diff --git a/packages/beacon-node/package.json b/packages/beacon-node/package.json
index b1104d2db75f..c47afa96c908 100644
--- a/packages/beacon-node/package.json
+++ b/packages/beacon-node/package.json
@@ -103,7 +103,7 @@
     "@chainsafe/persistent-merkle-tree": "^0.5.0",
     "@chainsafe/snappy-stream": "^5.1.2",
     "@chainsafe/ssz": "^0.10.2",
-    "@chainsafe/threads": "^1.10.0",
+    "@chainsafe/threads": "^1.11.0",
     "@ethersproject/abi": "^5.7.0",
     "@fastify/bearer-auth": "^9.0.0",
     "@fastify/cors": "^8.2.1",
diff --git a/packages/beacon-node/src/api/rest/base.ts b/packages/beacon-node/src/api/rest/base.ts
index b65e52fd8b01..7f7c03773a9b 100644
--- a/packages/beacon-node/src/api/rest/base.ts
+++ b/packages/beacon-node/src/api/rest/base.ts
@@ -28,6 +28,11 @@ export type RestApiServerMetrics = SocketMetrics & {
   errors: IGauge<"operationId">;
 };
 
+enum Status {
+  Listening = "listening",
+  Closed = "closed",
+}
+
 /**
  * REST API powered by `fastify` server.
  */
@@ -36,6 +41,8 @@ export class RestApiServer {
   protected readonly logger: Logger;
   private readonly activeSockets: HttpActiveSocketsTracker;
 
+  private status = Status.Closed;
+
   constructor(private readonly opts: RestApiServerOpts, modules: RestApiServerModules) {
     // Apply opts defaults
     const {logger, metrics} = modules;
@@ -94,7 +101,8 @@ export class RestApiServer {
     server.addHook("onError", async (req, _res, err) => {
       // Don't log ErrorAborted errors, they happen on node shutdown and are not useful
       // Don't log NodeISSyncing errors, they happen very frequently while syncing and the validator polls duties
-      if (err instanceof ErrorAborted || err instanceof NodeIsSyncing) return;
+      // Don't log eventstream aborted errors if server instance is being closed on node shutdown
+      if (err instanceof ErrorAborted || err instanceof NodeIsSyncing || this.status === Status.Closed) return;
 
       const {operationId} = req.routeConfig as RouteConfig;
 
@@ -114,6 +122,9 @@ export class RestApiServer {
    * Start the REST API server.
    */
   async listen(): Promise<void> {
+    if (this.status === Status.Listening) return;
+    this.status = Status.Listening;
+
     try {
       const host = this.opts.address;
       const address = await this.server.listen({port: this.opts.port, host});
@@ -123,6 +134,7 @@ export class RestApiServer {
       }
     } catch (e) {
       this.logger.error("Error starting REST api server", this.opts, e as Error);
+      this.status = Status.Closed;
       throw e;
     }
   }
@@ -131,6 +143,9 @@ export class RestApiServer {
    * Close the server instance and terminate all existing connections.
    */
   async close(): Promise<void> {
+    if (this.status === Status.Closed) return;
+    this.status = Status.Closed;
+
     // In NodeJS land calling close() only causes new connections to be rejected.
     // Existing connections can prevent .close() from resolving for potentially forever.
     // In Lodestar case when the BeaconNode wants to close we will just abruptly terminate
diff --git a/packages/beacon-node/src/chain/blocks/importBlock.ts b/packages/beacon-node/src/chain/blocks/importBlock.ts
index b06da6dfcdc5..7e091028891b 100644
--- a/packages/beacon-node/src/chain/blocks/importBlock.ts
+++ b/packages/beacon-node/src/chain/blocks/importBlock.ts
@@ -10,9 +10,11 @@ import {
 } from "@lodestar/state-transition";
 import {routes} from "@lodestar/api";
 import {ForkChoiceError, ForkChoiceErrorCode, EpochDifference, AncestorStatus} from "@lodestar/fork-choice";
+import {isErrorAborted} from "@lodestar/utils";
 import {ZERO_HASH_HEX} from "../../constants/index.js";
 import {toCheckpointHex} from "../stateCache/index.js";
 import {isOptimisticBlock} from "../../util/forkChoice.js";
+import {isQueueErrorAborted} from "../../util/queue/index.js";
 import {ChainEvent, ReorgEventData} from "../emitter.js";
 import {REPROCESS_MIN_TIME_TO_NEXT_SLOT_SEC} from "../reprocess.js";
 import {RegenCaller} from "../regen/interface.js";
@@ -317,7 +319,9 @@ export async function importBlock(
           finalizedBlockHash
         )
         .catch((e) => {
-          this.logger.error("Error pushing notifyForkchoiceUpdate()", {headBlockHash, finalizedBlockHash}, e);
+          if (!isErrorAborted(e) && !isQueueErrorAborted(e)) {
+            this.logger.error("Error pushing notifyForkchoiceUpdate()", {headBlockHash, finalizedBlockHash}, e);
+          }
         });
     }
   }
diff --git a/packages/beacon-node/src/chain/blocks/index.ts b/packages/beacon-node/src/chain/blocks/index.ts
index 60e3342385bb..c65f15a5476a 100644
--- a/packages/beacon-node/src/chain/blocks/index.ts
+++ b/packages/beacon-node/src/chain/blocks/index.ts
@@ -1,8 +1,8 @@
 import {WithOptionalBytes, allForks} from "@lodestar/types";
-import {toHex} from "@lodestar/utils";
-import {JobItemQueue} from "../../util/queue/index.js";
+import {toHex, isErrorAborted} from "@lodestar/utils";
+import {JobItemQueue, isQueueErrorAborted} from "../../util/queue/index.js";
 import {Metrics} from "../../metrics/metrics.js";
-import {BlockError, BlockErrorCode} from "../errors/index.js";
+import {BlockError, BlockErrorCode, isBlockErrorAborted} from "../errors/index.js";
 import {BlockProcessOpts} from "../options.js";
 import type {BeaconChain} from "../chain.js";
 import {verifyBlocksInEpoch} from "./verifyBlock.js";
@@ -111,6 +111,10 @@ export async function processBlocks(
       await importBlock.call(this, fullyVerifiedBlock, opts);
     }
   } catch (e) {
+    if (isErrorAborted(e) || isQueueErrorAborted(e) || isBlockErrorAborted(e)) {
+      return; // Ignore
+    }
+
     // above functions should only throw BlockError
     const err = getBlockError(e, blocks[0].block);
 
diff --git a/packages/beacon-node/src/chain/errors/blockError.ts b/packages/beacon-node/src/chain/errors/blockError.ts
index 21fee9dd5511..d9d42fdbc221 100644
--- a/packages/beacon-node/src/chain/errors/blockError.ts
+++ b/packages/beacon-node/src/chain/errors/blockError.ts
@@ -3,6 +3,7 @@ import {LodestarError} from "@lodestar/utils";
 import {toHexString} from "@chainsafe/ssz";
 import {CachedBeaconStateAllForks} from "@lodestar/state-transition";
 import {ExecutePayloadStatus} from "../../execution/engine/interface.js";
+import {QueueErrorCode} from "../../util/queue/index.js";
 import {GossipActionError} from "./gossipValidation.js";
 
 export enum BlockErrorCode {
@@ -116,6 +117,14 @@ export class BlockError extends LodestarError<BlockErrorType> {
   }
 }
 
+export function isBlockErrorAborted(e: unknown): e is BlockError {
+  return (
+    e instanceof BlockError &&
+    e.type.code === BlockErrorCode.EXECUTION_ENGINE_ERROR &&
+    e.type.errorMessage === QueueErrorCode.QUEUE_ABORTED
+  );
+}
+
 export function renderBlockErrorType(type: BlockErrorType): Record<string, string | number | null> {
   switch (type.code) {
     case BlockErrorCode.PRESTATE_MISSING:
diff --git a/packages/beacon-node/src/chain/prepareNextSlot.ts b/packages/beacon-node/src/chain/prepareNextSlot.ts
index 1c7e63e75811..c6f25b1bfc1b 100644
--- a/packages/beacon-node/src/chain/prepareNextSlot.ts
+++ b/packages/beacon-node/src/chain/prepareNextSlot.ts
@@ -2,7 +2,7 @@ import {computeEpochAtSlot, isExecutionStateType, computeTimeAtSlot} from "@lode
 import {ChainForkConfig} from "@lodestar/config";
 import {ForkSeq, SLOTS_PER_EPOCH, ForkExecution} from "@lodestar/params";
 import {Slot} from "@lodestar/types";
-import {Logger, sleep, fromHex} from "@lodestar/utils";
+import {Logger, sleep, fromHex, isErrorAborted} from "@lodestar/utils";
 import {routes} from "@lodestar/api";
 import {GENESIS_SLOT, ZERO_HASH_HEX} from "../constants/constants.js";
 import {Metrics} from "../metrics/index.js";
@@ -172,8 +172,10 @@ export class PrepareNextSlotScheduler {
         }
       }
     } catch (e) {
-      this.metrics?.precomputeNextEpochTransition.count.inc({result: "error"}, 1);
-      this.logger.error("Failed to run prepareForNextSlot", {nextEpoch, isEpochTransition, prepareSlot}, e as Error);
+      if (!isErrorAborted(e)) {
+        this.metrics?.precomputeNextEpochTransition.count.inc({result: "error"}, 1);
+        this.logger.error("Failed to run prepareForNextSlot", {nextEpoch, isEpochTransition, prepareSlot}, e as Error);
+      }
     }
   };
 }
diff --git a/packages/beacon-node/src/eth1/eth1DepositDataTracker.ts b/packages/beacon-node/src/eth1/eth1DepositDataTracker.ts
index c5e8605e83cd..a7fc91fafb06 100644
--- a/packages/beacon-node/src/eth1/eth1DepositDataTracker.ts
+++ b/packages/beacon-node/src/eth1/eth1DepositDataTracker.ts
@@ -162,8 +162,7 @@ export class Eth1DepositDataTracker {
   private async runAutoUpdate(): Promise<void> {
     let lastRunMs = 0;
 
-    // eslint-disable-next-line no-constant-condition
-    while (true) {
+    while (!this.signal.aborted) {
       lastRunMs = Date.now();
 
       try {
diff --git a/packages/beacon-node/src/node/nodejs.ts b/packages/beacon-node/src/node/nodejs.ts
index 7ea931dd8220..14243be2efa1 100644
--- a/packages/beacon-node/src/node/nodejs.ts
+++ b/packages/beacon-node/src/node/nodejs.ts
@@ -4,6 +4,7 @@ import {Registry} from "prom-client";
 import {PeerId} from "@libp2p/interface-peer-id";
 import {BeaconConfig} from "@lodestar/config";
 import {phase0} from "@lodestar/types";
+import {sleep} from "@lodestar/utils";
 import {LoggerNode} from "@lodestar/logger/node";
 import {Api, ServerApi} from "@lodestar/api";
 import {BeaconStateAllForks} from "@lodestar/state-transition";
@@ -74,6 +75,12 @@ enum LoggerModule {
   sync = "sync",
 }
 
+/**
+ * Short delay before closing db to give async operations sufficient time to complete
+ * and prevent "Database is not open" errors when shutting down beacon node.
+ */
+const DELAY_BEFORE_CLOSING_DB_MS = 500;
+
 /**
  * The main Beacon Node class.  Contains various components for getting and processing data from the
  * Ethereum Consensus ecosystem as well as systems for getting beacon node metadata.
@@ -316,11 +323,11 @@ export class BeaconNode {
       if (this.metricsServer) await this.metricsServer.stop();
       if (this.monitoring) this.monitoring.stop();
       if (this.restApi) await this.restApi.close();
-
       await this.chain.persistToDisk();
       await this.chain.close();
-      await this.db.stop();
       if (this.controller) this.controller.abort();
+      await sleep(DELAY_BEFORE_CLOSING_DB_MS);
+      await this.db.stop();
       this.status = BeaconNodeStatus.closed;
     }
   }
diff --git a/packages/beacon-node/src/util/clock.ts b/packages/beacon-node/src/util/clock.ts
index b7741790ab33..2f19a5a8ca6b 100644
--- a/packages/beacon-node/src/util/clock.ts
+++ b/packages/beacon-node/src/util/clock.ts
@@ -176,7 +176,7 @@ export class Clock extends EventEmitter implements IClock {
   private onNextSlot = (slot?: Slot): void => {
     const clockSlot = slot ?? getCurrentSlot(this.config, this.genesisTime);
     // process multiple clock slots in the case the main thread has been saturated for > SECONDS_PER_SLOT
-    while (this._currentSlot < clockSlot) {
+    while (this._currentSlot < clockSlot && !this.signal.aborted) {
       const previousSlot = this._currentSlot;
       this._currentSlot++;
 
@@ -189,8 +189,11 @@ export class Clock extends EventEmitter implements IClock {
         this.emit(ClockEvent.epoch, currentEpoch);
       }
     }
-    //recursively invoke onNextSlot
-    this.timeoutId = setTimeout(this.onNextSlot, this.msUntilNextSlot());
+
+    if (!this.signal.aborted) {
+      //recursively invoke onNextSlot
+      this.timeoutId = setTimeout(this.onNextSlot, this.msUntilNextSlot());
+    }
   };
 
   private msUntilNextSlot(): number {
diff --git a/packages/beacon-node/src/util/queue/errors.ts b/packages/beacon-node/src/util/queue/errors.ts
index d910f781a64c..edb0b3b87374 100644
--- a/packages/beacon-node/src/util/queue/errors.ts
+++ b/packages/beacon-node/src/util/queue/errors.ts
@@ -12,3 +12,7 @@ export class QueueError extends LodestarError<QueueErrorCodeType> {
     super(type);
   }
 }
+
+export function isQueueErrorAborted(e: unknown): e is QueueError {
+  return e instanceof QueueError && e.type.code === QueueErrorCode.QUEUE_ABORTED;
+}
diff --git a/packages/beacon-node/src/util/queue/index.ts b/packages/beacon-node/src/util/queue/index.ts
index 5a375c73d4f4..b55979b1f5ba 100644
--- a/packages/beacon-node/src/util/queue/index.ts
+++ b/packages/beacon-node/src/util/queue/index.ts
@@ -1,4 +1,4 @@
 export * from "./fnQueue.js";
 export * from "./itemQueue.js";
 export * from "./options.js";
-export {QueueError, QueueErrorCode} from "./errors.js";
+export {QueueError, QueueErrorCode, isQueueErrorAborted} from "./errors.js";
diff --git a/packages/cli/src/cmds/beacon/handler.ts b/packages/cli/src/cmds/beacon/handler.ts
index eedc5d3a334d..b2b0dd3fde4a 100644
--- a/packages/cli/src/cmds/beacon/handler.ts
+++ b/packages/cli/src/cmds/beacon/handler.ts
@@ -95,7 +95,22 @@ export async function beaconHandler(args: BeaconArgs & GlobalArgs): Promise<void
       abortController.abort();
     }, logger.info.bind(logger));
 
-    abortController.signal.addEventListener("abort", () => node.close(), {once: true});
+    abortController.signal.addEventListener(
+      "abort",
+      async () => {
+        try {
+          await node.close();
+          logger.debug("Beacon node closed");
+        } catch (e) {
+          logger.error("Error closing beacon node", {}, e as Error);
+          // Make sure db is always closed gracefully
+          await db.stop();
+          // Must explicitly exit process due to potential active handles
+          process.exit(1);
+        }
+      },
+      {once: true}
+    );
   } catch (e) {
     await db.stop();
 
diff --git a/packages/reqresp/src/ReqResp.ts b/packages/reqresp/src/ReqResp.ts
index 267003fa7e50..3fa9a43c3200 100644
--- a/packages/reqresp/src/ReqResp.ts
+++ b/packages/reqresp/src/ReqResp.ts
@@ -143,6 +143,7 @@ export class ReqResp {
   }
 
   async stop(): Promise<void> {
+    this.rateLimiter.stop();
     this.controller.abort();
   }
 
diff --git a/yarn.lock b/yarn.lock
index 0fe06c29c7a1..3bb4bfb1bdad 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -654,10 +654,10 @@
     "@chainsafe/as-sha256" "^0.4.1"
     "@chainsafe/persistent-merkle-tree" "^0.6.1"
 
-"@chainsafe/threads@^1.10.0":
-  version "1.10.0"
-  resolved "https://registry.npmjs.org/@chainsafe/threads/-/threads-1.10.0.tgz"
-  integrity sha512-1PRtW3s5welk2WUAMN0bjEGtQ3PSqLWAxlMTSeOYJ2NV+bgNgi8PsALX/xEiB/CHd8XG5gS2BlmYZ+Q3b4wR7Q==
+"@chainsafe/threads@^1.11.0":
+  version "1.11.0"
+  resolved "https://registry.yarnpkg.com/@chainsafe/threads/-/threads-1.11.0.tgz#4845f452d30901053991cf050696746a442a8933"
+  integrity sha512-l36K9eXqpE0PTnQThDBrxmkx0DX4UV2Qt0l9ASRHRbCUZW3SlSAS+b0//DfTQ2/OXeDVPuE7/72991lTOaKmdQ==
   dependencies:
     callsites "^3.1.0"
     debug "^4.2.0"
@@ -13472,7 +13472,7 @@ rfdc@^1.2.0, rfdc@^1.3.0:
 
 rimraf@^2.6.1:
   version "2.7.1"
-  resolved "https://registry.npmjs.org/rimraf/-/rimraf-2.7.1.tgz"
+  resolved "https://registry.yarnpkg.com/rimraf/-/rimraf-2.7.1.tgz#35797f13a7fdadc566142c29d4f07ccad483e3ec"
   integrity sha512-uWjbaKIK3T1OSVptzX7Nl6PvQ3qAGtKEtVRjRuazjfL3Bx5eI409VZSqgND+4UNnmzLVdPj9FqFJNPqBZFve4w==
   dependencies:
     glob "^7.1.3"