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This repository was archived by the owner on Jan 10, 2024. It is now read-only.
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Our lab uses tadpoles of the clawed frog _Xenopus laevis_ to study how appendgaes like tails and legs develop and regenerate, and how rare genetic mutations lead to infantile onset epilepsy in children.
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Our lab uses tadpoles of the clawed frog _Xenopus laevis_ to study how appendgaes like tails and legs develop and regenerate, and how rare genetic mutations lead to infantile onset epilepsy in children._Xenopus_ are an aquatic species that have been used to sudy how animals develop from a single cell to a complex organism. They are vertebrates and have four limbs (tetrapods), and their development uses many of the same genes, mechanisms and processes as human development.
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image="images/frog skeleton.jpg"
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image="images/xenopus embryos stage 8 copy.jpg"
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link="research"
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title="Our Research"
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Our current work focusses on two main projects.
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***REGENERATION**: We are interested in how the tadpole tail, which contains spinal cord, notochord, muscles, nerves, blood vessels and fin is able to regenerate following partial amputation. Most recently we have been exploring the possibility that the skin microbiome of tadpoles influcences regenerative success.
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***DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY (DEE)**: Using CRISPR/Cas9 to mimic mutations that lead to early onset epileptic syndromes in children, we have been developing techniques to track and characterise tadpole behaviour, brain activity and drug responsiveness. i
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image="images/photo.jpg"
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image="images/greentads.jpg"
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link="projects"
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title="Our Projects"
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flip=true
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Our lab is based in the Parker Building of the [Department of Zoology](www.otago.ac.nz/zoology)
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