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An R package for performing cell typing in SMI and other single cell data

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Nanostring-Biostats/InSituType

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InSituType

An R package for performing cell typing in SMI and other single cell data

Manuscript: https://www.biorxiv.org/content/10.1101/2022.10.19.512902v1.abstract

Citing Insitutype: Danaher P, Zhao E, Yang Z, Ross D, Gregory M, Reitz Z, Kim TK, Baxter S, Jackson S, He S, Henderson DA. Insitutype: likelihood-based cell typing for single cell spatial transcriptomics. bioRxiv. 2022 Jan 1.

System requirements

  • R (>= 3.5.0)
  • UNIX, Mac or Windows
  • Rcpp library (>= 1.0.9)
  • see DESCRIPTION for full dependencies

Demo

See the "vignettes" folder. Vignettes should run in <5 minutes.

Instructions for use

Run "insitutype" for unsupervised or semi-supervised clustering. Run "insitutypeML" for supervised cell typing. See the vignettes for example workflows.

Reproduction instructions

The full results of the Insitutype manuscript can be reproduced with the code in this repo: https://github.com/Nanostring-Biostats/InSituType-manuscript-analyses

Installation

devtools::install_github("https://github.com/Nanostring-Biostats/InSituType")

Installation should take < 2 mins on a normal desktop computer.

Function dependencies:

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