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Help_FAQ.php
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include ("permission_check.php");
?>
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<head>
<!-- Google Analytics Tracking -->
<?php include_once("analytics.php") ?>
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<?php
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<BR><BR><BR><BR><BR><BR><BR>
<div class='title_area'>
<font class="font1">FAQ</font>
</div>
<div class=WordSection1>
<p class=MsoNormal align=center style='text-align:center'><span
style='font-size:16.0pt;line-height:115%'>Hippocampome FAQ<o:p></o:p></span></p>
<p class=MsoNormal><a href="#design_criteria"><span style='font-size:16.0pt;
line-height:115%'>Project Design</span></a><span style='font-size:16.0pt;
line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#basket_axoaxonic"><span style='font-size:16.0pt;line-height:115%'>Why do
some neuron types with identical morphological patterns, for example CA1 Basket
and Axo-Axonic cells, form separate neuron types in Hippocampome.org?</span></a><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#guinea_pigs"><span style='font-size:16.0pt;line-height:115%'>Several of
the earlier hippocampal anatomy studies also employed guinea pigs - is there a
plan to include these data as well?</span></a><span class=MsoHyperlink><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#how_link"><span style='font-size:16.0pt;line-height:115%'>How are data
from different articles linked?</span></a><span style='font-size:16.0pt;
line-height:115%'><span style='mso-spacerun:yes'> </span><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#link_to_both"><span style='font-size:16.0pt;line-height:115%'>If a new
paper publishes data on cells with axonal/dendritic branching in SMo that lumps
together cells that have no projections to Sub with those that do (i.e., DG
Neurogliaform and MOPP), will the data be linked with both, or only one of the
two cell types defined in the knowledge base?</span></a><span
class=MsoHyperlink><span style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
class=MsoHyperlink><span style='font-size:16.0pt;line-height:115%;color:windowtext;
text-decoration:none;text-underline:none'>Q:<span style='mso-tab-count:1'> </span></span></span><a
href="#MEC_LEC"><span style='font-size:16.0pt;line-height:115%'>Reference is
made to MEC LII stellate cells but EC LIII pyramidal cells [without the M], and
EC LII basket-multipolar [without the M] but MEC LIII superficial trilayered
interneurons. Is this intentional?</span></a><span style='font-size:16.0pt;
line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal><a href="#curation"><span style='font-size:16.0pt;
line-height:115%'>Curation</span></a><span style='font-size:16.0pt;line-height:
115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#annotation"><span style='font-size:16.0pt;line-height:115%'>Who is doing
the annotating and review of the knowledge base?</span></a><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#survey_frequency"><span style='font-size:16.0pt;line-height:115%'>How
frequently is the literature surveyed to update the knowledge base?</span></a><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#suggest_articles"><span style='font-size:16.0pt;line-height:115%'>Are
there any mechanisms for Hippocampome.org users to suggest the inclusion/review
of specific articles?</span></a><span style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='tab-stops:0in'><a href="#Ephys"><span
style='font-size:16.0pt;line-height:115%'>Electrophysiology</span></a><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#Ephys_rats_over_mice"><span style='font-size:16.0pt;line-height:115%'>For
electrophysiology data, why are rats preferred over mice and other rodent
species?</span></a><span class=MsoHyperlink><span style='font-size:16.0pt;
line-height:115%'><o:p></o:p></span></span></p>
<p class=MsoNormal><a href="#NTP"><span style='font-size:16.0pt;
line-height:115%'>Neuron Term Portal</span></a><span style='font-size:16.0pt;
line-height:115%'> <o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#NTP_sources"><span style='font-size:16.0pt;line-height:115%'>
How are the definitions in the Neuron Term Portal derived?</span></a><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal><a href="#collaborations"><span style='font-size:16.0pt;
line-height:115%'>Collaborations</span></a><span style='font-size:16.0pt;
line-height:115%'> <o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#does_collaborate"><span style='font-size:16.0pt;line-height:115%'>Does
Hippocampome.org collaborate with any other web sites?</span></a><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal><a href="#future_directions"><span style='font-size:16.0pt;
line-height:115%'>Future Directions</span></a><span style='font-size:16.0pt;
line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#gap_junctions"><span style='font-size:16.0pt;line-height:115%'>There is
no mention of gap junctions - will these data be added later?</span></a><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><a href="#general"><span
style='font-size:16.0pt;line-height:115%'>General</span></a><span
style='font-size:16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span></span><a
href="#browsers"><span style='font-size:16.0pt;line-height:115%'>Which browsers
are formally supported by Hippocampome.org?</span></a><span style='font-size:
16.0pt;line-height:115%'><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:.75in'><span style='font-size:16.0pt;
line-height:115%'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.75in'><span style='font-size:16.0pt;
line-height:115%'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.75in'><span style='font-size:16.0pt;
line-height:115%'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.75in'><span style='font-size:16.0pt;
line-height:115%'><o:p> </o:p></span></p>
<b style='mso-bidi-font-weight:normal'><span style='font-size:16.0pt;
line-height:115%;font-family:"Times New Roman","serif";mso-fareast-font-family:
Calibri;mso-fareast-theme-font:minor-latin;mso-ansi-language:EN-US;mso-fareast-language:
EN-US;mso-bidi-language:AR-SA'><br clear=all style='mso-special-character:line-break;
page-break-before:always'>
</span></b>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'><o:p> </o:p></span></b></p>
<p class=MsoNormal><a name="design_criteria"><b style='mso-bidi-font-weight:
normal'><span style='font-size:16.0pt;line-height:115%'>Project Design<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:design_criteria'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="basket_axoaxonic"><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>Why
do some neuron types with identical morphological patterns, for example CA1
Basket and Axo-Axonic cells, form separate neuron types in Hippocampome.org?<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:basket_axoaxonic'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A:<span style='mso-tab-count:1'> </span>Although
the main categorization property is axo-dendritic pattern, the secondary
properties listed below are sufficient to uniquely separate neuron types.<span
style='mso-spacerun:yes'> </span>Such significance is placed on these
secondary properties because they can dramatically affect the behavior of the
type in a neuronal network. In the case of CA1 Axo-axonic cells, they specifically
target the axon initial segments of CA1 Pyramidal cells and ignore any other
targets. <o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'><span style='mso-tab-count:1'> </span>-Primary
neurotransmitter: e.g., CA1 Cajal-Retzius and CA1 Neurogliaform<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:16.0pt;
line-height:115%'>-Targeting specificity: e.g., CA1 Axo-axonic and CA1 Basket<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:16.0pt;
line-height:115%'>-Consistently differentiating patterns of biomarkers and/or
electrophysiological properties: e.g., CA1 Basket and CA1 Basket CCK+<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="guinea_pigs"><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>Several
of the earlier hippocampal anatomy studies also employed guinea pigs - is there
a plan to include these data as well?<o:p></o:p></span></b></a></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='mso-bookmark:guinea_pigs'><span style='font-size:16.0pt;line-height:
115%'>A:<span style='mso-tab-count:1'> </span>We curate information on
rodent species; consequently, information from guinea pigs is included.<span
style='mso-spacerun:yes'> </span>Because this information has been
infrequently encountered, it is sparse in the knowledge base.<o:p></o:p></span></span></p>
<span style='mso-bookmark:guinea_pigs'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="how_link"><b style='mso-bidi-font-weight:normal'><span style='font-size:
16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>How are
data from different articles linked?<span style='mso-spacerun:yes'> </span></span></b></a><b
style='mso-bidi-font-weight:normal'><span style='font-size:16.0pt;line-height:
115%'><o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A:<span style='mso-tab-count:1'> </span>All
data in Hippocampome.org are linked to a neuron type.<span
style='mso-spacerun:yes'> </span>This can be accomplished directly by
presentation of a reconstruction, schematic, or text description of the neuron;
or indirectly by a citation that provides such a description.<span
style='mso-spacerun:yes'> </span>In two special cases, data can be linked in
the absence of a description of the axo-dendritic pattern. <o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'><span style='mso-tab-count:1'> </span>The
special cases rely on identification by other prominent characteristics of the
neuron type: 1. soma location in the principal cell layer for DG Granule and
CA1, CA2, and CA3 Pyramidal neuron types, where they make up 90% or greater of
the cell bodies; and 2.<span style='mso-spacerun:yes'> </span>axonal tracts
for DG Granule (mossy fibers) and EC hippocampal projecting types (perforant
path). <o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="link_to_both"><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>If
a new paper publishes data on cells with axonal/dendritic branching in SMo that
lumps together cells that have no projections to Sub with those that do (i.e.,
DG Neurogliaform and MOPP), will the data be linked with both, or only one of
the two cell types defined in the knowledge base?<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:link_to_both'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A:<span style='mso-tab-count:1'> </span>The
data will be putatively linked to both cell types as long as the formal link
can be made to both.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a name="MEC_LEC"><span
class=MsoHyperlink><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%;color:windowtext;text-decoration:none;
text-underline:none'>Q:<span style='mso-tab-count:1'> </span>Reference is
made to MEC LII stellate cells but EC LIII pyramidal cells [without the M], and
EC LII basket-multipolar [without the M] but MEC LIII superficial trilayered
interneurons. Is this intentional?</span></b></span></a><span style='mso-bookmark:
MEC_LEC'><b style='mso-bidi-font-weight:normal'><span style='font-size:16.0pt;
line-height:115%'><o:p></o:p></span></b></span></p>
<span style='mso-bookmark:MEC_LEC'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A:<span style='mso-tab-count:1'> </span>Yes,
it is intentional. We assign the prefix MEC to neurons that have been
characterized solely (or are known to exist predominantly) in the Medial
Entorhinal Cortex, such as layer II spiny stellate cells. Similarly, the prefix
LEC is assigned to lateral entorhinal neurons. In contrast, neurons that are
believed to exist in both the medial and lateral entorhinal cortices are given
the prefix EC.<b style='mso-bidi-font-weight:normal'><o:p></o:p></b></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'><o:p> </o:p></span></p>
<p class=MsoNormal><a name=curation><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Curation<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:curation'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name=annotation><b style='mso-bidi-font-weight:normal'><span style='font-size:
16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>Who is doing
the annotating and review of the knowledge base?<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:annotation'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A:<span style='mso-tab-count:1'> </span>Currently,
the annotation and review of<span style='mso-spacerun:yes'> </span>the
knowledge base is performed by the authors of the publication (D. W. Wheeler,
C. M. White, C. L. Rees, A. O. Komendantov, D. J. Hamilton, G. A. Ascoli
"Hippocampome.org: A knowledge base of neuron types in the rodent
hippocampus", under review).<span style='mso-spacerun:yes'> </span>In the
future, we will endeavor to include mechanisms for direct input from the user
community.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="survey_frequency"><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>How
frequently is the literature surveyed to update the knowledge base?<o:p></o:p></span></b></a></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='mso-bookmark:survey_frequency'><span style='font-size:16.0pt;line-height:
115%'>A: <span style='mso-tab-count:1'> </span>The current plans are for quarterly
surveys of the literature.<span style='mso-spacerun:yes'> </span>A log will be
kept that tracks which new articles are being considered for inclusion into
Hippocampome.org during a future update.<o:p></o:p></span></span></p>
<span style='mso-bookmark:survey_frequency'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="suggest_articles"><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>Are
there any mechanisms for Hippocampome.org users to suggest the inclusion/review
of specific articles?<o:p></o:p></span></b></a></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='mso-bookmark:suggest_articles'><span style='font-size:16.0pt;line-height:
115%'>A:<span style='mso-tab-count:1'> </span>Users can utilize the
Feedback button in the main banner to address new or currently included
articles.<span style='mso-spacerun:yes'> </span>In addition, we are
automatically made aware of any PMID for which a user searches that is not in
the knowledge base.<o:p></o:p></span></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='mso-bookmark:suggest_articles'><span style='font-size:16.0pt;line-height:
115%'><o:p> </o:p></span></span></p>
<span style='mso-bookmark:suggest_articles'></span>
<p class=MsoNormal style='tab-stops:0in'><a name=Ephys><b style='mso-bidi-font-weight:
normal'><span style='font-size:16.0pt;line-height:115%'>Electrophysiology<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:Ephys'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="Ephys_rats_over_mice"><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>For
electrophysiology data, why are rats preferred over mice and other rodent
species?<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:Ephys_rats_over_mice'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A: <span style='mso-tab-count:1'> </span>Although
more rat electrophysiological data than mouse exists in the literature (77% of
the electrophysiological parameters sets were taken from rats, 20% from mice,
and 3% from guinea pigs), Hippocampome.org curates both and has a substantial
amount of mouse information.<span style='mso-spacerun:yes'> </span>In the
electrophysiological table for legibility reasons, it is only possible to
display one value.<span style='mso-spacerun:yes'> </span>To determine the
display value, we prioritize rat, patch-clamp, and body temperature data.<span
style='mso-spacerun:yes'> </span>However, clicking on any value will display
all of the information, including any from mouse (and from sharp electrodes,
room temperature, etc.).<span style='mso-spacerun:yes'> </span>Moreover, we
have plans to make the species displayed a selectable user option.<o:p></o:p></span></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'><o:p> </o:p></span></b></p>
<p class=MsoNormal style='tab-stops:0in'><a name=collaborations></a><a
name=NTP><span style='mso-bookmark:collaborations'><b style='mso-bidi-font-weight:
normal'><span style='font-size:16.0pt;line-height:115%'>Neuron Term Portal<span
class=msoIns><ins cite="mailto:Diek" datetime="2016-10-11T12:56"><o:p></o:p></ins></span></span></b></span></a></p>
<span style='mso-bookmark:NTP'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='mso-bookmark:collaborations'><a name="NTP_sources"><b style='mso-bidi-font-weight:
normal'><span style='font-size:16.0pt;line-height:115%'><span class=msoIns><ins
cite="mailto:Diek" datetime="2016-10-11T12:56">Q:<span style='mso-tab-count:
1'> </span></ins></span>How are the definitions in the Neuron Term Portal
derived?<o:p></o:p></span></b></a></span></p>
<span style='mso-bookmark:NTP_sources'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='mso-bookmark:collaborations'><span style='font-size:16.0pt;line-height:
115%'><span class=msoIns><ins cite="mailto:Diek" datetime="2016-10-11T12:56">A:
<span style='mso-tab-count:1'> </span></ins></span>The definitions are
derived from 26 sources: BIOPORTAL, CRISP, Gene Ontology, Hippocampome.org,
MeSH, NCBI Gene, NCBI Protein, Neurolex, Protein Ontology, Allen Brain Atlas,
ChEBI, MBF Bioscience, Medical College of Wisconsin, Merriam-Webster Medical,
NeuroElectro, NIST InChI Trust, Scholarpedia, UTHealth Neuroscience, Wolfram
MathWorld, Cambridge Dictionaries, Macmillan Dictionary, Merriam-Webster
Dictionary, Oxford Dictionaries, TheFreeDictionary, Wikipedia, Wiktionary.<b
style='mso-bidi-font-weight:normal'><span class=msoIns><ins cite="mailto:Diek"
datetime="2016-10-11T12:56"><o:p></o:p></ins></span></b></span></span></p>
<p class=MsoNormal><span style='mso-bookmark:collaborations'><span
style='font-size:16.0pt;line-height:115%'><span class=msoIns><ins
cite="mailto:Diek" datetime="2016-10-11T12:56"><o:p> </o:p></ins></span></span></span></p>
<p class=MsoNormal><span style='mso-bookmark:collaborations'><b
style='mso-bidi-font-weight:normal'><span style='font-size:16.0pt;line-height:
115%'>Collaborations</span></b></span><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'> <o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="does_collaborate"><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>Does
Hippocampome.org collaborate with any other web sites?</span></b></a><b
style='mso-bidi-font-weight:normal'><span style='font-size:16.0pt;line-height:
115%'><o:p></o:p></span></b></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A:<span style='mso-tab-count:1'> </span>We
fervently think that scientific progress is significantly expedited by
information sharing.<span style='mso-spacerun:yes'> </span>Two examples of
collaborative relations are with NeuroElectro and NIF.<span
style='mso-spacerun:yes'> </span><o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:16.0pt;
line-height:115%'>Hippocapome.org shared mined electrophysiological data with
NeuroElectro in May 2014 as a gold standard testbed to help validate the
NeuroElectro automated literature mining protocol. We will continue to monitor
future updates of NeuroElectro content for new additional information related
to hippocampus neurons.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in'><span style='font-size:16.0pt;
line-height:115%'>We have given NIF scraping access to our website for
inclusion of Hippocampome.org content in their search portal.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'><o:p> </o:p></span></p>
<p class=MsoNormal><a name="future_directions"><b style='mso-bidi-font-weight:
normal'><span style='font-size:16.0pt;line-height:115%'>Future Directions<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:future_directions'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name="gap_junctions"><b style='mso-bidi-font-weight:normal'><span
style='font-size:16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>There
is no mention of gap junctions - will these data be added later?<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:gap_junctions'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A:<span style='mso-tab-count:1'> </span>Yes,
we are in the early stages of annotation information concerning gap junctions
and other synaptic information, which will be added to Hippocampome.org in
future updates.<o:p></o:p></span></p>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'><o:p> </o:p></span></p>
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><a name=general><b
style='mso-bidi-font-weight:normal'><span style='font-size:16.0pt;line-height:
115%'>General<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:general'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><a
name=browsers><b style='mso-bidi-font-weight:normal'><span style='font-size:
16.0pt;line-height:115%'>Q:<span style='mso-tab-count:1'> </span>Which
browsers are formally supported by Hippocampome.org?<o:p></o:p></span></b></a></p>
<span style='mso-bookmark:browsers'></span>
<p class=MsoNormal style='margin-left:1.0in;text-indent:-.5in'><span
style='font-size:16.0pt;line-height:115%'>A:<span style='mso-tab-count:1'> </span>Hippocampome.org
formally supports current versions of Firefox, Chrome, Safari, and Explorer.<o:p></o:p></span></p>
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