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99 | 99 | "dateAdded": "2024-07-17T19:52:25Z",
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100 | 100 | "dateModified": "2024-07-18T03:49:36Z"
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101 | 101 | },
|
| 102 | + { |
| 103 | + "key": "I7G5VCZL", |
| 104 | + "version": 1997, |
| 105 | + "itemType": "preprint", |
| 106 | + "title": "Temporal Dynamics of Nucleus Accumbens Neurons in Male Mice During Reward Seeking", |
| 107 | + "creators": [ |
| 108 | + { |
| 109 | + "creatorType": "author", |
| 110 | + "firstName": "Terra A.", |
| 111 | + "lastName": "Schall" |
| 112 | + }, |
| 113 | + { |
| 114 | + "creatorType": "author", |
| 115 | + "firstName": "King-Lun", |
| 116 | + "lastName": "Li" |
| 117 | + }, |
| 118 | + { |
| 119 | + "creatorType": "author", |
| 120 | + "firstName": "Xiguang", |
| 121 | + "lastName": "Qi" |
| 122 | + }, |
| 123 | + { |
| 124 | + "creatorType": "author", |
| 125 | + "firstName": "Brian T.", |
| 126 | + "lastName": "Lee" |
| 127 | + }, |
| 128 | + { |
| 129 | + "creatorType": "author", |
| 130 | + "firstName": "William J.", |
| 131 | + "lastName": "Wright" |
| 132 | + }, |
| 133 | + { |
| 134 | + "creatorType": "author", |
| 135 | + "firstName": "Erin E.", |
| 136 | + "lastName": "Alpaugh" |
| 137 | + }, |
| 138 | + { |
| 139 | + "creatorType": "author", |
| 140 | + "firstName": "Rachel J.", |
| 141 | + "lastName": "Zhao" |
| 142 | + }, |
| 143 | + { |
| 144 | + "creatorType": "author", |
| 145 | + "firstName": "Jianwei", |
| 146 | + "lastName": "Liu" |
| 147 | + }, |
| 148 | + { |
| 149 | + "creatorType": "author", |
| 150 | + "firstName": "Qize", |
| 151 | + "lastName": "Li" |
| 152 | + }, |
| 153 | + { |
| 154 | + "creatorType": "author", |
| 155 | + "firstName": "Bo", |
| 156 | + "lastName": "Zeng" |
| 157 | + }, |
| 158 | + { |
| 159 | + "creatorType": "author", |
| 160 | + "firstName": "Lirong", |
| 161 | + "lastName": "Wang" |
| 162 | + }, |
| 163 | + { |
| 164 | + "creatorType": "author", |
| 165 | + "firstName": "Yanhua H.", |
| 166 | + "lastName": "Huang" |
| 167 | + }, |
| 168 | + { |
| 169 | + "creatorType": "author", |
| 170 | + "firstName": "Oliver M.", |
| 171 | + "lastName": "Schlüter" |
| 172 | + }, |
| 173 | + { |
| 174 | + "creatorType": "author", |
| 175 | + "firstName": "Eric J.", |
| 176 | + "lastName": "Nestler" |
| 177 | + }, |
| 178 | + { |
| 179 | + "creatorType": "author", |
| 180 | + "firstName": "Edward H.", |
| 181 | + "lastName": "Nieh" |
| 182 | + }, |
| 183 | + { |
| 184 | + "creatorType": "author", |
| 185 | + "firstName": "Yan", |
| 186 | + "lastName": "Dong" |
| 187 | + } |
| 188 | + ], |
| 189 | + "abstractNote": "The nucleus accumbens (NAc) regulates reward-motivated behavior, but the temporal dynamics of NAc neurons that enable “free-willed” animals to obtain rewards remain elusive. Here, we recorded Ca2+ activity from individual NAc neurons when mice performed self-paced lever-presses for sucrose. NAc neurons exhibited three temporally-sequenced clusters, defined by times at which they exhibited increased Ca2+ activity: approximately 0, -2.5 or -5 sec relative to the lever-pressing. Dopamine D1 receptor (D1)-expressing neurons and D2-neurons formed the majority of the -5-sec versus -2.5-sec clusters, respectively, while both neuronal subtypes were represented in the 0-sec cluster. We found that pre-press activity patterns of D1- or D2-neurons could predict subsequent lever-presses. Inhibiting D1-neurons at -5 sec or D2-neurons at -2.5 sec, but not at other timepoints, reduced sucrose-motivated lever-pressing. We propose that the time-specific activity of D1- and D2-neurons mediate key temporal features of the NAc through which reward motivation initiates reward-seeking behavior.", |
| 190 | + "genre": "", |
| 191 | + "repository": "bioRxiv", |
| 192 | + "archiveID": "", |
| 193 | + "place": "", |
| 194 | + "date": "2024-09-30", |
| 195 | + "series": "", |
| 196 | + "seriesNumber": "", |
| 197 | + "DOI": "10.1101/2024.09.27.615291", |
| 198 | + "citationKey": "", |
| 199 | + "url": "https://www.biorxiv.org/content/10.1101/2024.09.27.615291v1", |
| 200 | + "accessDate": "2024-10-11T20:04:07Z", |
| 201 | + "archive": "", |
| 202 | + "archiveLocation": "", |
| 203 | + "shortTitle": "", |
| 204 | + "language": "en", |
| 205 | + "libraryCatalog": "bioRxiv", |
| 206 | + "callNumber": "", |
| 207 | + "rights": "© 2024, Posted by Cold Spring Harbor Laboratory. The copyright holder for this pre-print is the author. All rights reserved. The material may not be redistributed, re-used or adapted without the author's permission.", |
| 208 | + "extra": "Pages: 2024.09.27.615291\nSection: New Results", |
| 209 | + "tags": [ |
| 210 | + { |
| 211 | + "tag": "Miniscope V3" |
| 212 | + }, |
| 213 | + { |
| 214 | + "tag": "Preprint" |
| 215 | + }, |
| 216 | + { |
| 217 | + "tag": "Wire-Free" |
| 218 | + } |
| 219 | + ], |
| 220 | + "collections": [ |
| 221 | + "KRCY8EJ7" |
| 222 | + ], |
| 223 | + "relations": {}, |
| 224 | + "dateAdded": "2024-10-11T20:04:07Z", |
| 225 | + "dateModified": "2024-10-11T20:04:49Z" |
| 226 | + }, |
102 | 227 | {
|
103 | 228 | "key": "KTXISN43",
|
104 | 229 | "version": 1967,
|
|
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