -bits -w_extend -samples_to_compare_to -new_samples -chromosome -individual_outputs ----------------------------------------------------------------- -Minimum match length: 0.5 cM -Allowed mismatching bits: 0 0 -Word size: 90 -Target region: all -Total IBD segments: 8 -Total runtime (sec): 0 From c9cb762aaba051675b9fab9bf58b05c077639dd1 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Tue, 21 Dec 2021 14:32:55 -0800 Subject: [PATCH 24/28] have to use experimental/filesystem> --- Individual.h | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/Individual.h b/Individual.h index 8a71434..2c2a04d 100644 --- a/Individual.h +++ b/Individual.h @@ -12,7 +12,7 @@ #include #include #include -#include +#include using namespace std; From 22c958658d8884dd5233ae705e748b44439a79cd Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Tue, 21 Dec 2021 14:53:04 -0800 Subject: [PATCH 25/28] Switchover all to experimental::filesystem --- Individual.cpp | 12 ++++++------ 1 file changed, 6 insertions(+), 6 deletions(-) diff --git a/Individual.cpp b/Individual.cpp index f1efc3a..4400b48 100644 --- a/Individual.cpp +++ b/Individual.cpp @@ -221,9 +221,9 @@ void Individual::setIndividualMatchFile(string chromosome) { string ext = ".tsv"; string dir = "dog_level_match_files/" + single_id; - filesystem::path _dir(dir); - if ( !filesystem::exists(_dir) ) { - filesystem::create_directories(_dir); + experimental::filesystem::path _dir(dir); + if ( !experimental::filesystem::exists(_dir) ) { + experimental::filesystem::create_directories(_dir); } string fileHandleName = dir + "/chr" + chromosome + ext; // cout << fileHandleName << endl; @@ -234,9 +234,9 @@ void Individual::setIndividualHomozFile(string chromosome) { string ext = ".tsv"; string dir = "dog_level_homoz_files/" + single_id; - filesystem::path _dir(dir); - if ( !filesystem::exists(_dir) ) { - filesystem::create_directories(_dir); + experimental::filesystem::path _dir(dir); + if ( !experimental::filesystem::exists(_dir) ) { + experimental::filesystem::create_directories(_dir); } string fileHandleName = dir + "/chr" + chromosome + ext; // cout << fileHandleName << endl; From 215c99186543985c5309f84f8209c6e432040be3 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Tue, 21 Dec 2021 15:01:18 -0800 Subject: [PATCH 26/28] have to manually link -lstdc++fs to compile --- Makefile | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/Makefile b/Makefile index c2563b9..a2e8642 100644 --- a/Makefile +++ b/Makefile @@ -14,7 +14,7 @@ $(OBJS): $(SRCS) $(CC) $(OPT) -c $*.cpp germline: $(OBJS) - $(CC) $(OPT) -o $(MAIN) $(OBJS) + $(CC) $(OPT) -o $(MAIN) $(OBJS) -lstdc++fs clean: -rm -f *.o $(MAIN) $(BMATCH) test/generated.match test/generated.log test/generated.err test/generated.out From 58d4a5d786627d0ab3b1f4cd35aeca06ef3f1761 Mon Sep 17 00:00:00 2001 From: Mike Zhong Date: Tue, 21 Dec 2021 16:06:12 -0800 Subject: [PATCH 27/28] Update to use a top level folder for individual outputs --- GERMLINE_0001.cpp | 4 +++- Individual.cpp | 4 ++-- Individuals.h | 1 + minimal_test/run_new.sh | 4 ++-- 4 files changed, 8 insertions(+), 5 deletions(-) diff --git a/GERMLINE_0001.cpp b/GERMLINE_0001.cpp index 371c7c8..e15626d 100644 --- a/GERMLINE_0001.cpp +++ b/GERMLINE_0001.cpp @@ -29,6 +29,7 @@ int main(int argc, char* argv[]) string params = argv[0]; ALL_SAMPLES.useEmbarkRFGermlineOutput = false; ALL_SAMPLES.chromosome = ""; + ALL_SAMPLES.individualOutputFolder = ""; bool bad_param = false; for(int i=1; i Date: Tue, 21 Dec 2021 16:13:13 -0800 Subject: [PATCH 28/28] Make flag now an input param for the top level folder to dump individual results to, adhere to existing pattern for easier integration into python --- minimal_test/run_new.sh | 4 ++-- .../dog_level_homoz_files/1027227}/chr01.tsv | 0 .../dog_level_homoz_files/1027228}/chr01.tsv | 0 .../dog_level_homoz_files/1027229}/chr01.tsv | 0 .../dog_level_homoz_files/1027230}/chr01.tsv | 0 minimal_test/test_a/dog_level_homoz_files/1027231/chr01.tsv | 0 .../{ => test_a}/dog_level_match_files/1027227/chr01.tsv | 0 minimal_test/test_a/dog_level_match_files/1027228/chr01.tsv | 0 .../{ => test_a}/dog_level_match_files/1027229/chr01.tsv | 0 .../{ => test_a}/dog_level_match_files/1027230/chr01.tsv | 0 .../{ => test_a}/dog_level_match_files/1027231/chr01.tsv | 1 - .../{ => test_b}/dog_level_homoz_files/1027227/chr01.tsv | 0 minimal_test/test_b/dog_level_homoz_files/1027228/chr01.tsv | 0 minimal_test/test_b/dog_level_homoz_files/1027229/chr01.tsv | 0 minimal_test/test_b/dog_level_homoz_files/1027230/chr01.tsv | 0 minimal_test/test_b/dog_level_homoz_files/1027231/chr01.tsv | 0 minimal_test/test_b/dog_level_match_files/1027227/chr01.tsv | 0 .../{ => test_b}/dog_level_match_files/1027228/chr01.tsv | 0 minimal_test/test_b/dog_level_match_files/1027229/chr01.tsv | 0 minimal_test/test_b/dog_level_match_files/1027230/chr01.tsv | 0 minimal_test/test_b/dog_level_match_files/1027231/chr01.tsv | 1 + 21 files changed, 3 insertions(+), 3 deletions(-) rename minimal_test/{dog_level_homoz_files/1027228 => test_a/dog_level_homoz_files/1027227}/chr01.tsv (100%) rename minimal_test/{dog_level_homoz_files/1027229 => test_a/dog_level_homoz_files/1027228}/chr01.tsv (100%) rename minimal_test/{dog_level_homoz_files/1027230 => test_a/dog_level_homoz_files/1027229}/chr01.tsv (100%) rename minimal_test/{dog_level_homoz_files/1027231 => test_a/dog_level_homoz_files/1027230}/chr01.tsv (100%) create mode 100644 minimal_test/test_a/dog_level_homoz_files/1027231/chr01.tsv rename minimal_test/{ => test_a}/dog_level_match_files/1027227/chr01.tsv (100%) create mode 100644 minimal_test/test_a/dog_level_match_files/1027228/chr01.tsv rename minimal_test/{ => test_a}/dog_level_match_files/1027229/chr01.tsv (100%) rename minimal_test/{ => test_a}/dog_level_match_files/1027230/chr01.tsv (100%) rename minimal_test/{ => test_a}/dog_level_match_files/1027231/chr01.tsv (66%) rename minimal_test/{ => test_b}/dog_level_homoz_files/1027227/chr01.tsv (100%) create mode 100644 minimal_test/test_b/dog_level_homoz_files/1027228/chr01.tsv create mode 100644 minimal_test/test_b/dog_level_homoz_files/1027229/chr01.tsv create mode 100644 minimal_test/test_b/dog_level_homoz_files/1027230/chr01.tsv create mode 100644 minimal_test/test_b/dog_level_homoz_files/1027231/chr01.tsv create mode 100644 minimal_test/test_b/dog_level_match_files/1027227/chr01.tsv rename minimal_test/{ => test_b}/dog_level_match_files/1027228/chr01.tsv (100%) create mode 100644 minimal_test/test_b/dog_level_match_files/1027229/chr01.tsv create mode 100644 minimal_test/test_b/dog_level_match_files/1027230/chr01.tsv create mode 100644 minimal_test/test_b/dog_level_match_files/1027231/chr01.tsv diff --git a/minimal_test/run_new.sh b/minimal_test/run_new.sh index 0acd9ff..03ef1f5 100644 --- a/minimal_test/run_new.sh +++ b/minimal_test/run_new.sh @@ -8,7 +8,7 @@ if [ "$1" == "old-new" ]; then -samples_to_compare_to 0000_old_dog_proxy_keys_germline_output.plinky \ -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ -chromosome 1 \ - -individual_outputs test_individual \ + -individual_outputs test_a \ < germline_params_old_new fi @@ -17,6 +17,6 @@ if [ "$1" == "new-new" ]; then -samples_to_compare_to 0000_new_dog_proxy_keys_germline_output.plinky \ -new_samples 0000_new_dog_proxy_keys_germline_output.plinky \ -chromosome 1 \ - -individual_outputs test_individual \ + -individual_outputs test_b \ < germline_params_new_new fi diff --git a/minimal_test/dog_level_homoz_files/1027228/chr01.tsv b/minimal_test/test_a/dog_level_homoz_files/1027227/chr01.tsv similarity index 100% rename from minimal_test/dog_level_homoz_files/1027228/chr01.tsv rename to minimal_test/test_a/dog_level_homoz_files/1027227/chr01.tsv diff --git a/minimal_test/dog_level_homoz_files/1027229/chr01.tsv b/minimal_test/test_a/dog_level_homoz_files/1027228/chr01.tsv similarity index 100% rename from minimal_test/dog_level_homoz_files/1027229/chr01.tsv rename to minimal_test/test_a/dog_level_homoz_files/1027228/chr01.tsv diff --git a/minimal_test/dog_level_homoz_files/1027230/chr01.tsv b/minimal_test/test_a/dog_level_homoz_files/1027229/chr01.tsv similarity index 100% rename from minimal_test/dog_level_homoz_files/1027230/chr01.tsv rename to minimal_test/test_a/dog_level_homoz_files/1027229/chr01.tsv diff --git a/minimal_test/dog_level_homoz_files/1027231/chr01.tsv b/minimal_test/test_a/dog_level_homoz_files/1027230/chr01.tsv similarity index 100% rename from minimal_test/dog_level_homoz_files/1027231/chr01.tsv rename to minimal_test/test_a/dog_level_homoz_files/1027230/chr01.tsv diff --git a/minimal_test/test_a/dog_level_homoz_files/1027231/chr01.tsv b/minimal_test/test_a/dog_level_homoz_files/1027231/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_match_files/1027227/chr01.tsv b/minimal_test/test_a/dog_level_match_files/1027227/chr01.tsv similarity index 100% rename from minimal_test/dog_level_match_files/1027227/chr01.tsv rename to minimal_test/test_a/dog_level_match_files/1027227/chr01.tsv diff --git a/minimal_test/test_a/dog_level_match_files/1027228/chr01.tsv b/minimal_test/test_a/dog_level_match_files/1027228/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_match_files/1027229/chr01.tsv b/minimal_test/test_a/dog_level_match_files/1027229/chr01.tsv similarity index 100% rename from minimal_test/dog_level_match_files/1027229/chr01.tsv rename to minimal_test/test_a/dog_level_match_files/1027229/chr01.tsv diff --git a/minimal_test/dog_level_match_files/1027230/chr01.tsv b/minimal_test/test_a/dog_level_match_files/1027230/chr01.tsv similarity index 100% rename from minimal_test/dog_level_match_files/1027230/chr01.tsv rename to minimal_test/test_a/dog_level_match_files/1027230/chr01.tsv diff --git a/minimal_test/dog_level_match_files/1027231/chr01.tsv b/minimal_test/test_a/dog_level_match_files/1027231/chr01.tsv similarity index 66% rename from minimal_test/dog_level_match_files/1027231/chr01.tsv rename to minimal_test/test_a/dog_level_match_files/1027231/chr01.tsv index ce458c9..5af97a0 100644 --- a/minimal_test/dog_level_match_files/1027231/chr01.tsv +++ b/minimal_test/test_a/dog_level_match_files/1027231/chr01.tsv @@ -1,3 +1,2 @@ 1027231 1 967977 1 1 4134195 6198709 1027231 1 967978 1 1 34470566 35816804 -1027231 1 1027230 1 1 4272138 6198709 diff --git a/minimal_test/dog_level_homoz_files/1027227/chr01.tsv b/minimal_test/test_b/dog_level_homoz_files/1027227/chr01.tsv similarity index 100% rename from minimal_test/dog_level_homoz_files/1027227/chr01.tsv rename to minimal_test/test_b/dog_level_homoz_files/1027227/chr01.tsv diff --git a/minimal_test/test_b/dog_level_homoz_files/1027228/chr01.tsv b/minimal_test/test_b/dog_level_homoz_files/1027228/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/test_b/dog_level_homoz_files/1027229/chr01.tsv b/minimal_test/test_b/dog_level_homoz_files/1027229/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/test_b/dog_level_homoz_files/1027230/chr01.tsv b/minimal_test/test_b/dog_level_homoz_files/1027230/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/test_b/dog_level_homoz_files/1027231/chr01.tsv b/minimal_test/test_b/dog_level_homoz_files/1027231/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/test_b/dog_level_match_files/1027227/chr01.tsv b/minimal_test/test_b/dog_level_match_files/1027227/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/dog_level_match_files/1027228/chr01.tsv b/minimal_test/test_b/dog_level_match_files/1027228/chr01.tsv similarity index 100% rename from minimal_test/dog_level_match_files/1027228/chr01.tsv rename to minimal_test/test_b/dog_level_match_files/1027228/chr01.tsv diff --git a/minimal_test/test_b/dog_level_match_files/1027229/chr01.tsv b/minimal_test/test_b/dog_level_match_files/1027229/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/test_b/dog_level_match_files/1027230/chr01.tsv b/minimal_test/test_b/dog_level_match_files/1027230/chr01.tsv new file mode 100644 index 0000000..e69de29 diff --git a/minimal_test/test_b/dog_level_match_files/1027231/chr01.tsv b/minimal_test/test_b/dog_level_match_files/1027231/chr01.tsv new file mode 100644 index 0000000..a2111a2 --- /dev/null +++ b/minimal_test/test_b/dog_level_match_files/1027231/chr01.tsv @@ -0,0 +1 @@ +1027231 1 1027230 1 1 4272138 6198709