diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 38cb4c52..19dcf9e8 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -12,7 +12,6 @@ jobs:
         os:
           - ubuntu-latest
         python-version:
-          - 3.5
           - 3.6
           - 3.7
           - 3.8
@@ -47,7 +46,6 @@ jobs:
         os:
           - macos-latest
         python-version:
-          - 3.5
           - 3.6
           - 3.7
           - 3.8
@@ -82,7 +80,6 @@ jobs:
         os:
           - windows-latest
         python-version:
-          - 3.5
           - 3.6
           - 3.7
           - 3.8
@@ -147,6 +144,7 @@ jobs:
         env:
             WRAPT_INSTALL_EXTENSIONS: true  # Require extensions.
             CIBW_SKIP: pp*                  # Skip wheels for PyPy.
+            CIBW_BUILD: cp36-*              # only build on 3.6 for stable cp36-abi3
       - uses: actions/upload-artifact@v2
         with:
           name: dist
diff --git a/setup.cfg b/setup.cfg
index b854d8bb..ae8b02da 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -17,7 +17,6 @@ classifiers =
     Development Status :: 5 - Production/Stable
     License :: OSI Approved :: BSD License
     Programming Language :: Python :: 3
-    Programming Language :: Python :: 3.5
     Programming Language :: Python :: 3.6
     Programming Language :: Python :: 3.7
     Programming Language :: Python :: 3.8
@@ -32,7 +31,7 @@ project_urls =
 
 [options]
 zip_safe = false
-python_requires = >= 3.5
+python_requires = >= 3.6
 packages = find:
 package_dir =
     =src
@@ -45,6 +44,7 @@ where=src
 
 [bdist_wheel]
 universal = false
+py_limited_api=cp36
 
 # --- Test and coverage configuration ------------------------------------------
 
@@ -74,13 +74,11 @@ envlist =
 
 [gh-actions]
 python =
-    3.5: py35, py35-without-extensions, py35-install-extensions, py35-disable-extensions
     3.6: py36, py36-without-extensions, py36-install-extensions, py36-disable-extensions
     3.7: py37, py37-without-extensions, py37-install-extensions, py37-disable-extensions
     3.8: py38, py38-without-extensions, py38-install-extensions, py38-disable-extensions
     3.9: py39, py39-without-extensions, py39-install-extensions, py39-disable-extensions
     3.10: py310, py310-without-extensions, py310-install-extensions, py310-disable-extensions
-    pypy-2.7: pypy-without-extensions
     pypy-3.6: pypy-without-extensions
     pypy-3.7: pypy-without-extensions
 
diff --git a/setup.py b/setup.py
index 1e182e36..295bcf3b 100644
--- a/setup.py
+++ b/setup.py
@@ -24,6 +24,7 @@
         "wrapt._wrappers",
         sources=["src/wrapt/_wrappers.c"],
         optional=not force_extensions,
+        py_limited_api=True,
     )
 ]
 
diff --git a/src/wrapt/_wrappers.c b/src/wrapt/_wrappers.c
index ea704d19..5c3b6e17 100644
--- a/src/wrapt/_wrappers.c
+++ b/src/wrapt/_wrappers.c
@@ -1,7 +1,9 @@
 /* ------------------------------------------------------------------------- */
 
-/* stable ABI Python >= 3.5 */
-#define Py_LIMITED_API 0x03050000
+#ifndef Py_LIMITED_API
+/* stable ABI Python >= 3.6, keep in sync with setup.cfg py_limited_api */
+#define Py_LIMITED_API 0x03060000
+#endif
 
 #include "Python.h"