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blood-metabolites-regulation

This repository contains the analysis scripts for the study, Reconstructing the blood metabolome and genotype using long-range chromatin interactions1. The study identifies target genes of 130 genetic variants that modulate about 400 blood metabolites2 using chromatin interactions (from Hi-C)3 and expression quantitative trait loci (eQTL)4 data.

References

  1. Fadason, T. et al. Reconstructing the blood metabolome and genotype using long-range chromatin interactions. BiorXiv, (2019).
  2. Shin, S.-Y. et al. An atlas of genetic influences on human blood metabolites. Nat. Genet. 46, 543–550 (2014).
  3. Rao, S. S. P. et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159, 1665–1680 (2014).
  4. Ardlie, K. G. et al. The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans. Science (80-. ). 348, 648–660 (2015).