DESCRIPTION

Package: gdscIC50
Title: Pipeline for GDSC Curve Fitting
Version: 0.99.4
Authors@R: c(person("Howard", "Lightfoot", email = "hl7@sanger.ac.uk", role = c("aut", "cre")),
            person("Dieudonne", "van der Meer", email = "dvm@sanger.ac.uk", role = c("aut")),
            person("Daniel J.", "Vis", email = "d.vis@nki.nl", role = "aut"),
            person("Genome Research Limited", role = "cph"),
            person("The Netherlands Cancer Institute (NKI)", role = "cph")
            )
Description: Fits dose response curves for data from the Genomics of Drug 
             Sensitivity of Cancer (GDSC). The gdscIC50 package wrangles GDSC raw 
             data before fitting sigmoidal dose reponse curves using a non-linear
             mixed effects model. IC50 values and estimated along with the area 
             under the curve (AUC). The curve fitting code is based on that originally
             available as https://github.com/NKI-CCB/MixedIC50. The method is 
             published in Vis, D.J. et al. Pharmacogenomics 2016, 17(7):691-700
             https://www.ncbi.nlm.nih.gov/pubmed/27180993.
Depends:
    R (>= 3.0.0)
License: GPL-3 + file LICENSE
LazyData: true
Imports:
    dplyr,
    tidyr,
    ggplot2,
    nlme,
    caTools,
    lazyeval
RoxygenNote: 7.2.1
Suggests: knitr,
    rmarkdown,
    testthat,
    htmltools,
    pander,
    svglite
VignetteBuilder: knitr
Encoding: UTF-8