Knowledge-based evaluation of the results.ipynb

{
 "cells": [
   {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Knowledge-based Evaluation of the Results \n"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# This notebook contains knowledge-based evaluations for the extracted IC genes, the example has been done on LIHC results "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 37,
   "metadata": {},
   "outputs": [],
   "source": [
    "import requests\n",
    "import re\n",
    "import numpy as np\n",
    "import csv\n",
    "import pandas as pd\n",
    "import joblib\n",
    "from tqdm import tqdm_notebook\n",
    "import time \n",
    "import scipy.stats as stats\n",
    "from openpyxl import load_workbook\n",
    "from gprofiler import GProfiler"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Pubmed evaluation: are the IC genes enriched in cancer type publications against all genes present in the fused network?"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Functions to extract the number of publications associated to a single term (extract_single), \n",
    "#two terms with \"or\" condition (extract_or) and two terms with \"and\" condition (extract_and)\n",
    "def extract_single(one):\n",
    "    try:\n",
    "        contains = ''\n",
    "        while contains == '':\n",
    "            try:\n",
    "                #%5Btw%5D is used to make sure that the searching term is included in the title, abstract, other abstract, \n",
    "                #MeSH terms, MeSH Subheadings, Publication Types or Substance Names.\n",
    "                contains = requests.get(\"https://pubmed.ncbi.nlm.nih.gov/?term=%28{}%5Btw%5D%29\".format(one))\n",
    "                break\n",
    "            except:\n",
    "                time.sleep(5)\n",
    "                continue\n",
    "            \n",
    "        m = re.search('<meta name=\"log_resultcount\" content=\"[0-9]+\"', str(contains.content))\n",
    "        return int(m.group(0)[38:-1])\n",
    "    except:\n",
    "        m1 = re.search('<meta name=\"log_source_db\" content=\".+\" />',str(contains.content))\n",
    "        if m1 is not None:\n",
    "            return 1\n",
    "        if m1 is None:\n",
    "            return 0\n",
    "        \n",
    "def extract_or(*args):\n",
    "    query = \"https://pubmed.ncbi.nlm.nih.gov/?term=%28{}%5Btw%5D%29\".format(args[0].replace(\" \", \"+\"))\n",
    "    for a in args[1:]:\n",
    "        query += \"+OR+%28{}%5Btw%5D%29\".format(a.replace(\" \", \"+\"))\n",
    "    try:\n",
    "        contains = ''\n",
    "        while contains == '':\n",
    "            try:\n",
    "                contains = requests.get(query)\n",
    "                break\n",
    "            except:\n",
    "                time.sleep(5)\n",
    "                continue\n",
    "        m = re.search('<meta name=\"log_resultcount\" content=\"[0-9]+\"', str(contains.content))\n",
    "        return int(m.group(0)[38:-1])\n",
    "    except:\n",
    "        m1 = re.search('<meta name=\"log_source_db\" content=\".+\" />',str(contains.content))\n",
    "        if m1 is not None:\n",
    "            return 1\n",
    "        if m1 is None:\n",
    "            return 0\n",
    "        \n",
    "def extract_and(*args): \n",
    "    query = \"https://pubmed.ncbi.nlm.nih.gov/?term=%28{}%5Btw%5D%29\".format(args[0].replace(\" \", \"+\"))\n",
    "    for a in args[1:]:\n",
    "        query += \"+AND+%28{}%5Btw%5D%29\".format(a.replace(\" \", \"+\"))\n",
    "    contains = ''\n",
    "    while contains == '':\n",
    "        try:\n",
    "            contains = requests.get(query)\n",
    "            break\n",
    "        except:\n",
    "            time.sleep(5)\n",
    "            continue\n",
    "    m = re.search('<meta name=\"log_resultcount\" content=\"[0-9]+\"', str(contains.content))\n",
    "    if m is not None:\n",
    "        return int(m.group(0)[38:-1])\n",
    "    if m is None:\n",
    "        m1 = re.search('<meta name=\"log_source_db\" content=\".+\" />',str(contains.content))\n",
    "        if m1 is not None:\n",
    "            return 1\n",
    "        if m1 is None:\n",
    "            return 0"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Results are tested on LIHC IC genes\n",
    "cancer_type='lihc'\n",
    "\n",
    "ICgenes = pd.read_csv('./Results/'+str(cancer_type)+'_ICgenes.csv', sep=';', header=None)\n",
    "all_o = set(ICgenes[0])\n",
    "all_t = set(ICgenes[1])\n",
    "dict_o={}\n",
    "dict_t={}\n",
    "\n",
    "#Extraction of the number of publications for each gene\n",
    "for i in tqdm_notebook(all_t):\n",
    "        dict_t[i] = extract_single(i)\n",
    "#Extraction of the number of publications for the cancer type\n",
    "for i in tqdm_notebook(all_o):\n",
    "        dict_o[i] = extract_single(i)\n",
    "            \n",
    "n_t_tot=[]\n",
    "n_o_tot=[]\n",
    "tot=[]\n",
    "common=[]\n",
    "name1=[]\n",
    "name2=[]\n",
    "\n",
    "#Extraction of the number of publications of the two terms (gene, cancer type)\n",
    "#considering OR/AND conditions\n",
    "for i,j in dict_o.items():\n",
    "    for key,value in tqdm_notebook(dict_t.items()):\n",
    "        n_tot = extract_or(i, key)\n",
    "        n_common = extract_and(i, key)\n",
    "        name1.append(key)\n",
    "        name2.append(i)\n",
    "        n_t_tot.append(value)\n",
    "        n_o_tot.append(j)\n",
    "        tot.append(n_tot)\n",
    "        if n_common == n_tot:\n",
    "            common.append(0)\n",
    "        if n_common != n_tot:\n",
    "            common.append(n_common)\n",
    "\n",
    "#Save results in csv file:\n",
    "#first column contains the gene names, second column the cancer type, \n",
    "#third column is the number of publications for each gene, fourth column contains the number of publications for the cancer type\n",
    "#fifth and sixth columns contain the number of publications for condition OR and AND of the two terms gene/cancer type\n",
    "df = pd.DataFrame(list(zip(name1,name2,n_t_tot,n_o_tot,tot,common)), columns =['genes', 'cancer','pubmed_genes','pubmed_cancer','OR','AND']) \n",
    "df.to_csv('./Results/'+str(t)+'_pubmedresults_ICgenes.csv', index=None, header=None)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "#To compute the enrichment we need to count the cancer-type-related publications for all genes in the LIHC fused network\n",
    "cancer_type='lihc'\n",
    "\n",
    "all_genes = pd.read_csv('./Results/'+str(cancer_type)+'_allgenes.csv', sep=';', header=None)\n",
    "all_o = set(all_genes[0])\n",
    "all_t = set(all_genes[1])\n",
    "dict_o={}\n",
    "dict_t={}\n",
    "\n",
    "#Extraction of the number of publications for each gene\n",
    "for i in tqdm_notebook(all_t):\n",
    "        dict_t[i] = extract_single(i)\n",
    "#Extraction of the number of publications for the cancer type\n",
    "for i in tqdm_notebook(all_o):\n",
    "        dict_o[i] = extract_single(i)\n",
    "            \n",
    "n_t_tot=[]\n",
    "n_o_tot=[]\n",
    "tot=[]\n",
    "common=[]\n",
    "name1=[]\n",
    "name2=[]\n",
    "\n",
    "#Extraction of the number of publications of the two terms (gene, cancer type)\n",
    "#considering OR/AND conditions\n",
    "for i,j in dict_o.items():\n",
    "    for key,value in tqdm_notebook(dict_t.items()):\n",
    "        n_tot = extract_or(i, key)\n",
    "        n_common = extract_and(i, key)\n",
    "        name1.append(key)\n",
    "        name2.append(i)\n",
    "        n_t_tot.append(value)\n",
    "        n_o_tot.append(j)\n",
    "        tot.append(n_tot)\n",
    "        if n_common == n_tot:\n",
    "            common.append(0)\n",
    "        if n_common != n_tot:\n",
    "            common.append(n_common)\n",
    "\n",
    "#Save results in csv file:\n",
    "#first column contains the gene names, second column the cancer type, \n",
    "#third column is the number of publications for each gene, fourth column contains the number of publications for the cancer type\n",
    "#fifth and sixth columns contain the number of publications for condition OR and AND of the two terms gene/cancer type\n",
    "df = pd.DataFrame(list(zip(name1,name2,n_t_tot,n_o_tot,tot,common)), columns =['genes', 'cancer','pubmed_genes','pubmed_cancer','OR','AND']) \n",
    "df.to_csv('./Results/'+str(t)+'_pubmedresults_allgenes.csv', index=None, header=None)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 31,
   "metadata": {},
   "outputs": [],
   "source": [
    "def parse_line(l):\n",
    "    try:\n",
    "        s = l.strip().split(\",\")\n",
    "        return s[0],s[1],int(s[-4]),int(s[-3]), int(s[-2]), int(s[-1])\n",
    "    except:\n",
    "        print(l)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 32,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Read the previously saved files\n",
    "with open('./Results/'+str(cancer_type)+'_pubmedresults_ICgenes.csv') as f:\n",
    "    all_lines = [parse_line(l) for l in f.readlines()]\n",
    "with open('./Results/'+str(cancer_type)+'_pubmedresults_allgenes.csv') as f:\n",
    "    all_all = [parse_line(l) for l in f.readlines()]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "13012\n",
      "839\n"
     ]
    }
   ],
   "source": [
    "print(len(all_all))\n",
    "print(len(all_lines))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Extract the number of publications for the two terms (gene/cancer type) with AND condition\n",
    "def pub_and(all_l):\n",
    "    y = []\n",
    "    x = list(range(len(all_l)))\n",
    "    for i in x:\n",
    "        y.append([int(x[-1]) for x in all_l])\n",
    "    return np.array(y),x"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "metadata": {},
   "outputs": [],
   "source": [
    "y_all,_ = pub_and(all_all)\n",
    "y_IC,_ = pub_and(all_lines)\n",
    "k=len(np.nonzero(y_IC[0])[0])\n",
    "M=len(np.nonzero(y_all[0])[0])\n",
    "N=len(all_all)\n",
    "s=len(all_lines)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "1.045115648264007e-12\n"
     ]
    }
   ],
   "source": [
    "#Fisher's exact test to demostrate that the IC genes are enriched for cancer-type-specific publications\n",
    "_, pvalue = stats.fisher_exact([[k, s-k],[M-k, N-(M-k)]])  \n",
    "print(pvalue)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# DrugBank evaluation: are the IC genes enriched in druggable targets against all other genes in the network?"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "metadata": {},
   "outputs": [],
   "source": [
    "#The file DB_pharmacologically_active.csv is directly downloaded from DrugBank\n",
    "DrugBank=pd.read_csv(\"./Supplementary data/DB_pharmacologically_active.csv\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [],
   "source": [
    "#The count_DrugBank function is used to extract the pharmacologically active targets among the input list of genes\n",
    "def count_DrugBank(data):\n",
    "    res=[]\n",
    "    for i in data:\n",
    "        if any(DrugBank['Gene Name']==i):\n",
    "            res.append(DrugBank[DrugBank['Gene Name']==i])\n",
    "    res=pd.concat(res)\n",
    "    res=res.reset_index(drop=True)\n",
    "    return res"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "69\n",
      "839\n"
     ]
    }
   ],
   "source": [
    "DB_ICgenes = count_DrugBank(ICgenes[1])\n",
    "#Print the total number of actionable IC genes\n",
    "print(len(set(DB_ICgenes['Gene Name'])))\n",
    "#Print the total number of IC genes\n",
    "print(len(set(ICgenes[1])))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "481\n",
      "13011\n"
     ]
    }
   ],
   "source": [
    "DB_allgenes = count_DrugBank(all_genes[1])\n",
    "#Print the total number of actionable genes from the fused networl\n",
    "print(len(set(DB_allgenes['Gene Name'])))\n",
    "#Print the total number of genes from the fused network\n",
    "print(len(set(all_genes[1])))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "1.5976548100792317e-11\n"
     ]
    }
   ],
   "source": [
    "#Fisher's exact test to demostrate that the IC genes are enriched in druggable targets\n",
    "k=len(set(DB_ICgenes['Gene Name']))\n",
    "s=len(set(ICgenes[1]))\n",
    "M=len(set(DB_allgenes['Gene Name']))\n",
    "N=len(set(all_genes[1]))\n",
    "_, pvalue = stats.fisher_exact([[k, s-k],[(M)-k, (N)-((M)-k)]])  \n",
    "print(pvalue)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# g:Profiler Enrichment analysis of the IC genes"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 38,
   "metadata": {},
   "outputs": [],
   "source": [
    "#Using g:Profiler we perform enrichment analysis on the IC genes\n",
    "gp = GProfiler(return_dataframe=True)\n",
    "gp_comm=gp.profile(organism='hsapiens', query=list(ICgenes[1]),no_evidences=False)\n",
    "gp_comm.to_csv('./Enrichment_'+str(cancer_type)+'_ICgenes.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 39,
   "metadata": {},
   "outputs": [
    {
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       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>source</th>\n",
       "      <th>native</th>\n",
       "      <th>name</th>\n",
       "      <th>p_value</th>\n",
       "      <th>significant</th>\n",
       "      <th>description</th>\n",
       "      <th>term_size</th>\n",
       "      <th>query_size</th>\n",
       "      <th>intersection_size</th>\n",
       "      <th>effective_domain_size</th>\n",
       "      <th>precision</th>\n",
       "      <th>recall</th>\n",
       "      <th>query</th>\n",
       "      <th>parents</th>\n",
       "      <th>intersections</th>\n",
       "      <th>evidences</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>REAC</td>\n",
       "      <td>REAC:R-HSA-1430728</td>\n",
       "      <td>Metabolism</td>\n",
       "      <td>4.866241e-87</td>\n",
       "      <td>True</td>\n",
       "      <td>Metabolism</td>\n",
       "      <td>2072</td>\n",
       "      <td>553</td>\n",
       "      <td>315</td>\n",
       "      <td>10594</td>\n",
       "      <td>0.569620</td>\n",
       "      <td>0.152027</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[REAC:0000000]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, PON1, FMO3, MGST1, RPS20, ...</td>\n",
       "      <td>[[REAC], [REAC], [REAC], [REAC], [REAC], [REAC...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0055114</td>\n",
       "      <td>oxidation-reduction process</td>\n",
       "      <td>3.009886e-82</td>\n",
       "      <td>True</td>\n",
       "      <td>\"A metabolic process that results in the remov...</td>\n",
       "      <td>1028</td>\n",
       "      <td>745</td>\n",
       "      <td>204</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.273826</td>\n",
       "      <td>0.198444</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0008152]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, KDM7A, FMO3, MGST1, IYD, U...</td>\n",
       "      <td>[[TAS, NAS, IEA], [IDA, IBA, IEA], [IEA], [IEA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0016491</td>\n",
       "      <td>oxidoreductase activity</td>\n",
       "      <td>1.542436e-73</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Catalysis of an oxidation-reduction (redox) r...</td>\n",
       "      <td>768</td>\n",
       "      <td>761</td>\n",
       "      <td>169</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.222076</td>\n",
       "      <td>0.220052</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0003824]</td>\n",
       "      <td>[NDUFAB1, KDM7A, FMO3, MGST1, IYD, UQCRC1, HSD...</td>\n",
       "      <td>[[NAS], [IDA, IEA], [IBA, IEA], [IDA], [IDA, I...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0046395</td>\n",
       "      <td>carboxylic acid catabolic process</td>\n",
       "      <td>4.026219e-65</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>276</td>\n",
       "      <td>745</td>\n",
       "      <td>101</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.135570</td>\n",
       "      <td>0.365942</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0016054, GO:0019752]</td>\n",
       "      <td>[PON1, OTC, ACAA1, HSD17B10, ACAT1, ACACB, BCK...</td>\n",
       "      <td>[[IDA], [IDA], [IMP, IBA, TAS], [TAS], [IMP, I...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0016054</td>\n",
       "      <td>organic acid catabolic process</td>\n",
       "      <td>4.026219e-65</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>276</td>\n",
       "      <td>745</td>\n",
       "      <td>101</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.135570</td>\n",
       "      <td>0.365942</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0006082, GO:0044248, GO:0044282, GO:1901575]</td>\n",
       "      <td>[PON1, OTC, ACAA1, HSD17B10, ACAT1, ACACB, BCK...</td>\n",
       "      <td>[[IDA], [IDA], [IMP, IBA, TAS], [TAS], [IMP, I...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0044281</td>\n",
       "      <td>small molecule metabolic process</td>\n",
       "      <td>6.617864e-62</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways involving...</td>\n",
       "      <td>1987</td>\n",
       "      <td>745</td>\n",
       "      <td>253</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.339597</td>\n",
       "      <td>0.127328</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0008152]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, PON1, IYD, CPS1, OTC, ITIH...</td>\n",
       "      <td>[[NAS, IEA], [IDA, TAS], [IDA, TAS, IEA], [IDA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>GO:CC</td>\n",
       "      <td>GO:0005739</td>\n",
       "      <td>mitochondrion</td>\n",
       "      <td>3.312159e-60</td>\n",
       "      <td>True</td>\n",
       "      <td>\"A semiautonomous, self replicating organelle ...</td>\n",
       "      <td>1631</td>\n",
       "      <td>774</td>\n",
       "      <td>223</td>\n",
       "      <td>18856</td>\n",
       "      <td>0.288114</td>\n",
       "      <td>0.136726</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0005737, GO:0043231]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, MGST1, UQCRC1, CPS1, OTC, ...</td>\n",
       "      <td>[[IDA, ISS, IBA, TAS, NAS, IEA], [IDA, ISS, TA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0044282</td>\n",
       "      <td>small molecule catabolic process</td>\n",
       "      <td>8.601402e-60</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>447</td>\n",
       "      <td>745</td>\n",
       "      <td>119</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.159732</td>\n",
       "      <td>0.266219</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0009056, GO:0044281]</td>\n",
       "      <td>[PON1, OTC, ACAA1, HAGH, HSD17B10, ACAT1, ACAC...</td>\n",
       "      <td>[[IDA], [IDA], [IMP, IBA, TAS], [IEA], [TAS], ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0019752</td>\n",
       "      <td>carboxylic acid metabolic process</td>\n",
       "      <td>3.406416e-58</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways involving...</td>\n",
       "      <td>1066</td>\n",
       "      <td>745</td>\n",
       "      <td>178</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.238926</td>\n",
       "      <td>0.166979</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0043436]</td>\n",
       "      <td>[NDUFAB1, PON1, IYD, CPS1, OTC, ITIH4, ITIH1, ...</td>\n",
       "      <td>[[NAS, IEA], [IDA, TAS], [IDA, IBA], [IDA, IBA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0043436</td>\n",
       "      <td>oxoacid metabolic process</td>\n",
       "      <td>5.231939e-57</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways involving...</td>\n",
       "      <td>1157</td>\n",
       "      <td>745</td>\n",
       "      <td>184</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.246980</td>\n",
       "      <td>0.159032</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0006082]</td>\n",
       "      <td>[NDUFAB1, PON1, IYD, CPS1, OTC, ITIH4, ITIH1, ...</td>\n",
       "      <td>[[NAS, IEA], [IDA, TAS], [IDA, IBA], [IDA, IBA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0006082</td>\n",
       "      <td>organic acid metabolic process</td>\n",
       "      <td>1.526251e-56</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways involving...</td>\n",
       "      <td>1177</td>\n",
       "      <td>745</td>\n",
       "      <td>185</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.248322</td>\n",
       "      <td>0.157179</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0044237, GO:0044281, GO:0071704]</td>\n",
       "      <td>[NDUFAB1, PON1, IYD, CPS1, OTC, ITIH4, ITIH1, ...</td>\n",
       "      <td>[[NAS, IEA], [IDA, TAS], [IDA, IBA], [IDA, IBA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>KEGG</td>\n",
       "      <td>KEGG:01100</td>\n",
       "      <td>Metabolic pathways</td>\n",
       "      <td>1.763580e-48</td>\n",
       "      <td>True</td>\n",
       "      <td>Metabolic pathways</td>\n",
       "      <td>1482</td>\n",
       "      <td>475</td>\n",
       "      <td>229</td>\n",
       "      <td>7788</td>\n",
       "      <td>0.482105</td>\n",
       "      <td>0.154521</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[KEGG:00000]</td>\n",
       "      <td>[NDUFAB1, MGST1, UQCRC1, CPS1, HSD17B6, OTC, A...</td>\n",
       "      <td>[[KEGG], [KEGG], [KEGG], [KEGG], [KEGG], [KEGG...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>REAC</td>\n",
       "      <td>REAC:R-HSA-71291</td>\n",
       "      <td>Metabolism of amino acids and derivatives</td>\n",
       "      <td>4.121741e-44</td>\n",
       "      <td>True</td>\n",
       "      <td>Metabolism of amino acids and derivatives</td>\n",
       "      <td>368</td>\n",
       "      <td>553</td>\n",
       "      <td>101</td>\n",
       "      <td>10594</td>\n",
       "      <td>0.182640</td>\n",
       "      <td>0.274457</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[REAC:R-HSA-1430728]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, RPS20, IYD, CPS1, OTC, RPL...</td>\n",
       "      <td>[[REAC], [REAC], [REAC], [REAC], [REAC], [REAC...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0022900</td>\n",
       "      <td>electron transport chain</td>\n",
       "      <td>1.750555e-43</td>\n",
       "      <td>True</td>\n",
       "      <td>\"A process in which a series of electron carri...</td>\n",
       "      <td>188</td>\n",
       "      <td>745</td>\n",
       "      <td>69</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.092617</td>\n",
       "      <td>0.367021</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0006091, GO:0055114]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, UQCRC1, HSD17B6, MAOB, NDU...</td>\n",
       "      <td>[[TAS, NAS], [IDA, IBA, IEA], [IBA, TAS, IEA],...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>GO:CC</td>\n",
       "      <td>GO:0005743</td>\n",
       "      <td>mitochondrial inner membrane</td>\n",
       "      <td>1.051425e-42</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The inner, i.e. lumen-facing, lipid bilayer o...</td>\n",
       "      <td>482</td>\n",
       "      <td>774</td>\n",
       "      <td>103</td>\n",
       "      <td>18856</td>\n",
       "      <td>0.133075</td>\n",
       "      <td>0.213693</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0019866, GO:0031966]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, UQCRC1, CPS1, OTC, MRPS34,...</td>\n",
       "      <td>[[IDA, ISS, TAS, NAS], [ISS, TAS, IEA], [IBA, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>GO:CC</td>\n",
       "      <td>GO:0005759</td>\n",
       "      <td>mitochondrial matrix</td>\n",
       "      <td>1.133647e-40</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The gel-like material, with considerable fine...</td>\n",
       "      <td>476</td>\n",
       "      <td>774</td>\n",
       "      <td>100</td>\n",
       "      <td>18856</td>\n",
       "      <td>0.129199</td>\n",
       "      <td>0.210084</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0005739, GO:0070013]</td>\n",
       "      <td>[NDUFAB1, CPS1, OTC, HAGH, ACSM2B, HSD17B10, M...</td>\n",
       "      <td>[[IDA, ISS], [IDA, TAS], [TAS, NAS, IEA], [IEA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0032787</td>\n",
       "      <td>monocarboxylic acid metabolic process</td>\n",
       "      <td>1.379676e-39</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways involving...</td>\n",
       "      <td>661</td>\n",
       "      <td>745</td>\n",
       "      <td>118</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.158389</td>\n",
       "      <td>0.178517</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0019752]</td>\n",
       "      <td>[NDUFAB1, PON1, ACAA1, HAGH, ACSM2B, ACAT1, AC...</td>\n",
       "      <td>[[NAS, IEA], [TAS], [IMP, IBA, TAS, IEA], [TAS...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>GO:CC</td>\n",
       "      <td>GO:0019866</td>\n",
       "      <td>organelle inner membrane</td>\n",
       "      <td>2.497385e-39</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The inner, i.e. lumen-facing, lipid bilayer o...</td>\n",
       "      <td>543</td>\n",
       "      <td>774</td>\n",
       "      <td>105</td>\n",
       "      <td>18856</td>\n",
       "      <td>0.135659</td>\n",
       "      <td>0.193370</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0031090, GO:0031967]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, UQCRC1, CPS1, OTC, MRPS34,...</td>\n",
       "      <td>[[IDA, ISS, TAS, NAS], [ISS, TAS, IEA], [IBA, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>GO:CC</td>\n",
       "      <td>GO:0005740</td>\n",
       "      <td>mitochondrial envelope</td>\n",
       "      <td>3.184945e-39</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The double lipid bilayer enclosing the mitoch...</td>\n",
       "      <td>766</td>\n",
       "      <td>774</td>\n",
       "      <td>125</td>\n",
       "      <td>18856</td>\n",
       "      <td>0.161499</td>\n",
       "      <td>0.163185</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0005739, GO:0031967]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, MGST1, UQCRC1, CPS1, OTC, ...</td>\n",
       "      <td>[[IDA, ISS, TAS, NAS], [ISS, TAS, IEA], [IEA],...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0022904</td>\n",
       "      <td>respiratory electron transport chain</td>\n",
       "      <td>5.605852e-37</td>\n",
       "      <td>True</td>\n",
       "      <td>\"A process in which a series of electron carri...</td>\n",
       "      <td>118</td>\n",
       "      <td>745</td>\n",
       "      <td>52</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.069799</td>\n",
       "      <td>0.440678</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0022900, GO:0045333]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, UQCRC1, NDUFB2, ETFB, COX6...</td>\n",
       "      <td>[[TAS, NAS], [IDA, IBA, IEA], [IBA, TAS, IEA],...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0006091</td>\n",
       "      <td>generation of precursor metabolites and energy</td>\n",
       "      <td>2.109517e-36</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>544</td>\n",
       "      <td>745</td>\n",
       "      <td>103</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.138255</td>\n",
       "      <td>0.189338</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0044237]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, UQCRC1, HSD17B6, MAOB, ACA...</td>\n",
       "      <td>[[TAS, NAS], [IDA, IBA, IEA], [IBA, TAS, IEA],...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:1901575</td>\n",
       "      <td>organic substance catabolic process</td>\n",
       "      <td>2.408112e-36</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>2239</td>\n",
       "      <td>745</td>\n",
       "      <td>226</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.303356</td>\n",
       "      <td>0.100938</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0009056, GO:0071704]</td>\n",
       "      <td>[PON1, RPS20, ZRANB1, CPS1, HSD17B6, OTC, AP2S...</td>\n",
       "      <td>[[IDA], [TAS], [IMP, IBA], [IMP], [TAS], [IDA]...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>GO:CC</td>\n",
       "      <td>GO:0031966</td>\n",
       "      <td>mitochondrial membrane</td>\n",
       "      <td>4.077199e-36</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Either of the lipid bilayers that surround th...</td>\n",
       "      <td>723</td>\n",
       "      <td>774</td>\n",
       "      <td>117</td>\n",
       "      <td>18856</td>\n",
       "      <td>0.151163</td>\n",
       "      <td>0.161826</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0005740, GO:0031090]</td>\n",
       "      <td>[NDUFAB1, SLC25A13, MGST1, UQCRC1, CPS1, OTC, ...</td>\n",
       "      <td>[[IDA, ISS, TAS, NAS], [ISS, TAS, IEA], [IEA],...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0009056</td>\n",
       "      <td>catabolic process</td>\n",
       "      <td>8.014430e-36</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>2693</td>\n",
       "      <td>745</td>\n",
       "      <td>252</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.338255</td>\n",
       "      <td>0.093576</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0008152]</td>\n",
       "      <td>[PON1, RPS20, ZRANB1, CPS1, HSD17B6, OTC, AP2S...</td>\n",
       "      <td>[[IDA], [TAS], [IMP, IBA], [IMP], [TAS], [IDA]...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0072329</td>\n",
       "      <td>monocarboxylic acid catabolic process</td>\n",
       "      <td>1.388879e-35</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>130</td>\n",
       "      <td>745</td>\n",
       "      <td>53</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.071141</td>\n",
       "      <td>0.407692</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0032787, GO:0046395]</td>\n",
       "      <td>[ACAA1, ACAT1, ACACB, CRAT, PCK2, LONP2, MLYCD...</td>\n",
       "      <td>[[IMP, IBA, TAS], [IBA, IEA], [IEA], [TAS], [I...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0044248</td>\n",
       "      <td>cellular catabolic process</td>\n",
       "      <td>4.903740e-35</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>2314</td>\n",
       "      <td>745</td>\n",
       "      <td>228</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.306040</td>\n",
       "      <td>0.098531</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0009056, GO:0044237]</td>\n",
       "      <td>[PON1, RPS20, ZRANB1, CPS1, OTC, AP2S1, ACAA1,...</td>\n",
       "      <td>[[IDA], [TAS], [IMP, IBA], [IMP], [IDA], [TAS]...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0017144</td>\n",
       "      <td>drug metabolic process</td>\n",
       "      <td>1.047816e-34</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways involving...</td>\n",
       "      <td>600</td>\n",
       "      <td>745</td>\n",
       "      <td>106</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.142282</td>\n",
       "      <td>0.176667</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0044237]</td>\n",
       "      <td>[SLC25A13, CPS1, ACAA1, MAOB, RORA, ST6GAL1, A...</td>\n",
       "      <td>[[IDA], [IMP], [TAS], [TAS, NAS, IEA], [IEA], ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>REAC</td>\n",
       "      <td>REAC:R-HSA-611105</td>\n",
       "      <td>Respiratory electron transport</td>\n",
       "      <td>7.567367e-34</td>\n",
       "      <td>True</td>\n",
       "      <td>Respiratory electron transport</td>\n",
       "      <td>100</td>\n",
       "      <td>553</td>\n",
       "      <td>49</td>\n",
       "      <td>10594</td>\n",
       "      <td>0.088608</td>\n",
       "      <td>0.490000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[REAC:R-HSA-163200]</td>\n",
       "      <td>[NDUFAB1, UQCRC1, NDUFB2, ETFB, COX6A1, NDUFS7...</td>\n",
       "      <td>[[REAC], [REAC], [REAC], [REAC], [REAC], [REAC...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0009063</td>\n",
       "      <td>cellular amino acid catabolic process</td>\n",
       "      <td>2.391782e-33</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>129</td>\n",
       "      <td>745</td>\n",
       "      <td>51</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.068456</td>\n",
       "      <td>0.395349</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0006520, GO:0046395, GO:1901565]</td>\n",
       "      <td>[OTC, HSD17B10, ACAT1, BCKDHB, TXN2, GSTZ1, FA...</td>\n",
       "      <td>[[IDA], [TAS], [IMP, TAS], [IMP, IBA, TAS], [T...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>GO:CC</td>\n",
       "      <td>GO:0070469</td>\n",
       "      <td>respirasome</td>\n",
       "      <td>5.293353e-33</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The protein complexes that form the electron ...</td>\n",
       "      <td>101</td>\n",
       "      <td>774</td>\n",
       "      <td>45</td>\n",
       "      <td>18856</td>\n",
       "      <td>0.058140</td>\n",
       "      <td>0.445545</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0016020, GO:0110165]</td>\n",
       "      <td>[NDUFAB1, UQCRC1, NDUFB2, COX6A1, COX7A2, NNT,...</td>\n",
       "      <td>[[IDA, ISS, NAS, IEA], [TAS, IEA], [IDA, IBA, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>891</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0046874</td>\n",
       "      <td>quinolinate metabolic process</td>\n",
       "      <td>3.593839e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways involving...</td>\n",
       "      <td>5</td>\n",
       "      <td>745</td>\n",
       "      <td>4</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.005369</td>\n",
       "      <td>0.800000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0017144, GO:0043648, GO:0072524]</td>\n",
       "      <td>[QPRT, KMO, ACMSD, HAAO]</td>\n",
       "      <td>[[IDA, IBA, IEA], [IEA], [IDA, IEA], [IDA, IBA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>892</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0006572</td>\n",
       "      <td>tyrosine catabolic process</td>\n",
       "      <td>3.593839e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>5</td>\n",
       "      <td>745</td>\n",
       "      <td>4</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.005369</td>\n",
       "      <td>0.800000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0006570, GO:0009074, GO:1901606]</td>\n",
       "      <td>[GSTZ1, FAH, HGD, HPD]</td>\n",
       "      <td>[[IEA], [IBA, TAS, IEA], [TAS, IEA], [ISS, IBA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>893</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0010901</td>\n",
       "      <td>regulation of very-low-density lipoprotein par...</td>\n",
       "      <td>3.593839e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Any process that modulates the rate, frequenc...</td>\n",
       "      <td>5</td>\n",
       "      <td>745</td>\n",
       "      <td>4</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.005369</td>\n",
       "      <td>0.800000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0034372, GO:0051128, GO:0051239]</td>\n",
       "      <td>[APOA5, APOC3, APOA1, APOA2]</td>\n",
       "      <td>[[IDA], [IDA, IC], [IDA], [IDA]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>894</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0043691</td>\n",
       "      <td>reverse cholesterol transport</td>\n",
       "      <td>3.657633e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The directed movement of peripheral cell chol...</td>\n",
       "      <td>21</td>\n",
       "      <td>745</td>\n",
       "      <td>7</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.009396</td>\n",
       "      <td>0.333333</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0030301]</td>\n",
       "      <td>[APOC3, APOA1, APOE, APOA2, ABCA1, APOM, LCAT]</td>\n",
       "      <td>[[IC], [IMP, IBA], [IDA], [IDA], [IMP, IEA], [...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>895</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0006067</td>\n",
       "      <td>ethanol metabolic process</td>\n",
       "      <td>3.657633e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways involving...</td>\n",
       "      <td>21</td>\n",
       "      <td>745</td>\n",
       "      <td>7</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.009396</td>\n",
       "      <td>0.333333</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0016999, GO:0034308]</td>\n",
       "      <td>[SULT2A1, ALDH2, ADH6, ADH1A, ADH1B, SULT1A2, ...</td>\n",
       "      <td>[[IDA], [TAS, IEA], [IDA, IBA, TAS], [IBA, TAS...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>896</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0017171</td>\n",
       "      <td>serine hydrolase activity</td>\n",
       "      <td>3.725912e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Catalysis of the hydrolysis of a substrate by...</td>\n",
       "      <td>191</td>\n",
       "      <td>761</td>\n",
       "      <td>21</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.027595</td>\n",
       "      <td>0.109948</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0016825]</td>\n",
       "      <td>[MASP2, F7, F11, LONP2, HPN, HGFAC, PROC, CLPP...</td>\n",
       "      <td>[[IDA, IBA, IEA], [IDA, TAS, IEA], [TAS, NAS, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>897</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0016825</td>\n",
       "      <td>hydrolase activity, acting on acid phosphorus-...</td>\n",
       "      <td>3.725912e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Catalysis of the hydrolysis of any acid phosp...</td>\n",
       "      <td>191</td>\n",
       "      <td>761</td>\n",
       "      <td>21</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.027595</td>\n",
       "      <td>0.109948</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0016787]</td>\n",
       "      <td>[MASP2, F7, F11, LONP2, HPN, HGFAC, PROC, CLPP...</td>\n",
       "      <td>[[IDA, IBA, IEA], [IDA, TAS, IEA], [TAS, NAS, ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>898</th>\n",
       "      <td>REAC</td>\n",
       "      <td>REAC:R-HSA-159740</td>\n",
       "      <td>Gamma-carboxylation of protein precursors</td>\n",
       "      <td>3.740293e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>Gamma-carboxylation of protein precursors</td>\n",
       "      <td>10</td>\n",
       "      <td>553</td>\n",
       "      <td>5</td>\n",
       "      <td>10594</td>\n",
       "      <td>0.009042</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[REAC:R-HSA-159854]</td>\n",
       "      <td>[F7, PROC, F10, F2, PROS1]</td>\n",
       "      <td>[[REAC], [REAC], [REAC], [REAC], [REAC]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>899</th>\n",
       "      <td>REAC</td>\n",
       "      <td>REAC:R-HSA-159782</td>\n",
       "      <td>Removal of aminoterminal propeptides from gamm...</td>\n",
       "      <td>3.740293e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>Removal of aminoterminal propeptides from gamm...</td>\n",
       "      <td>10</td>\n",
       "      <td>553</td>\n",
       "      <td>5</td>\n",
       "      <td>10594</td>\n",
       "      <td>0.009042</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[REAC:R-HSA-159854]</td>\n",
       "      <td>[F7, PROC, F10, F2, PROS1]</td>\n",
       "      <td>[[REAC], [REAC], [REAC], [REAC], [REAC]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>900</th>\n",
       "      <td>HP</td>\n",
       "      <td>HP:0004431</td>\n",
       "      <td>Complement deficiency</td>\n",
       "      <td>3.865265e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>An immunodeficiency defined by the absent or s...</td>\n",
       "      <td>27</td>\n",
       "      <td>271</td>\n",
       "      <td>9</td>\n",
       "      <td>4225</td>\n",
       "      <td>0.033210</td>\n",
       "      <td>0.333333</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[HP:0005339]</td>\n",
       "      <td>[CFH, MASP2, C6, C5, C9, C3, C1R, CFI, CFB]</td>\n",
       "      <td>[[HP], [HP], [HP], [HP], [HP], [HP], [HP], [HP...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>901</th>\n",
       "      <td>KEGG</td>\n",
       "      <td>KEGG:00360</td>\n",
       "      <td>Phenylalanine metabolism</td>\n",
       "      <td>3.897963e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>Phenylalanine metabolism</td>\n",
       "      <td>17</td>\n",
       "      <td>475</td>\n",
       "      <td>6</td>\n",
       "      <td>7788</td>\n",
       "      <td>0.012632</td>\n",
       "      <td>0.352941</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[KEGG:00000]</td>\n",
       "      <td>[MAOB, GOT1, GOT2, GLYAT, HPD, PAH]</td>\n",
       "      <td>[[KEGG], [KEGG], [KEGG], [KEGG], [KEGG], [KEGG]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>902</th>\n",
       "      <td>CORUM</td>\n",
       "      <td>CORUM:2905</td>\n",
       "      <td>Respiratory chain complex I (intermediate), mi...</td>\n",
       "      <td>4.008476e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>Respiratory chain complex I (intermediate), mi...</td>\n",
       "      <td>11</td>\n",
       "      <td>174</td>\n",
       "      <td>5</td>\n",
       "      <td>3629</td>\n",
       "      <td>0.028736</td>\n",
       "      <td>0.454545</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[CORUM:0000000]</td>\n",
       "      <td>[NDUFS7, NDUFA2, NDUFS5, NDUFV2, NDUFS3]</td>\n",
       "      <td>[[CORUM], [CORUM], [CORUM], [CORUM], [CORUM]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>903</th>\n",
       "      <td>HP</td>\n",
       "      <td>HP:0010895</td>\n",
       "      <td>Abnormal circulating glycine concentration</td>\n",
       "      <td>4.093377e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>Any deviation from the normal concentration of...</td>\n",
       "      <td>16</td>\n",
       "      <td>271</td>\n",
       "      <td>7</td>\n",
       "      <td>4225</td>\n",
       "      <td>0.025830</td>\n",
       "      <td>0.437500</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[HP:0010894]</td>\n",
       "      <td>[PNPO, PCCB, MMAB, AMT, MUT, MMAA, GLYCTK]</td>\n",
       "      <td>[[HP], [HP], [HP], [HP], [HP], [HP], [HP]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>904</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0001936</td>\n",
       "      <td>regulation of endothelial cell proliferation</td>\n",
       "      <td>4.190408e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Any process that modulates the frequency, rat...</td>\n",
       "      <td>178</td>\n",
       "      <td>745</td>\n",
       "      <td>21</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.028188</td>\n",
       "      <td>0.117978</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0001935, GO:0050678]</td>\n",
       "      <td>[APOH, PROX1, APOE, XDH, LRG1, ANG, hsa-mir-10...</td>\n",
       "      <td>[[IDA], [IDA], [IDA], [IDA], [IEA], [IDA], [ID...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>905</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0006956</td>\n",
       "      <td>complement activation</td>\n",
       "      <td>4.190408e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Any process involved in the activation of any...</td>\n",
       "      <td>178</td>\n",
       "      <td>745</td>\n",
       "      <td>21</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.028188</td>\n",
       "      <td>0.117978</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0002252, GO:0002253, GO:0006959]</td>\n",
       "      <td>[CFH, MASP2, C6, CPB2, C5, VTN, C9, C4BPB, C3,...</td>\n",
       "      <td>[[IDA, TAS, IEA], [IDA, TAS, IEA], [TAS, IEA],...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>906</th>\n",
       "      <td>REAC</td>\n",
       "      <td>REAC:R-HSA-5365859</td>\n",
       "      <td>RA biosynthesis pathway</td>\n",
       "      <td>4.232697e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>RA biosynthesis pathway</td>\n",
       "      <td>22</td>\n",
       "      <td>553</td>\n",
       "      <td>7</td>\n",
       "      <td>10594</td>\n",
       "      <td>0.012658</td>\n",
       "      <td>0.318182</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[REAC:R-HSA-5362517]</td>\n",
       "      <td>[ALDH8A1, RDH5, RDH16, DHRS4, DHRS3, ADH1A, ADH4]</td>\n",
       "      <td>[[REAC], [REAC], [REAC], [REAC], [REAC], [REAC...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>907</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0061134</td>\n",
       "      <td>peptidase regulator activity</td>\n",
       "      <td>4.271062e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Modulates the activity of a peptidase, any en...</td>\n",
       "      <td>222</td>\n",
       "      <td>761</td>\n",
       "      <td>23</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.030223</td>\n",
       "      <td>0.103604</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0030234]</td>\n",
       "      <td>[ITIH4, ITIH1, PEBP1, FETUB, SERPIND1, SERPINA...</td>\n",
       "      <td>[[TAS, IEA], [IEA], [IEA], [ISS, IBA, IEA], [I...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>908</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0071949</td>\n",
       "      <td>FAD binding</td>\n",
       "      <td>4.319968e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Interacting selectively and non-covalently wi...</td>\n",
       "      <td>34</td>\n",
       "      <td>761</td>\n",
       "      <td>8</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.010512</td>\n",
       "      <td>0.235294</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0050660]</td>\n",
       "      <td>[DAO, KMO, AOX1, XDH, ACOX1, LDHD, ACOX2, PRODH2]</td>\n",
       "      <td>[[IDA, IEA], [IDA, IEA], [IEA], [IEA], [IEA], ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>909</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0016229</td>\n",
       "      <td>steroid dehydrogenase activity</td>\n",
       "      <td>4.319968e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Catalysis of an oxidation-reduction (redox) r...</td>\n",
       "      <td>34</td>\n",
       "      <td>761</td>\n",
       "      <td>8</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.010512</td>\n",
       "      <td>0.235294</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0016491]</td>\n",
       "      <td>[HSD17B6, HSD17B10, HSD3B7, HSD17B4, RDH5, RDH...</td>\n",
       "      <td>[[IEA], [IDA, TAS, IEA], [TAS, NAS, IEA], [IDA...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>910</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:1901607</td>\n",
       "      <td>alpha-amino acid biosynthetic process</td>\n",
       "      <td>4.499553e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>67</td>\n",
       "      <td>745</td>\n",
       "      <td>12</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.016107</td>\n",
       "      <td>0.179104</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0008652, GO:1901605]</td>\n",
       "      <td>[CPS1, OTC, MTHFD1, AGXT2, GOT1, GOT2, BHMT2, ...</td>\n",
       "      <td>[[NAS], [IDA, IBA, IEA], [IMP, IEA], [IDA], [I...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>911</th>\n",
       "      <td>HP</td>\n",
       "      <td>HP:0001397</td>\n",
       "      <td>Hepatic steatosis</td>\n",
       "      <td>4.566141e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>The presence of steatosis in the liver.</td>\n",
       "      <td>106</td>\n",
       "      <td>271</td>\n",
       "      <td>19</td>\n",
       "      <td>4225</td>\n",
       "      <td>0.070111</td>\n",
       "      <td>0.179245</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[HP:0006561]</td>\n",
       "      <td>[SLC25A13, PGM1, APOB, PCK2, ETFB, ACADM, ATP7...</td>\n",
       "      <td>[[HP], [HP], [HP], [HP], [HP], [HP], [HP], [HP...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>912</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0000098</td>\n",
       "      <td>sulfur amino acid catabolic process</td>\n",
       "      <td>4.607695e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"The chemical reactions and pathways resulting...</td>\n",
       "      <td>15</td>\n",
       "      <td>745</td>\n",
       "      <td>6</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.008054</td>\n",
       "      <td>0.400000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0000096, GO:0009063, GO:0044273]</td>\n",
       "      <td>[TXN2, PCYOX1, MPST, TST, CDO1, MAT1A]</td>\n",
       "      <td>[[TAS], [IEA], [TAS], [TAS], [IBA, TAS, IEA], ...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>913</th>\n",
       "      <td>TF</td>\n",
       "      <td>TF:M10055_1</td>\n",
       "      <td>Factor: RXR-alpha; motif: NNGNNRNNNARAGGTCANNG...</td>\n",
       "      <td>4.656763e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>Factor: RXR-alpha; motif: NNGNNRNNNARAGGTCANNG...</td>\n",
       "      <td>1104</td>\n",
       "      <td>743</td>\n",
       "      <td>70</td>\n",
       "      <td>19945</td>\n",
       "      <td>0.094213</td>\n",
       "      <td>0.063406</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[TF:M10055_0]</td>\n",
       "      <td>[IL32, SLC6A13, PEBP1, HSD3B7, EMC9, SEC23A, S...</td>\n",
       "      <td>[[TF], [TF], [TF], [TF], [TF], [TF], [TF], [TF...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>914</th>\n",
       "      <td>REAC</td>\n",
       "      <td>REAC:R-HSA-159418</td>\n",
       "      <td>Recycling of bile acids and salts</td>\n",
       "      <td>4.881600e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>Recycling of bile acids and salts</td>\n",
       "      <td>16</td>\n",
       "      <td>553</td>\n",
       "      <td>6</td>\n",
       "      <td>10594</td>\n",
       "      <td>0.010850</td>\n",
       "      <td>0.375000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[REAC:R-HSA-194068]</td>\n",
       "      <td>[SLC27A5, SLC10A1, SLCO1B1, BAAT, ALB, STARD5]</td>\n",
       "      <td>[[REAC], [REAC], [REAC], [REAC], [REAC], [REAC]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>915</th>\n",
       "      <td>GO:BP</td>\n",
       "      <td>GO:0090050</td>\n",
       "      <td>positive regulation of cell migration involved...</td>\n",
       "      <td>4.895846e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Any process that increases the frequency, rat...</td>\n",
       "      <td>38</td>\n",
       "      <td>745</td>\n",
       "      <td>9</td>\n",
       "      <td>17906</td>\n",
       "      <td>0.012081</td>\n",
       "      <td>0.236842</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0002042, GO:0043536, GO:0090049, GO:1903672]</td>\n",
       "      <td>[hsa-mir-101-1, hsa-mir-101-2, hsa-mir-10a, hs...</td>\n",
       "      <td>[[IDA], [IDA], [IGI], [IGI], [IDA, ISS], [IGI]...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>916</th>\n",
       "      <td>CORUM</td>\n",
       "      <td>CORUM:6417</td>\n",
       "      <td>Fibrinogen complex</td>\n",
       "      <td>4.973539e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>Fibrinogen complex</td>\n",
       "      <td>3</td>\n",
       "      <td>174</td>\n",
       "      <td>3</td>\n",
       "      <td>3629</td>\n",
       "      <td>0.017241</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[CORUM:0000000]</td>\n",
       "      <td>[FGG, FGA, FGB]</td>\n",
       "      <td>[[CORUM], [CORUM], [CORUM]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>917</th>\n",
       "      <td>CORUM</td>\n",
       "      <td>CORUM:6405</td>\n",
       "      <td>MITRAC12-SURF1-COX1 complex</td>\n",
       "      <td>4.973539e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>MITRAC12-SURF1-COX1 complex</td>\n",
       "      <td>3</td>\n",
       "      <td>174</td>\n",
       "      <td>3</td>\n",
       "      <td>3629</td>\n",
       "      <td>0.017241</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[CORUM:0000000]</td>\n",
       "      <td>[SURF1, COA3, MT-CO1]</td>\n",
       "      <td>[[CORUM], [CORUM], [CORUM]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>918</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0004165</td>\n",
       "      <td>dodecenoyl-CoA delta-isomerase activity</td>\n",
       "      <td>4.981318e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Catalysis of the reaction: 3-cis-dodecenoyl-C...</td>\n",
       "      <td>3</td>\n",
       "      <td>761</td>\n",
       "      <td>3</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.003942</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0016863]</td>\n",
       "      <td>[EHHADH, ECI1, ECI2]</td>\n",
       "      <td>[[IEA], [NAS, IEA], [IEA]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>919</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0008431</td>\n",
       "      <td>vitamin E binding</td>\n",
       "      <td>4.981318e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Interacting selectively and non-covalently wi...</td>\n",
       "      <td>3</td>\n",
       "      <td>761</td>\n",
       "      <td>3</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.003942</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0019842, GO:0097159, GO:1901363]</td>\n",
       "      <td>[AFM, SEC14L2, TTPA]</td>\n",
       "      <td>[[IDA, IPI, IBA], [NAS], [ISS, IBA, TAS, IEA]]</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>920</th>\n",
       "      <td>GO:MF</td>\n",
       "      <td>GO:0070653</td>\n",
       "      <td>high-density lipoprotein particle receptor bin...</td>\n",
       "      <td>4.981318e-02</td>\n",
       "      <td>True</td>\n",
       "      <td>\"Interacting selectively and non-covalently wi...</td>\n",
       "      <td>3</td>\n",
       "      <td>761</td>\n",
       "      <td>3</td>\n",
       "      <td>18126</td>\n",
       "      <td>0.003942</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>query_1</td>\n",
       "      <td>[GO:0070325]</td>\n",
       "      <td>[APOC3, APOA1, APOA2]</td>\n",
       "      <td>[[IPI, IBA], [IPI, IBA], [IPI, IBA]]</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>921 rows × 16 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "    source              native  \\\n",
       "0     REAC  REAC:R-HSA-1430728   \n",
       "1    GO:BP          GO:0055114   \n",
       "2    GO:MF          GO:0016491   \n",
       "3    GO:BP          GO:0046395   \n",
       "4    GO:BP          GO:0016054   \n",
       "5    GO:BP          GO:0044281   \n",
       "6    GO:CC          GO:0005739   \n",
       "7    GO:BP          GO:0044282   \n",
       "8    GO:BP          GO:0019752   \n",
       "9    GO:BP          GO:0043436   \n",
       "10   GO:BP          GO:0006082   \n",
       "11    KEGG          KEGG:01100   \n",
       "12    REAC    REAC:R-HSA-71291   \n",
       "13   GO:BP          GO:0022900   \n",
       "14   GO:CC          GO:0005743   \n",
       "15   GO:CC          GO:0005759   \n",
       "16   GO:BP          GO:0032787   \n",
       "17   GO:CC          GO:0019866   \n",
       "18   GO:CC          GO:0005740   \n",
       "19   GO:BP          GO:0022904   \n",
       "20   GO:BP          GO:0006091   \n",
       "21   GO:BP          GO:1901575   \n",
       "22   GO:CC          GO:0031966   \n",
       "23   GO:BP          GO:0009056   \n",
       "24   GO:BP          GO:0072329   \n",
       "25   GO:BP          GO:0044248   \n",
       "26   GO:BP          GO:0017144   \n",
       "27    REAC   REAC:R-HSA-611105   \n",
       "28   GO:BP          GO:0009063   \n",
       "29   GO:CC          GO:0070469   \n",
       "..     ...                 ...   \n",
       "891  GO:BP          GO:0046874   \n",
       "892  GO:BP          GO:0006572   \n",
       "893  GO:BP          GO:0010901   \n",
       "894  GO:BP          GO:0043691   \n",
       "895  GO:BP          GO:0006067   \n",
       "896  GO:MF          GO:0017171   \n",
       "897  GO:MF          GO:0016825   \n",
       "898   REAC   REAC:R-HSA-159740   \n",
       "899   REAC   REAC:R-HSA-159782   \n",
       "900     HP          HP:0004431   \n",
       "901   KEGG          KEGG:00360   \n",
       "902  CORUM          CORUM:2905   \n",
       "903     HP          HP:0010895   \n",
       "904  GO:BP          GO:0001936   \n",
       "905  GO:BP          GO:0006956   \n",
       "906   REAC  REAC:R-HSA-5365859   \n",
       "907  GO:MF          GO:0061134   \n",
       "908  GO:MF          GO:0071949   \n",
       "909  GO:MF          GO:0016229   \n",
       "910  GO:BP          GO:1901607   \n",
       "911     HP          HP:0001397   \n",
       "912  GO:BP          GO:0000098   \n",
       "913     TF         TF:M10055_1   \n",
       "914   REAC   REAC:R-HSA-159418   \n",
       "915  GO:BP          GO:0090050   \n",
       "916  CORUM          CORUM:6417   \n",
       "917  CORUM          CORUM:6405   \n",
       "918  GO:MF          GO:0004165   \n",
       "919  GO:MF          GO:0008431   \n",
       "920  GO:MF          GO:0070653   \n",
       "\n",
       "                                                  name       p_value  \\\n",
       "0                                           Metabolism  4.866241e-87   \n",
       "1                          oxidation-reduction process  3.009886e-82   \n",
       "2                              oxidoreductase activity  1.542436e-73   \n",
       "3                    carboxylic acid catabolic process  4.026219e-65   \n",
       "4                       organic acid catabolic process  4.026219e-65   \n",
       "5                     small molecule metabolic process  6.617864e-62   \n",
       "6                                        mitochondrion  3.312159e-60   \n",
       "7                     small molecule catabolic process  8.601402e-60   \n",
       "8                    carboxylic acid metabolic process  3.406416e-58   \n",
       "9                            oxoacid metabolic process  5.231939e-57   \n",
       "10                      organic acid metabolic process  1.526251e-56   \n",
       "11                                  Metabolic pathways  1.763580e-48   \n",
       "12           Metabolism of amino acids and derivatives  4.121741e-44   \n",
       "13                            electron transport chain  1.750555e-43   \n",
       "14                        mitochondrial inner membrane  1.051425e-42   \n",
       "15                                mitochondrial matrix  1.133647e-40   \n",
       "16               monocarboxylic acid metabolic process  1.379676e-39   \n",
       "17                            organelle inner membrane  2.497385e-39   \n",
       "18                              mitochondrial envelope  3.184945e-39   \n",
       "19                respiratory electron transport chain  5.605852e-37   \n",
       "20      generation of precursor metabolites and energy  2.109517e-36   \n",
       "21                 organic substance catabolic process  2.408112e-36   \n",
       "22                              mitochondrial membrane  4.077199e-36   \n",
       "23                                   catabolic process  8.014430e-36   \n",
       "24               monocarboxylic acid catabolic process  1.388879e-35   \n",
       "25                          cellular catabolic process  4.903740e-35   \n",
       "26                              drug metabolic process  1.047816e-34   \n",
       "27                      Respiratory electron transport  7.567367e-34   \n",
       "28               cellular amino acid catabolic process  2.391782e-33   \n",
       "29                                         respirasome  5.293353e-33   \n",
       "..                                                 ...           ...   \n",
       "891                      quinolinate metabolic process  3.593839e-02   \n",
       "892                         tyrosine catabolic process  3.593839e-02   \n",
       "893  regulation of very-low-density lipoprotein par...  3.593839e-02   \n",
       "894                      reverse cholesterol transport  3.657633e-02   \n",
       "895                          ethanol metabolic process  3.657633e-02   \n",
       "896                          serine hydrolase activity  3.725912e-02   \n",
       "897  hydrolase activity, acting on acid phosphorus-...  3.725912e-02   \n",
       "898          Gamma-carboxylation of protein precursors  3.740293e-02   \n",
       "899  Removal of aminoterminal propeptides from gamm...  3.740293e-02   \n",
       "900                              Complement deficiency  3.865265e-02   \n",
       "901                           Phenylalanine metabolism  3.897963e-02   \n",
       "902  Respiratory chain complex I (intermediate), mi...  4.008476e-02   \n",
       "903         Abnormal circulating glycine concentration  4.093377e-02   \n",
       "904       regulation of endothelial cell proliferation  4.190408e-02   \n",
       "905                              complement activation  4.190408e-02   \n",
       "906                            RA biosynthesis pathway  4.232697e-02   \n",
       "907                       peptidase regulator activity  4.271062e-02   \n",
       "908                                        FAD binding  4.319968e-02   \n",
       "909                     steroid dehydrogenase activity  4.319968e-02   \n",
       "910              alpha-amino acid biosynthetic process  4.499553e-02   \n",
       "911                                  Hepatic steatosis  4.566141e-02   \n",
       "912                sulfur amino acid catabolic process  4.607695e-02   \n",
       "913  Factor: RXR-alpha; motif: NNGNNRNNNARAGGTCANNG...  4.656763e-02   \n",
       "914                  Recycling of bile acids and salts  4.881600e-02   \n",
       "915  positive regulation of cell migration involved...  4.895846e-02   \n",
       "916                                 Fibrinogen complex  4.973539e-02   \n",
       "917                        MITRAC12-SURF1-COX1 complex  4.973539e-02   \n",
       "918            dodecenoyl-CoA delta-isomerase activity  4.981318e-02   \n",
       "919                                  vitamin E binding  4.981318e-02   \n",
       "920  high-density lipoprotein particle receptor bin...  4.981318e-02   \n",
       "\n",
       "     significant                                        description  \\\n",
       "0           True                                         Metabolism   \n",
       "1           True  \"A metabolic process that results in the remov...   \n",
       "2           True  \"Catalysis of an oxidation-reduction (redox) r...   \n",
       "3           True  \"The chemical reactions and pathways resulting...   \n",
       "4           True  \"The chemical reactions and pathways resulting...   \n",
       "5           True  \"The chemical reactions and pathways involving...   \n",
       "6           True  \"A semiautonomous, self replicating organelle ...   \n",
       "7           True  \"The chemical reactions and pathways resulting...   \n",
       "8           True  \"The chemical reactions and pathways involving...   \n",
       "9           True  \"The chemical reactions and pathways involving...   \n",
       "10          True  \"The chemical reactions and pathways involving...   \n",
       "11          True                                 Metabolic pathways   \n",
       "12          True          Metabolism of amino acids and derivatives   \n",
       "13          True  \"A process in which a series of electron carri...   \n",
       "14          True  \"The inner, i.e. lumen-facing, lipid bilayer o...   \n",
       "15          True  \"The gel-like material, with considerable fine...   \n",
       "16          True  \"The chemical reactions and pathways involving...   \n",
       "17          True  \"The inner, i.e. lumen-facing, lipid bilayer o...   \n",
       "18          True  \"The double lipid bilayer enclosing the mitoch...   \n",
       "19          True  \"A process in which a series of electron carri...   \n",
       "20          True  \"The chemical reactions and pathways resulting...   \n",
       "21          True  \"The chemical reactions and pathways resulting...   \n",
       "22          True  \"Either of the lipid bilayers that surround th...   \n",
       "23          True  \"The chemical reactions and pathways resulting...   \n",
       "24          True  \"The chemical reactions and pathways resulting...   \n",
       "25          True  \"The chemical reactions and pathways resulting...   \n",
       "26          True  \"The chemical reactions and pathways involving...   \n",
       "27          True                     Respiratory electron transport   \n",
       "28          True  \"The chemical reactions and pathways resulting...   \n",
       "29          True  \"The protein complexes that form the electron ...   \n",
       "..           ...                                                ...   \n",
       "891         True  \"The chemical reactions and pathways involving...   \n",
       "892         True  \"The chemical reactions and pathways resulting...   \n",
       "893         True  \"Any process that modulates the rate, frequenc...   \n",
       "894         True  \"The directed movement of peripheral cell chol...   \n",
       "895         True  \"The chemical reactions and pathways involving...   \n",
       "896         True  \"Catalysis of the hydrolysis of a substrate by...   \n",
       "897         True  \"Catalysis of the hydrolysis of any acid phosp...   \n",
       "898         True          Gamma-carboxylation of protein precursors   \n",
       "899         True  Removal of aminoterminal propeptides from gamm...   \n",
       "900         True  An immunodeficiency defined by the absent or s...   \n",
       "901         True                           Phenylalanine metabolism   \n",
       "902         True  Respiratory chain complex I (intermediate), mi...   \n",
       "903         True  Any deviation from the normal concentration of...   \n",
       "904         True  \"Any process that modulates the frequency, rat...   \n",
       "905         True  \"Any process involved in the activation of any...   \n",
       "906         True                            RA biosynthesis pathway   \n",
       "907         True  \"Modulates the activity of a peptidase, any en...   \n",
       "908         True  \"Interacting selectively and non-covalently wi...   \n",
       "909         True  \"Catalysis of an oxidation-reduction (redox) r...   \n",
       "910         True  \"The chemical reactions and pathways resulting...   \n",
       "911         True            The presence of steatosis in the liver.   \n",
       "912         True  \"The chemical reactions and pathways resulting...   \n",
       "913         True  Factor: RXR-alpha; motif: NNGNNRNNNARAGGTCANNG...   \n",
       "914         True                  Recycling of bile acids and salts   \n",
       "915         True  \"Any process that increases the frequency, rat...   \n",
       "916         True                                 Fibrinogen complex   \n",
       "917         True                        MITRAC12-SURF1-COX1 complex   \n",
       "918         True  \"Catalysis of the reaction: 3-cis-dodecenoyl-C...   \n",
       "919         True  \"Interacting selectively and non-covalently wi...   \n",
       "920         True  \"Interacting selectively and non-covalently wi...   \n",
       "\n",
       "     term_size  query_size  intersection_size  effective_domain_size  \\\n",
       "0         2072         553                315                  10594   \n",
       "1         1028         745                204                  17906   \n",
       "2          768         761                169                  18126   \n",
       "3          276         745                101                  17906   \n",
       "4          276         745                101                  17906   \n",
       "5         1987         745                253                  17906   \n",
       "6         1631         774                223                  18856   \n",
       "7          447         745                119                  17906   \n",
       "8         1066         745                178                  17906   \n",
       "9         1157         745                184                  17906   \n",
       "10        1177         745                185                  17906   \n",
       "11        1482         475                229                   7788   \n",
       "12         368         553                101                  10594   \n",
       "13         188         745                 69                  17906   \n",
       "14         482         774                103                  18856   \n",
       "15         476         774                100                  18856   \n",
       "16         661         745                118                  17906   \n",
       "17         543         774                105                  18856   \n",
       "18         766         774                125                  18856   \n",
       "19         118         745                 52                  17906   \n",
       "20         544         745                103                  17906   \n",
       "21        2239         745                226                  17906   \n",
       "22         723         774                117                  18856   \n",
       "23        2693         745                252                  17906   \n",
       "24         130         745                 53                  17906   \n",
       "25        2314         745                228                  17906   \n",
       "26         600         745                106                  17906   \n",
       "27         100         553                 49                  10594   \n",
       "28         129         745                 51                  17906   \n",
       "29         101         774                 45                  18856   \n",
       "..         ...         ...                ...                    ...   \n",
       "891          5         745                  4                  17906   \n",
       "892          5         745                  4                  17906   \n",
       "893          5         745                  4                  17906   \n",
       "894         21         745                  7                  17906   \n",
       "895         21         745                  7                  17906   \n",
       "896        191         761                 21                  18126   \n",
       "897        191         761                 21                  18126   \n",
       "898         10         553                  5                  10594   \n",
       "899         10         553                  5                  10594   \n",
       "900         27         271                  9                   4225   \n",
       "901         17         475                  6                   7788   \n",
       "902         11         174                  5                   3629   \n",
       "903         16         271                  7                   4225   \n",
       "904        178         745                 21                  17906   \n",
       "905        178         745                 21                  17906   \n",
       "906         22         553                  7                  10594   \n",
       "907        222         761                 23                  18126   \n",
       "908         34         761                  8                  18126   \n",
       "909         34         761                  8                  18126   \n",
       "910         67         745                 12                  17906   \n",
       "911        106         271                 19                   4225   \n",
       "912         15         745                  6                  17906   \n",
       "913       1104         743                 70                  19945   \n",
       "914         16         553                  6                  10594   \n",
       "915         38         745                  9                  17906   \n",
       "916          3         174                  3                   3629   \n",
       "917          3         174                  3                   3629   \n",
       "918          3         761                  3                  18126   \n",
       "919          3         761                  3                  18126   \n",
       "920          3         761                  3                  18126   \n",
       "\n",
       "     precision    recall    query  \\\n",
       "0     0.569620  0.152027  query_1   \n",
       "1     0.273826  0.198444  query_1   \n",
       "2     0.222076  0.220052  query_1   \n",
       "3     0.135570  0.365942  query_1   \n",
       "4     0.135570  0.365942  query_1   \n",
       "5     0.339597  0.127328  query_1   \n",
       "6     0.288114  0.136726  query_1   \n",
       "7     0.159732  0.266219  query_1   \n",
       "8     0.238926  0.166979  query_1   \n",
       "9     0.246980  0.159032  query_1   \n",
       "10    0.248322  0.157179  query_1   \n",
       "11    0.482105  0.154521  query_1   \n",
       "12    0.182640  0.274457  query_1   \n",
       "13    0.092617  0.367021  query_1   \n",
       "14    0.133075  0.213693  query_1   \n",
       "15    0.129199  0.210084  query_1   \n",
       "16    0.158389  0.178517  query_1   \n",
       "17    0.135659  0.193370  query_1   \n",
       "18    0.161499  0.163185  query_1   \n",
       "19    0.069799  0.440678  query_1   \n",
       "20    0.138255  0.189338  query_1   \n",
       "21    0.303356  0.100938  query_1   \n",
       "22    0.151163  0.161826  query_1   \n",
       "23    0.338255  0.093576  query_1   \n",
       "24    0.071141  0.407692  query_1   \n",
       "25    0.306040  0.098531  query_1   \n",
       "26    0.142282  0.176667  query_1   \n",
       "27    0.088608  0.490000  query_1   \n",
       "28    0.068456  0.395349  query_1   \n",
       "29    0.058140  0.445545  query_1   \n",
       "..         ...       ...      ...   \n",
       "891   0.005369  0.800000  query_1   \n",
       "892   0.005369  0.800000  query_1   \n",
       "893   0.005369  0.800000  query_1   \n",
       "894   0.009396  0.333333  query_1   \n",
       "895   0.009396  0.333333  query_1   \n",
       "896   0.027595  0.109948  query_1   \n",
       "897   0.027595  0.109948  query_1   \n",
       "898   0.009042  0.500000  query_1   \n",
       "899   0.009042  0.500000  query_1   \n",
       "900   0.033210  0.333333  query_1   \n",
       "901   0.012632  0.352941  query_1   \n",
       "902   0.028736  0.454545  query_1   \n",
       "903   0.025830  0.437500  query_1   \n",
       "904   0.028188  0.117978  query_1   \n",
       "905   0.028188  0.117978  query_1   \n",
       "906   0.012658  0.318182  query_1   \n",
       "907   0.030223  0.103604  query_1   \n",
       "908   0.010512  0.235294  query_1   \n",
       "909   0.010512  0.235294  query_1   \n",
       "910   0.016107  0.179104  query_1   \n",
       "911   0.070111  0.179245  query_1   \n",
       "912   0.008054  0.400000  query_1   \n",
       "913   0.094213  0.063406  query_1   \n",
       "914   0.010850  0.375000  query_1   \n",
       "915   0.012081  0.236842  query_1   \n",
       "916   0.017241  1.000000  query_1   \n",
       "917   0.017241  1.000000  query_1   \n",
       "918   0.003942  1.000000  query_1   \n",
       "919   0.003942  1.000000  query_1   \n",
       "920   0.003942  1.000000  query_1   \n",
       "\n",
       "                                              parents  \\\n",
       "0                                      [REAC:0000000]   \n",
       "1                                        [GO:0008152]   \n",
       "2                                        [GO:0003824]   \n",
       "3                            [GO:0016054, GO:0019752]   \n",
       "4    [GO:0006082, GO:0044248, GO:0044282, GO:1901575]   \n",
       "5                                        [GO:0008152]   \n",
       "6                            [GO:0005737, GO:0043231]   \n",
       "7                            [GO:0009056, GO:0044281]   \n",
       "8                                        [GO:0043436]   \n",
       "9                                        [GO:0006082]   \n",
       "10               [GO:0044237, GO:0044281, GO:0071704]   \n",
       "11                                       [KEGG:00000]   \n",
       "12                               [REAC:R-HSA-1430728]   \n",
       "13                           [GO:0006091, GO:0055114]   \n",
       "14                           [GO:0019866, GO:0031966]   \n",
       "15                           [GO:0005739, GO:0070013]   \n",
       "16                                       [GO:0019752]   \n",
       "17                           [GO:0031090, GO:0031967]   \n",
       "18                           [GO:0005739, GO:0031967]   \n",
       "19                           [GO:0022900, GO:0045333]   \n",
       "20                                       [GO:0044237]   \n",
       "21                           [GO:0009056, GO:0071704]   \n",
       "22                           [GO:0005740, GO:0031090]   \n",
       "23                                       [GO:0008152]   \n",
       "24                           [GO:0032787, GO:0046395]   \n",
       "25                           [GO:0009056, GO:0044237]   \n",
       "26                                       [GO:0044237]   \n",
       "27                                [REAC:R-HSA-163200]   \n",
       "28               [GO:0006520, GO:0046395, GO:1901565]   \n",
       "29                           [GO:0016020, GO:0110165]   \n",
       "..                                                ...   \n",
       "891              [GO:0017144, GO:0043648, GO:0072524]   \n",
       "892              [GO:0006570, GO:0009074, GO:1901606]   \n",
       "893              [GO:0034372, GO:0051128, GO:0051239]   \n",
       "894                                      [GO:0030301]   \n",
       "895                          [GO:0016999, GO:0034308]   \n",
       "896                                      [GO:0016825]   \n",
       "897                                      [GO:0016787]   \n",
       "898                               [REAC:R-HSA-159854]   \n",
       "899                               [REAC:R-HSA-159854]   \n",
       "900                                      [HP:0005339]   \n",
       "901                                      [KEGG:00000]   \n",
       "902                                   [CORUM:0000000]   \n",
       "903                                      [HP:0010894]   \n",
       "904                          [GO:0001935, GO:0050678]   \n",
       "905              [GO:0002252, GO:0002253, GO:0006959]   \n",
       "906                              [REAC:R-HSA-5362517]   \n",
       "907                                      [GO:0030234]   \n",
       "908                                      [GO:0050660]   \n",
       "909                                      [GO:0016491]   \n",
       "910                          [GO:0008652, GO:1901605]   \n",
       "911                                      [HP:0006561]   \n",
       "912              [GO:0000096, GO:0009063, GO:0044273]   \n",
       "913                                     [TF:M10055_0]   \n",
       "914                               [REAC:R-HSA-194068]   \n",
       "915  [GO:0002042, GO:0043536, GO:0090049, GO:1903672]   \n",
       "916                                   [CORUM:0000000]   \n",
       "917                                   [CORUM:0000000]   \n",
       "918                                      [GO:0016863]   \n",
       "919              [GO:0019842, GO:0097159, GO:1901363]   \n",
       "920                                      [GO:0070325]   \n",
       "\n",
       "                                         intersections  \\\n",
       "0    [NDUFAB1, SLC25A13, PON1, FMO3, MGST1, RPS20, ...   \n",
       "1    [NDUFAB1, SLC25A13, KDM7A, FMO3, MGST1, IYD, U...   \n",
       "2    [NDUFAB1, KDM7A, FMO3, MGST1, IYD, UQCRC1, HSD...   \n",
       "3    [PON1, OTC, ACAA1, HSD17B10, ACAT1, ACACB, BCK...   \n",
       "4    [PON1, OTC, ACAA1, HSD17B10, ACAT1, ACACB, BCK...   \n",
       "5    [NDUFAB1, SLC25A13, PON1, IYD, CPS1, OTC, ITIH...   \n",
       "6    [NDUFAB1, SLC25A13, MGST1, UQCRC1, CPS1, OTC, ...   \n",
       "7    [PON1, OTC, ACAA1, HAGH, HSD17B10, ACAT1, ACAC...   \n",
       "8    [NDUFAB1, PON1, IYD, CPS1, OTC, ITIH4, ITIH1, ...   \n",
       "9    [NDUFAB1, PON1, IYD, CPS1, OTC, ITIH4, ITIH1, ...   \n",
       "10   [NDUFAB1, PON1, IYD, CPS1, OTC, ITIH4, ITIH1, ...   \n",
       "11   [NDUFAB1, MGST1, UQCRC1, CPS1, HSD17B6, OTC, A...   \n",
       "12   [NDUFAB1, SLC25A13, RPS20, IYD, CPS1, OTC, RPL...   \n",
       "13   [NDUFAB1, SLC25A13, UQCRC1, HSD17B6, MAOB, NDU...   \n",
       "14   [NDUFAB1, SLC25A13, UQCRC1, CPS1, OTC, MRPS34,...   \n",
       "15   [NDUFAB1, CPS1, OTC, HAGH, ACSM2B, HSD17B10, M...   \n",
       "16   [NDUFAB1, PON1, ACAA1, HAGH, ACSM2B, ACAT1, AC...   \n",
       "17   [NDUFAB1, SLC25A13, UQCRC1, CPS1, OTC, MRPS34,...   \n",
       "18   [NDUFAB1, SLC25A13, MGST1, UQCRC1, CPS1, OTC, ...   \n",
       "19   [NDUFAB1, SLC25A13, UQCRC1, NDUFB2, ETFB, COX6...   \n",
       "20   [NDUFAB1, SLC25A13, UQCRC1, HSD17B6, MAOB, ACA...   \n",
       "21   [PON1, RPS20, ZRANB1, CPS1, HSD17B6, OTC, AP2S...   \n",
       "22   [NDUFAB1, SLC25A13, MGST1, UQCRC1, CPS1, OTC, ...   \n",
       "23   [PON1, RPS20, ZRANB1, CPS1, HSD17B6, OTC, AP2S...   \n",
       "24   [ACAA1, ACAT1, ACACB, CRAT, PCK2, LONP2, MLYCD...   \n",
       "25   [PON1, RPS20, ZRANB1, CPS1, OTC, AP2S1, ACAA1,...   \n",
       "26   [SLC25A13, CPS1, ACAA1, MAOB, RORA, ST6GAL1, A...   \n",
       "27   [NDUFAB1, UQCRC1, NDUFB2, ETFB, COX6A1, NDUFS7...   \n",
       "28   [OTC, HSD17B10, ACAT1, BCKDHB, TXN2, GSTZ1, FA...   \n",
       "29   [NDUFAB1, UQCRC1, NDUFB2, COX6A1, COX7A2, NNT,...   \n",
       "..                                                 ...   \n",
       "891                           [QPRT, KMO, ACMSD, HAAO]   \n",
       "892                             [GSTZ1, FAH, HGD, HPD]   \n",
       "893                       [APOA5, APOC3, APOA1, APOA2]   \n",
       "894     [APOC3, APOA1, APOE, APOA2, ABCA1, APOM, LCAT]   \n",
       "895  [SULT2A1, ALDH2, ADH6, ADH1A, ADH1B, SULT1A2, ...   \n",
       "896  [MASP2, F7, F11, LONP2, HPN, HGFAC, PROC, CLPP...   \n",
       "897  [MASP2, F7, F11, LONP2, HPN, HGFAC, PROC, CLPP...   \n",
       "898                         [F7, PROC, F10, F2, PROS1]   \n",
       "899                         [F7, PROC, F10, F2, PROS1]   \n",
       "900        [CFH, MASP2, C6, C5, C9, C3, C1R, CFI, CFB]   \n",
       "901                [MAOB, GOT1, GOT2, GLYAT, HPD, PAH]   \n",
       "902           [NDUFS7, NDUFA2, NDUFS5, NDUFV2, NDUFS3]   \n",
       "903         [PNPO, PCCB, MMAB, AMT, MUT, MMAA, GLYCTK]   \n",
       "904  [APOH, PROX1, APOE, XDH, LRG1, ANG, hsa-mir-10...   \n",
       "905  [CFH, MASP2, C6, CPB2, C5, VTN, C9, C4BPB, C3,...   \n",
       "906  [ALDH8A1, RDH5, RDH16, DHRS4, DHRS3, ADH1A, ADH4]   \n",
       "907  [ITIH4, ITIH1, PEBP1, FETUB, SERPIND1, SERPINA...   \n",
       "908  [DAO, KMO, AOX1, XDH, ACOX1, LDHD, ACOX2, PRODH2]   \n",
       "909  [HSD17B6, HSD17B10, HSD3B7, HSD17B4, RDH5, RDH...   \n",
       "910  [CPS1, OTC, MTHFD1, AGXT2, GOT1, GOT2, BHMT2, ...   \n",
       "911  [SLC25A13, PGM1, APOB, PCK2, ETFB, ACADM, ATP7...   \n",
       "912             [TXN2, PCYOX1, MPST, TST, CDO1, MAT1A]   \n",
       "913  [IL32, SLC6A13, PEBP1, HSD3B7, EMC9, SEC23A, S...   \n",
       "914     [SLC27A5, SLC10A1, SLCO1B1, BAAT, ALB, STARD5]   \n",
       "915  [hsa-mir-101-1, hsa-mir-101-2, hsa-mir-10a, hs...   \n",
       "916                                    [FGG, FGA, FGB]   \n",
       "917                              [SURF1, COA3, MT-CO1]   \n",
       "918                               [EHHADH, ECI1, ECI2]   \n",
       "919                               [AFM, SEC14L2, TTPA]   \n",
       "920                              [APOC3, APOA1, APOA2]   \n",
       "\n",
       "                                             evidences  \n",
       "0    [[REAC], [REAC], [REAC], [REAC], [REAC], [REAC...  \n",
       "1    [[TAS, NAS, IEA], [IDA, IBA, IEA], [IEA], [IEA...  \n",
       "2    [[NAS], [IDA, IEA], [IBA, IEA], [IDA], [IDA, I...  \n",
       "3    [[IDA], [IDA], [IMP, IBA, TAS], [TAS], [IMP, I...  \n",
       "4    [[IDA], [IDA], [IMP, IBA, TAS], [TAS], [IMP, I...  \n",
       "5    [[NAS, IEA], [IDA, TAS], [IDA, TAS, IEA], [IDA...  \n",
       "6    [[IDA, ISS, IBA, TAS, NAS, IEA], [IDA, ISS, TA...  \n",
       "7    [[IDA], [IDA], [IMP, IBA, TAS], [IEA], [TAS], ...  \n",
       "8    [[NAS, IEA], [IDA, TAS], [IDA, IBA], [IDA, IBA...  \n",
       "9    [[NAS, IEA], [IDA, TAS], [IDA, IBA], [IDA, IBA...  \n",
       "10   [[NAS, IEA], [IDA, TAS], [IDA, IBA], [IDA, IBA...  \n",
       "11   [[KEGG], [KEGG], [KEGG], [KEGG], [KEGG], [KEGG...  \n",
       "12   [[REAC], [REAC], [REAC], [REAC], [REAC], [REAC...  \n",
       "13   [[TAS, NAS], [IDA, IBA, IEA], [IBA, TAS, IEA],...  \n",
       "14   [[IDA, ISS, TAS, NAS], [ISS, TAS, IEA], [IBA, ...  \n",
       "15   [[IDA, ISS], [IDA, TAS], [TAS, NAS, IEA], [IEA...  \n",
       "16   [[NAS, IEA], [TAS], [IMP, IBA, TAS, IEA], [TAS...  \n",
       "17   [[IDA, ISS, TAS, NAS], [ISS, TAS, IEA], [IBA, ...  \n",
       "18   [[IDA, ISS, TAS, NAS], [ISS, TAS, IEA], [IEA],...  \n",
       "19   [[TAS, NAS], [IDA, IBA, IEA], [IBA, TAS, IEA],...  \n",
       "20   [[TAS, NAS], [IDA, IBA, IEA], [IBA, TAS, IEA],...  \n",
       "21   [[IDA], [TAS], [IMP, IBA], [IMP], [TAS], [IDA]...  \n",
       "22   [[IDA, ISS, TAS, NAS], [ISS, TAS, IEA], [IEA],...  \n",
       "23   [[IDA], [TAS], [IMP, IBA], [IMP], [TAS], [IDA]...  \n",
       "24   [[IMP, IBA, TAS], [IBA, IEA], [IEA], [TAS], [I...  \n",
       "25   [[IDA], [TAS], [IMP, IBA], [IMP], [IDA], [TAS]...  \n",
       "26   [[IDA], [IMP], [TAS], [TAS, NAS, IEA], [IEA], ...  \n",
       "27   [[REAC], [REAC], [REAC], [REAC], [REAC], [REAC...  \n",
       "28   [[IDA], [TAS], [IMP, TAS], [IMP, IBA, TAS], [T...  \n",
       "29   [[IDA, ISS, NAS, IEA], [TAS, IEA], [IDA, IBA, ...  \n",
       "..                                                 ...  \n",
       "891  [[IDA, IBA, IEA], [IEA], [IDA, IEA], [IDA, IBA...  \n",
       "892  [[IEA], [IBA, TAS, IEA], [TAS, IEA], [ISS, IBA...  \n",
       "893                   [[IDA], [IDA, IC], [IDA], [IDA]]  \n",
       "894  [[IC], [IMP, IBA], [IDA], [IDA], [IMP, IEA], [...  \n",
       "895  [[IDA], [TAS, IEA], [IDA, IBA, TAS], [IBA, TAS...  \n",
       "896  [[IDA, IBA, IEA], [IDA, TAS, IEA], [TAS, NAS, ...  \n",
       "897  [[IDA, IBA, IEA], [IDA, TAS, IEA], [TAS, NAS, ...  \n",
       "898           [[REAC], [REAC], [REAC], [REAC], [REAC]]  \n",
       "899           [[REAC], [REAC], [REAC], [REAC], [REAC]]  \n",
       "900  [[HP], [HP], [HP], [HP], [HP], [HP], [HP], [HP...  \n",
       "901   [[KEGG], [KEGG], [KEGG], [KEGG], [KEGG], [KEGG]]  \n",
       "902      [[CORUM], [CORUM], [CORUM], [CORUM], [CORUM]]  \n",
       "903         [[HP], [HP], [HP], [HP], [HP], [HP], [HP]]  \n",
       "904  [[IDA], [IDA], [IDA], [IDA], [IEA], [IDA], [ID...  \n",
       "905  [[IDA, TAS, IEA], [IDA, TAS, IEA], [TAS, IEA],...  \n",
       "906  [[REAC], [REAC], [REAC], [REAC], [REAC], [REAC...  \n",
       "907  [[TAS, IEA], [IEA], [IEA], [ISS, IBA, IEA], [I...  \n",
       "908  [[IDA, IEA], [IDA, IEA], [IEA], [IEA], [IEA], ...  \n",
       "909  [[IEA], [IDA, TAS, IEA], [TAS, NAS, IEA], [IDA...  \n",
       "910  [[NAS], [IDA, IBA, IEA], [IMP, IEA], [IDA], [I...  \n",
       "911  [[HP], [HP], [HP], [HP], [HP], [HP], [HP], [HP...  \n",
       "912  [[TAS], [IEA], [TAS], [TAS], [IBA, TAS, IEA], ...  \n",
       "913  [[TF], [TF], [TF], [TF], [TF], [TF], [TF], [TF...  \n",
       "914   [[REAC], [REAC], [REAC], [REAC], [REAC], [REAC]]  \n",
       "915  [[IDA], [IDA], [IGI], [IGI], [IDA, ISS], [IGI]...  \n",
       "916                        [[CORUM], [CORUM], [CORUM]]  \n",
       "917                        [[CORUM], [CORUM], [CORUM]]  \n",
       "918                         [[IEA], [NAS, IEA], [IEA]]  \n",
       "919     [[IDA, IPI, IBA], [NAS], [ISS, IBA, TAS, IEA]]  \n",
       "920               [[IPI, IBA], [IPI, IBA], [IPI, IBA]]  \n",
       "\n",
       "[921 rows x 16 columns]"
      ]
     },
     "execution_count": 39,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "gp_comm"
   ]
  }
 ],
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