how to accelerate the noise filter by ARSyNbac?

[xflicsu]

I use ARSyNbac to remove the noise of my expression matrix (60 x 130000) with following commond:

arsyn <- ARSyNbac(data_RNA, modelName = "RNA", beta = 0.5, batchEstimation = FALSE, filterNoise = TRUE)

But it spend several hours without finishing this work.

So, how to accelerate this process?

[soniatarazona]

Sorry for the delay in the response. Could you fix the problem? I am wondering whether it might be a matter of memory (130,000 variables). Which is your experimental design?