diff --git a/monai/data/dataset.py b/monai/data/dataset.py
index 5e403d6fdb..eba850225d 100644
--- a/monai/data/dataset.py
+++ b/monai/data/dataset.py
@@ -387,6 +387,12 @@ def _cachecheck(self, item_transformed):
             except PermissionError as e:
                 if sys.platform != "win32":
                     raise e
+            except RuntimeError as e:
+                if "Invalid magic number; corrupt file" in str(e):
+                    warnings.warn(f"Corrupt cache file detected: {hashfile}. Deleting and recomputing.")
+                    hashfile.unlink()
+                else:
+                    raise e
 
         _item_transformed = self._pre_transform(deepcopy(item_transformed))  # keep the original hashed
         if hashfile is None: